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Drug Development and Industrial Pharmacy Volume 41, 2015 - Issue 7
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Research Articles

Trans-ungual delivery of itraconazole hydrochloride by iontophoresis

Avadhesh KushwahaDepartment of Pharmaceutics, The University of Mississippi, University, MS, USA,
,
Melissa JacobNational Center for Natural Product Research, The University of Mississippi, University, MS, USA,
,
H. N. Shiva KumarInstitute for Drug Delivery and Biomedical Research, Bangalore, India, and
,
Shobharani HiremathInstitute for Drug Delivery and Biomedical Research, Bangalore, India, and
,
Sacchidanand AradhyaInstitute for Drug Delivery and Biomedical Research, Bangalore, India, and ;Bangalore Medical College and Research Institute, Bangalore, India
,
Michael A. RepkaDepartment of Pharmaceutics, The University of Mississippi, University, MS, USA,
&
S. Narasimha MurthyDepartment of Pharmaceutics, The University of Mississippi, University, MS, USA, ;Institute for Drug Delivery and Biomedical Research, Bangalore, India, and Correspondence[email protected]
 show all
Pages 1089-1094 | Received 03 Apr 2014, Accepted 18 May 2014, Published online: 08 Dec 2014

References

  • Elewski BE. Onychomycosis: pathogenesis, diagnosis, and management. Clin Microbiol Rev 1998;11:415–29
  • Hao J, Smith KA, Li SK. Iontophoretically enhanced ciclopirox delivery into and across human nail plate. J Pharm Sci 2009;98:3608–16
  • Murdan S. Drug delivery to the nail following topical application. Int J Pharm 2002;236:1–26
  • Murthy SN, Waddell DC, Shivakumar HN, et al. Iontophoretic permselective property of human nail. J Dermatol Sci 2007;46:150–2
  • Nair AB, Kim HD, Chakraborty B, et al. Ungual and trans-ungual iontophoretic delivery of terbinafine for the treatment of onychomycosis. J Pharm Sci 2009;98:4130–40
  • Nair AB, Vaka SR, Sammeta SM, et al. Trans-ungual iontophoretic delivery of terbinafine. J Pharm Sci 2009;98:1788–96
  • Nair AB, Kim HD, Davis SP, et al. An ex vivo toe model used to assess applicators for the iontophoretic ungual delivery of terbinafine. Pharm Res 2009;26:2194–201
  • Nair AB, Sammeta SM, Kim HD, et al. Alteration of the diffusional barrier property of the nail leads to greater terbinafine drug loading and permeation. Int J Pharm 2009;22;375:22–7
  • Shivakumar HN, Juluri A, Desai BG, Murthy SN. Ungual and transungual drug delivery. Drug Dev Ind Pharm 2012;38:901–11
  • Nair AB, Chakraborty B, Murthy SN. Effect of polyethylene glycols on the trans-ungual delivery of terbinafine. Curr Drug Deliv 2010;7:407–14
  • Nair AB, Vaka SR, Murthy SN. Transungual delivery of terbinafine by iontophoresis in onychomycotic nails. Drug Dev Ind Pharm 2011;37:1253–8
  • Murthy SN. Iontophoresis for treating nail diseases. Ther Deliv 2013;4:647–50
  • Murthy SN, Maibach HI. Topical nail products and ungual drug delivery. Florida: CRC Press; 2013:165–87
  • Gupta AK, Simpson F. Device-based therapies for onychomycosis treatment. Skin Therapy Lett 2012;17:4–9
  • Trey SM, Wicks DA, Mididoddi PK, Repka MA. Delivery of itraconazole from extruded HPC films. Drug Dev Ind Pharm 2007;33:727–35
  • Tao T, Zhao Y, Wu J, Zhou B. Preparation and evaluation of itraconazole dihydrochloride for the solubility and dissolution rate enhancement. Int J Pharm 2009;367:109–14
  • Li XC, Jacob MR, Khan SI, et al. Potent in vitro antifungal activities of naturally occurring acetylenic acids. Antimicrob Agents Chemother 2008;52:2442–8
  • Sobue S, Sekiguchi K, Nabeshima T. Intracutaneous distributions of fluconazole, itraconazole, and griseofulvin in Guinea pigs and binding to human stratum corneum. Antimicrob Agents Chemother 2004;48:216–23
  • Myoung Y, Choi HK. Permeation of ciclopirox across porcine hoof membrane: effect of pressure sensitive adhesives and vehicles. Eur J Pharm Sci 2003;20:319–25
  • Mertin D, Lippold BC. In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: prediction of the penetration rate of antimycotics through the nail plate and their efficacy. J Pharm Pharmacol 1997;49:866–72

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