339
Views
30
CrossRef citations to date
0
Altmetric
Research Article

Preparation and characterization of laminated thiolated chitosan-based freeze-dried wafers for potential buccal delivery of macromolecules

&
Pages 611-618 | Received 21 Sep 2013, Accepted 05 Dec 2013, Published online: 10 Feb 2014

References

  • Mathias NR, Hussain MA. Non-invasive systemic drug delivery: developability considerations for alternate routes of administration. J Pharm Sci 2010;99:1–20
  • Lee JW, Park J-H, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials 2008;29:2113–24
  • Khafagy E, Morishita M, Onuki Y, Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Del Rev 2007;59:1521–46
  • Hearnden V, Sankar V, Hull K, et al. New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Adv Drug Del Rev 2012;64:16–28
  • Morishita M, Peppas NA. Is the oral route possible for peptide and protein drug delivery? Drug Discov Today. 2006;11:905–10
  • Deurloo MJ, Hermens WA, Romeyn SG, et al. Absorption enhancement of intranasally administered insulin by sodium taurodihydrofusidate (STDHF) in rabbits and rats. Pharm Res 1989;6:853–6
  • Senel S, Kremer MJ, Kas S, et al. Enhancing effect of chitosan on peptide drug delivery across buccal mucosa. Biomaterials 2000;21:2067–71
  • Li C, Bhatt PP, Johnston TP. Transmucosal delivery of oxytocin to rabbits using a mucoadhesive buccal patch. Pharm Dev Tech 1997;2:265–74
  • Hoogstraate JAJ, Wertz PW. Drug delivery via the buccal mucosa. Pharm Sci Tech Today 1998;1:309–16
  • Junginger HE, Hoogstraate JAJ, Coos JV. Recent advances in buccal delivery and absorption: in vitro and in vivo studies. J Control Release 1999;62:149–59
  • Schurr W, Knoll B, Ziegler R, et al. Comparative study of intravenous, nasal, oral, and buccal TRH administration among healthy subjects. J Endocrinol Invest 1985;8:41–4
  • Heiber SJ, Ebert CD, Dave SC, et al. In vivo buccal delivery of calcitonin. J Control Release 1994;28:269–70
  • Hauptstein S, Hintzen F, Müller C, et al. Development and in vitro evaluation of a buccal drug delivery system based on preactivated thiolated pectin. Drug Dev Ind Pharm 2013. [Epub ahead of print]. doi:10.3109/03639045.2013.836213
  • Lee VH. Enzymatic barriers to peptide and protein absorption. Crit Rev Ther Drug Carrier Syst 1988;5:69–97
  • Veuillez F, Kalia YN, Jacques Y, et al. Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm 2001;51:93–109
  • Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery – a promising option for orally less efficient drugs. J Control Release 2006;114:15–40
  • Thanou M, Verhoef JC, Marbach P, Junginger HE. Intestinal absorption of octreotide: N-trimethyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo. J Pharm Sci 2000;89:951–7
  • Vandevord PJ, Matthew HW, Desilva SP, et al. Evaluation of the biocompatibility of a chitosan scaffold in mice. J Biomed Mater Res 2002;59:585–90
  • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nano-particles in drug delivery. J Control Release 2004;100:5–28
  • Van Der Lubben IM, Verhoef JC, Borchard G, Junginger HE. Chitosan and its derivatives in mucosal drug and vaccine delivery. Eur J Pharm Sci 2001;14:201–7
  • Read RC, Naylor SC, Potter CW, et al. Effective nasal influenza vaccine delivery using chitosan. Vaccine 2005;23:4367–74
  • Giunchedi P, Juliano C, Gavini E, et al. Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. Eur J Pharm Biopharm 2002;53:233–9
  • De Campos AM, Diebold Y, Carvalho EL, et al. Chitosan nanoparticles as new ocular drug delivery systems: in vitro stability, in vivo fate, and cellular toxicity. Pharm Res 2004;21:803–10
  • Kast CE, Bernkop-Schnürch A. Thiolated polymers – thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials 2001;22:2345–52
  • Giovino C, Ayensu I, Tetteh J, Boateng JS. Development and characterisation of chitosan films impregnated with insulin loaded PEG-β-PLA nanoparticles (NPs): a potential approach for buccal delivery of macromolecules. Int J Pharm 2012;428:143–51
  • Giovino C, Ayensu I, Tetteh J, Boateng JS. An integrated buccal delivery system combining chitosan films impregnated with peptide loaded PEG-b-PLA nanoparticles. Coll Surf B: Biointerf 2013;112:9–15
  • Ayensu I, Mitchell JC, Boateng JS. Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Coll Surf B: Biointerf 2012;91:258–65
  • Boateng JS, Matthews KH, Auffret AD, et al. Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent cast films containing an insoluble drug. Drug Dev Ind Pharm 2012;38:47–54
  • Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA. Development and in vitro evaluation of thiolated chitosan – poly (methacrylic-acid) nanoparticles as a local mucoadhesive delivery system. Int J Biol Macromol 2011;48:403–7
  • Bernkop-Schnürch A, Hornof M, Zoidl T. Thiolated polymers – thiomers: modification of chitosan with 2-iminothiolane. Int J Pharm 2003;260:229–37
  • Ayensu I, Mitchell JC, Boateng JS. Formulation and evaluation of lyophilised thiolated chitosan wafers for buccal mucosal delivery of protein. AAPS J 2011;13 S2:M1144
  • Kelly SM, Jess TJ, Price NC. How to study proteins by circular dichroism. Biochim Biophys Acta 2005;1751:119–39
  • Wu ZM, Zhang XG, Zheng C, et al. Disulphide-crosslinked chitosan hydrogel for cell viability and controlled protein release. Eur J Pharm Sci 2009;37:198–206
  • Hornof MD, Kast CE, Bernkop-Schnürch A. In vitro evaluation of the viscoelastic behaviour of chitosan – thioglycolic acid conjugates. Eur J Pharm Biopharm 2003;55:185–90
  • Sreenivas SA, Pai KV. Synthesis of thiolated chitosans: promising polymers for prolonged mucoadhesive drug delivery. Int J Pharmtech Res 2009;1:670–8
  • Qin C, Li H, Xiao Q, et al. Water-solubility of chitosan and its antimicrobial activity. Carbo Polym 2006;63:367–74
  • Peppas NA, Bury PA. Surface interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 1985;2:257–75
  • Ayensu I, Mitchell JC, Boateng JS. Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins. Int J Biol Macromol 2012;50:905–9
  • Ayensu I, Mitchell JC, Boateng JS. In-vitro characterisation of thiolated chitosan based lyophilized formulations for buccal mucosa delivery of proteins. Carbo Polym 2012;89:935–41
  • Eouani C, Piccerelle P, Prinderre P, et al. In-vitro comparative study of buccal mucoadhesive performance of different polymeric films. Eur J Pharm Biopharm 2001;52:45–55
  • Clausen AE, Kast CE, Bernkop-Schnürch A. The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm Res 2002;19:602–8
  • Sogias IA, Williams AC, Khutoryanskiy VV. Why is chitosan mucoadhesive? Biomacromol 2008;9:1837–42
  • Ayensu I, Boateng JS. Development and evaluation of lyophilized thiolated-chitosan wafers for buccal delivery of protein. J Sci Tech 2012;32:11–17
  • Roldo M, Hornof M, Caliceti P, Bernkop-Schnürch A. Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation. Eur J Pharm Biopharm 2004;57:115–21
  • Vallee A, Humblot V, Methivier C, Pradier C. Glutathione adsorption from UHV to the liquid phase at various pH on gold and subsequent modification of protein interaction. Surf Intersurf Anal 2008;40:395–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.