Formulation and in vitro evaluation of self-emulsifying formulations of Cinnarizine

References

• Kommuru TR, Gurley B, Khan MA, Reddy IK. (2001). Self-emulsifying drug delivery systems (SEDDS) of Coenzyme Q10: Formulation development and bioavailability assessment. Int J Pharm, 212:233–246.
   PubMed Web of Science ®Google Scholar
• Gershanik T, Benita S. (2000). Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm, 50:179–188.
   PubMed Web of Science ®Google Scholar
• Gursoy RN, Benita S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother, 58:173–182.
   PubMed Web of Science ®Google Scholar
• Tang JL, Sun J, He ZG. (2007). Self-emulsifying drug delivery system: Strategy for improving oral delivery of poorly soluble drugs. Current Drug Therapy, 2:85–93.
   Google Scholar
• Pouton CW. (1997) Formulation of self- emulsifying drug delivery systems. Adv Drug Deliv Rev, 25:47–58.
   Web of Science ®Google Scholar
• Pouton CW. (2000). Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems. Eur J Pharm Sci, 11(Suppl 2):S93–S98.
   PubMed Web of Science ®Google Scholar
• Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko FJ, Pouton CW. (1992). Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res, 9:87–93.
   PubMed Web of Science ®Google Scholar
• Friman S, Bäckman L. (1996). A new microemulsion formulation of cyclosporin: Pharmacokinetic and clinical features. Clin Pharmacokinet, 30:181–193.
   PubMed Web of Science ®Google Scholar
• Pouton CW, Porter CJ. (2008). Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies. Adv Drug Deliv Rev, 60:625–637.
   PubMed Web of Science ®Google Scholar
• Buyukozturk F, Benneyan JC, Carrier RL. (2010). Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics. J Control Release, 142:22–30.
   PubMed Web of Science ®Google Scholar
• Hauss DJ. (2007). Oral lipid-based formulations. Adv Drug Deliv Rev, 59:667–676.
   PubMed Web of Science ®Google Scholar
• Machida Y, Inouye K, Tokumura T, Iwata M, Nagai T. (1989). Preparation and evaluation of intragastric buoyant preparations. Drug Des Deliv, 4:155–161.
   PubMedGoogle Scholar
• Parikh RK, Parikh DC, Delvadia RR, Patel SM. (2006). A Novel multi-compartment dissolution apparatus for evaluation of floating dosage form containing poorly soluble weakly basic drug. Dissolution Technologies, 13:14–19.
   Google Scholar
• Nielsen FS, Petersen KB, Müllertz A. (2008). Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state. Eur J Pharm Biopharm, 69:553–562.
   PubMed Web of Science ®Google Scholar
• Shen H, Zhong M. (2006). Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol, 58:1183–1191.
   PubMed Web of Science ®Google Scholar
• Shao B, Tang J, Ji H, Liu H, Liu Y, Zhu D et al. (2010). Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems. Drug Dev Ind Pharm, 36:1356–1363.
   PubMed Web of Science ®Google Scholar
• Wei JD, Ho HO, Chen CH, Ke WT, Chen ET, Sheu MT. (2010). Characterisation of fenofibrate dissolution delivered by a self-microemulsifying drug-delivery system. J Pharm Pharmacol, 62:1685–1696.
   PubMed Web of Science ®Google Scholar
• ABITEC (2007). Capmul PG-12, EP/NF. Available from http://www.abiteccorp.com/uploads/File/Capmul%20Tech%20Data/Capmul%20PG-12%20EP_NF%20TDS%20I5.pdf. Last accessed 17 November 2010.
   Google Scholar
• Li P, Ghosh A, Wagner RF, Krill S, Joshi YM, Serajuddin AT. (2005). Effect of combined use of non-ionic surfactant on formation of oil-in-water microemulsions. Int J Pharm, 288:27–34.
   PubMed Web of Science ®Google Scholar
• Bergström CA, Norinder U, Luthman K, Artursson P. (2002). Experimental and computational screening models for prediction of aqueous drug solubility. Pharm Res, 19:182–188.
   PubMed Web of Science ®Google Scholar
• Li A, Yalkowsky SH. (1994). Solubility of organic solutes in ethanol/water mixtures. J Pharm Sci, 83:1735–1740.
   PubMed Web of Science ®Google Scholar
• Spernath A, Aserin A. (2006). Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci, 128–130:47–64.
   PubMed Web of Science ®Google Scholar
• Bergström CA, Wassvik CM, Johansson K, Hubatsch I. (2007). Poorly soluble marketed drugs display solvation limited solubility. J Med Chem, 50:5858–5862.
   PubMed Web of Science ®Google Scholar
• Fagerberg JH, Tsinman O, Sun N, Tsinman K, Avdeef A, Bergström CAS. (2010). Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media. Mol Pharm, 7:1419–1430.
   PubMed Web of Science ®Google Scholar
• Gao ZG, Choi HG, Shin HJ, Park KM, Lim SJ, Hwang KJ, Kim CK. (1998). Physicochemical characterization and evaluation of a microemulsion system for oral delivery of Cyclosporin. A. Int J Pharm, 161:75–86.
   Web of Science ®Google Scholar
• Yamagata T, Kusuhara H, Morishita M, Takayama K, Benameur H, Sugiyama Y. (2007). Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release, 124:1–5.
   PubMed Web of Science ®Google Scholar
• Itoh K, Tozuka Y, Oguchi T, Yamamoto K. (2002). Improvement of physicochemical properties of N-4472 part I formulation design by using self-microemulsifying system. Int J Pharm, 238:153–160.
   PubMed Web of Science ®Google Scholar
• Rane SS, Anderson BD. (2008). What determines drug solubility in lipid vehicles: Is it predictable? Adv Drug Deliv Rev, 60:638–656.
   PubMed Web of Science ®Google Scholar
• Mukherjee T, Plakogiannis M. (2010). Development and oral bioavailability assessment of a supersaturated self-emulsifying drug delivery (SMEDDS) of albendazole. J Pharm Pharmacol, 62:1112–1119.
   PubMed Web of Science ®Google Scholar
• Devani M, Ashford M, Craig DQ. (2004). The emulsification and solubilisation properties of polyglycolysed oils in self-emulsifying formulations. J Pharm Pharmacol, 56:307–316.
   PubMed Web of Science ®Google Scholar
• Levy MY, Benita, S. (1990). Drug release from submicronized O/W emulsion: A novel in vitro kinetic evaluation model. Int J Pharm, 66:29–37.
   Web of Science ®Google Scholar
• Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI, Kim DD et al. (2009). Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm, 374:66–72.
   PubMed Web of Science ®Google Scholar
• Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G et al. (2004). Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm, 274:65–73.
   PubMed Web of Science ®Google Scholar