105
Views
7
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLECausation and Prevention

MS-MLPA Reveals Progressive Age-Dependent Promoter Methylation of Tumor Suppressor Genes and Possible Role of IGSF4 Gene in Colorectal Carcinogenesis of Microsatellite Instable Tumors

, &
Pages 94-102 | Published online: 08 Dec 2009

REFERENCES

  • Kondo, Y.; Issa, J.P. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev 2004, 23, 29–39.
  • Toyota, M.; Ohe-Toyota, M.; Ahuja, N.; Issa, J.P. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA 2000, 97, 710–715.
  • Jubb, A.M.; Bell, S.M.; Quirke, P. Methylation and colorectal cancer. J Pathol 2001, 195, 111–134.
  • Jones, P.A.; Laird, P.W. Cancer epigenetics comes of age. Nat Genet 1999, 21, 163–167.
  • Ishiguro, A.; Takahata, T.; Saito, M.; Yoshiya, G.; Tamura, Y.; Sasaki, M.; Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer. J. Gastroenterol. Hepatol 2006, 21, 1334–1339.
  • Xu, X.L.; Yu, J.; Zhang, H.Y.; Sun, M.H.; Gu, J.; Du, X.; Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 2004, 10, 3441–3454.
  • Trzeciak, L.; Hennig, E.; Kolodziejski, J.; Nowacki, M.; Ostrowski, J. Mutations, methylation, and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa. Cancer Lett 2001, 163, 17–23.
  • Potocnik, U.; Glavac, D.; Golouh, R.; Ravnik-Glavac, CausesM. of microsatellite instability in colorectal tumors: implications for hereditary non-polyposis colorectal cancer screening. Cancer Genet Cytogenet 2001, 126, 85–96.
  • Issa, J.P.; Ottaviano, Y.L.; Celano, P.; Hamilton, S.R.; Davidson, N.E.; Baylin, S.B. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994, 7, 536–540.
  • Woodson, K.; Weisenberger, D.J.; Campan, M.; Laird, P.W.; Tangrea, J.; Johnson, L.L.; Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. Cancer Epidemiol Biomarkers Prev 2005, 14, 1219–1223.
  • Toyooka, S.; Toyooka, K.O.; Harada, K.; Miyajima, K.; Makarla, P.; Sathyanarayana, U.G.; Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas. Cancer Res 2002, 62, 3382–3386.
  • Hibi, K.; Nakayama, H.; Kodera, Y.; Ito, K.; Akiyama, S.; Nakao, A. CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer. Br J Cancer 2004, 90, 1030–1033.
  • Lind, G.E.; Thorstensen, L.; Lovig, T.; Meling, G.I.; Hamelin, R.; Rognum, T.O.; A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer 2004, 3, 28.
  • Bai, A.H.; Tong, J.H.; To, K.F.; Chan, M.W.; Man, E.P.; Lo, K.W.; Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. Int J Cancer 2004, 112, 846–853.
  • Toyota, M.; Ahuja, N.; Ohe-Toyota, M.; Herman, J.G.; Baylin, S.B.; Issa, J.P. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999, 96, 8681–8686.
  • Yamashita, K.; Dai, T.; Dai, Y.; Yamamoto, F.; Perucho, M. Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell 2003, 4, 121–131.
  • Weisenberger, D.J.; Siegmund, K.D.; Campan, M.; Young, J.; Long, T.I.; Faasse, M.A.; CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006, 38, 787–793.
  • Issa, J.P. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004, 4, 988–993.
  • Ionov, Y.; Peinado, M.A.; Malkhosyan, S.; Shibata, D.; Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993, 363, 558–561.
  • Aaltonen, L.A.; Peltomaki, P.; Leach, F.S.; Sistonen, P.; Pylkkanen, L.; Mecklin, J.P.; Clues to the pathogenesis of familial colorectal cancer. Science 1993, 260, 812–816.
  • Thibodeau, S.N.; Bren, G.; Schaid, D. Microsatellite instability in cancer of the proximal colon. Science 1993, 260, 816–819.
  • Peltomaki, P.; Aaltonen, L.A.; Sistonen, P.; Pylkkanen, L.; Mecklin, J.P.; Jarvinen, H.; Genetic mapping of a locus predisposing to human colorectal cancer. Science 1993, 260, 810–812.
  • Ogino, S.; Cantor, M.; Kawasaki, T.; Brahmandam, M.; Kirkner, G.J.; Weisenberger, D.J.; CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006, 55, 1000–1006.
  • Herman, J.G.; Graff, J.R.; Myohanen, S.; Nelkin, B.D.; Baylin, S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996, 93, 9821–9826.
  • Eads, C.A.; Danenberg, K.D.; Kawakami, K.; Saltz, L.B.; Blake, C.; Shibata, D.; MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 2000, 28, e32.
  • Nygren, A.O.; Ameziane, N.; Duarte, H.M.; Vijzelaar, R.N.; Waisfisz, Q.; Hess, C.J.; Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res 2005, 33, e128.
  • Jeuken, J.W.; Cornelissen, S.J.; Vriezen, M.; Dekkers, M.M.; Errami, A.; Sijben, A.; MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas. Lab Invest 2007, 87, 1055–1065.
  • Scott, R.H.; Douglas, J.; Baskcomb, L.; Nygren, A.O.; Birch, J.M.; Cole, T.R.; Methylation-specific MLPA (MS-MLPA) robustly detects and distinguishes 11p15 abnormalities associated with overgrowth and growth retardation. J Med Genet 2007, 45(2), 106–13.
  • Schouten, J.P.; McElgunn, C.J.; Waaijer, R.; Zwijnenburg, D.; Diepvens, F.; Pals, G. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res 2002, 30, e57.
  • Livak, K.J.; Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25, 402–408.
  • Ahuja, N.; Li, Q.; Mohan, A.L.; Baylin, S.B.; Issa, J.P. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 1998, 58, 5489–5494.
  • Nakagawa, H.; Nuovo, G.J.; Zervos, E.E.; Martin, E.W.Jr.; Salovaara, R.; Aaltonen, L.A.; Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 2001, 61, 6991–6995.
  • Yuasa, Y. DNA methylation in cancer and ageing. Mech Ageing Dev 2002, 123, 1649–1654.
  • Ogino, S.; Odze, R.D.; Kawasaki, T.; Brahmandam, M.; Kirkner, G.J.; Laird, P.W.; Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. Am J Surg Pathol 2006, 30, 1175–1183.
  • Ogino, S.; Goel, A. Molecular classification and correlates in colorectal cancer. J Mol Diagn 2008, 10, 13–27.
  • Ogino, S.; Kawasaki, T.; Kirkner, G.J.; Kraft, P.; Loda, M.; Fuchs, C.S. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn 2007, 9, 305–314.
  • Shen, L.; Toyota, M.; Kondo, Y.; Lin, E.; Zhang, L.; Guo, Y.; Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci USA 2007, 104, 18654–18659.
  • Li, J.; Zhang, Z.; Bidder, M.; Funk, M.C.; Nguyen, L.; Goodfellow, P.J.; IGSF4 promoter methylation and expression silencing in human cervical cancer. Gynecol Oncol 2005, 96, 150–158.
  • Deng, G.; Chen, A.; Hong, J.; Chae, H.S.; Kim, Y.S. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res 1999, 59, 2029–2033.
  • Belshaw, N.J.; Elliott, G.O.; Williams, E.A.; Mathers, J.C.; Buckley, L.; Bahari, B.; Methylation of the ESR1 CpG island in the colorectal mucosa is an “all or nothing” process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse. Biochem Soc Trans 2005, 33, 709–711.
  • Foley, E.F.; Jazaeri, A.A.; Shupnik, M.A.; Jazaeri, O.; Rice, L.W. Selective loss of estrogen receptor beta in malignant human colon. Cancer Res 2000, 60, 245–248.
  • Arai, T.; Takubo, K. Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly. Pathol Int 2007, 57, 303–314.
  • Watanabe, T.; Kobunai, T.; Toda, E.; Yamamoto, Y.; Kanazawa, T.; Kazama, Y.; Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers. Cancer Res 2006, 66, 9804–9808.
  • Deng, G.; Peng, E.; Gum, J.; Terdiman, J.; Sleisenger, M.; Kim, Y.S. Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer. Br J Cancer 2002, 86, 574–579.
  • Murakami, InvolvementY. of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Cancer Sci 2005, 96, 543–552.
  • Masuda, M.; Yageta, M.; Fukuhara, H.; Kuramochi, M.; Maruyama, T.; Nomoto, A.; The tumor-suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol Chem 2002, 277, 31014–31019.
  • Kuramochi, M.; Fukuhara, H.; Nobukuni, T.; Kanbe, T.; Maruyama, T.; Ghosh, H.P.; TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 2001, 27, 427–430.
  • Surace, E.I.; Lusis, E.; Murakami, Y.; Scheithauer, B.W.; Perry, A.; Gutmann, D.H. Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. J Neuropathol Exp Neurol 2004, 63, 1015–1027.
  • Jass, J.R. Classification of colorectal cancer based on correlation of clinical, morphological, and molecular features. Histopathology 2007, 50, 113–130.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.