Effects of Naturally Occurring Polymethyoxyflavonoids on Cell Growth, P-Glycoprotein Function, Cell Cycle, and Apoptosis of Daunorubicin-Resistant T Lymphoblastoid Leukemia Cells

REFERENCES

• Seedhouse, C.H.; Grundy, M.; White, P.; Li, Y.; Fisher, J.; Yakunina, D.; Moorman, A.V.; Hoy, T.; Russell, N.; Burnett, A.; Pallis, M. Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trials. Clin Cancer Res 2007, 13, 7059–7066.
   PubMed Web of Science ®Google Scholar
• Zhang, D.; Fan, D. Multidrug resistance in gastric cancer: recent research advances and ongoing therapeutic challenges. Expert Rev Anticancer Ther 2007, 7, 1369–1378.
   PubMed Web of Science ®Google Scholar
• den Boer, M.L.; Pieters, R.; Kazemier, K.M., Janka-Schaub, G.E.; Henze, G.; Veerman, A.J. The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia. Leukemia 1998, 12, 912–920.
   PubMed Web of Science ®Google Scholar
• Ikegawa, T.; Ushigome, F.; Koyabu, N.; Morimoto, S.; Shoyama, Y.; Naito, M.; Tsuruo, T.; Ohtani, H.; Sawada, Y. Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett 2000, 160, 21–28.
   PubMed Web of Science ®Google Scholar
• Ikegawa, T.; Ohtani, H.; Koyabu, N.; Juichi, M.; Iwase, Y.; Ito, C.; Furukawa, H.; Naito, M.; Tsuruo, T.; Sawada, Y. Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett 2000, 177, 89–93.
   Web of Science ®Google Scholar
• Chaudhary, P.M.; Roninson, I.B. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991, 66, 85–94.
   PubMed Web of Science ®Google Scholar
• Ludescher, C.; Gattringer, C.; Drach, J.; Hofmann, J.; Grunicke, H. Rapid functional assay for the detection of multidrug-resistant cells using the fluorescent dye rhodamine 123. Blood 1991, 78, 1385–1387.
   PubMed Web of Science ®Google Scholar
• Ludescher, C.; Thalar, J.; Drach, D.; Drach, J.; Spitaler, M.;Gattringer, C.; Huber, H.; Homann, J. Detection of activity of P-glycoprotein in human tumor samples using rhodamine 123. Br J Haematol 1992, 82, 161–168.
   PubMed Web of Science ®Google Scholar
• Neyfakh, A.A. Use of fluorescent dyes as molecular probes for the study of multidrug resistance. Exp Cell Res 1988, 174, 168–176.
   PubMed Web of Science ®Google Scholar
• Aslanian, A.M.; Fletcher, B.S.; Kilberg, M.S. Asparagine synthetase expression alone is sufficient to induce L-asparaginase resistance in MOLT-4 human leukemia cells. Biochem J 2001, 357, 321–328.
   PubMed Web of Science ®Google Scholar
• Flescher, E.; Rotem, R.; Kwon, P.; Azare, J.; Jaspers, I.; Cohen, D. Aspirin enhance multidrug resistance gene 1 expression in human MOLT-4 T lymphoma cells. Anticancer Res 2000, 20, 4441–4444.
   PubMed Web of Science ®Google Scholar
• Liu, Z.L.; Onda, K.; Tanaka, S.; Toma, T.; Hirano, T.; Oka, K.. Induction of multidrug resistance in MOLT-4 cells by anti-cancer agents is closely related to increased expression of functional P-glycoprotein and MDR1 mRNA. Cancer Chemother Pharmacol 2002, 49, 391–397.
   PubMed Web of Science ®Google Scholar
• Hirano, T.; Oka, K.; Akiba, M. Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Res Commun Chem Pathol Pharmacol 1989, 64, 69–78.
   PubMedGoogle Scholar
• Hirano, T.; Abe, K.; Gotoh, M.; Oka, K. Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 1995, 72, 1380–1388.
   PubMed Web of Science ®Google Scholar
• Ishiwa, J.; Sato, T.; Mimaki, Y.; Sashida, Y.; Yano, M.; Ito, A. A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. J Rheumatol 2000, 27, 20–25.
   PubMed Web of Science ®Google Scholar
• Kawaii, S.; Tomono, Y.; Katase, E.; Ogawa, K.; Yano, M. Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotechnol Biochem 1999, 63, 896–899.
   PubMed Web of Science ®Google Scholar
• Ohtani, H.; Ikegawa, T.; Honda, Y.; Kohyama, N.; Morimoto, S.; Shoyama, Y.; Juichi, M.; Naito, M.; Tsuruo, T.; Sawada, Y. Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. Pharm Res 2007, 24, 1936–1943.
   PubMed Web of Science ®Google Scholar
• Morley, K.L.; Ferguson, P.J.; Koropatnick, J. Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. Cancer Lett 2007, 251, 168–178.
   PubMed Web of Science ®Google Scholar
• Nagase, H.; Omae, N.; Omori, A.; Nakagawasai, O.; Tadano, T.; Yokosuka, A.; Sashida, Y.; Mimaki, Y.; Yamakuni, T.; Ohizumi, Y. Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. Biochem Biophys Res Comm 2005, 337, 1330–1336.
   PubMed Web of Science ®Google Scholar
• Hu, X.-M.; Hirano, T.; Oka, K. Arsenic trioxide induces apoptosis equally to T lymphoblastoid leukemia MOLT-4 cells and P-gp expressing daunorubicin-resistant MOLT-4 cells. Cancer Chemother Pharmacol 2003, 51, 119–126.
   PubMed Web of Science ®Google Scholar
• Hu, X.M.; Hirano, T.; Oka, K. Arsenic trioxide induces apoptosis in MOLT-4 and its daunorubicin-resistant MOLT-4 cell lines via depletion of intracellular glutathione, disruption of mitochondrial membrane potential and activation of caspase-3. Cancer Chemother Pharmacol 2003, 52, 47–58.
   PubMed Web of Science ®Google Scholar
• Efferth, T.; Konkimalla, V.B.; Wang, Y.F.; Sauerbrey, A.; Meinhardt, S.; Zintl, F.; Mattern, J.; Volm, M. Prediction of broad spectrum resistance of tumors towards anticancer drugs. Clin Cancer Res 2008, 14, 2405–2412.
   PubMed Web of Science ®Google Scholar
• Schrickx, J.A.; Fink-Gremmels, J. Implications of ABC transporters on the disposition of typical veterinary medicinal products. Eur J Pharmacol 2008, 585(2–3), 510–519.
   PubMed Web of Science ®Google Scholar
• Takano, K.; Tabata, Y.; Kitao, Y.; Murakami, R.; Suzuki, H.; Yamada, M.; Iinuma, M.; Yoneda, Y.; Ogawa, S.; Hori, O. Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin. Am J Physiol Cell Physiol 2007, 292, C353–361.
   PubMed Web of Science ®Google Scholar
• Pan, M.H.; Chen, W.J.; Lin-Shiau, S.Y.; Ho, C.T.; Lin, J.K. Tangeretin induces cell-cycle G1 arrest through inhibitingcyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 1992, 23, 1677–1684.
   Google Scholar
• Hirano, T.; Gotoh, M.; Oka, K. Natural flavonoids and lignans as candidates for non-cytotoxic antiproliferative antileukemia. Life Sci 1994, 55, 1061–1069.
   PubMed Web of Science ®Google Scholar
• Psahoulia, F.H.; Drosopoulos, K.G.; Doubravska, L.; Andera, L.; Pintzas, A. Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol Cancer Ther 2007, 6, 2591–2599.
   PubMed Web of Science ®Google Scholar
• Wang, J.; Yu, Y.; Hashimoto, F.; Sakata, Y.; Fujii, M.; Hou, D.X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int J Mol Med 2004, 14, 627–632.
   PubMed Web of Science ®Google Scholar