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Original Article

Practical methods for improving flow properties of active pharmaceutical ingredients

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Pages 1460-1469 | Received 23 Jun 2008, Accepted 06 May 2009, Published online: 20 Nov 2009

References

  • Hancock BC, Carlson GT, Ladipo DD, Langdon BA, Mullarney MP. (2002). Comparison of the mechanical properties of the crystalline and amorphous forms of a drug substance. Int J Pharm, 241:73–85.
  • Kumar TM, Misra A. (2006). Formulation and evaluation of insulin dry powder for inhalation. Drug Dev Ind Pharm, 32:677–86.
  • Visser J. (1989). An invited review: Van der Waals and other cohesive forces affecting powder fluidization. Powder Technol, 58:1–10.
  • Hickey AJ, Concessio NM, VanOort MM, Platz RM. (1994). Factors influencing the dispersion of dry powders as aerosols. Pharm Tech, 18:58–64.
  • Podczeck F. (1998). Adhesion forces in interactive powder mixtures of a micronized drug and carrier particles of various particle size distributions. J Adhes Sci Technol, 12:1323–39.
  • Rasenack N, Steckel H, Muller BW. (2003). Micronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization process. J Pharm Sci, 92:35–44.
  • York P. (1994). Powdered raw materials: Characterizing batch uniformity. Respir Drug Deliv, 4:83–91.
  • Senjkovic R, Becirevic M, Usmiani I. (1992). Effect of fillers on the properties of paracetamol and acetylsalicylic-acid tablets prepared by direct compression. Pharm Ind, 54:555–7.
  • Calatayud JM, Garcia JV. (1993). Online solid-phase reactors for unsegmented continuous-flow drug analysis. Trends Anal Chem, 12:428–36.
  • Antikainen OK, Rantanen JT, Yliruusi JK. (2000). Use of the Kohonen self-organising map to predict the flowability of powders. STP Pharm Sci, 10:349–54.
  • Millan M, Caraballo I, Rabasco AM. (1998). The role of the drug/excipient particle size ratio in the percolation model for tablets. Pharm Res, 15:216–20.
  • Podczeck F. (1998). The relationship between physical properties of lactose monohydrate and the aerodynamic behaviour of adhered drug particles. Int J Pharm, 160:119–30.
  • Devilliers MM. (1995). Influence of cohesive properties of micronized drug powders on particle-size analysis. J Pharm Biomed Anal, 13:191–8.
  • Concessio NM, VanOort MM, Knowles MR, Hickey AJ. (1999). Pharmaceutical dry powder aerosols: Correlation of powder properties with dose delivery and implications for pharmacodynamic effect. Pharm Res, 16:828–34.
  • Ong JTH, Chowhan ZT, Samuels GJ. (1993). Drug-excipient interactions resulting from powder mixing. 6. Role of various surfactants. Int J Pharm, 96:231–42.
  • Podczeck F, Newton M, James MB. (1995). The assessment of particle friction of a drug substance and a drug carrier substance. J Mater Sci, 30:6083–89.
  • Sheskey PJ, Robb RT, Moore RD, Boyce BM. (1995). Effects of lubricant level, method of mixing, and duration of mixing on a controlled-release matrix tablet containing hydroxypropyl methylcellulose. Drug Dev Ind Pharm, 21:2151–65.
  • Wang LH, Chowhan ZT. (1990). Drug-excipient interactions resulting from powder mixing. 5. Role of sodium lauryl sulfate. Int J Pharm, 60:61–78.
  • Rizk S, Guyot JC, Duru C, Gaudy D. (1995). Influence of lubricant properties on compression behaviour and drug dissolution rate of scleroglucan hydrophilic matrix. Int J Pharm, 126:57–63.
  • Morris LE, Moore JC, Schwartz JB. (1996). Characterization and performance of a new direct compression excipient for chewable tablets: Xylitab(R). Drug Dev Ind Pharm, 22:925–32.
  • Turkoglu M, Ozarslan R, Sakr A. (1995). Artificial neural-network analysis of a direct compression tabletting study. Eur J Pharm Biopharm, 41:315–22.
  • York P. (1992). Crystal engineering and particle design for the powder compaction process. Drug Dev Ind Pharm, 18:677–721.
  • Wong ACY. (2000). Characterisation of the flowability of glass beads by bulk densities ratio. Chem Eng Sci, 55:3855–9.
  • Faqih A, Chaudhuri B, Alexander AWA, Muzzio FJ, Tomassone MS. (2006). Flow induced dilation of cohesive granular materials. AIChE, 52:4124–32.
  • Leuenberger G, Ludwig R, Apelian D. (2002). Modeling of conductivity versus density behavior in green-state powder metallurgy compacts. J Nondestruct Eval, 21:111–6.
  • Aly SAS. (2006). The resistance to compression index as a parameter to evaluate the efficacy of lubricants in pharmaceutical tabletting. J Drug Delivery Sci Technol, 16:151–5.
  • Pingali KC, Muzzio FJ, Shinbrot T. (2009). An observed correlation between flow and electrical properties of pharmaceutical blends. Powder Technol, 192:157–65.
  • Egermann H, Frank P. (1990). Novel approach to estimate quality of binary random powder mixtures: Samples of constant volume. II—Applications of equation to optimize tableting conditions. J Pharm Sci, 81:667–9.
  • Kornchankul W, Hamed E, Parikh N, Sakr A. (2002). Effect of the drug proportion and mixing time on the content uniformity of a low dose drug in a high shear mixer. Pharmazie, 57:49–53.
  • Otsuka M, Gao J, Matsuda Y. (1993). Effects of mixer and mixing time on the pharmaceutical properties of theophilline tablets containing various kinds of lactose as diluents. Drug Dev Ind Pharm, 19:333–48.
  • Carr RL. (1965). Evaluating flow properties of solids. Chem Eng, 72:163–8.
  • Lindberg NO, Palsson M, Pihl AC, Freeman R., Freeman T, Zetzener H, Enstad G. (2004). Flowability measurements of pharmaceutical powder mixtures with poor flow using five different techniques. Drug Dev Ind Pharm, 30:785–91.
  • Eilbeck J, Rowley G, Carter PA, Fletcher EJ. (2000). Effect of contamination of pharmaceutical equipment on powder triboelectrification. Int J Pharm, 195:7–11.
  • Nishiyama T, Yunoki K, Honda T, Yazawa H. (1998). Evaluation of the electrostatic properties of pharmaceutical powders during pneumatic conveying. Nippon Kagaku Kaishi, 201–6.
  • Rowley G. (2001). Quantifying electrostatic interactions in pharmaceutical solid systems. Int J Pharm, 227:47–55.
  • Michrafy A, Ringenbacher D, Tchoreloff P. (2002). Modelling the compaction behaviour of powders: Application to pharmaceutical powders. Powder Technol, 127:257–66.
  • Oyebola MT, Podczeck F, Barrett D. (2004). The influence of particle size and relative humidity of air on the shear properties of pharmaceutical powders. Eur J Pharm Sci, 23:S46.
  • Engers DA, Fricke MN, Storey RP, Newman AW, Morris KR. (2006). Triboelectrification of pharmaceutically relevant powders during low-shear tumble blending. J Electrstat, 12:826–35.
  • Watanabe H, Samimi A, Ding YL, Ghadiri M, Matsuyama T, Pitt KG. (2006). Measurement of charge transfer due to single particle impact. Part Part Syst Char, 23:133–7.
  • Alexander AA, Choudhuri B, Faqih AM, Muzzio FJ, Davies C, Tomassone MS. (2006). Avalanching flow of cohesive powders. Powder Technol, 164:13–21.

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