Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain

References

• Carmo Carreiras M, Mendes E, Jesus Perry M, et al. The multifactorial nature of alzheimer’s disease for developing potential therapeutics. Curr Top Med Chem. 2013;13:1745–70
   PubMed Web of Science ®Google Scholar
• Di Stefano A, Iannitelli A, Laserra S, et al. Drug delivery strategies for alzheimer's disease treatment. Exp Opin Drug Deliv 2011;8:581–603
   PubMed Web of Science ®Google Scholar
• Rocha S. Targeted drug delivery across the blood brain barrier in alzheimer's disease. Curr Pharm Des 2013;19:6635–46
   PubMed Web of Science ®Google Scholar
• Frey WH. Inventor neurologic agents for nasal administration to the brain (wo1991007947). US1991
   Google Scholar
• Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv Drug Deliv Rev 2012;64:614–28
   PubMed Web of Science ®Google Scholar
• Ong W-Y, Shalini S-M, Costantino L. Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders. Curr Med Chem 2014;21:4247–56
   PubMed Web of Science ®Google Scholar
• Zargar V, Asghari M, Dashti A. A review on chitin and chitosan polymers: structure, chemistry, solubility, derivatives, and applications. Chem Bioeng Rev 2015;2:204–26
   Web of Science ®Google Scholar
• Jain A, Gulbake A, Shilpi S, et al. A new horizon in modifications of chitosan: syntheses and applications. Crit Rev Ther Drug Carrier Syst 2013;30:91–181
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Haertel C, Maelicke A, et al. Galantamine slows down plaque formation and behavioral decline in the 5xfad mouse model of Alzheimer’s disease. PLoS One 2014;9:e89454
   PubMed Web of Science ®Google Scholar
• Calvo P, Remunan-Lopez C, Vila-Jato JL, et al. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res 1997;14:1431–6
   PubMed Web of Science ®Google Scholar
• Subbiah R, Ramalingam P, Ramasundaram S, et al. N,n,n-trimethyl chitosan nanoparticles for controlled intranasal delivery of hbv surface antigen. Carbohydr Polym 2012;89:1289–97
   PubMed Web of Science ®Google Scholar
• Moffat AC, Osselton MD, Widdop B. Clarke's analysis of drugs and poisons. London: Pharmaceutical Press; 2011
   Google Scholar
• Wang L, Li L, Sun Y, et al. In vitro and in vivo evaluation of chitosan graft glyceryl monooleate as peroral delivery carrier of enoxaparin. Int J Pharm 2014;471:391–9
   PubMed Web of Science ®Google Scholar
• Wang X, Zheng C, Wu Z, et al. Chitosan-nac nanoparticles as a vehicle for nasal absorption enhancement of insulin. J Biomed Mat Res Part B Appl Biomater 2009;88:150–61
   PubMed Web of Science ®Google Scholar
• Wilson B, Samanta MK, Santhi K, et al. Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine. Nanomedicine 2010;6:144–52
   PubMed Web of Science ®Google Scholar
• Ma O, Lavertu M, Sun J, et al. Precise derivatization of structurally distinct chitosans with rhodamine b isothiocyanate. Carbohydr Polym 2008;72:616–24
   Web of Science ®Google Scholar
• Hernandez CM, Gearhart DA, Parikh V, et al. Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats. J Pharmacol Exp Ther 2006;316:679–94
   PubMed Web of Science ®Google Scholar
• Migliore MM, Vyas TK, Campbell RB, et al. Brain delivery of proteins by the intranasal route of administration: a comparison of cationic liposomes versus aqueous solution formulations. J Pharm Sci 2010;99:1745–61
   PubMed Web of Science ®Google Scholar
• Spijker S. Dissection of rodent brain regions. In: Li KW, ed. Neuroproteomics. Berlin: Humana Press; 2011:13–26
   Google Scholar
• Pearson BL, Corley MJ, Vasconcellos A, et al. Heparan sulfate deficiency in autistic postmortem brain tissue from the subventricular zone of the lateral ventricles. Behav Brain Res 2013;243:138–45
   PubMed Web of Science ®Google Scholar
• Mistry A, Stolnik S, Illum L. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm 2009;379:146–57
   PubMed Web of Science ®Google Scholar
• Rejman J, Oberle V, Zuhorn I, et al. Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochem J 2004;377:159–69
   PubMed Web of Science ®Google Scholar
• Dong Y, Ng WK, Shen S, et al. Scalable ionic gelation synthesis of chitosan nanoparticles for drug delivery in static mixers. Carbohydr Polym 2013;94:940–5
   PubMed Web of Science ®Google Scholar
• Fan W, Yan W, Xu Z, et al. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids Surf B 2012;90:21–7
   PubMed Web of Science ®Google Scholar
• Abdel-Hafez SM, Hathout RM, Sammour OA. Towards better modeling of chitosan nanoparticles production: screening different factors and comparing two experimental designs. Int J Biol Macromol 2014;64:334–40
   PubMed Web of Science ®Google Scholar
• Shu X, Zhu K. The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release. Eur J Pharm Biopharm 2002;54:235–43
   PubMed Web of Science ®Google Scholar
• Alam S, Khan ZI, Mustafa G, et al. Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study. Int J Nanomed 2012;7:5705
   PubMed Web of Science ®Google Scholar
• Sharma V, Ali M, Baboota S, et al. Preparation and characterization of chitosan nanoparticles for nose to brain delivery of a cholinesterase inhibitor. Indian J Pharm Sci 2007;69:712
   Google Scholar
• Janes KA, Fresneau MP, Marazuela A, et al. Chitosan nanoparticles as delivery systems for doxorubicin. J Control Release 2001;73:255–67
   PubMed Web of Science ®Google Scholar
• Hosseini SF, Zandi M, Rezaei M, et al. Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydr Polym 2013;95:50–6
   PubMed Web of Science ®Google Scholar
• Traykova M, Trakov T, Hadjimitova V, et al. Antioxidant properties of galantamine hydrobromide. Zeitschr Naturforschung C 2003;58:361–5
   PubMed Web of Science ®Google Scholar
• Bastida J, Viladomat F, Llabres JM, et al. Alkaloids from narcissus confusus. Phytochemistry 1987;26:1519–24
   Web of Science ®Google Scholar
• Li H-Y, Ma G-E, Xu Y, et al. Alkaloids of Lycoris guangxiensis 1. Planta Med 1987;53:259–61
   PubMedGoogle Scholar
• Fazil M, Md S, Haque S, et al. Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. Eur J Pharm Sci 2012;47:6–15
   PubMed Web of Science ®Google Scholar
• Motwani SK, Chopra S, Talegaonkar S, et al. Chitosan–sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation. Eur J Pharm Biopharm 2008;68:513–25
   PubMed Web of Science ®Google Scholar
• Ali SW, Rajendran S, Joshi M. Synthesis and characterization of chitosan and silver loaded chitosan nanoparticles for bioactive polyester. Carbohydr Polym 2011;83:438–46
   Web of Science ®Google Scholar
• Park C-W, Son D-D, Kim J-Y, et al. Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system. Int J Pharm 2012;436:32–40
   PubMed Web of Science ®Google Scholar
• Qi L, Xu Z, Jiang X, et al. Preparation and antibacterial activity of chitosan nanoparticles. Carbohydr Res 2004;339:2693–700
   PubMed Web of Science ®Google Scholar
• Dash S, Murthy PN, Nath L, et al. Kinetic modeling on drug release from controlled drug delivery systems. Acta Polon Pharm 2010;67:217–23
   PubMed Web of Science ®Google Scholar
• Fröhlich E, Roblegg E. Mucus as barrier for drug delivery by nanoparticles. J Nanosci Nanotechnol 2014;14:126–36
   PubMed Web of Science ®Google Scholar
• das Neves J, Bahia MF, Amiji MM, et al. Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale. Exp Opin Drug Deliv 2011;8:1085–104
   PubMed Web of Science ®Google Scholar
• Brettschneider J, Del Tredici K, Lee VM-Y, et al. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci 2015;16:109–20
   PubMed Web of Science ®Google Scholar
• Fjell AM, McEvoy L, Holland D, et al. What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Prog Neurobiol 2014;117:20–40
   PubMed Web of Science ®Google Scholar
• Sepulcre J, Sabuncu MR, Becker A, et al. In vivo characterization of the early states of the amyloid-beta network. Brain 2013;136:2239–52
   PubMed Web of Science ®Google Scholar
• Serino S, Cipresso P, Morganti F, et al. The role of egocentric and allocentric abilities in alzheimer's disease: a systematic review. Ageing Res Rev 2014;16:32–44
   PubMed Web of Science ®Google Scholar