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Hemoglobin
international journal for hemoglobin research
Volume 23, 1999 - Issue 3
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Original Article

Compound Heterozygosity for β+-Thalassemia [-31 (A→G)] and a New Variant with Low Oxygen Affinity, Hb Sagami [β139(H17)Asn→Thr]

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Pages 267-271 | Received 17 Nov 1998, Accepted 18 Jan 1999, Published online: 07 Jul 2009

References

  • Nakanishi T., Miyazaki A., Kishikawa M., Shimizu A., Aoki Y., Kikuchi M. Hb Sagami [β139(H 17)Asn→Thr]: a new hemoglobin variant not detected by isoelectrofocusing and propanol test, was detected by electrospray ionization mass spectrometry. J. Mass Spectrom. 1998; 33: 565–569
  • Nakanishi T., Miyazaki A., Kishikawa M., Shimizu A., Aoki Y., Kikuchi M. Hb Peterborough [β111(G13)Val→Phe] in Japan; rapid identification by ESI/MS using proteolytic digests of oxidized globin. Hemoglobin 1998; 22: 23–35
  • Nakanishi T., Miyazaki A., Kishikawa M, Shimizu A., Kishida O., Sumi S., Tsubakio T., Imai K. A new hemoglobin variant found during Hb A1c measurement: Hb Hokusetsu[β52(D3)Asp→Gly]. Hemoglobin 1998; 22: 355–371
  • Orkin S. H., Kazazian H. H., Jr., Antonarakis S. E., Goff S. C., Boehm C D., Sexton J. P., Waber P. G., Giardina P. J.V. Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster. Nature 1982; 296: 627–631
  • Takihara Y., Nakamura T., Yamada H., Takagi Y., Fukumaki Y. A novel mutation in the TATA box in a Japanese patient with β+-thalassemia. Blood 1986; 67: 547–550
  • Imai K. Measurement of accurate equilibrium curves by an automatic oxygenation apparatus. Methods in Enzymology, E. Antonini, L. Rossi-Bernardi, E. Chiancone. Academic Press, Inc., New York NYUSA 1981; Vol. 76: 438–449
  • Moo-Penn W. F., Johnson M. H., Jue D. L., Lonser R. Hb Hinsdale [β139(H17) Asn→Lys]: a variant in the central cavity showing reduced affinity for oxygen and 2,3-diphosphoglycerate. Hemoglobin 1989; 13: 455–464
  • Harano T., Harano K., Xia G. X., Shishime T., Kono M., Imai K. Hb Geelong [β139(H17)Asn→Asp] found in a Japanese male. Hemoglobin 1997; 21: 377–383
  • Como P. F., Hocking D. R., Swinton G. W., Trent R. J., Holland R. A.B., Tibben E. A., Wilkinson T., Kronenberg H. Hb Geelong [β139(H17)Asn→Asp]. Hemoglobin 1991; 15: 85–95
  • Lafferty J., Ali M., Matthew K., Eng B., Patterson M., Waye J. S. Identification of a new high oxygen affinity hemoglobin variant: Hb Aurora [β 139(H 17)Asn→Tyr]. Hemoglobin 1995; 19: 335–341

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