A novel monolithic controlled delivery system of resveratrol for enhanced hepatoprotection: nanoformulation development, pharmacokinetics and pharmacodynamics

References

• Sridhar R, Lakshminarayanan R, Madhaiyan K, et al. Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals. Chem Soc Rev 2015;44:790–814.
   PubMed Web of Science ®Google Scholar
• Yu D, Ruan P, Meng Z, Zhou J. The structure-dependent electric release and enhanced oxidation of drug in graphene oxide-based nanocarrier loaded with anticancer herbal drug berberine. J Pharm Sci 2015;104:2489–500.
   PubMed Web of Science ®Google Scholar
• Duc Hanh N, Mitrevej A, Sathirakul K, et al. Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement. Drug Dev Ind Pharm 2013;41:207–17.
   PubMed Web of Science ®Google Scholar
• Shi F, Zhang Y, Yang G, et al. Preparation of a micro/nanotechnology based multi-unit drug delivery system for a Chinese medicine Niuhuang Xingxiao Wan and assessment of its antitumor efficacy. Int J Pharm 2015;492:244–7.
   PubMed Web of Science ®Google Scholar
• Shakibaei M, Harikumar KB, Aggarwal BB. Resveratrol addiction: to die or not to die. Mol Nutr Food Res 2009;53:115–28.
   PubMed Web of Science ®Google Scholar
• Frémont L. Biological effects of resveratrol. Life Sci 2000;66:663–73.
   PubMed Web of Science ®Google Scholar
• Chiva-Blanch G, Arranz S, Lamuela-Raventos RM, Estruch R. Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: evidences from human studies. Alcohol Alcohol 2013;48:270–7.
   PubMed Web of Science ®Google Scholar
• Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 2003;36:79–87.
   PubMed Web of Science ®Google Scholar
• Jannin V, Musakhanian J, Marchaud D. Approaches for the development of solid and semi-solid lipid-based formulations. Adv Drug Deliv Rev 2008;60:734–46.
   PubMed Web of Science ®Google Scholar
• Valenzano DR, Terzibasi E, Genade T, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 2006;16:296–300.
   PubMed Web of Science ®Google Scholar
• Akhter S, Ahmad I, Ahmad MZ, et al. Nanomedicines as cancer therapeutics: current status. Curr Cancer Drug Targets 2013;13:362–78.
   PubMed Web of Science ®Google Scholar
• Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003;425:191–6.
   PubMed Web of Science ®Google Scholar
• Bishayee A, Darvesh AS, Politis T, McGory R. Resveratrol and liver disease: from bench to bedside and community. Liver Int 2010;30:1103–14.
   PubMed Web of Science ®Google Scholar
• Di Pascoli M, Diví M, Rodríguez-Vilarrupla A, et al. Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol 2013;58:904–10.
   PubMed Web of Science ®Google Scholar
• Yu W, Fu YC, Wang W. Cellular and molecular effects of resveratrol in health and disease. J Cell Biochem 2012;113:752–9.
   PubMed Web of Science ®Google Scholar
• Han G, Xia J, Gao J, et al. Anti-tumor effects and cellular mechanisms of resveratrol. Drug Discov Ther 2015;9:1–12.
   PubMed Web of Science ®Google Scholar
• Sahbaz Y, Williams HD, Nguyen TH, et al. Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations. Mol Pharm 2015:12:1980–91.
   PubMed Web of Science ®Google Scholar
• Kwok PC, Chan HK. Nanotechnology versus other techniques in improving drug dissolution. Curr Pharm Des 2014;20:474–82.
   PubMed Web of Science ®Google Scholar
• Jain S, Patel N, Lin S. Solubility and dissolution enhancement strategies: current understanding and recent trends. Drug Dev Ind Pharm 2014;41:875–87.
   PubMed Web of Science ®Google Scholar
• Nunes S, Madureira R, Campos D, et al. Solid lipid nanoparticles as oral delivery systems of phenolic compounds: overcoming pharmacokinetic limitations for nutraceutical applications. Crit Rev Food Sci Nutr 2016. [Epub ahead of print]. doi: 10.1080/10408398.2015.1031337.
   PubMedGoogle Scholar
• Moyano-Mendez JR, Fabbrocini G, Stefano DD, et al. Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin. Drug Dev Ind Pharm 2014;40:1300–7.
   PubMed Web of Science ®Google Scholar
• Duarte A, Martinho A, Luís Â, et al. Resveratrol encapsulation with methyl-β-cyclodextrin for antibacterial and antioxidant delivery applications. LWT Food Sci Technol 2015;63:1254–60.
   Web of Science ®Google Scholar
• Yang L, Wang CZ, Ye JZ, Li HT. Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats. Fitoterapia 2011;82:834–40.
   PubMed Web of Science ®Google Scholar
• Pangeni R, Sharma S, Mustafa G, et al. Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson’s disease by reducing oxidative stress. Nanotechnology 2014;25:485102.
   PubMed Web of Science ®Google Scholar
• Das S, Ng KY, Ho PC. Formulation and optimization of zinc-pectinate beads for the controlled delivery of resveratrol. AAPS PharmSciTech 2010;11:729–42.
   PubMed Web of Science ®Google Scholar
• Walle T, Hsieh F, DeLegge MH, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004;32:1377–82.
   PubMed Web of Science ®Google Scholar
• Chen X, He H, Wang G, et al. Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies. Biomed Chromatogr 2007;21:257–65.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351–8.
   PubMed Web of Science ®Google Scholar
• Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952;195:133–40.
   PubMed Web of Science ®Google Scholar
• Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of SOD. Indian J Biochem Biophys 1984;21:130–2.
   PubMed Web of Science ®Google Scholar
• Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxide. J Lab Clin Med 1967;70:158–63.
   PubMed Web of Science ®Google Scholar
• Singh A, Ahmad I, Akhter S, et al. Thymoquinone: major molecular targets, prominent pharmacological actions and drug delivery concerns. Curr Bioact Compd 2012;8:334–44.
   Google Scholar
• Bonifácio BV, Silva PB, Ramos MA, et al. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomedicine 2013;9:1–15.
   PubMed Web of Science ®Google Scholar
• Summerlin N, Soo E, Thakur S, et al. Resveratrol nanoformulations: challenges and opportunities. Int J Pharm 2015;479:282–90.
   PubMed Web of Science ®Google Scholar
• Soo E, Thakur S, Qu Z, et al. Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach. J Colloid Interface Sci 2016;462:368–74.
   PubMed Web of Science ®Google Scholar
• Kawakami S, Hashida M. Glycosylation-mediated targeting of carriers. J Control Release 2014;190:542–55.
   PubMed Web of Science ®Google Scholar
• Gokce EH, Korkmaz E, Dellera E, et al. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomedicine 2012;7:1841–50.
   PubMed Web of Science ®Google Scholar
• Aburahma MH, Badr-Eldin SM. Compritol 888 ATO: a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals. Expert Opin Drug Deliv 2014;11:1865–83.
   PubMed Web of Science ®Google Scholar
• Singh A, Ahmad I, Akhter S, et al. Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies. Colloids Surf B Biointerfaces 2013;102:822–32.
   PubMed Web of Science ®Google Scholar
• Jiang W, Kim BYS, Rutka JT, Chan WCW. Nanoparticle-mediated cellular response is size-dependent. Nat Nanotechnol 2008;3:145–50.
   PubMed Web of Science ®Google Scholar
• Shang L, Nienhaus K, Nienhaus GU. Engineered nanoparticles interacting with cells: size matters. J Nanobiotechnol 2014;12:b67.
   Google Scholar
• Ramalingam P, Ko YT. Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles. Colloids Surf B Biointerfaces 2016;139:52–61.
   PubMed Web of Science ®Google Scholar
• Singh G, Pai RS. Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential. Expert Opin Drug Deliv 2014;11:647–59.
   PubMed Web of Science ®Google Scholar
• Singh G, Pai RS. Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies. Drug Deliv 2015;22:522–30.
   PubMed Web of Science ®Google Scholar