83
Views
5
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLEClinical Translational Therapeutics

A Phase I Study Of Docetaxel, Oxaliplatin, & Capecitabine (DOC) As First-Line Therapy of Patients With Locally Advanced or Metastatic Adenocarcinoma of Stomach and GE Junction

, &
Pages 833-838 | Published online: 14 Sep 2010

REFERENCES

  • Alexander, H.R.; Kelsen, D.P.; Tepper, J.E. Cancer of the stomach. In Cancer: Principles and Practice of Oncology, V.T. DeVita, S. Hellman, S.A. Rosenberg (eds). Philadelphia, PA: Lppincott-Raven, 1997, 1021–1054.
  • Ajani, J.A. Evolving chemotherapy for advanced gastric cancer. Oncologist 2005, 10(Suppl. 3), 574–587.
  • Cen, P.; Ajani, J.A. Medical treatment for advanced gastroesophageal adenocarcinoma. Curr Opin Gastroenterol 2007, 23, 631–635.
  • Ohtsu, A. Chemotherapy for metastatic gastric cancer: past, present, and future. J Gastroenterol 2008, 43, 256–264.
  • Catalano, V.; Labianca, R.; Beretta, G.D.; Gatta, G.; de Brand, F.; Van Custem, E. Gastric cancer. Crit Rev Oncol Hematol 2009, 71, 127–164.
  • Liu, G.; Franssen, E.; Fitch, M.I., Warner, E. Patients preference for oral versus intravenous palliative chemotherapy. J Clin Oncol 1997, 15, 110–115.
  • Miwa, M.; Ura, M.; Nishida, M.; Sawada, N.; Ishikawa, T.; Mori, K.; Shimma, N.; Umeda, I.; Ishitsuka, H. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumors by enzymes concentrated in human liver and cancer tissues. Eur J Cancer 1998, 34, 1274–1281.
  • Ishikawa, T.; Utoh, M.; Sawada, N.; Nishida, M.; Fukase, Y.; Sekiguchi, F.; Ishitsuka, H. Tumor selective delivery of 5-FU by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts. Bichem Pharmacol 1998, 55, 1091–1097.
  • Schüller, J.; Cassidy, J.; Dumont, E.; Roos, B.; Durston, S.; Banken, L.; Utoh, M.; Mori, K.; Weidekamm, E.; Reigner, B. Preferential activation of capecitabine in tumor following oral administration in colorectal cancer patients. Cancer Chemother Pharmacol 2000, 45, 291–297.
  • Takebayashi, Y.; Akiyama, S.; Akiba, S.; Yamada, K.; Miyadera, K.; Sumizawa, T.; Yamada, Y.; Murata, F.; Aikou, T. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 1996, 88, 1110–1117.
  • Ishikawa, T.; Sekiguchi, F.; Fukase, Y.; Sawada, N.; Ishitsuka, H. Positive correlation between efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 1998, 58, 685–690.
  • Koizumi, W.; Saigenji, K.; Ujiie, S.; Terashima, M.; Sakata, Y.; Taguchi, T.; Clinical Study Group of Capecitabine. A pilot phase II study of capecitabine in advanced or recurrent gastric cancer. Oncology 2003, 64, 232–236.
  • Ajani, J. Review of capecitabine as oral treatment of gastric, gastroesophageal, and esophageal cancers. Cancer 2006, 107, 221–231.
  • Dhillon, S.; Scott, L.J. Capecitabine: in advanced gastric and oesophagogastric cancer. Drugs 2007, 67, 601–610.
  • Sulkes, A.; Smyth, J.; Sessa, C.; Dirix, LY.; Vermorken, J.B.; Kaye, S.; Wanders, J.; Franklin, H.; LeBail, N.; Verweij, J. Taxotere in advanced gastric cancer: results of a phase II clinical trial. EORTC Early Clinical Trials Group. Br J Cancer 1994, 70, 380–383.
  • Einzig, A.; Neuberg, D.; Remick, S.C.; Karp, D.D.; O'Dwyer, P.J.; Stewart, J.A.; Benson, A.B. 3rd. Phase II trial of Taxotere in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy: the Eastern Cooperative Oncology Group (ECOG) results of protocol E1293. Med Oncol 1996, 13, 87–93.
  • Graziono, F.; Catalano, V.; Baldelli, A.M.; Giordani, P.; Testa, E.; Lai, V.; Catalano, G.; Battelli, N.; Cascinu, S. A phase II study of weekly docetaxel as salvage chemotherapy for advanced gastric cancer. Ann Oncol 2000, 11, 1263–1266.
  • Ajani, J.A. Docetaxel for gastric and esophageal carcinomas. Oncology 2002, 16, S89–S105.
  • Deeks, E.D.; Scott, L.J. Docetaxel: in gastric cancer. Drugs 2007, 67, 1893–1901.
  • Hainsworth, J.D. Practical aspects of weekly docetaxel administration schedules. Oncologist 2004, 9, 538–545.
  • Rivera, E.; Meijia, J.A.; Arun, B.K.; Adinin, R.B.; Walters, R.S.; Brewster, A.; Broglio, K.R.; Yin, G.; Esmaeli, B.; Hortobagyi, G.N.; Valero, V. Phase 3 study comparing the use of docetaxel on an every 3-week versus weekly schedule in the treatment of metastatic breast cancer. Cancer 2008, 112, 1455–1461.
  • Roth, A.D.; Maibach, R.; Martinelli, G.; Fazio, N.; Aapro, M.S.; Pagani, O.; Morant, R.; Borner, M.M.; Herrmann, R.; Honegger, H.; Cavalli, F.; Alberto, P.; Castiglione, M.; Goldhirsch A. Taxotere-platinol(TC): an effective drug combination in gastric cancer. Ann Oncol 2000, 11, 301–306.
  • Giordano, K.F.; Jatoi, A.; Stella, P.J.; Foster, N.; Tschetter, L.K.; Alberts, S.R.; Dakhil, S.R.; Mailliard, J.A.; Flynn, P.J.; Nikcevich, D.A. Docetaxel and capecitabine in patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction: a phase II study from the North Central Cancer Treatment Group. Ann Oncol 2006, 17, 652–656.
  • Raymond, E.; Faivre, S.; Woynarowski, J.M.; Chaney, S.G. Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol 1998, 25, 4–12.
  • Louvet, C.; Andre, T.; Tigaud, J.M.; Gamelin, E.; Douillard, J.Y.; Brunet, R.; François, E.; Jacob, J.H.; Levoir, D.; Taamma, A.; Rougier, P.; Cvitkovic, E.; de Gramont, A. Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol 2002, 20, 4543–4548.
  • Borner, M.; Dietrich, D.; Stupp, R.; Morant, R.; Honegger, H.; Wernli, M.; Herrmann, R.; Pestalozzi, B.C.; Saletti, P.; Hanselmann, S.; Müller, S.; Brauchli, P.; Castiglione-Gertsch, M.; Goldhirsch, A.; Roth, A.D. Phase II study of capecitabine and oxaliplatin in first- and second line treatment of advanced or metastatic colorectal cancer. J Clin Oncol 2002, 20, 1759–1766.
  • Kim, D.Y.; Kim, J.H.; Lee, S.H.; Kim, T.Y.; Heo, D.S.; Bang, Y.J.; Kim, N.K. Phase II study of oxaliplatin, 5-fluorouracail and leucovorin in previously platinum-treated patients with advanced gastric cancer. Ann Oncol 2003, 14, 383–387.
  • Cunningham, D.; Starling, N.; Rao, S.; Iveson, T.; Nicolson, M.; Coxon, F.; Middleton, G.; Daniel, F.; Oates, J.; Norman, A.R.; Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United Kingdom. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 2008, 358, 36–46.
  • Raymond, E.; Buquet-Fagot, C.; Djelloul, S.; Mester, J.; Cvitkovic, E.; Allain, P.; Louvet, C.; Gespach, C. Antitumor activity of oxaliplatin in combination with 5-fluorouracil and the thymidylate synthase inhibitor AG337 in human colon, breast and ovarian cancers. Anticancer Drugs 1997, 8, 876–885.
  • Sawada, N.; Ishikawa, T.; Fukase, Y.; Nishida, M.; Yoshikubo, T.; Ishitsuka, H. Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xerografts. Clin Cancer Res 1998, 4, 1013–1019.
  • Yamamoto, S.; Kurebayashi, J.; Kurosumi, M.; Kunisue, H.; Otsuki, T.; Tanaka, K.; Sonoo, H. Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xerografts. Cancer Chemother Pharmacol 2001, 48, 283–288.
  • Wagner, A.D.; Grothe, W.; Haerting, J.; Kleber, G.; Grothey, A.; Fleig, W.E. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J Clin Oncol 2006, 24, 2903–2909.
  • Van Custem, E.; Moiseyenko, V.M.; Tjulandin, S.; Majlis, A.; Constenla, M.; Boni, C.; Rodrigues, A.; Fodor, M.; Chao, Y.; Voznyi, E.; Risse, M.L.; Ajani, J.A. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol 2006, 24, 4991–4997.
  • Ajani, J.A.; Moiseyenko, V.M.; Tjulandin, S.; Majlis, A.; Constenla, M.; Boni, C.; Rodrigues, A.; Fodor, M.; Chao, Y.; Voznyi, E.; Awad, L.; Van Cutsem, E. Quality of life with docetaxel plus cisplatin and fluorouracil compared with cisplatin and fluorouracil from a phase III trial for advanced gastric and gastroesophageal adenocarcinoma: the V-325 Study Group. J Clin Oncol 2007, 25, 3210–3216.
  • Ilson, D.H. Docetaxel, cisplatin, and fluorouracil in gastric cancer: does the punishment fit the crime? J Clin Oncol 2007, 25, 3188–3190.
  • Roth, A.D.; Fazio, N.; Stupp, R.; Falk, S.; Bernhard, J.; Saletti, P.; Köberle, D.; Borner, M.M.; Rufibach, K.; Maibach, R.; Wernli, M.; Leslie, M.; Glynne-Jones, R.; Widmer, L.; Seymour, M.; de Braud, F. Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin; and epirubucin, cisplatin, and fluorouracil as systemic treatment for advanced gastric carcinoma: a randomized trial of the Swiss Group for Clinical Cancer Research. J Clin Oncol 2007, 25, 3217–3223.
  • Evans, D.; Miner, T.; Akerman, P.; Millis, R.; Jean, M.; Kennedy, T.; Safran, H. A phase I study of docetaxel, oxaliplatin, and capecitabine in patients with metastatic gastroesophageal cancer. Am J Clin Oncol 2007, 30, 346–349.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.