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ORIGINAL ARTICLESClinical Translational Therapeutics

The Role of Neoadjuvant Therapy in Sphincter-Saving Surgery for Mid and Distal Rectal Cancer

, MD & , MD, MPH
Pages 259-267 | Published online: 26 Oct 2009

REFERENCES

  • Janjan, N.A.; Khoo, V.S.; Abbruzzese, J.; Pazdur, R.; Dubrow, R.; Cleary, K.R.; Allen, P.K.; Lynch, P.M.; Glober, G.; Wolff, R.; Rich, T.A.; Skibber, J. Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M. D. Anderson Cancer Center experience. Int. J. Radiat. Oncol. Biol. Phys. 1999, 44, 1027–1038.
  • Kim, D.W.; Lim, S.B.; Kim, D.Y.; Kim, T.H.; Jung, K.H.; Kim, D.H.; Chang, H.J.; Sohn, D.K.; Hong, C.W.; Choi, H.S.; Jeong, S.Y.; Park, J.G. Pre-operative chemo-radiotherapy improves the sphincter preservation rate in patients with rectal cancer located within 3 cm of the anal verge. Eur. J. Surg. Oncol., 2006, 32, 162–167.
  • Graf, W.; Dahlberg, M.; Osman, M.M.; Holmberg, L.; Pahlman, L.; Glimelius, B. Short-term preoperative radiotherapy results in down-staging of rectal cancer: a study of 1316 patients. Radiother. Oncol., 1997, 43(2), 133–137.
  • Marijnen, C.A.; Nagtegaal, I.D.; Klein Kranenbarg, E.; Hermans, J.; van de Velde, C.J.; Leer, J.W.; van Krieken, J.H. Pathology Review Committee the Cooperative Clinical Investigators. No downstaging after short-term preoperative radiotherapy in rectal cancer patients. J. Clin. Oncol. 2001, 19(7), 1976–1984.
  • Goldberg, P.A.; Nicholls, R.J.; Porter, N.H.; Love, S.; Grimsey, J.E. Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: reduction in local treatment failure. Eur. J. Cancer. 1994, 30A(11), 1602–1606.
  • Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Swedish Rectal Cancer Trial. Br. J. Surg. 1993, 80(10), 1333–1336.
  • Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl. J. Med. 1997, 336(14), 980–987.
  • Folkesson, J.; Birgisson, H.; Pahlman, L.; Cedermark, B.; Glimelius, B.; Gunnarsson, U. Swedish rectal cancer trial: Long lasting benefits from radiotherapy on survival and local recurrence rate. J. Clin. Oncol. 2005, 23(24), 5644–5650.
  • Kapiteijn, E.; Marijnen, C.A.; Nagtegaal, I.D.; Putter, H.; Steup, W.H.; Wiggers, T.; Rutten, H.J.; Pahlman, L.; Glimelius, B.; van Krieken, J.H.; Leer, J.W.; van de Velde, C.J.; Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N. Engl. J. Med. 2001, 345(9), 638–646.
  • Marijnen, C.A.M.; Peeters, K.C.M.J.; Putter, H.; Klein Kranenbarg, E.; Stiggelbout, A.M.; Leer, J.W.H.; van de Velde, C.J.H.; for the Cooperative investigators of the TME trial. Long term results, toxicity and quality of life in the TME trial. Radiother. Oncol. 2004, 73 Suppl 1, 127–128 [Abstract].
  • Peeters, K.C.; Marijnen, C.A.; Nagtegaal, I.D.; Kranenbarg, E.K.; Putter, H.; Wiggers, T.; Rutten, H.; Pahlman, L.; Glimelius, B.; Leer, J.W.; van de Velde, C.J.;Dutch Colorectal Cancer Group. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann. Surg. 2007, 246(5), 693–701.
  • Bujko, K.; Nowacki, M.P.; Oledzki, J.; Sopylo, R.; Skoczylas, J.; Chwalinski, M. Sphincter preservation after short-term preoperative radiotherapy for low rectal cancer–presentation of own data and a literature review. Acta Oncol. 2001, 40(5), 593–601.
  • Widder, J.; Herbst, F.; Dobrowsky, W.; Schmid, R.; Pokrajac, B.; Jech, B.; Chiari, C.; Stift, A.; Maier, A.; Karner-Hanusch, J.; Teleky, B.; Wrba, F.; Jakesz, R.; Poetter, R. Preoperative short-term radiation therapy (25 Gy, 2.5 Gy twice daily) for primary resectable rectal cancer (phase II). Br. J. Cancer. 2005, 92(7), 1209–1214.
  • Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Medical Research Council Rectal Cancer Working Party. Lancet. 1996, 348(9042), 1610–1614.
  • Wagman, R.; Minsky, B.D.; Cohen, A.M.; Guillem, J.G.; Paty, P.P. Sphincter preservation in rectal cancer with preoperative radiation therapy and coloanal anastomosis: long term follow-up. Int. J. Radiat. Oncol. Biol. Phys. 1998, 42(1), 51–57.
  • Rouanet, P.; Saint-Aubert, B.; Lemanski, C.; Senesse, P.; Gourgou, S.; Quenet, F.; Ycholu, M.; Kramar, A.; Dubois, J. Restorative and nonrestorative surgery for low rectal cancer after high-dose radiation: long-term oncologic and functional results. Dis. Colon. Rectum. 2002, 45(3), 305–315.
  • Rengan, R.; Paty, P.; Wong, W.D.; Guillem, J.; Weiser, M.; Temple, L.; Saltz, L.; Minsky, B.D. Distal cT2N0 rectal cancer: is there an alternative to abdominoperineal resection?. J. Clin. Oncol. 2005, 23(22), 4905–49012.
  • Gerard, J.-P.; Chapet, O; Nemoz, C.; Hartweig, J.; Romestaing, P.; Coquard, R.; Barbet, N.; Maingnon, P.; Mahe, M.; Baulieux, J.; Partensky, C.; Papillon, M.; Glehen, O.; Crozet, B.; Grandjean, J.-P.; Adeleine, P. Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: The Lyon R96–02 randomized trial. J. Clin. Oncol. 2004, 22(12), 2404–2409.
  • Grann, A.; Feng, C.; Wong, D.; Saltz, L.; Paty, P.P.; Guillem, J.G.; Cohen, A.M.; Minsky, B.D. Preoperative combined modality therapy for clinically resectable uT3 rectal adenocarcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2001, 49(4), 987–995.
  • Valentini, V.; Coco, C.; Cellini, N.; Picciocchi, A.; Genovesi, D.; Mantini, G.; Barbaro, B.; Cogliandolo, S.; Mattana, C.; Ambesi Impiombato, F.; Tedesco, M.; Cosimelli, M. Preoperative chemoradiation for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, and sphincter preservation. Int. J. Radiat. Oncol. Biol. Phys. 1998, 40(5), 1067–1075.
  • Janjan, N.A.; Crane, C.N.; Feig, B.W.; Cleary, K.; Dubrow, R.; Curley, S.A.; Ellis, L.M.; Vauthey, J.; Lenzi, R.; Lynch, P.; Wolff, R.; Brown, T.; Pazdur, R.; Abbruzzese, J.; Hoff, P.M.; Allen, P.; Brown, B.; Skibber, J. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2000, 47(3), 713–718.
  • Sauer, R.; Becker, H.; Hohenberger, W.; Rodel, C.; Wittekind, C.; Fietkau, R.; Martus, P.; Tschmelitsch, J.; Hager, E.; Hess, C.F.; Karstens, J.H.; Liersch, T.; Schmidberger, H.; Raab, R.; German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N. Engl. J. Med. 2004, 351(17), 1731–1740.
  • Bujko, K.; Nowacki, M.P.; Nasierowska-Guttmejer, A.; Michalski, W.; Bebenek, M.; Pudelko, M.; Kryj, M.; Oledzki, J.; Szmeja, J.; Sluszniak, J.; Serkies, K.; Kladny, J.; Pamucka, M.; Kukolowicz, P. Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother. Oncol. 2004, 72(1), 15–24.
  • Bosset, J.F.; Calais, G.; Mineur, L.; Maingon, P.; Radosevic-Jelic, L.; Daban, A.; Bardet, E.; Beny, A.; Briffaux, A.; Collette, L. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results–EORTC 22921. J. Clin. Oncol. 2005, 23(24), 5620–5627.
  • Bosset, J.F.; Collette, L.; Calais, G.; Mineur, L.; Maingon, P.; Radosevic-Jelic, L.; Daban, A.; Bardet, E.; Beny, A.; Ollier, J.C.; EORTC Radiotherapy Group Trial 22921. Chemotherapy with preoperative radiotherapy in rectal cancer. N. Engl. J. Med. 2006, 355(11), 1114–1123.
  • Guillem, J.G.; Chessin, D.B.; Shia, J.; Moore, H.G.; Mazumdar, M.; Bernard, B.; Paty, P.B.; Saltz, L.; Minsky, B.D.; Weiser, M.R.; Temple, L.K.; Cohen, A.M.; Wong, W.D. Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point. J. Clin. Oncol. 2005, 23(15), 3475–3459.
  • Gerard, J.P.; Chapet, O.; Nemoz, C.; Romestaing, P.; Mornex, F.; Coquard, R.; Barbet, N.; Atlan, D.; Adeleine, P.; Freyer, G. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0–04 phase II trial. J. Clin. Oncol. 2003, 21(6), 1119–1124.
  • Mehta, V.K.; Cho, C.; Ford, J.M.; Jambalos, C.; Poen, J.; Koong, A.; Lin, A.; Bastidas, J.A.; Young, H.; Dunphy, E.P.; Fisher, G. Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2003, 55(1), 132–137.
  • Rodel, C.; Grabenbauer, G.G.; Papadopoulos, T.; Hohenberger, W.; Schmoll, H.J.; Sauer, R. Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J. Clin. Oncol. 2003, 21(16), 3098–3104.
  • Gambacorta, M.A.; Valentini, V.; Coco, C.; Morganti, A.G.; Smaniotto, D.; Micciche, F.; Mantini, G.; Barbaro, B.; Garcia-Vargas, J.E.; Magistrelli, P.; Picciocchi, A.; Cellini, N. Chemoradiation with raltitrexed and oxaliplatin in preoperative treatment of stage II III resectable rectal cancer: Phase I and II studies. Int. J. Radiat. Oncol. Biol. Phys. 2004, 60(1), 139–148.
  • Gambacorta, M.A.; Valentini, V.; Morganti, A.G.; Mantini, G.; Micciche, F.; Ratto, C.; Di Miceli, D.; Rotondi, F.; Alfieri, S.; Doglietto, G.B.; Vargas, J.G.; De Paoli, A.; Rossi, C.; Cellini, N. Chemoradiation with raltitrexed (Tomudex) in preoperative treatment of stage II III resectable rectal cancer: a phase II study. Int. J. Radiat. Oncol. Biol. Phys. 2004, 60(1), 130–138.
  • Aschele, C.; Friso, M.L.; Pucciarelli, S.; Lonardi, S.; Sartor, L.; Fabris, G.; Urso, E.D.; Del Bianco, P.; Sotti, G.; Lise, M.; Monfardini, S. A phase I II study of weekly oxaliplatin, 5-fluorouracil continuous infusion and preoperative radiotherapy in locally advanced rectal cancer. Ann. Oncol. 2005, 16(7), 1140–1146.
  • Valentini, V.; Coco, C.; Cellini, N.; Picciocchi, A.; Fares, M.C.; Rosetto, M.E.; Mantini, G.; Morganti, A.G.; Barbaro, B.; Cogliandolo, S.; Nuzzo, G.; Tedesco, M.; Ambesi Impiombato, F.; Cosimelli, M.; Rotman, M. Ten years of preoperative chemoradiation for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, and sphincter preservation in three consecutive studies. Int. J. Radiat. Oncol. Biol. Phys. 2001, 51(12), 371–383.
  • Valentini, V.; Coco, C.; Minsky, B.D.; Gambacorta, M.A.; Cosimelli, M.; Bellavita, R.; Morganti, A.G.; La Torre, G.; Trodella, L.; Genovesi, D.; Portaluri, M.; Maurizi-Enrici, R.; Barbera, F.; Maranzano, E.; Lupattelli, M. Randomized, multicenter, phase IIb study of preoperative chemoradiotherapy in T3 mid-distal rectal cancer: raltitrexed +oxaliplatin + radiotherapy versus cisplatin + 5-fluorouracil + radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2008, 70(2), 403–412.
  • Chung, K.Y.; Minsky, B.; Schrag, D.; O’Reilly, E.; D’Adamo, D.; Hollywood, E.; Quinones, L.; Saltz, L. Phase I trial of preoperative cetuximab with continous infusion 5-fluorouracil and pelvic radiation in patients with local-regionally advanced rectal cancer. ASCO Annual Meeting Proceedings. 2006, Vol. 24, No. 18S, 161S, Abstract: 3560.
  • Machiels, J.P.; Sempoux, C.; Scalliet, P.; Coche, J.C.; Humblet, Y.; Van Cutsem, E.; Kerger, J.; Canon, J.L.; Peeters, M.; Aydin, S.; Laurent, S.; Kartheuser, A.; Coster, B.; Roels, S.; Daisne, J.F.; Honhon, B.; Duck, L.; Kirkove, C.; Bonny, M.A.; Haustermans, K. Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann. Oncol. 2007, 18(4), 738–744.
  • Willett, C.G.; Boucher, Y.; Duda, D.G.; di Tomaso, E.; Munn, L.L.; Tong, R.T.; Kozin, S.V.; Petit, L.; Jain, R.K.; Chung, D.C.; Sahani, D.V.; Kalva, S.P.; Cohen, K.S.; Scadden, D.T.; Fischman, A.J.; Clark, J.W.; Ryan, D.P.; Zhu, A.X.; Blaszkowsky, L.S.; Shellito, P.C.; Mino-Kenudson, M.; Lauwers, G.Y. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J. Clin. Oncol. 2005, 23(31), 8136–8139.
  • Chau, I.; Brown, G.; Cunningham, D.; Tait, D.; Wotherspoon, A.; Norman, A.R.; Tebbutt, N.; Hill, M.; Ross, P.J.; Massey, A.; Oates, J. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J. Clin. Oncol. 2006, 24(4), 668–674.
  • Zmora, O.; Dasilva, G.M.; Gurland, B.; Pfeffer, R.; Koller, M.; Nogueras, J.J.; Wexner, S.D. Does rectal wall tumor eradication with preoperative chemoradiation permit a change in the operative strategy?. Dis. Colon. Rectum. 2004, 47(10), 1607–1612.
  • Ruo, L.; Tickoo, S.; Klimstra, D.S.; Minsky, B.D.; Saltz, L.; Mazumdar, M.; Paty, P.B.; Wong, W.D.; Larson, S.M.; Cohen, A.M.; Guillem, J.G. Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann. Surg. 2002, 236(1), 75–81.
  • Pucciarelli, S.; Toppan, P.; Friso, M.L.; Russo, V.; Pasetto, L.; Urso, E.; Marino, F.; Ambrosi, A.; Lise, M. Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Dis. Colon. Rectum. 2004, 47(11), 1798–1807.
  • Onaitis, M.W.; Noone, R.B.; Fields, R.; Hurwitz, H.; Morse, M.; Jowell, P.; McGrath, K.; Lee, C.; Anscher, M.S.; Clary, B.; Mantyh, C.; Pappas, T.N.; Ludwig, K.; Seigler, H.F.; Tyler, D.S. Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival. Ann. Surg. Oncol. 2001, 8(10), 801–806.
  • Guillem, J.G.; Chessin, D.B.; Cohen, A.M.; Shia, J.; Mazumdar, M.; Enker, W.; Paty, P.B.; Weiser, M.R.; Klimstra, D.; Saltz, L.; Minsky, B.D.; Wong, W.D. Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer. Ann. Surg. 2005, 241(5), 829–838.
  • Bouzourene, H.; Bosman, F.T.; Seelentag, W.; Matter, M.; Coucke, P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer. 2002, 94(4), 1121–1130.
  • Vecchio, F.M.; Valentini, V.; Minsky, B.D.; Padula, G.D.; Venkatraman, E.S.; Balducci, M.; Micciche, F.; Ricci, R.; Morganti, A.G.; Gambacorta, M.A.; Maurizi, F.; Coco, C. The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2005, 62(3), 752–760.
  • Gavioli, M.; Luppi, G.; Losi, L.; Bertolini, F.; Santantonio, M.; Falchi, A.M.; D’Amico, R.; Conte, P.F.; Natalini, G. Incidence and clinical impact of sterilized disease and minimal residual disease after preoperative radiochemotherapy for rectal cancer. Dis. Colon. Rectum. 2005, 48(10), 1851–1857.
  • Rodel, C.; Martus, P.; Papadoupolos, T.; Fuzesi, L.; Klimpfinger, M.; Fietkau, R.; Liersch, T.; Hohenberger, W.; Raab, R.; Sauer, R.; Wittekind, C. Prognostic Significance of Tumor Regression After Preoperative Chemoradiotherapy for Rectal Cancer. J. Clin. Oncol. 2005, 23(34), 8688–8696.
  • Stipa, F.; Chessin, D.B.; Shia, J.; Paty, P.B.; Weiser, M.; Temple, L.K.F.; Minsky, B.D.; Wong, W.D.; Guillem, J.G. A pathologic complete response of rectal cancer to preoperative combined-modality therapy results in improved oncological outcome compared with those who achieve no downstaging on the basis of preoperative endorectal ultrasonography. Ann. Surg. Oncol. 2006, 13(8), 1047–1053.
  • Rosenberg, R.; Nekarda, H.; Zimmermann, F.; Becker, K.; Lordick, F.; Hofler, H.; Molls, M.; Siewert, J.R. Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival. J. Surg. Oncol. 2008, 97(1), 8–13.
  • Habr-Gama, A.; Perez, R.O.; Nadalin, W.; Sabbaga, J.; Ribeiro, U. Jr.; Silva e Sousa, A.H. Jr.; Campos, F.G.; Kiss, D.R.; Gama-Rodrigues, J. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann. Surg. 2004, 240(4), 711–718.
  • Schaffzin, D.M.; Wong, W.D. Endorectal ultrasound in the preoperative evaluation of rectal cancer. Clin. Colorectal. Cancer. 2004, 4(2), 124–132. Review.
  • Vanagunas, A.; Lin, D.E.; Stryker, S.J. Accuracy of endoscopic ultrasound for restaging rectal cancer following neoadjuvant chemoradiation therapy. Am. J. Gastroenterol. 2004, 38(1), 35–40.
  • Rau, B.; Hunerbein, M.; Barth, C.; Wust, P.; Haensch, W.; Riess, H.; Felix, R.; Schlag, P.M. Accuracy of endorectal ultrasound after preoperative radiochemotherapy in locally advanced rectal cancer. Surg. Endosc. 1999, 13(10), 980–984.
  • Kwok, H.; Bissett, I.P.; Hill, G.L. Preoperative staging of rectal cancer. Int. J. Colorectal. Dis. 2000, 15(1), 9–20. Review.
  • Kuo, L.J.; Chern, M.C.; Tsou, M.H.; Liu, M.C.; Jian, J.J.; Chen, C.M.; Chung, Y.L.; Fang, W.T. Interpretation of magnetic resonance imaging for locally advanced rectal carcinoma after preoperative chemoradiation therapy. Dis. Colon. Rectum. 2005, 48(1), 23–28.
  • Chen, C.C.; Lee, R.C.; Lin, J.K.; Wang, L.W.; Yang, S.H. How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy?. Dis. Colon. Rectum. 2005, 48(4), 722–728.
  • Denecke, T.; Rau, B.; Hoffmann, K.-T.; Hildebrandt, B.; Ruf, J.; Gutberlet, M.; Huenerbein, M.; Felix, R.; Wust, P.; Amthauer, H. Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: Is there a benefit in using functional imaging?. Eur. Radiol. 2005, 15(8), 1658–1666.
  • Guillem, J.G.; Moore, H.G.; Akhurst, T.; Klimstra, D.S.; Ruo, L.; Mazumdar, M.; Minsky, B.D.; Saltz, L.; Wong, W.D.; Larson, S. Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: A means for determining longterm outcomes of rectal cancer. J. Am. Coll. Surg. 2004, 199(1), 1–7.
  • Calvo, F.A.; Domper, M.; Matute, R.; Martinez-Lazaro, R.; Arranz, J.A.; Desco, M.; Alvarez, E.; Carreras, J.L. 18F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation. Int. J. Radiat. Oncol. Biol. Phys. 2004, 58(2), 528–535.
  • Amthauer, H.; Denecke, T.; Rau, B.; Hildebrandt, B.; Huenerbein, M.; Ruf, J.; Schneider, U.; Gutberlet, M.; Schlag, P.M.; Felix, R.; Wust, P. Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: Correlation with endorectal ultrasound and histopathology. Eur. J. Nucl. Med. 2004, 31(6), 811–819.
  • Capirci, C.; Rampin, L.; Erba, P.A.; Galeotti, F.; Crepaldi, G.; Banti, E.; Gava, M.; Fanti, S.; Mariani, G.; Muzzio, P.C.; Rubello, D. Sequential FDG-PET/CT reliably predicts response of locally advanced rectal cancer to neo-adjuvant chemo-radiation therapy. Eur. J. Nucl. Med. Mol. Imaging. 2007, 34(10), 1583–1593.
  • Avril, N.; Sassen, S.; Schmalfeldt, B.; Naehrig, J.; Rutke, S.; Weber, W.A.; Werner, M.; Graeff, H.; Schwaiger, M.; Kuhn, W. Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer. J. Clin. Oncol. 2005, 23(30), 7445–7453.
  • Dose Schwarz, J.; Bader, M.; Jenicke, L.; Hemminger, G.; Janicke, F.; Avril, N. Early prediction of response to chemotherapy in metastatic breast cancer using sequential 18F-FDG PET. J. Nucl. Med. 2005, 46(7), 1144–1150.
  • Williams, N.S.; Dixon, M.F.; Johnston, D. Reappraisal of the 5 centimeter rule of distal excision for carcinoma of the rectum: a study of distal intramural spread and of patients’ survival. Br. J. Surg. 1983, 70(3), 150–154.
  • Madsen, P.M.; Christiansen, J. Distal intramural spread of rectal carcinomas. Dis. Colon. Rectum. 1986, 29(4), 279–282.
  • Vernava, A.M. 3rd; Moran, M.; Rothenberger, D.A.; Wong, W.D. A prospective evaluation of distal margins in carcinoma of the rectum. Surg. Gynecol. Obstet. 1992, 175(4), 333–336.
  • Shirouzu, K.; Isomoto, H.; Kakegawa, T. Distal spread of rectal cancer and optimal distal margin of resection for sphincter-preserving surgery. Cancer. 1995, 76(3). 388–392.
  • Andreola, S.; Leo, E.; Belli, F.; Bonfanti, G.; Sirizzotti, G.; Greco, P.; Valvo, F.; Tomasic, G.; Gallino, G.F. Adenocarcinoma of the lower third of the rectum surgically treated with a <10-MM distal clearance: preliminary results in 35 N0 patients. Ann. Surg. Oncol. 2001, 8(7), 611–615.
  • Kuvshinoff, B.; Maghfoor, I.; Miedema, B.; Bryer, M.; Westgate, S.; Wilkes, J.; Ota, D. Distal margin requirements after preoperative chemoradiotherapy for distal rectal carcinomas: are < or = 1 cm distal margins sufficient?. Ann. Surg. Oncol. 2001, 8(2), 163–169.
  • Moore, H.G.; Riedel, E.; Minsky, B.D.; Saltz, L.; Paty, P.; Wong, D.; Cohen, A.M.; Guillem, J.G. Adequacy of 1-cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined-modality therapy. Ann. Surg. Oncol. 2003, 10(1), 80–85.
  • Guillem, J.G.; Chessin, D.B.; Shia, J.; Suriawinata, A.; Riedel, E.; Moore, H.G.; Minsky, B.D.; Wong, W.D. A prospective pathologic analysis using whole mount sections of rectal cancer following preoperative combined modality therapy: Implications for sphincter preservation. Ann. Surg. 2007, 245, 1, 88–93.
  • Luna-Perez, P.; Bustos-Cholico, E.; Alvarado, I.; Maffuz, A.; Rodriguez-Ramirez, S.; Gutierrez de la Barrera, M.; Labastida, S. Prognostic significance of circumferential margin involvement in rectal adenocarcinoma treated with preoperative chemoradiotherapy and low anterior resection. J. Surg. Oncol. 2005, 90(1), 20–25.
  • Rullier, E.; Laurent, C.; Bretagnol, F.; Rullier, A.; Vendrely, V.; Zerbib, F. Sphincter-saving resection for all rectal carcinomas. The end of the 2-cm distal rule. Ann. Surg. 2005, 241(3), 465–469.

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