Studies on in vitro and in vivo transdermal flux enhancement of methotrexate by a combinational approach in comparison to oral delivery

References

• Kim Y-C, Park J-H, Ludovice PJ, Prausnitz MR. (2008). Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol. Int J Pharm, 352:129–38.
   PubMed Web of Science ®Google Scholar
• Femenía-Font A, Balaguer-Fernández C, Merino V, López-Castellano A. (2006). Combination strategies for enhancing transdermal absorption of sumatriptan through skin. Int J Pharm, 323:125–30.
   PubMed Web of Science ®Google Scholar
• Prausnitz MR, Mitragotri S, Langer R. (2004). Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov, 3:115–24.
   PubMed Web of Science ®Google Scholar
• Cramer MP, Saks SR. (1994). Value of controlled release dosage forms. Pharmacoeconomics, 5:482–504.
   PubMed Web of Science ®Google Scholar
• Williams AC, Barry BW. (2004). Penetration enhancers. Adv Drug Deliv Rev, 56:603–18.
   PubMed Web of Science ®Google Scholar
• Friend D, Catz P, Heller J. (1989). Simple alkyl esters as skin penetration enhancers. J Control Release, 9:33–41.
   Web of Science ®Google Scholar
• Liu W, Hu M, Liu WS, Xue C, Xu H, Yang XL. (2008). Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate. Int J Pharm, 364:135–41.
   PubMed Web of Science ®Google Scholar
• Kalia YN, Naik A, Garrison J, Guy RH. (2004). Iontophoretic drug delivery. Adv Drug Deliv Rev, 56:619–58.
   PubMed Web of Science ®Google Scholar
• Li SK, Higuchi WI, Zhu H, Kern SE, Miller DJ, Hastings MS. (2003). In vitro and in vivo comparisons of constant resistance AC iontophoresis and DC iontophoresis. J Control Release, 91:327–43.
   PubMed Web of Science ®Google Scholar
• Prausnitz MR, Lau B, Milano C, Conner S, Langer R, Weaver J. (1993). A quantitative study of electroporation showing a plateau in net molecular transport. J Biophys, 65414–22.
   Google Scholar
• Mitragotri S, Blankschtein D, Langer R. (1995). Ultrasound-mediated transdermal protein delivery. Science, 269:850–3.
   PubMed Web of Science ®Google Scholar
• Kost J, Mitragotri S, Gabbay R, Pishko M, Langer R. (2000). Transdermal monitoring of glucose and other analytes using ultrasound. Nat Med, 6:347–50.
   PubMedGoogle Scholar
• Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, . (2001). Lack of pain associated with microfabricated microneedles. Anesth Analg, 92:502–4.
   PubMed Web of Science ®Google Scholar
• Anand Subramony J, Sharma A, Phipps JB. (2006). Microprocessor controlled transdermal drug delivery. Int J Pharm, 317:1–6.
   PubMedGoogle Scholar
• Yan G, Li SK, Higuchi WI. (2005). Evaluation of constant current alternating current iontophoresis for transdermal drug delivery. J Control Release, 110:141–50.
   PubMed Web of Science ®Google Scholar
• Tapper R. (1993) .Iontophoretic treatment system. US patent 5224927.
   Google Scholar
• Howard JP, Drake TR, Kellogg DL. (1995). Effects of alternating current iontophoresis on drug delivery. Arch Phys Med Rehabil, 76:463–6.
   PubMed Web of Science ®Google Scholar
• Stagni G, Shukla C. (2003). Pharmacokinetics of methotrexate in rabbit skin and plasma after iv-bolus and iontophoretic administrations. J Control Release, 93:283–92.
   PubMed Web of Science ®Google Scholar
• VanDooren-Greebe RJ, Kuijpers ALA, Mulder J, De Boo T, van der Kerhof PCM. (1994). Methotrexate revisited: Effects of long term treatment in psoriasis. Br J Dermatol, 130:204–10.
   PubMed Web of Science ®Google Scholar
• Falamarzian M, Varhosaz J. (1998). The effect of structural changes on swelling kinetics of polybasic/hydrophobic pH-sensitive hydrogels. Drug Dev Ind Pharm, 24:667–9.
   PubMed Web of Science ®Google Scholar
• Kim SW, Bae YH, Okano T. (1992). Hydrogels: Swelling, drug loading, and release. Pharm Res, 9:283–90.
   PubMed Web of Science ®Google Scholar
• Alvarez-Figueroa MJ, Blanco-Mendez J. (2001). Transdermal delivery of methotrexate: Iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int J Pharm, 215:57–65.
   PubMed Web of Science ®Google Scholar
• Alvarez-Figueroa MJ, Delgado-Charro MB, Blanco-Mendez J. (2001). Passive and iontophoretic transdermal penetration of methotrexate. Int J Pharm, 212:101–7.
   PubMed Web of Science ®Google Scholar
• Vaidyanathan R, Chaubal MG, Vasavada RC. (1985). Effect of pH and solubility on in vivo skin penetration of methotrexate from 50% (v/v) propylene glycol–water vehicle. Int J Pharm, 25:85–93.
   Web of Science ®Google Scholar
• Weintein GD, McCullough JL, Olsen E. (1989). Topical methotrexate therapy for psoriasis. Arch Dermatol, 125:227–30.
   PubMed Web of Science ®Google Scholar
• Hwang GC, Lin AY, Chen W, Sharpe RJ. (1995). Development and optimization of a methotrexate topical formulation. Drug Dev Ind Pharm, 21:1941–52.
   Web of Science ®Google Scholar
• Singh J, Singh S. (1995). Transdermal iontophoresis: Effect of penetration enhancer and iontophoresis on drug transport and surface characteristics of human epidermis. Curr Probl Dermatol, 22:179–83.
   PubMedGoogle Scholar
• Trotta M, Pattarino F, Gasco MR. (1996). Influence of counterions on the skin permeation of methotrexate from water–oil microemulsions. Pharm Acta Helv, 71:135–40.
   PubMedGoogle Scholar
• Chatterjee DJ, Li WY, Koda RT. (1997). Effect of vehicles and penetration enahncers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin. Pharm Res, 14:1058–65.
   PubMed Web of Science ®Google Scholar
• Lu G, Jun HW, Suh H. (1997). Percutaneous absorption and disposition studies of methotrexate in rabbits and rats. BioPharm Drug Dispos, 18:409–22.
   PubMed Web of Science ®Google Scholar
• Prasad R, Koul V, Anand S, Khar RK. (2007). Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: In vitro study. Int J Pharm, 333:70–8.
   PubMed Web of Science ®Google Scholar
• Pillai O, Panchagnula R. (2004). Transdermal iontophoresis of insulin. VI. Influence of pretreatment with fatty acids on permeation across rat skin. Skin Pharmacol Physiol, 17:289–97.
   PubMed Web of Science ®Google Scholar
• Ingram AJ, Grasso P. (1975). Patch testing in the rabbit using a modified human patch test method. Br J Dermatol, 109:191–8.
   Google Scholar
• Lashmar UT, Hadgraft J, Thomas N. (1989). Topical application of penetration enhancers to the skin of nude mice: A histopathological study. J Pharm Pharmacol, 41:118–21.
   PubMed Web of Science ®Google Scholar
• Peppas N, Ritger PL. (1987). A simple equation for description of solute release. II. Fickian and anomalous release from swellable device. J Control Release, 5:37–42.
   Google Scholar
• Pillai O, Panchagnula R. (2003). Transdermal iontophoresis of insulin. V. Effect of terpenes. J Control Release, 88:287–96.
   PubMed Web of Science ®Google Scholar
• Cullander C. (1992). What are the pathways of iontophoretic current flow through mammalian skin?. Adv Drug Deliv Rev, 9:119–35.
   Web of Science ®Google Scholar
• Denet AR, Vanbever R, Préat V. (2004). Skin electroporation for transdermal and topical delivery. Adv Drug Deliv Rev, 56:659–74.
   PubMed Web of Science ®Google Scholar
• Dujardin N, Staes E, Kalia Y, Clarys P, Guy R, Preat V. (2002). In vivo assessment of skin electroporation using square wave pulses. J Control Release, 79:219–27.
   PubMed Web of Science ®Google Scholar