108
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Critical concentrations in the dilution of oral self-microemulsifying drug delivery systems

&
Pages 531-538 | Received 01 Apr 2009, Accepted 02 Sep 2009, Published online: 30 Oct 2009

References

  • Takagi T, Ramachandran Ch, Bermejo M, Yamashita S, Yu L, Amidon G. (2006). A provisional biopharmaceutical classification of top 200 oral drug products in the United States, Great Britain, Spain and Japan. Mol Pharm, 3(6):631–43.
  • Jannin V, Musakhanian J, Marchaud D. (2008). Approaches for the development of solid and semi-solid lipid-based formulations. Adv Drug Deliv Rev, 60:734–46.
  • Porter Ch, Trevaskis N, Charman W. (2007). Lipid and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov, 6(3):231–48.
  • Hong JY, Kim JK, Song YK, Park JS, Kim CK. (2006). A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption. J Control Release, 110:332–8.
  • Pouton CW. (2000). Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying, and self-microemulsifying drug delivery systems. Eur J Pharm Sci, 11(2):S93–8.
  • Pouton CW. (2006). Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci, 29:278–87.
  • Zhang P, Liu Y, Feng N, Xu J. (2008). Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm, 355:269–76.
  • Chen Y, Li G, Wu X, Chen Z, Hang J, Qin B, . (2008). Self-microemulsifying drug delivery system (SMEDDS) of Vinpocetine: Formulation development and in vitro assessment. Biol Pharm Bull, 31(1):118–25.
  • Patel AR, Vavia PR. (2007). Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J, 9(3):E344–52.
  • Perlman ME, Murdande SB, Gumkowski MJ, Shah TS, Rodricks CM, Thornton-Manning J, . (2008). Development of a self-microemulsifying formulation that reduces the food effect for torcetrapib. Int J Pharm, 351:15–22.
  • Woo JS, Song YK, Hong JY, Lim SJ, Kim CK. (2008). Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci, 33:159–65.
  • Gursoy R, Benita S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother, 58:173–82.
  • Gao P, Rush B, Pfund W, Huang T, Bauer J, Morozowich W, . (2003). Development of a supersaturable SEDDS (S‐SEDDS) formulation of paclitaxel with improved oral bioavailability. J Pharm Sci, 92(12):2386–98.
  • Kapitza SB, Michel B, van Hoogevest P, Leigh M, Imanidis G. (2007). Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model. Eur J Pharm Biopharm, 66:146–58.
  • O'Driscoll C. (2002). Lipid-based formulations for the intestinal lymphatic delivery. Eur J Pharm Sci, 15:405–15.
  • Dahan A, Hoffman A. (2005). Evaluation of chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophillic drugs. Eur J Pharm Sci, 24:381–8.
  • Kuentz M, Wyttenbach N, Kuhlmann O. (2007). Application of a statistical method to the absorption of a new model drug from micellar and lipid formulations—evaluation of qualitative excipient effects. Pharm Dev Technol, 12:275–83.
  • Porter Ch, Charman W. (2001). In vitro assessment of oral lipid based formulations. Adv Drug Deliv Rev, 50, S127–47.
  • Brogård M, Troedsson E, Thuresson K, Ljusberg-Wahren H. (2007). A new standardized lipolysis approach for the characterization of emulsions and dispersions. J Coll Interface Sci, 308:500–7.
  • Kossena GA, Charman W, Boyd BJ, Porter Ch. (2005). Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug. J Pharm Sci, 94(3):481–92.
  • Porter Ch, Kaukonen AM, Taillardat-Bertschinger A, Boyd BJ, O'Connor JM, Edwards GA, . (2004). Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Study with halofantrine. J Pharm Sci, 93(5):1110–21.
  • Sek L, Porter C, Kaukonen, Charman W. (2002). Evaluation of the in-vitro digestion profiles for long and medium chain triglycerides and the phase behaviour of the lipolytic products. J Pharm Pharmacol, 54:29–41.
  • Cuiné JF, Charman WN, Pouton C, Edwards G, Porter Ch. (2007). Increasing the proportional content of surfactants (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. Pharm Res, 24(4):748–57.
  • Fatouros DG, Nielsen FS, Douroumis D, Hdjileontiadis LJ, Müllertz A. (2008). In vitro–in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks. Eur J Pharm Biopharm, 69:887–98.
  • Ditner C, Bravo R, Imanidis G, Kuentz M. (2009). A systematic dilution study of self-microemulsifying drug delivery systems in artificial intestinal fluid using dynamic laser light backscattering. Drug Dev Ind Pharm, 35:199–208.
  • Pouton CW. (2005). Formulation of poorly water-soluble drugs for oral drug administration. Bull Tech Gattefossé, 39–51.
  • Lopez-Montilla JC, Herrera-Morales PE, Pandey S, Shah DO. (2002). Spontaneous emulsification: Mechanisms, physicochemical aspects, modeling, and applications. J Dispers Sci Technol, 23(1–3):219–68.
  • Sher H, Zallen R. (1970). Critical density in percolation processes. J Chem Phys, 53(9):3759–61.
  • Lagües M, Ober R, Taupin C. (1978). Study of structure and electrical conductivity in microemulsions: Evidence for percolation mechanism and phase inversion. J Phys Lett, 39(24):L487–91.
  • Alany RG, Tucker IG, Davies NM, Rades T. (2001). Characterisation of colloidal structures of pseudoternary phase diagrams formed by oil/water/amphiphile systems. Drug Dev Ind Pharm, 27(1):31–8.
  • Sager W, Eicke HF. (1991). The experimentalists’ kit to describe microemulsions. Colloid Surf, 57:343–53.
  • Chakraborty I, Moulik SP. (2005). Physicochemical studies on microemulsions 9. Conductance percolation of AOT-derived W/O microemulsion with aliphatic and aromatic hydrocarbon oils. J Coll Interface Sci, 289:530–41.
  • Fanun M. (2007). Conductivity, viscosity, NMR and diclofenac solubilisation capacity studies of mixed nonionic surfactants microemulsions. J Mol Liq, 135:5–13.
  • Lurie DJ, Mäder K. (2005). Monitoring drug delivery processes by EPR and related techniques—principles and applications. Adv Drug Deliv Rev, 57:1171–90.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.