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Research Article

Design, characterization and ex vivo evaluation of chitosan film integrating of insulin nanoparticles composed of thiolated chitosan derivative for buccal delivery of insulin

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Pages 691-698 | Received 08 Nov 2013, Accepted 19 Jan 2014, Published online: 14 Feb 2014

References

  • Pozzilli P, Manfrini S, Costanza F, et al. Biokinetics of buccal spray insulin in patients with type 1 diabetes. Metabolism 2005;54:930–4
  • Xu H-B, Huang K-X, Zhu Y-S, et al. Hypoglycaemic effect of a novel insulin buccal formulation on rabbits. Pharmacol Res 2002;46:459–67
  • Giovino C, Ayensu I, Tetteh J, et al. Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): a potential approach for buccal delivery of macromolecules. Int J Pharm 2012;428:143–51
  • Soppimath KS, Aminabhavi TM, Kulkarni AR, et al. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001;70:1–20
  • Holpuch AS, Hummel GJ, Tong M, et al. Nanoparticles for local drug delivery to the oral mucosa: proof of principle studies. Pharmaceut Res 2010;27:1224–36
  • Aungst BJ, Rogers NJ. Comparison of the effects of various transmucosal absorption promoters on buccal insulin delivery. Int J Pharm 1989;53:227–35
  • Avachat AM, Gujar KN, Wagh KV. Development and evaluation of tamarind seed xyloglucan based mucoadhesive buccal films of rizatriptan benzoate. Carbohyd Polym 2013;91:537–42
  • Boateng JS, Stevens HN, Eccleston GM, et al. Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Dev Ind Pharm 2009;35:986–96
  • Sudhakar Y, Kuotsu K, Bandyopadhyay A. Buccal bioadhesive drug delivery—a promising option for orally less efficient drugs. J Control Release 2006;114:15–40
  • Boyapally H, Nukala RK, Bhujbal P, et al. Controlled release from directly compressible theophylline buccal tablets. Colloids Surfaces B 2010;77:227–33
  • Pongjanyakul T, Suksri H. Alginate-magnesium aluminum silicate films for buccal delivery of nicotine. Colloids Surfaces B 2009;74:103–13
  • Morrow DI, McCarron PA, Woolfson AD, et al. Novel patch-based systems for the localised delivery of ALA-esters. J Photochem Photobio B 2010;101:59–69
  • Dixit R, Puthli S. Oral strip technology: overview and future potential. J Control Release 2009;139:94–107
  • Darwish AM, El-Sayed AM, El-Harras SA,et al. Clinical efficacy of novel unidirectional buccoadhesive vs. vaginoadhesive bromocriptine mesylate discs for treating pathologic hyperprolactinemia. Fertil Steril 2008;90:1864–8
  • Lee Y, Chien YW. Oral mucosa controlled delivery of LHRH by bilayer mucoadhesive polymer systems. J Control Release 1995;37:251–61
  • Remuñán-López C, Portero A, Vila-Jato JL, et al. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release 1998;55:143–52
  • Sudhakar Y, Kuotsu K, Bandyopadhyay A. Buccal bioadhesive drug delivery – a promising option for orally less efficient drugs. J Control Release 2006;114:15–40
  • Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. J Control Release 2004;100:5–28
  • Inouye K, Machida Y, Sannan T, et al. Buoyant sustained release tablets based on chitosan. Drug Design Deliv 1988;2:165–75
  • Remuñán-lópez C, Bodmeier R. Mechanical and water vapor transmission properties of polysaccharide films. Drug Dev Ind Pharm 1996;22:1201–9
  • Aungst BJ, Rogers NJ. Site dependence of absorption-promoting actions of laureth-9, Na salicylate, Na2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery. Pharmaceut Res 1988;5:305–8
  • Bernkop-Schnürch A, Hornof M, Zoidl T. Thiolated polymers—thiomers: synthesis and in vitro evaluation of chitosan–2-iminothiolane conjugates. Int J Pharm 2003;260:229–37
  • Seifalian A, Solouk A, Solati Hashjin M, et al. Optimization of acrylic acid grafting onto POSS-PCU nanocomposite using response surface methodology. Iran Polym J (English). 2011;20:91–107
  • Chopra S, Motwani SK, Ahmad FJ, et al. Simple, sensitive, selective and validated spectrophotometric methods for the estimation of a biomarker trigonelline from polyherbal gels. Spectrochim Acta A 2007;68:516–22
  • Bottenberg P, Cleymaet R, Muynck C, et al. Development and testing of bioadhesive, fluoride‐containing slow‐release tablets for oral use. J Pharm Pharmacol 1991;43:457–64
  • Desai KGH, Pramod Kumar T. Preparation and evaluation of a novel buccal adhesive system. AAPS PharmSci 2004;5:1–9
  • Nafee NA, Boraie M, Ismail FA, et al. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharmaceut 2003;53:199–212
  • Vasantha PV, Puratchikody A, Mathew ST, et al. Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate. Saudi Pharmaceut J 2011;19:207–14
  • Navneeth V, Pronobesh C. Preparation of mucoadhesive buccal patches of carvedilol and evaluation for in-vitro drug permeation through porcine buccal membrane. African J Pharm Pharmacol 2011;5:1228–33
  • Cilurzo F, Cupone IE, Minghetti P, et al. Fast dissolving films made of maltodextrins. Eur J Pharm Biopharm 2008;70:895–900
  • Harris D, Robinson JR. Bioadhesive polymers in peptide drug delivery. Biomaterials 1990;11:652–8
  • Kurosaki Y, Kimura T. Regional variation in oral mucosal drug permeability. Crit Rev Ther Drug 2000;17–58
  • Lee VH, Yamamoto A. Penetration and enzymatic barriers to peptide and protein absorption. Adv Drug Deliver Rev 1989;4:171–207
  • Veuillez F, Kalia Y, Jacques Y, et al. Factors and strategies for improving buccal absorption of peptides. Eur J Pharm Biopharm 2001;51:93–109
  • Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliver Rev 2005;57:1666–91
  • Borchard G, Lueβen HL, de Boer AG, et al. The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J Control Release 1996;39:131–8
  • Illum L, Farraj NF, Davis SS. Chitosan as a novel nasal delivery system for peptide drugs. Pharmaceut Res 1994;11:1186–9
  • Patel VM, Prajapati BG, Patel MM. Effect of hydrophilic polymers on buccoadhesive Eudragit patches of propranolol hydrochloride using factorial design. AAPS PharmSci 2007;8:E119–26
  • Viridén A, Wittgren B, Larsson A. Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets. Eur J Pharm Sci 2009;36:297–309
  • Kaur A, Kaur G. Mucoadhesive buccal patches based on interpolymer complexes of chitosan–pectin for delivery of carvedilol. Saudi Pharm J 2012;20:21–7
  • Hyppölä R, Husson I, Sundholm F. Evaluation of physical properties of plasticized ethyl cellulose films cast from ethanol solution Part I. Int J Pharm 1996;133:161–70
  • Rossi S, Sandri G, Caramella CM. Buccal drug delivery: A challenge already won? Drug Discov Today: Technologies 2005;2:59–65
  • Figueiras A, Hombach J, Veiga F, et al. In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery. Eur J Pharm Biopharm 2009;71:339–45
  • Bagan J, Paderni C, Termine N, et al. Mucoadhesive polymers for oral transmucosal drug delivery: a review. Curr Pharm Design 2012;18:5497–514
  • Ishida M, Machida Y, Nambu N, et al. New mucosal dosage form of insulin. Chem Pharm Bull 1981;29:810–16
  • Oh CK, Ritschel W. Biopharmaceutic aspects of buccal absorption of insulin. Method Find Exp Clin 1990;12:205–12
  • Oh C, Ritschel W. Absorption characteristics of insulin through the buccal mucosa. Methods Find Expl Clin 1990;12:275–9
  • Bernkop-Schnürch A, Guggi D, Pinter Y. Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J Control Release 2004;94:177–86
  • Bernkop-Schnürch A, Hornof M, Guggi D. Thiolated chitosans. Eur J Pharm Biopharm 2004;57:9–17

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