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Drug Development and Industrial Pharmacy Volume 35, 2009 - Issue 11
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Original Article

Preparation and evaluation of N-caproyl chitosan nanoparticles surface modified with glycyrrhizin for hepatocyte targeting

AiHua Lin Pharmaceutics Laboratory of TCM, The Second Faculty of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR ChinaCorrespondence[email protected]
,
Jun Chen School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, PR China
,
YiMing Liu Pharmaceutics Laboratory of TCM, The Second Faculty of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China
,
Shigui Deng Pharmaceutics Laboratory of TCM, The Second Faculty of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China
,
Zhifeng Wu Pharmaceutics Laboratory of TCM, The Second Faculty of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China
,
Yu Huang Pharmaceutics Laboratory of TCM, The Second Faculty of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China
&
QiNeng Ping Department of Pharmaceutical Technology, Faculty of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, PR China
 show all
Pages 1348-1355 | Received 24 Sep 2008, Accepted 01 Apr 2009, Published online: 16 Oct 2009

References

  • Torchilin VP. (2005). Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate. Adv Drug Deliv Rev, 57:95–109.
  • Stayton PS, Hoffman AS, Murthy N, Lackey C, Cheung C, Tan P, . (2000). Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. J Control Release, 65:203–20.
  • Balthasar S, Michaelis K, Dinauer N, Von Briesen H, Kreuter J, Langer K. (2005). Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes. Biomaterials, 26:2723–32.
  • Aspden TJ, Mason JD, Jones NS, Lowe J, Skaugrud O, Illum L. (1997). Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers. J Pharm Sci, 4:509–13.
  • Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y. (2001). Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency. J Control Release, 70:399–421.
  • Aktaş Y, Andrieux K, Alonso MJ, Calvo P, Gürsoy RN, Couvreur P, . (2005). Preparation and in vitro evaluation of chitosan nanoparticles containing a caspase inhibitor. Int J Pharm, 298:378–83.
  • Chan P, Kurisawa M, Chung JE, Yang YY. (2007). Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials, 28:540–9.
  • Kim TH, Nah JW, Cho MH, Park TG, Cho CS. (2006). Receptor mediated gene delivery into antigen presenting cells using mannosylated chitosan/DNA nanoparticles. J Nanosci Nanotechnol, 6:2796–803.
  • Jiang H-L, Kwon J-T, Kim Y-K, Kim E-M, Arote R, Jeong H-J, . (2007). Galactosylated chitosan-graft-polyethylenimine as a gene carrier for hepatocyte targeting. Gene Ther, 14:1389–98.
  • Mao SJ, Hou SX, Zhang LK, Wei DP, Bi YQ. (2005). Uptake of albumin nanoparticle surface modified with glycyrrhizin by primary cultured rat hepatocytes. World J Gastroenterol, 28:3075–9.
  • Negishi M, Irie A, Nagata N, Ichikawa A. (1991). Specific binding of glycyrrhetinic acid to the rat liver membrane. Biochim Biophys Acta, 1066:77–82.
  • Ismair MG, Stanca C, Ha HR, Renner EL, Meier PJ, Kullak-Ublick GA. (2003). Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. Hepatol Res, 26:343–7.
  • Lin AH, Liu YM, Ping QN. (2007). Preparation and characterization of adriamycin-loaded chitosan nanoparticles surface-modified with glycyrrhizin. J China Pharm Uni, 38:507–11.
  • Lin AH, Liu YM, Ping QN. (2007). Studies of free amino groups on the surface of chitosan nanoparticles and its characteristics. Yao Xue Xue Bao, 42:323–8.
  • Lin AH, Liu YM, Huang Y, Sun JB, Wu ZF, Zhang X, . (2008). Glycyrrhizin surface-modified chitosan nanoparticles for hepatocyte-targeted delivery. Int J Pharm, 359:247–53.
  • Lee KY, Ha WS, Park WH. (1995). Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials, 16:1211–6.
  • Lee DW, Powers K, Baney R. (2004). Physicochemical properties and blood compatibility of acylated chitosan nanoparticles. Carbohyd polym, 58:371–7.
  • Tien CL, Lacroix M, Ispas-Szabo P, Mateescu M. (2003). N-acylated chitosan: Hydrophobic matrices for controlled drug release. J control Release, 93:1–13.
  • Gupta PK, Hung CT. (1989). Quantitative evaluation of targeted drug delivery systems. Int J Pharm, 56:217–26.
  • Nguyen LT, Ishida T, Ukitsu S, Li WH, Tachibana R, Kiwada H. (2003). Culture time-dependent gene expression in isolated primary cultured rat hepatocytes by transfection with the cationic liposomal vector TFL-3. Biol Pharm Bull, 26:880–5.
  • Remant Bahadur KC, Aryal S, Bhattarai SR, Bhattarai N, Kim CH, Kim HY. (2006). Stabilization of gold nanoparticles by hydrophobically-modified polycations. J Biomater Sci Polym Ed, 17:579–89.
  • López-León T, Carvalho ELS, Seijo B, Ortega-Vinuesa JL, Bastos-González D. (2005). Physicochemical characterization of chitosan nanoparticles: Electrokinetic and stability behavior. J Colloid Interface Sci, 283:344–51.
  • Fernàndez-Urrusuno R, Calvo P, C, Vila-Jato JL, Alonso MJ. (1999). Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharm Res, 16:1576–81.
  • Yu JJ, Lee HA, Kim JH, Kong WH, Kim Y, Cui ZY, . (2007). Bio-distribution and anti-tumor efficacy of PEG/PLA nanoparticles loaded doxorubicin. J Drug Target, 15:279–84.

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