Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 23, 1999 - Issue 2
22
Views
3
CrossRef citations to date
0
Altmetric
Original Article

The β+-thalassemia mutation [IVS-II-5 (G→C)] creates an alternative splicing site in the second intervening sequence

&
Pages 171-176 | Received 31 Jul 1998, Accepted 09 Nov 1998, Published online: 05 Aug 2009

References

  • Orkin S. H., Kazazian H. H., Jr, Antonarakis S. E., Goff S. C., Boehm C. D., Sexton J. P., Waber P. G., Giardina P. J. V. Linkage of β thalassemia mutations and β‐globin gene polymorphisms with DNA polymorphisms in human β‐globin gene cluster. Nature 1982; 296: 627–631
  • Treisman R., Orkin S. H., Maniatis T. Specific transcription and RNA splicing defect in five cloned β thalassemia genes. Nature 1983; 302: 591–596
  • Metherall J. E., Collins F. S., Pan J., Weissman S. M., Forget B. G. β→ Thalassemia caused by a base substitution that creates an alternative splice acceptor site in an intron. EMBO J. 1986; 5: 2551–2557
  • Atweh G. F., Wong C., Reed R., Antonarakis S. E., Zhu D., Ghosh P. K., Maniatis T., Forget B. G., Kazazian H. H., Jr. A new mutation in 1VS‐1 of the human β globin gene fused to the human β thalassemia due to abnormal splicing. Blood 1987; 70: 147–151
  • Jiang N. H., Liang S., Su C., Nechtman J. F., Stoming T. A. A novel β‐thalassemia mutation ‘1VS‐II‐5 (G→C)’ in a Chinese family from Guangxi Province, P. R. China. Hemoglobin 1993; 17: 563–567
  • Jiang N. H., Liang S. The genotypes and phenotypes of β thalassemia in Guangxi province. Chinese Hematol. Childr. 1996; 1: 49–53
  • Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York 1989
  • Docherty K., Clark A. R. Transcription of exogenous genes in mammalian cells. Gene Transcription, B. D. Hames, S. J. Higgins. Oxford University Press, Oxford 1993; 69–103

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.