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Drug Development and Industrial Pharmacy Volume 20, 1994 - Issue 3
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Research Article

Effect of Mixing Time on the Lubricating Properties of Magnesium Stearate and the Final Characteristics of the Compressed Tablets

Jun-Ichi Kikuta Pharmaceutical Development Laboratories, Takeda Chemical Industries, Ltd, 17-85, Juso-honmachl 2-chome, Yodogawa-ku, Osaka, 532, Japan
&
Nobuyuki Kitamori Pharmaceutical Development Laboratories, Takeda Chemical Industries, Ltd, 17-85, Juso-honmachl 2-chome, Yodogawa-ku, Osaka, 532, Japan
Pages 343-355 | Published online: 20 Oct 2008

References

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  • Bossert J., Stamm A. Effect of mixing on the lubricant of crystalline lactose by magnesium stearate. Drug Dev. Ind. Pharm. 1980; 6: 573–589
  • Frattini C., Simioni L. Should magnesium stearate be assessed in the formulation of solid dosage forms by weight or by surface area. Drug Dev. Ind. Pharm. 1984; 10: 1117–1130
  • Kahn K. A., Musikabhumma P., Rubinstein M. H. The effect of mixing time of magnesium stearate on the tabletting properties of dried microcrystalline cellulose. Pharm. Acta Helv. 1983; 58: 109–111
  • Lerk C. F., Bolhuis G. K., Smedema S. S. Interaction of lubricants and colloidal silica during mixing with excipients I. Its effect on tabletting. Pharm. Acta Helv. 1977; 52: 33–39
  • Ragnarson G., Holzer A. W., Sjogren J. The Influence of mixing time and colloidal silica on the lubricating properties of magnesium stearate. Int. J. Pharm. 1979; 3: 127–131
  • Shah A. C., Mlodozeniec A. R. Mechanism of surface lubrication: Influence of lubricant - excipient mixing on processing characteristics of powders and properties of compressed tablets. J. Pharm. Sci. 1977; 66: 1377–1382
  • Hussain M. S.H., York P., Timmins P. A study of the formation of magnesium stearate film on sodium chloride using energy-dispersive X-ray analysis. Int. J. Pharm. 1988; 42: 89–95
  • Kikuta J., Kitamori N. Evaluation of the die wall friction during tablet ejection. Powder Technol. 1983; 35: 195–200

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