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Hemoglobin
international journal for hemoglobin research
Volume 14, 1990 - Issue 3
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Original Article

International Hemoglobin Information Center

Pages 249-325 | Published online: 07 Jul 2009

References

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  • Yang K., Chen S., Jia P., Ma Y., Wu S., Liang C., Chen X., Zhang M., Tu Z., Gong S. Hemoglobin Jinan [β139 (H17) Asn→Asp), a new abnormal hemoglobin found in China. Hemoglobin, in press
  • Salkie M. L., Gordon P. A., Rigal W. M., Lam H., Wilson J. B., Headlee M. E., Huisman T. H.J. Hb A2-Canada or α2→2 99 (G1) Asp→Asn, a newly discovered delta chain variant with increased oxygen affinity occurring in cis to β-thalassemia. Hemoglobin 1982; 6: 223–231
  • Juricic D., Crepinko I., Efremov G. D., Lam H., Webber B. B., Headlee M. G., Huisman T. H.J. Hb A2 Zagreb or α2→2 125 (H3) Gln→Glu in association with →β-thalassemia in a Yugoslavian female. Hemoglobin 1983; 7: 443–448
  • Nakatsuji T., Webber B., Lam H., Wilson J. B., Huisman T. H.J., Sciarratta G. V., Sansone G., Molaro G. L. A new γ chain variant: Hb F-Pordenone [γ6 (A3) Glu→Gln: 75 Ile: 136 Ala]. Hemoglobin 1982; 6: 397–401
  • Nakatsuji T., Headlee M., Lam H., Wilson J. B., Huisman T. H.J. Hb F-Bonaire-Ga or α2Aβ2 39 (C5) Gln→Arg, characterized by high pressure liquid chromatographic and microsequencing procedures. Hemoglobin 1982; 6: 599–606
  • Honig G. R., Koshy M., Schroeder W. A., Shelton J. B., Shelton J. R. Hemoglobin F Lodz (GγI 44 Ser→Arg) a newly identified variant from an American infant of Polish descent. Biochim. Biophys. Acta 1982; 707: 213–216
  • Serjeant G. R., Serjeant B. E., Lehmann H., Dukes M., Robb L. Hb F Kingston [Gγ 55 (D6) Met→Arg). FEBS Lett. 1982; 150: 77–80
  • Nakatsuji T., Lam H., Huisman T. H.J. Hb F-Kennestone or α2Gγ2 (EF1) 77 His→Arg observed in a Caucasian baby. Hemoglobin 1983; 7: 267–270
  • Nakatsuji T., Lam H., Carver J, Huisman T. H.J. Hb F-Marietta or GγI 80 [EF4] Asp→Asn, observed in a Caucasian baby. Hemoglobin 1982; 6: 407–411
  • Nakatsuji T., Lam H., Wilson J. B., Webber B. B., Huisman T. H.J. Hb F-Columbus-Ga or α2Gγ2 94 (FG1) Asp→Asn. Hemoglobin 1982; 6: 593–598
  • Shelton J. B., Shelton J. R., Espinueva Z., Huynh V., Schroeder W. A., Powars D. Hemoglobin F-Caltech: Al2Gγ2 120 Lys→Gln. Hemoglobin 1982; 6: 577–592
  • Care A., Marinucci M., Massa A., Maffi D, Sposi N. M., Improta T., Tentori L. Hb F-Siena [α2AγT2 121 (GH4) Gly→Lys]. A new fetal hemoglobin variant. Hemoglobin 1983; 7: 79–83
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  • Wong S. C., Ali M. A.M., Pond J. R., Rubin S. M., Johnson S. E.N., Wilson J. B., Huisman T. HJ. Hb J-Singa (α-78 Asn→Asp), a newly discovered hemoglobin variant with the same amino acid substitution as one of the two present in Hb J-Singapore (α-78 Asn→Asp, α-79 Ala→Gly). Biochim. Biophys. Acta 1984; 784: 187–188
  • Sciarratta G. V., Ivaldi G., Parodi M. I., Sansone G., Molaro G. L., Salkie M. L., Wilson J. B., Reese A. L., Huisman T. H.J. The characterization of Hemoglobin Manitoba or α2 102 (G9) Ser→Arg β2 and Hemoglobin Contaldo or α2 103 (G10) His→Arg β2 by high performance liquid chromatography. Hemoglobin 1984; 8: 169–181
  • Cai Y-L., Wang H-B., Yang X-Y., Liu Z-H., Ao Z-F., Gong D-H., Ma J-P., Wang M-J., Ma D-R., Xu Y-Q., Chen E-H. A new fast-moving hemoglobin variant, Hb J Luhe β8 (A5) Lys→Gln. Chinese Hematol. J. 1982; 3: 263–265
  • Wong S. C., All M. A.M., Lam H., Webber B. B., Wilson J. B., Huisman T. H.J. Hemoglobin Hamilton or α2β2 11 (A8) Val→Ile, a silent β-chain variant detected by Triton X-100 acid-urea polyacrylamide gel electrophoresis. Am. J. Hematol. 1984; 16: 47–52
  • Williamson D., Brennan S. O., Muir H., Carrell R. W. Hemoglobin Collingwood β60 (E4) Val→Ala -a new unstable hemoglobin. Hemoglobin 1983; 7: 511–519
  • Jen P. C., Chen L. C., Chen P. F., Wong Y., Chen L. F., Guo Y. Y., Chang F. Q., Chow Y. C., Chiu Y. Hemoglobin Quin-Hai, β78 (EF2) Leu→Arg, a new abnormal hemoglobin found in Guangdong, China. Hemoglobin 1983; 7: 407–412
  • Hedlund B., Paine S., Smith C. M., II, Raines J., Morrison W. T., Adams J., III. Hemoglobin Minneapolis-Laos [β-118 (GH1) Phe→Tyr] a new hemoglobin variant with normal functional properties. Hemoglobin 1984; 8: 75–78
  • Brennan S. O., Williamson D., Smith M. B., Cauchi M. N., Macphee A., Carrell R. W. Hb A2 Victoria →24 (β6) Gly→Asp, a new → chain variant occurring with β-thalassemia. Hemoglobin 1984; 8: 163–168
  • Garcia C. R., Navarro J. L., Lam H., Webber B. B., Headlee M. G., Wilson J. B., Huisman T. H.J. Hb α2-Manzanaresor α2→2 121 (GH4) Glu→Val, an unstable → chain variant observed in a Spanish family. Hemoglobin 1983; 7: 435–442
  • Nakatsuji T., Lam H., Huisman T. H.J. Hb F-Calluna or α2γ2 (12 Thr→Arg; 75 Ile; 136 Ala) in a Caucasian baby. Hemoglobin 1983; 7: 563–566
  • Zeng Y. T., Huang S. Z., Nakatsuji T., Huisman T. H.J. -GγAγ-Thalassemia and γ-chain variants in Chinese newborn babies. Am. J. Hematol. 1985; 18: 235–242
  • Nakatsuji T., Shimizu K., Huisman T. H.J. Hb F-La Grange or α2γ2 101 (G3) Glu→Lys; 75 Ile; 136 Gly; a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn. Biochim. Biophys. Acta 1984; 789: 224–228
  • Blouquit Y., Thillet J., Beuzard Y., Vernant J. P., Dreyfus B. Structural and functional studies of Hemoglobin J Calabria: β64 (E8) Gly→Asp. Biochim. Biophys. Acta 1977; 492: 426–432
  • Moo-Penn W. F., Baine R. M., Jue D. L., Johnson M. H., McGuffey J. E., Benson J. M. Hemoglobin Evanston: α14 (A12) Trp→Arg, a variant hemoglobin associated with α-thalassemia-2. Biochim. Biophys. Acta 1983; 747: 65–70
  • Wada Y., Hayashi A., Masanori I., Katakuse T., Ichihara H., Nakabushi T., Matsuo T., Sakurai T., Matsuda H. Characterization of a new fetal hemoglobin variant, Hb F-Izumi Aγ6 Glu→Gly, by molecular secondary ion mass spectrometry. Biochim. Biophys. Acta 1983; 749: 244
  • Rochette J., Poyart C., Varet B., Wajcman H. A new hemoglobin variant altering the α1β2 contact: Hb Chemilly α2β2 99 (G1) Asp→Val. FEBS Lett. 1984; 166: 8–12
  • Rochette J., Varet B., Boissel J. P., Clough K., Labie D., Wajcman H., Bohn B., Magne P., Poyart C. Structure and function of Hb Saint-Jacques (α2β2 140 (H18) Ala→Thr): A new high oxygen-affinity variant with altered bisphosphoglycerate binding. Biochim. Biophys. Acta 1984; 785: 14–21
  • Harano T., Harano K., Shibata S., Ueda S., Mori H., Seki M. Hemoglobin Aichi [α50 (CE8) His→Arg]: A new slightly unstable hemoglobin variant discovered in Japan. FEBS Lett. 1984; 169: 297–299
  • Chih-Chuan L., Fei X., Kegong Y., Song-Sen C., Peichen J., Maoqi Z., Zhiheng Z. Hemoglobin GuiZhou or α2 77 (EF6) PRO→ARG β2, a new slow-moving hemoglobin variant observed in China. Hemoglobin 1984; 2: 387–390
  • Zeng Y-T., Huang S-Z., Qiu X-K., Cheng G-C., Ren Z-R., Jin Q-C., Chen C-Y., Jiao C-T., Tang Z-G., Liu R-H., Bao X-H., Zeng L-Z., Duan Y-Q., Zhang G-Y. Hemoglobin Chongqing (α2 (NA2) Leu→Arg) and Hemoglobin Harbin (α16 (A14) Lys→Met) found in China. Hemoglobin 1984; 8: 569–581
  • Houjun L., Dexiang L., Zhiguo L., Ping L., Ly L., Ji C., Shaozhi H. Anew fast-moving hemoglobin variant, Hb J-Tashikuergan α19 (AB1) Ala→Glu. Hemoglobin 1984; 8: 391–395
  • Jeppsson J. O., Kallman L., Lindgren G., Fagerstam L. G. Hb Linkoping (β36 Pro→Thr): a new hemoglobin mutant characterized by reversed-phase high performance liquid chromatography. J. Chromatog. 1984; 297: 31–36
  • Blouquit Y., Delanoe-Garin J., Lacombe C., Arous N., Cayre Y., Peduzzi J., Braconnier F., Galacteros F. Structural study of hemoglobin Hazebrouck, β38 (C4) Thr→Pro: A new abnormal hemoglobin with instability and low oxygen affinity (FEBS 1563). FEBS Lett. 1984; 172: 155–158
  • Rahbar S., Asmerom Y., Blume K. G. A silent hemoglobin variant detected by HPLC: Hemoglobin City of Hope β69 (E13) GLY→SER. Hemoglobin 1984; 8: 333–342
  • Williamson D., Brennan S. O., Strosberg H., Whitty J., Carell R. W. Hemoglobin A2 Fitzroy →142 ALA→ASP: A new Delta-Chain variant. Hemoglobin 1984; 8: 325–332
  • Moo-Penn W. F., Johnson M. H., McGuffey J. E., Jue D. L. Hemoglobin Shelby [β131 (H9) GLN→LYS]: A correction to the structure of Hemoglobin Deaconess and Hemoglobin Leslie. Hemoglobin 1984; 8: 583–593
  • Harano K., Harano T., Shibata S., Ueda S., Mori H., Seki M. Hb Okazaki β93 (F8) Cys→Arg], a new hemoglobin variant with increased oxygen affinity and instability. FEBS Lett. 1984; 173: 45–47
  • Jones R. T., Head C., Shih M. F.-C., Shih D. T.-B., Dana B., Jones M. B., Koler R. D. Hemoglobin Linkoping [β36 (C2) Pro→Thr] in a large Finnish family from Astoria, Oregon, USA. Hemoglobin 1986; 10: 455–467
  • Jones R. T., Barwick R. C., Head C. G., Shih F. C., Shih T. B. Hemoglobin Long Island. Abstract #151, 20th Congress of International Society of Haematology, Buenos AiresArgentina, 1984
  • Delano J., North M. L., Arous N., Bardakdjian J., Pflumio F., Brunagel M. L., Lacombe C., Poyart C., Galacteros F., Rosa J., Blouquit Y. Hb Saverne: a new variant having an elongated β chain. Blood 1984; 64: 56a, Suppl. 1
  • Wilson C. I.D., Cave R. J., Lehmann H., Close M., Imai K. Haemoglobin Warwickshire (β5 [A2] Pro→Arg): A possible ‘fine tuning’ of 2,3-DPG affinity by β5 Pro (FEBS 1918). FEBS. Lett. 1984; 176: 331–333
  • Guis M., Mentzer W. C., Jue D. L., Johnson M. H., McGuffey J. E., Moo-Penn W. F. Hemoglobin Twin Peaks α113 (GH1) Leu→His. Hemoglobin 1985; 9: 175–177
  • Chen S. S., Webber B. B., Wilson J. B., Huisman T. H.J. Hb Gainesville-GA or α2β2 46 (CD5) Gly→Arg. Hemoglobin 1985; 9: 179–181
  • Delanoe-Garin J., Arous N., Blouquit Y., Hafsia R., Bardakdjian J., Lacombe C., Rosa J., Galacteros F. Hemoglobin Kenitra α2β2 69 (E13) Gly→Arg. A new β variant of elevated expression associated with α-thalassemia, found in a Moroccan woman. Hemoglobin 1985; 9: 1–9
  • Devaraj R., Wilson J. B., Huisman T. H.J. Hb Regina or α2β2 96 (FG3) Leu→Val, a high oxygen affinity variant discovered by cation-exchange HPLC. Am. J. Hematoi 1985; 19: 195–200
  • Ohba Y., Imanaka M., Matsuoka M., Hattori Y., Miyaji T., Funaki C., Shibata K., Shimokata H., Kuzuya F., Miwa S. A new unstable, high oxygen affinity hemoglobin: Hb Nagoya or B97 (FG4) His→Pro. Hemoglobin 1985; 9: 11–24
  • Wilson J. B., Webber B. B., Huisman T. H.J. Annotation: Hb Leslie-rsthe same as Hb Shelby or α2β2 131 (H9) Gln→Lys. Hemoglobin 1984; 8: 595–596
  • Chen S. S., Wilson J. B., Webber B. B., Huisman T. H.J., Miwa S., Amenomori Y. Hb F-Tokyo or α2Gγ2 34 (β16) Val→Ile, a silent γ chain variant detected by reverse phase high performance liquid chromatography. Hemoglobin 1985; 9: 25–32
  • Chen S. S., Wilson J. B., Huisman T. H.J. Hb F-Pendergrass, and AγI variant with a Pro→Arg substitution at position γ36 (C2). Hemoglobin 1985; 9: 73–77
  • Al-Awamy B. H., Niazi G. A., Al-Mouzan M. L., Chen S. S., Wilson J. B., Webber B. B., Huisman T. H.J. Hb F-Damman or α2Aγ2 79 (EF3) Asp→Asn. Hemoglobin 1985; 9: 171–173
  • Blouquit Y., Lena-Russo D., Delanoe J., Arous N., Bardakdjian J., Lacombe C., Vovan L., Orsini A., Rosa J., Galacteros F. Hb Marseille α2β2 1 (A1) NH2-Met, 2 (A2) His→3 (A3) Pro: First variant having a N-terminal elongated B chain. Blood 1984; 64: 55a, Suppl. 1
  • Shimasaki S. A new hemoglobin variant. Hemoglobin Nunobiki [α141 (HC3) Arg→Cys]. Notable influence of the carboxy-terminal cysteine upon various physico-chemical characteristics of hemoglobin. J. Clin. Invest. 1985; 75: 695–701
  • Adams J. G., III, Morrison W. T., Pullen D. J., Abney R. L., III, Steinberg M. H. Hemoglobin Mississippi (MS): a new hemoglobin variant with three distinct electrophoretic mobilities. Clin. Res. 1985; 33: 603A
  • Merault G., Keclard L., Saint-Martin C., Jasmin K., Campier A., Delanoe-Garin J., Arous N., Fortune R., Theodore M., Seytor S., Rosa J., Blouquit Y., Galacteros F. Hemoglobin Roseau-Pointe → Pitre α2β2 90 (F6) Glu→Gly: a new hemoglobin variant with slight instability and low oxygen affinity. FEBS Lett. 1985; 184: 10–13
  • Como P. F., Hocking D., Trent R. J., Kronenberg H. Hb Geelong: β2139 (H17) Asn→Asp. A new hemoglobin with thalassemia-like characteristics. Presented as abstract at February meeting of N.S.W. Thalassemia Society. 1985
  • Barwick R. C., Jones R. T., Head C. G., Shih M. F-C., Prchal J. T., Shin D. T-B. Hb Long Island: A hemoglobin variant with a methionyl extension at the NH2 terminus and a prolyl substitution for the normal histidyl residue 2 of the β chain. Proc. Natl. Acad. Sci., USA 1985; 82: 4602–4605
  • Blouquit Y., Arous N., Lena D., Delanoe-Garin J., Lacombe C., Bardakdjian J., Vovan L., Orsini A., Rosa J., Galacteros F. Hb Marseille [α2β2 N methionyl-2 (NA2) His→Pro]: a new β chain variant having an extended N-terminus. FEBS Lett. 1984; 178: 315–318
  • Shelton J. B., Shelton J. R., Schroeder W. A., Powars D. R. Hb Aztec or α276 (EF5) Met→Thrβ2 detection of a silent mutant by high performance liquid chromatography. Hemoglobin 1985; 9: 325–332
  • Harano T., Harano K., Ueda S. Hb Owari [α121 (H4) Val→Met]: a new hemoglobin variant with a neutral-to-neutral amino acid substitution detected by isoelectric focusing. Hemoglobin 1986; 10: 127–134
  • Bowman J. E., Bloom R., Chen S-S., Webber B. B., Wilson J. B., Kutlar F., Kutlar A., Huisman T. H.J. Hb Chicago or α2 136 (H19) Leu→Met β2. Hemoglobin 1986; 10: 495–505
  • Rahbar S., Louis J., Lee T., Asmerom Y. Hemoglobin North Chicago (β36 [C2] Proline→Serine): A new high affinity hemoglobin. Hemoglobin 1985; 9: 559–576
  • Huisman T. H.J., Wilson J. B., Kutlar A., Yang K-G., Chen S-S., Webber B. B., Altay C., Martinez Villegas A. Hb J-Antakya or α2β2 65 (E9) Lys→Met in a Turkish family and HbComplutense or α2β2 127(H5)Gln→Glu in a Spanish family; correction of a previously published identification. Biochim. Biophys. Acta. 1986; 871: 229–231
  • Harano T., Harano K., Ueda S., Imai N., Kitazumi T. A new electrophoretically-silent hemoglobin variant: Hemoglobin Kofu or α2β2 84 (EF8) Thr→Ile. Hemoglobin 1986; 10: 417–420
  • Ohba Y., Miyaji T., Murakami M., Kadowaki S., Fujita T., Oimomi M., Hatanaka H., Ishikawa K., Baba S., Hitaka K., Imai K. Hb Himeji or β140 (H18) Ala→Asp, a slightly unstable hemoglobin with increased N-terminal glycation. Hemoglobin 1986; 10: 109–125
  • Harano K., Harano T., Ueda S., Ohkushi T., Imai K. A new hemoglobin variant, Hb Mito [β144 (HC1) Lys→Glu], with increased oxygen affinity. FEBS Lett. 1985; 192: 75–78
  • Ohba Y., Igarashi M., Tsukahara M., Nakashima M., Sanada C., Ami M., Arai Y., Miyaji T. Hb A Yokoshima, α2→2225 (β7) Gly→Asp, a new → chain variant found in a Japanese Family. Hemoglobin 1985; 9: 613–615
  • Fujita S., Ohta Y., Saito S., Kobayashi Y., Naritomi Y., Kawaguchi T., Imamura T., Wada Y., Hayashi A. Hemoglobin A2 Honai (α2→290 (F6) Glu→Val): A new delta chain variant. Hemoglobin 1985; 9: 597–607
  • Hu H., Ma M. Hb F-Urumqi GγI 22 (B4) Asp→Gly: a new fetal hemoglobin variant found in a Uygur baby. Hemoglobin 1986; 10: 15–20
  • Chen S-S., Webber B. B., Kutlar A., Wilson J. B., Huisman T. H.J. Hb F-Cobb or α2Aγ237 (C3) Trp-Gly. Hemoglobin 1985; 9: 617–619
  • Chen S-S., Wilson J. B., Webber B. B., Huisman T. H.J. Hb F-Beech Island or α2Aγ253 (D4) Ala-Asp. Hemoglobin. 1985; 9: 525–529
  • Boissel J-P., Kasper T. J., Shah S. C., Malone J. I., Bunn H. F. Amino-terminal processing of proteins: Hemoglobin South Florida, a variant with retention of initiator methionine and Nα-acetylatton. Proc. Natl. Acad. Sci., USA 1985; 82: 8448–8452
  • Barwick R. C., Head C. G., Shih M. F-C., Block S. H., Jones R. T. Hb T-Cambodia [Beta 26 (B8) Glu-Lys, Beta 121 (GH4) Glu-Gln]: a new doubly substituted beta globin variant found in a Cambodian family. Blood 1985; 66: 68a, Suppl. 1
  • Moo-Penn W. F., McGuffey J. E., Jue D. L., Johnson M. H., Schum T. Hemoglobin New Mexico: β100(G2) Pro→Arg. A variant hemoglobin associated with erythrocytosis (βBA 32356). Biochim. Biophys. Acta 1985; 832: 192–196
  • Lacombe C., Craescu C. T., Blouquit Y., Kister J., Poyart C., Delanoe-Garin J., Arous N., Bardakdjian J., Riou J., Rosa J., Schaeffer C., Galacteros F. Structural and functional studies of hemoglobin Poissy α2β2 56 (D7) Gly→Arg and 86 (F2) Ala→Pro. Eur. J. Biochem. 1985; 153: 655–662
  • Como P. F., Raven J. L., Wilkinson T., Kronenberg H. Comparison of the six hemoglobin variants occurring at the α6 (A4) position with particular reference to the α6 Asp→Gly substitution found in Perth, Western Australia. Haematology Society of Australia. PerthWestern Australia October, 1984
  • Chen S. S., Webber B. B., Wilson J. B., Huisman T. H.J. Hb F-Forest Park, a new Aγ variant with two amino acid substitutions, 75(E19)Ile-Thr and 73(E17)Asp-Asn, which can be identified in adults by gene-mapping analysis. Biochim. Biophys. Acta 1985; 832: 242–247
  • Wada Y., Fujita T., Kidoguchi K., Hayashi A. Fetal hemoglobin variants in 80,000 Japanese neonates: High prevalence of Hb F Yamaguchi (AγT80Asp→Asn). Hum. Genet. 1986; 72: 196–202
  • Monplaisir N., Merault G., Poyart C., Rhoda M. D., Craescu C. T., Vidaud M., Galacteros F., Blouquit Y., Rosa J. Hb S Antilles (α2β2 6 Glu-Val, 23 Val-Ileu): A new variant with lower solubility than Hb S and producing sickle cell disease in heterozygotes. Proc. Natl. Acad. Sci., USA 1986; 83: 9363–9367
  • Jones R. T., Head C., Shih M. F-C., Shih D. T-B., Dana B., Jones M. B., Koler R. D. Hemoglobin Linkoping [β36 (C2) Pro→Thr] in a large Finnish family from Astoria, Oregon, USA. Hemoglobin 1986; 10: 455–467
  • Ogata K., Ito T., Okazaki T., Dan K., Nomura T., Nozawa Y., Kajita A. Hemoglobin Sendagi (β42 Phe→Val): a new unstable hemoglobin variant having an amino acid substitution atCD1 of the β-chain. Hemoglobin 1986; 10: 469–481
  • Baiget M., Gomez Pereira C., Jue D. L., Johnson M. H., McGuffey J. E., Moo-Penn W. F. A case of Hemoglobin Indianapolis [β112(G14) Cys→Arg] in an individual from Cordoba, Spain. Hemoglobin 1986; 10: 483–494
  • DePablos J. M., Wilson J. B., Kutlar A., Chen S. S., Huisman T. H.J. Hb F-AlbaicinorGγ8 (AS) Lys→Glu or Gln. Hemoglobin 1986; 10: 655–659
  • Kutlar A., Kutlar F., Wilson J. B., Webber B. B., Gonzalez Redondo J. M., Huisman T. H.J. Hb F-Clarke or α2Gγ265 (E9) Lys→Asn. Hemoglobin 1987; 11: 185–188
  • Kleman K., Lubin B., Wilson J. B., Kutlar A., Webber B. B., Huisman T. H.J. HbF-Oakland or α2GγT226 (β8) Glu→Lys. Hemoglobin 1987; 11: 181–183
  • Indrak K., Wiedermann B. F., Batek F., Wilson J. B., Webber B. B., Kutlar A., Huisman T. H.J. Hb Olomouc or α2β286 (F2) Ala→Asp, a new high oxygen affinity variant. Hemoglobin 1987; 11: 151–155
  • Jen P. C., Liu Y. Hemoglobin Guangzhou, α64 (E13) Asp→-Gly, a new abnormal hemoglobin found in Guangzhou, China. Hemoglobin 1987; 11: 23–30
  • Zhou Z-q., Chen L-c., Chen P-f., Zhang K-q., Wang Y-h. Hemoglobin Hangzhou, α64(E13)Asp→Gly, a new variant found in China. Hemoglobin 1987; 11: 31–33
  • Ohba Y., Yamamoto K., Kawata R., Miyaji T. Hyperunstable Hemoglobin Toyama α2l36(H19) Leu→Arg β2 detection and identification by in vitro biosynthesis with radioactive amino acids. Hemoglobin 1987; 11: 539–556
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  • Como P. F., Hocking D., Trent R. A., Wilkinson T., Wylie B. R., Bruce D., Kronenberg H. 1986; 515, Hb Geelong (β139 Asn→Asp) and Hb Stanmore (β111 Val→Ala). Two new unstable haemoglobins which illustrate the problem of distinguishing a haemoglobin with a thalassaemic phenotype from one inherited along with beta-thalassemia in either cis or trans. Book of Abstracts XXI Congr. Internatl. Soc. Haematol. and XIX Congr. Internatl. Soc. Blood Transfusion
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  • Baklouti F., Giraud Y., Francina A., Richard G., Perier C., Geyssant A., Jaubert J., Brizard C., Delaunay J. Hemoglobin Grange-Blanche [β27(B9) Ala→Val], a new variant with normal expression and increased affinity for oxygen. FEBS Lett. 1987; 223: 59–62
  • Wada Y., Ikkala E., Imai K., Matsuo T., Matsuda H., Lehtinen M., Hayashi A., Lehmann H. Structure and function of a new hemoglobin variant, Hb Meilahti α2β236(C2)Pro→Thr), characterized by mass spectrometry. Acta Haematol. 1987; 78: 109–113
  • Zeng Y. T., Ren Z. R., Chen M. J., Zhao J. Q., Qiu X. K., Huang S. Z. A new unstable haemoglobin variant: Hb Shanghai [β131 (H9) Gln→Pro] found in China. Br. J. Haematol. 1987; 67: 221–223
  • Gilbert A. T., Fleming P. J., Sumner D. R., Hughes W. G., Ip F., Kwan Y. L., Holland R. A.B. Hemoglobin Randwick or β15(A12) Trp→Gly: A new unstable β-chain hemoglobin variant. Hemoglobin 1988; 12: 149–161
  • Mrad A., Blouquit Y., Lacombe C., Blibech R., Arous N., Bardakdjian J., Kastally R., Rosa J., Galacteros F. Hb Tunis: A new β chain variant α2β2 (H2) 124 Pro→Ser, identified by HPLC. Hemoglobin 1988; 12: 23–30
  • DePablos J. M., Kutlar A., Wilson J. B., Webber B. B., Hu H., Huisman T. H.J. HbD-Granada or α2β222 (β4) Glu→Val. Hemoglobin 1987; 11: 563–565
  • Baklouti F., Giraud Y., Francina A., Richard G., Favre-Gilly J., Delaunay J. Hemoglobin Pierre-Bénite [β90(F6) Glu→Asp], a new high affinity variant found in a French family. Hemoglobin 1988; 12: 171–177
  • Altay C., Gurgey A., Wilson J. B., Hu H., Webber B. B., Kutlar F., Huisman T. H.J. Hb F-Baskent or α2Aγ 128 (H6) Ala→Thr. Hemoglobin 1988; 12: 87–89
  • Malcorra-Azpiazu J. J., Balda-Aguirre M. I., Diaz-Chico J. C., Hu H., Wilson J. B., Webber B. B., Kutlar F., Kutlar A., Huisman T. H.J. Hb Las Palmasor α2β2 49 (CD8) Ser→Phe, a mildly unstable hemoglobin variant. Hemoglobin 1988; 12: 163–170
  • Baudin-Chich V., Wajcman H., Gombaud-Saintonge G., Arous N., Riou J., Briere J., Galacteros F. Hemoglobin Brest [β127 (H5) Gln→Lys] a new unstable human hemoglobin variant located at the α1 β1 interface with specific electrophoretic behavior. Hemoglobin 1988; 12: 179–188
  • Ali M. A.M., Pinkerton P., Chow S. W.S., Zaetz S. D., Wilson J. B., Webber B. B., Hu H., Kutlar A., Kutlar F., Huisman T. H.J. Some rare hemoglobin variants with altered oxygen affinity; Hb Linkoping [β36 (C2) Pro→Thr], Hb Caribbean [β91 (F7) Leu→Arg], and Hb Sunnybrook [β36 (C2) Pro→Arg]. Hemoglobin 1988; 12: 137–148
  • Jogessar V. B., Westermeyer K., Webber B. B., Wilson J. B., Hu H., Gonzalez-Redondo J. M., Kutlar A., Huisman T. H.J. Hb Natal or α2 (minus Tyr-Arg) β2, a high oxygen affinity a chain variant with a deleted carboxy-terminus resulting from a TAC→TAA (Tyr→terminating codon) mutation in codon α 140. Biochim. Biophys. Acta 1988; 951: 36–41
  • Harano T., Harano K., Imai N., Ueda S., Seki M. An electrophoretically silent hemoglobin variant, Hb Hekinan [α27(B8) Glu→Asp] found in a Japanese. Hemoglobin 1988; 12: 61–65
  • Malcorra-Azpiazu J. J., Balda-Aguirre M. I., Diaz-Chico J. C., Kutlar F., Kutlar A., Wilson J. B., Hu H., Huisman T. H.J. Hb Le Lamentin or α220 (B1) His→Gln β2 found in a Spanish family. Hemoglobin 1988; 12: 201–205
  • Wajcman H., Blouquit Y., Gombaud-Saintonge G., Riou J., Galacteros F. Hemoglobin Fontainebleau [α21 (B2) Ala→Pro], a new silent mutant hemoglobin. Hemoglobin 1989; 13: 421–428
  • Wacjman J., Gombaud-Saintonge G., Galacteros F., Martha M., Vertongen F. Hb Belliard (α56 (E5) Lys→Asn] a new fast-moving α chain variant found in a subject of Spanish origin. Hemoglobin 1989; 13: 157–162
  • Gonzalez-Redondo J. M., Wilson J. B., Kutlar A., Huisman T. H.J., Sicilia A., Romero C., Fernandes Fuertes I. Hb J-Pontoise or α263 (E12) Ala→Aspβ2 in four members of a Spanish family. Hemoglobin 1987; 11: 47–50
  • Bardakdjian-Michau J., Lacombe C., Blouquit Y., Craescu C. T., Galacteros F., Lena-Russo D., Orsini A., Vovan L. Hemoglobin N-Timone [α2β28 (A5) Lys→Glu]: A new fast-moving variant with normal stability and oxygen affinity. Hemoglobin 1989; 13: 743–747
  • Gilbert A. T., Fleming P. J., Sumner D. R., Hughes W. G., Holland R. A.B., Tibben E. A. Hemoglobin Windsor or β11 (A8) Val→Asp: A new unstable β-chain hemoglobin variant producing a hemolytic anemia. Hemoglobin 1989; 13: 437–453
  • Gonzalez-Redondo J. M., Stoming T. A., Kutlar F., Kutlar A., Hu H., Wilson J. B., Huisman T. H.J. Hb Monroe or α2β230 (β12) Arg→Thr, a variant associated with β-thalassemia due to a G→C substitution adjacent to the donor splice site of the first intron. Hemoglobin 1989; 13: 67–74
  • Honig G. R., Telfer M. C., Rosenblum B. B., Vida L. N. Hb Warsaw (β42 Phe→Val): An unstable hemoglobin with decreased oxygen affinity. I. Hematologic and clinical expression. Am. J. Hematol. 1989; 32: 36–41
  • Bernini L. F., Giordano P. C. Hemoglobin Tilburg: α2-β273 (E17) Asp→Gly. A new hemoglobin with reduced oxygen affinity. Biochim. Biophys. Acta 1988; 957: 281–285
  • Hidaka K., Iuchi I., Miyake K., Nakahara H., Iwakawa G. Hb Fukuyama [β77 (EF1) His→Tyr]: A new abnormal hemoglobin discovered in a Japanese. Hemoglobin 1988; 12: 391–394
  • Bardakdjian J., Kister J., Rhoda M. D., Marden M., Arous N., DeLeon J., North M. L., Lacombe C., Blouquit Y., Castracane C., Riou J., Rosa J., Galacteros F. Hb J-Cordoba [α2Aβ295 (FG2) Lys→Met] a new Hb variant found in Argentina. Hemoglobin 1988; 12: 1–11
  • Ohba Y., Imai K., Kumada I., Ohsawa A., Miyaji T. Hb Moriguchi or α2β297 (FG4) His→Tyr substitution at the α1-β2 interface. Hemoglobin 1989; 13: 367–376
  • Kobayashi Y., Fukumaki Y., Komatsu N., Ohba Y., Miyaji T., Miura Y. A novel globin structural mutant, Showa-Yakushiji (β110 Leu-Pro) causing a β-thalassemia phenotype. Blood 1987; 70: 1688–1691
  • Blanke S., Johnsen A., Wimberley P. D., Mortensen H. B. Hemoglobin Hafnia: α2 (β116 (G18) His→Gln)2; a new hemoglobin variant mistaken for glycated hemoglobin. Biochim. Biophys. Acta 1988; 955: 214–219
  • Keclard L., Campier A., Merault G., Auperin A., Riou J., Rosa J., Galacteros F. Hemoglobin Nevers [α2β2130 (H8) Tyr→Ser] a new silent variant found in France. Hemoglobin, in press
  • Villegas A., Martin G., Wilson J. B., Webber B. B., Hu H., Kutlar A., Kutlar F., Huisman T. H.J. Hb Extremadura or α2β2 133 (H11) Val→Leu, a mildly unstable hemoglobin in a Spanish female. Hemoglobin 1989; 13: 505–508
  • Moo-Penn W. F., Jue D. L., Johnson M. H., Olsen K. W., Shih D., Jones R. T., Lux S. E., Rodgers P., Arnone A. Hemoglobin Brockton [β138(H16) Ala→Pro]: An unstable variant near the C-terminus of the β-subunitswith normal oxygen-binding properties. Biochemistry 1988; 27: 7614–7619
  • Moo-Penn W. F., Johnson M. H., Jue D. L., Lonser R. Hemoglobin Hinsdale [β139(H17)Asn→Lys]: A variant in the central cavity showing reduced affinity for oxygen and 2,3-diphosphoglycerate. Hemoglobin 1989; 13: 455–464
  • de Pablos J. M., Clegg J. B. Hb F-Granada or α2Gγ222 (B4) Asp→Val: A new human fetal hemoglobin variant. Hemoglobin 1988; 12: 405–407
  • Kutlar A., Kutlar F., Wilson J. B., Webber B. B., Hu H., Huisman T. H.J. Hb F-Austell or α2Gγ240 (C6) Arg→Lys. Hemoglobin 1988; 12: 409–411
  • Hidaka K., Iuchi I., Nakahara H., Iwakawa C. Hb F-Fukuyama or AγT43 (CD2) Asp→Asn. Hemoglobin 1989; 13: 93–96
  • Blouquit Y., Bardakdjian J., Lena-Russo D., Arous N., Perrimond H., Orsini A., Rosa J., Galacteros F. Hemoglobin Bruxelles: α2β241 or 42 (C7 orCD1) Phe→deleted. Hemoglobin 1989; 13: 465–474
  • Moo-Penn W. F., Swan D C, Hine T. K., Baine R. M., Jue D. L., Benson J. M., Johnson M. H., Virshup D. M., Zinkham W. H. Hb Catonsville (glutamic acid inserted between Pro-37(C2)α and Thr-38(C3)α) -Nonallelic gene conversion in the globin system?. J. Biol. Chem. 1989; 264: 21454–21457
  • Kawata R., Ohba Y., Yamamoto K., Miyaji T., Makita R., Ohga K., Watanabe S., Miwa S. Hyperunstable Hemoglobin Koriyama Anti-Hb Gun Hill insertion of five residues in the β chain. Hemoglobin 1988; 12: 311–321
  • Delanoe-Garin J., Blouquit Y., Arous N., Kister J., Poyart C., North M. L., Bardakdjian J., Lacombe C., Rosa J., Galacteros F. Hemoglobin Saverne: A new variant with elongated β chains: Structural and functional properties. Hemoglobin 1988; 12: 337–352
  • Gale R. E., Blair N. E., Huehns E. R., Clegg J. B. Hb A-like sickle haemoglobin: Hb S-Providence. Br. J. Haematol. 1988; 70: 251–252
  • Langdown J. V., Williamson D., Knight C. B., Rubenstein D., Carrell R. W. Case Report-A new doubly substituted sickling haemoglobin: HbS-Oman. Br. J. Haematol. 1989; 71: 443–444
  • Brennan S. O., Williamson D., Symmans W. A., Carrell R. W. Two de novo mutations in one β globin chain: Hemoglobin Atlanta-Coventry, β75 Leu-Pro and β141 Leu→deleted. Hemoglobin 1986; 10: 225–237
  • Ahmad A., Naqvi S., Ehsanullah S., Zaidi Z. H. Abnormal hemoglobins11 = Hb (Karachi), an α chain abnormality at position 5 Ala→Pro. JPMA 1986; 36: 206–208
  • Codrington J. F., Codrington F. A., Wisse J. H., Wilson J. B., Webber B. B., Wong S. C., Huisman T. H.J. Hb Chad or α223 (β4) Glu→Lysβ2 observed in members of a Surinam family in association with α-thalassemia-2 and with HbS. Hemoglobin 1989; 13: 543–556
  • Bardakdjian-Michau J., Rosa J., Galacteros F., Lancelot M., Marquart F. X. Hb Reims [α223 (B4) Glu→Glyβ2]: A new α chain variant with slightly decreased stability. Hemoglobin 1989; 13: 733–735
  • Groff P., Galacteros F., Kalmes G., Blouquit Y., Wajcman H. Hb Luxembourg [α24(β5)Tyr→His]: A new unstable variant. Hemoglobin 1989; 13: 429–436
  • Ohba Y., Imai K., Uenaka R., Ami M., Fujisawa K., Itoh K., Hirakawa K., Miyaji T. Hb Miyano or α 41 (C6) Thr→Ser: A new high oxygen affinity α chain variant found in an erythremic blood donor. Hemoglobin 1989; 13: 637–647
  • Giordano P. C., Fodde R., Amons R., Ploem J. E., Bernini L. F. Hemoglobin J-Anatolia [α61 (E10) Lys→Thr]: Structural characterization and gene localization of a new a chain variant. Hemoglobin, in press.
  • Wilson J. B., Webber B. B., Kutlar A., Reese A. L., McKie V. C., Lutcher C. L., Felice A. E., Huisman T. H.J. Hb Evans or α262 (EII) Val→Met β2; an unstable hemoglobin causing a mild hemolytic anemia. Hemoglobin 1989; 13: 557–566
  • Baklouti F., Baudin-Chich V., Kister J., Marden M., Teyssier G., Poyart C., Delaunay J., Wajcman H. Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [α88 (F9) Ala→Ser]. Eur. J. Biochem. 1988; 177: 307–312
  • Wajcman H., Delaunay J., Francina A., Rosa J., Galacteros F. Hemoglobin Nouakchott [α114 (GH2) Pro→Leu]: A new hemoglobin variant displaying an unusual increase in hydrophobicity. Biochim. Biophys. Acta 1989; 998: 25–31
  • Harkness M., Harkness D. R., Kutlar F., Kutlar A., Wilson J. B., Webber B. B., Codrington J. F., Huisman T. H.J. Hb Sun Prairie or α2 130 (H 13) Ala→Proβ2, a new unstable variant occurring in low quantities. Hemoglobin, in press.
  • McDonald M. J., Michalski L. A., Turci S. M., Guillette R. A., Jue D. L., Johnson M. H., Moo-Penn W. F. Structural, functional, and subunit assembly properties of Hemoglobin Attleboro [α138 (H21) Ser→Pro], a variant possessing a site mutation at a critical C-terminai residue. Biochemistry 1990; 29: 173–178
  • Harano T., Harano K., Ueda S., Imai K., Ohkuma A., Koya Y., Takahashi H. Hb Fukuoka [β2 (NA2) His→Tyr]: A new abnormal hemoglobin with a substituted amino acid at the 2,3-diphosphoglycerate binding site. Hemoglobin, in press
  • Yang K. G., Kutlar F., George E., Wilson J. B., Kutlar A., Stoming T. A., Gonzalez-Redondo J. M., Huisman T. H.J. Molecular characterization of β-globin gene mutations in Malay patients with Hb E-β-thalassaemia and thalassaemia major. Br. J. Haematol. 1989; 72: 73–80
  • Vidaud M., Gattoni R., Stevenin J., Vidaud D., Amselem S., Chibani J., Rosa J., Goossens M. A 5′ splice-region G→C mutation in exon 1 of the human β-globin gene inhibits pre-mRNA splicing: A mechanism for β→-thalassemia. Proc. Natl. Acad. Sci., USA 1989; 86: 1041–1045
  • Li H. J., Zhao X. N., Li H. W., Liang K. X., Wang R. P., Chang T. T., Wilson J. B., Webber B. B., Huisman T. H.J. A new slow-moving hemoglobin variant Hb Tianshui or α2β239 (C5)Gln→Arg, observed in a Chinese family living in Gansu. Hemoglobin, in press
  • Honig G. R., Vida L. N., Rosenblum B. B., Perutz M. F., Fermi G. Hemoglobin Warsaw [PheB42(CD1)→Val], an unstable variant with decreased oxygen affinity -Characterization of its synthesis, functional properties, and structure. J. Biol. Chem. 1990; 265: 126–132
  • Wilson J. B., Webber B. B., Kutlar A., Huisman T. H.J. Hb Gainesville-GA or α2β246 (CD5) Gly→Arg; second report. Hemoglobin 1989; 13: 623–624
  • Sciarratta G. V., Ivaldi G. Hb Matera [β55 (D6) Met→Lys]: A new unstable hemoglobin variant in an Italian family. Hemoglobin, in press
  • Williamson D., Nutkins J., Rosthoj S., Brennan S. O., Carrell R. W. Characterization of Hb Aalborg, a new unstable hemoglobin variant, by fast atom bombardment mass spectrometry. Hemoglobin, in press
  • Dash S., Wilson J. B., Webber B. B., Kutlar A., Huisman T. H.J. Hb Chandigarh or α2β294 (FG1) Asp→Gly observed in an Indian family. Hemoglobin 1989; 13: 749–752
  • Jones R. T., Saointz H. I., Head C., Shih D. T.B., Fairbanks V. F. Hb Johnstown [β109 (G11) Val→Leu]: A new electrophoretically silent variant that causes erythrocytosis. Hemoglobin, in press
  • Wajcman H., Mrad A., Blouquit Y., Parmentier C., Riou J., Galacteros F. Hemoglobin Villejuif [β123 (H1) Thr→Ile]: A new variant found in coincidence with polycythemia vera. Am. J. Hematol. 1989; 32: 294–297
  • Harano T., Harano K., Ueda S., Imai K., Marubashi S. Hb Yamagata [β132 (H10) Lys→Asn]: A new abnormal hemoglobin in a Japanese family. Hemoglobin, in press.
  • Ulukutlu L., Ozsahin H., Wilson J. B., Webber B. B., Hu H., Kutlar A., Kutlar F., Huisman T. H.J. Hb Brockton [α2β2138 (H16) Ala→Pro] observed in a Turkish girl. Hemoglobin 1989; 13: 509–513
  • Martins M. C., Rosado L., Wilson J. B., Kutlar A., Hu H., Huisman T. H.J. Hb Himeji or α2β2 140 (H18) Ala→Asp in a Portuguese family. Hemoglobin 1989; 13: 411–415
  • Plaseska D., Li H-J., Wilson J. B., Kutlar F., Kutlar A., Huisman T. H.J., Kulpa J. Hb F-Brooklyn or α2Gγ266 (E10) Lys→-Gln. Hemoglobin, in press.
  • Priest J. R., Watterson J., Jones R. T., Faassen A. E., Hedlund B. E. Mutant fetal hemoglobin causing cyanosis in a newborn. Pediatrics 1989; 83: 734–736
  • Glader B. E. Hemoglobin FM-Fort Ripley: Another lesson from the neonate. Pediatrics 1989; 83: 792–793
  • Guang W., Ma M., Qian D. Hb F-Xin-Jin or GγT 119 (GH2) Gly→Arg: A new unstable fetal hemoglobin variant. Hemoglobin, in press.
  • Plaseska D., Kutlar F., Wilson J. B., Webber B. B., Zeng Y-T., Huisman T. H.J. Hb F-Jiangsu, the first γ chain variant with a valine→methionine substitution: α2Aγ2134 (H12) Val→Met. Hemoglobin, in press.
  • Harano T., Harano K., Doi K., Ueda S., Imai K., Ohba Y., Kutlar F., Huisman T. H.J. Hb F-Onoda or α2Gγ2 146 (HC3) His→Tyr, a newly discovered fetal hemoglobin variant in a Japanese newborn. Hemoglobin, in press.
  • Codrington J. F., Kutlar F., Harris H. F., Wilson J. B., Stoming T. A., Huisman T. H.J. Hb α2-Wrens or α2→298 (FG5) Val→Met, an unstable → chain variant identified by sequence analysis of amplified DNA. Biochim. Biophys. Acta 1989; 1009: 87–89
  • Wilson J. B., Webber B. B., Hu H., Kutlar A., Kutlar F., Codrington J. F., Prchal J. T., Hall K. M., de Pablos J. M., Rodriguez I., Huisman T. H.J. Hb Birmingham and Hb Galicia: two unstable β chain variants characterized by small deletions and insertions. Blood, in press.
  • Ohba Y., Ami M., Imai K., Komatsu K., Amatsu K. HbMasuda [β114 (G16) Leu→Met, 119 (GH2) Gly→Asp], a hemoglobin with two substitutions in the β chain. Hemoglobin. 1990; 13: 753–759

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