158
Views
38
CrossRef citations to date
0
Altmetric
Research Article

Surfactant Dissolution and Water Solubilization in Chlorine-Free Liquified Gas Propellants

&
Pages 935-945 | Published online: 20 Oct 2008

References

  • Montreal Protocol on Substances That Deplete the Ozone Layer. Liaison Office of the United Nations Environmental Program, New York 1989
  • Daly J. J., Jr., SanGiovanni M. L. Replacement for CFC propellants: A technical/environmental overview. Spray Tech Marketing 1993; 3: 34–38
  • Ravishankara A. R., Tumipseed A. A., Jensen N. R., Barone S., Mills M., Howard C. J., Solomon S. Do hydrofluorocarbons destroy stratospheric ozone?. Science 1994; 263: 71–75
  • Dalby R. N., Byron P. R. Metered-dose inhalers containing flammable propellants: perspectives and some safety evaluation procedures. Pharm. Tech. 1991; 15: 54–66
  • Byron P. R., Miller N. C., Blondino F. E., Visich J. E., Ward G. H. Some aspects of alternative propellant solvency. Respiratory Drug Delivery, P. R. Byron, R. N. Dalby, S. J. Farr. Interpharm Press, Philadelphia, PA 1994; IV: 231–242
  • Purewal T. S., Greenleaf D. J. Medicinal aerosol formulations. European Patent #0,372,777, 1990
  • Dalby R. N., Byron P. R. Comparison of output particle size distributions for pressurized aerosols formulated as solutions or suspensions. Pharm. Res. 1988; 5: 36–39
  • Phillips E. M., Byron P. R. Surfactant promoted crystal growth of micronized methylprednisolone in trichloromonofluoromethane. Int. J. Pharm. 1994; 110: 9–19
  • Wang Y. C. J., Kowal R. R. Review of excipients and pH's for parenteral products used in the United States. J. Parent. Drug Assoc 1980; 34: 452–462
  • Evans R. M., Farr S. J., Armstrong N. A., Chatham S. M. Formulation and in vitro evaluation of pressurized inhalation aerosols containing isotropic systems of lecithin and water. Pharm. Res. 1991; 8: 629–635
  • Byron P. R., Patton J. S. Drug delivery via the respiratory tract. J. Aerosol Med. 1994; 7: 49–75
  • Ross S., Oliver J. P. A new method for the determination of critical micelle concentrations of un-ionized association colloids in aqueous or in non-aqueous solutions. J. Phys. Chem. 1959; 63: 1671–1674
  • Ross S., Baldwin V. H., Jr. The interaction between iodine and micelles of amphipathic agents in nonaqueous solutions. J. Colloid Inter. Sci. 1966; 21: 284–292
  • Byron P. R. Aerosol formulation, generation, and delivery using metered systems. Respiratory Drug Delivery, P. R. Byron. CRC Press, Boca Raton, FL 1990; 167–205
  • United States Pharmacopeia and National Formulary. USP Convention, Inc., Rockville, MD 1995; 547, 2259, 2290, 2307, 2308
  • Fendler J. H. Surfactants in apolar media. Membrane Mimetic Chemistry. Characterizations and Applications of Micelles, Microemulsions, Monolayers, Bilayers, Vesicles, Host-Guest Systems, and Polyions, J. H. Fendler. John Wiley & Sons, New York 1982; 48–77
  • Byron P. R., Blondino F. E. Metered dose inhaler formulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent. U.S. Patent #5,492,688, 1996
  • Byron P. R., Blondino F. E. Pharmaceutically acceptable agents for, solubilizing, wetting, emulsifying or lubricating in metered dose inhaler formulations which use HFC-227 propellant. U.S. Patent #5,508,023, 1996
  • Higuchi T. Solubility. Pharmaceutical Compounding and Dispensing, R. A. Lyman. Lippincott, Philadelphia, PA 1949; 159–190
  • Boulden M. E. Use of dimethyl ether for reduction of VOC content. Spray Tech. Marketing 1992; 2: 30–36
  • Bohnenn L. J. M. Recent European developments in DME technology. 1988, Aerosol Age, September, 26-29
  • Martin A., Swarbrick J., Cammarata A. States of matter and phase equilibria. Physical Pharmacy, 3rd Ed., A. Martin, J. Swarbrick, A. Cammarata. Lea & Febiger, Philadelphia, PA 1983; 62–92
  • , DuPont. Blends of Dymel® 22/A (40/60) azeotrope and hydrocarbons provide virtually constant pressure over wide range of component concentration, Dymel Aerosol Propellants Information, Technical Bulletin #ATB-10 Wilmington, DE
  • Evans R. M., Attwood D., Chatham S. M., Farr S. J. A novel strategy for the formulation of medicinal aerosols. J. Aerosol Sci. 1989; 20: 1309–1312
  • Luisi P. L., Magid L. J. Solubilization of enzymes and nucleic acids in hydrocarbon micellar solutions. CRC Crit. Rev. Biochem. 1986; 20: 409–474
  • Eastoe J., Young W. K., Robinson B. H., Steytler D. C. Scattering studies of microemulsions in lowdensity alkanes. J. Chem. Soc. Faraday Trans. 1990; 86: 2883–2889
  • Ross S., Morrison I. D. Emulsions. Colloidal Systems and Interface, S. Ross, I. D. Morrison. John Wiley & Sons, New York, NY 1988; 267–293
  • Miller N. C. The effects of water in inhalation suspension aerosol formulations. Respiratory Drug Delivery, P. R. Byron. CRC Press, Boca Raton, FL 1990; 249–257
  • Dalby R. N., Phillips E. M., Byron P. R. Determination of drug solubility in aerosol propellants. Pharm. Res. 1991; 8: 1206–1209
  • Phillips E. M., Byron P. R., Dalby R. N. Axial ratio measurements for early detection of crystal growth in suspension-type metered dose inhalers. Pharm. Res. 1993; 10: 454–456
  • Soine W. H., Blondino F. E., Byron P. R. Chemical stability in pressurized inhalers formulated as solutions. J. Biopharm. Sci. 1992; 3: 41–47

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.