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Research Article

Automated actuation of nasal spray products: effect of hand-related variability on the in vitro performance of Flonase nasal spray

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Pages 711-718 | Received 24 Aug 2012, Accepted 10 Feb 2013, Published online: 17 Apr 2013

References

  • Dayal P, Shaik MS, Singh M. Evaluation of different parameters that affect droplet-size distribution from nasal sprays using the Malvern Spraytec. J Pharm Sci 2004;93:1725–42
  • Foo MY, Cheng YS, Su WC, Donovan MD. The influence of spray properties on intranasal deposition. J Aerosol Med 2007;20:495–508
  • Guo C, Doub WH. The influence of actuation parameters on in vitro testing of nasal spray products. J Pharm Sci 2006;95:2029–40
  • Guo C, Stine KJ, Kauffman JF, Doub WH. Assessment of the influence factors on in vitro testing of nasal sprays using Box--Behnken experimental design. Eur J Pharm Sci 2008;35:417–26
  • Kippax P, Suman JD, Williams G. Enhancing the in vitro assessment of nasal sprays. Pharm Technol Eur 2008;July 2008
  • Aggarwal R, Cardozo A, Homer JJ. The assessment of topical nasal drug distribution. Clin Otolaryngol Allied Sci 2004;29:201–5
  • Cheng YS, Holmes TD, Gao J, et al. Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. J Aerosol Med 2001;14:267–80
  • US FDA. Draft guidance for industry: bioavailability and bioequivalence studies for nasal aerosols and nasal sprays for local action. Rockville (MD): Center for Drug Evaluation and Research, US Department of Health and Human Services; 2003
  • Kippax PG, Krarup H, Suman JD. Applications for droplet sizing: manual versus automated actuation of nasal sprays. Pharm Technol 2004;August 2004:30--9
  • Doughty DV, Vibbert C, Kewalramani A, et al. Automated actuation of nasal spray products: determination and comparison of adult and pediatric settings. Drug Dev Ind Pharm 2011;37:359–66

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