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Drug Development and Industrial Pharmacy Volume 38, 2012 - Issue 11
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Research Article

A comparative study of Vitamin E TPGS/HPMC supersaturated system and other solubilizer/polymer combinations to enhance the permeability of a poorly soluble drug through the skin

Indrajit Ghosh
&
Bozena Michniak-KohnErnest Mario School of Pharmacy, Rutgers-The State University of NJ, Piscataway, NJ, USACorrespondence[email protected]
Pages 1408-1416 | Received 07 Sep 2011, Accepted 20 Dec 2011, Published online: 01 Feb 2012

References

  • Guy RH. (1996). Current status and future prospects of transdermal drug delivery. Pharm Res, 13:1765–1769.
  • Barry BW. (1987). Mode of action of penetration enhancers in human skin. J Control Release, 6:85–97.
  • Davis AF, Hadgraft J. (1993). Supersaturated solutions as topical drug delivery systems. Pharmaceutical Skin Penetration Enhancement. Marcel Dekker Inc., New York, pp. 243–267.
  • Iervolino M, Raghavan SL, Hadgraft J. (2000). Membrane penetration enhancement of ibuprofen using supersaturation. Int J Pharm, 198:229–238.
  • Jonathan Hadgraft. (1999). Passive enhancement strategies in topical and transdermal drug delivery. International Journal of Pharmaceutics, 184:1–6.
  • Pellett MA, Davis AF, Hadgraft J. (1994). Effect of supersaturation on membrane transport: 2. Piroxicam. Int J Pharm, 111:1–6.
  • Davis AF, Hadgraft J. (1991). Effect of supersaturation on membrane transport: 1. Hydrocortisone acetate. Int J Pharm, 76:1–8.
  • Raghavan SL, Trividic A, Davis AF, Hadgraft J. (1999). Crystallization of hydrocortisone acetate: Influence of polymers. Int J Pharm, 193:231–237.
  • Raghavan SL, Trividic A, Davis AF, Hadgraft J. (2000). Effect of cellulose polymers on supersaturation and in vitro membrane transport of hydrocortisone acetate. Int J Pharm, 193:231–237.
  • Santos P, Machado M, Watkinson AC, Hadgraft J, Lane ME. (2009). The effect of drug concentration on solvent activity in silicone membranes. Int J Pharm, 377:70–75.
  • Schwarb FP, Imanidis G, Smith EW, Haigh JM, Surber C. (1999). Effect of concentration and degree of saturation of topical fluocinonide formulations on in vitro membrane transport and in vivo availability on human skin. Pharm Res, 16:909–915.
  • Repka MA, McGinity JW. (2000). Influence of vitamin E TPGS on the properties of hydrophilic films produced by hot-melt extrusion. Int J Pharm, 202:63–70.
  • Sheu MT, Chen SY, Chen LC, Ho HO. (2003). Influence of micelle solubilization by tocopheryl polyethylene glycol succinate (TPGS) on solubility enhancement and percutaneous penetration of estradiol. J Control Release, 88:355–368.
  • Thakur RA, Michniak BB, Meidan VM. (2007). Transdermal and buccal delivery of methylxanthines through human tissue in vitro. Drug Dev Ind Pharm, 33:513–521.
  • Ma X, Taw J, Chiang C. (1996). Control of drug crystallization in transdermal matrix system. International Journal of Pharmaceutics, 42:115–119.
  • Varma MV, Panchagnula R. (2005). Enhanced oral paclitaxel absorption with vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo. Eur J Pharm Sci, 25:445–453.
  • Rajebahadur M, Zia H, Nues A, Lee C. (2006). Mechanistic study of solubility enhancement of nifedipine using vitamin E TPGS or solutol HS-15. Drug Deliv, 13:201–206.
  • Yu L, Bridgers A, Polli J, Vickers A, Long S, Roy A et al. (1999). Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability. Pharm Res, 16:1812–1817.
  • Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH. (2008). Effect of propylene glycol on ibuprofen absorption into human skin in vivo. J Pharm Sci, 97:185–197.

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