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Hemoglobin
international journal for hemoglobin research
Volume 40, 2016 - Issue 2
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Original Article

A New Intergenic α-Globin Deletion (ααΔ125) Found in a Kabyle Population

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Pages 108-112 | Received 13 Oct 2015, Accepted 25 Nov 2015, Published online: 25 Feb 2016

References

  • Higgs, DR. The molecular basis of α-thalassemia. Cold Spring Harb Perspect Med. 2013;3(1):a011718. doi: 10.1101/cshperspect.a011718
  • Liebhaber SA, Goossens M, Kan YW. Homology and concerted evolution at the α1 and α2 loci of human α-globin. Nature. 1981;290(5801):26–29
  • Liebhaber SA, Cash FE, Ballas SK. Human α-globin gene expression. The dominant role of the α2-locus in mRNA and protein synthesis. J Biol Chem. 1986;261(32):15327–15333
  • Harteveld CL, Higgs DR. α-Thalassaemia. Orphanet J Rare Dis. 2010;5:13. doi: 10.1186/1750-1172-5-13
  • Foulon K, Rochette J, Cadet E. A novel β-thalassemic allele due to a two nucleotide deletion: β76 (GC). Hemoglobin. 2007;31(1):31–37
  • Dode C, Rochette J, Krishnamoorthy R. Locus assignment of human α globin mutations by selective amplification and direct sequencing. Br J Haematol. 1990;76(2):275–281
  • Chong SS, Boehm CD, Higgs DR, Cutting GR. Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia. Blood. 2000;95(1):360–362
  • Liu YT, Old JM, Miles K, et al. Rapid detection of α-thalassaemia deletions and α-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol. 2000;108(2):295–299
  • Funnell AP, Vernimmen D, Lim WF, et al. Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells. BMC Mol Biol. 2014;15:8. doi: 10.1186/1471-2199-15-8
  • Hess JF, Schmid CW, Shen CK. A gradient of sequence divergence in the human adult α-globin duplication units. Science. 1984;226(4670):67–70
  • Higgs DR, Hill AV, Bowden DK, et al. Independent recombination events between the duplicated human α globin genes; implications for their concerted evolution. Nucleic Acids Res. 1984;12(18):6965–6977
  • Poodt J, Martens HA, Walsh IB, et al. A newly identified deletion of 970 bp at the α-globin locus that removes the promoter region of the α1 gene. Hemoglobin. 2006;30(4):471–477
  • Rugless MJ, Fisher CA, Old JM, et al. A large deletion in the human α-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype. Hum Mol Genet. 2008;17(19):3084–3093
  • Nakatsuji T, Landman H, Huisman THJ. An elongated segment of DNA observed between two human α globin genes. Hum Genet. 1986;74(4):368–371
  • Fadhlaoui-Zid K, Haber M, Martinez-Cruz B, et al. Genome-wide and paternal diversity reveal a recent origin of human populations in North Africa. PLoS One. 2013;8(11):e80293. doi: 10.1371/journal.pone.0080293

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