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ORIGINAL ARTICLECellular and Molecular Biology

Expression of HERV-K Correlates With Status of MEK–ERK and p16INK4A–CDK4 Pathways in Melanoma Cells

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Pages 1031-1037 | Published online: 27 Sep 2010

REFERENCES

  • Li, J.; Xu, M.; Yang, Z.; Li, A.; Dong, J. Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. Cancer Invest 2010, 28, 350–356.
  • Rotolo, S.; Diotti, R.; Gordon, R.E.; Qiao, R.F.; Yao, Z.; Phelps, R.G.; Dong, J. Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells. Int J Cancer 2005, 115, 164–169.
  • Zhao, Y.; Zhang, Y.; Yang, Z.; Li, A.; Dong, J. Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis. Biochem Biophys Res Commun 2008, 370, 509–513.
  • Muster, T.; Waltenberger, A.; Grassauer, A.; Hirschl, S.; Caucig, P.; Romirer, I.; Fodinger, D.; Seppele, H.; Schanab, O.; Magin-Lachmann, C.; Lower, R.; Jansen, B.; Pehamberger, H.; Wolff, K. An endogenous retrovirus derived from human melanoma cells. Cancer Res 2003, 63, 8735–8741.
  • Voisset, C.; Weiss, R.A.; Griffiths, D.J., Human RNA “rumor” viruses: the search for novel human retroviruses in chronic disease. Microbiol Mol Biol Rev 2008, 72, 157–196.
  • Singh, S.; Kaye, S.; Gore, M.E.; McClure, M.O.; Bunker, C.B. The role of human endogenous retroviruses in melanoma. Br J Dermatol 2009, 161, 1225–1231.
  • Ahn, K.; Kim, H.S. Structural and quantitative expression analyses of HERV gene family in human tissues. Mol Cells 2009, 28, 99–103.
  • Beimforde, N.; Hanke, K.; Ammar, I.; Kurth, R.; Bannert, N. Molecular cloning and functional characterization of the human endogenous retrovirus K113. Virology 2008, 371, 216–225.
  • Turner, G.; Barbulescu, M.; Su, M.; Jensen-Seaman, M.I.; Kidd, K.K.; Lenz, J. Insertional polymorphisms of full-length endogenous retroviruses in humans. Curr Biol 2001, 11, 1531–1535.
  • Lower, R.; Boller, K.; Hasenmaier, B.; Korbmacher, C.; Muller-Lantzsch, N.; Lower, J.; Kurth, R. Identification of human endogenous retroviruses with complex mRNA expression and particle formation. Proc Natl Acad Sci U S A 1993, 90, 4480–4484.
  • Seifarth, W.; Frank, O.; Zeilfelder, U.; Spiess, B.; Greenwood, A.D.; Hehlmann, R.; Leib-Mosch, C. Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray. J Virol 2005, 79, 341–352.
  • Kalter, S.S.; Helmke, R.J.; Heberling, R.L.; Panigel, M.; Fowler, A.K.; Strickland, J.E.; Hellman, A. Brief communication: C-type particles in normal human placentas. J Natl Cancer Inst 1973, 50, 1081–1084.
  • Pothlichet, J.; Mangeney, M.; Heidmann, T. Mobility and integration sites of a murine C57BL/6 melanoma endogenous retrovirus involved in tumor progression in vivo. Int J Cancer 2006, 119, 1869–1877.
  • Tchenio, T.; Heidmann, T. Defective retroviruses can disperse in the human genome by intracellular transposition. J Virol 1991, 65, 2113–2118.
  • Mangeney, M.; Pothlichet, J.; Renard, M.; Ducos, B.; Heidmann, T. Endogenous retrovirus expression is required for murine melanoma tumor growth in vivo. Cancer Res 2005, 65, 2588–2591.
  • Oricchio, E.; Sciamanna, I.; Beraldi, R.; Tolstonog, G.V.; Schumann, G.G.; Spadafora, C. Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression. Oncogene 2007, 26, 4226–4233.
  • Serafino, A.; Balestrieri, E.; Pierimarchi, P.; Matteucci, C.; Moroni, G.; Oricchio, E.; Rasi, G.; Mastino, A.; Spadafora, C.; Garaci, E.; Vallebona, P.S. The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation. Exp Cell Res 2009, 315, 849–862.
  • Mettling, C.; Desmetz, C.; Fiser, A.L.; Reant, B.; Corbeau, P.; Lin, Y.L. Galphai protein-dependant extracellular signal-regulated kinase-1/2 activation is required for HIV-1 reverse transcription. AIDS 2008, 22, 1569–1576.
  • Richmond-Sinclair, N.M.; Lee, E.; Cummings, M.C.; Williamson, R.; Muller, K.; Green, A.C.; Hayward, N.K.; Whiteman, D.C. Histologic and epidemiologic correlates of P-MAPK, Brn-2, pRb, p53, and p16 immunostaining in cutaneous melanomas. Melanoma Res 2008, 18, 336–345.
  • Ghiorzo, P.; Villaggio, B.; Sementa, A.R.; Hansson, J.; Platz, A.; Nicolo, G.; Spina, B.; Canepa, M.; Palmer, J.M.; Hayward, N.K.; Bianchi-Scarra, G. Expression and localization of mutant p16 proteins in melanocytic lesions from familial melanoma patients. Hum Pathol 2004, 35, 25–33.
  • Buscher, K.; Hahn, S.; Hofmann, M.; Trefzer, U.; Ozel, M.; Sterry, W.; Lower, J.; Lower, R.; Kurth, R.; Denner, J. Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell lines. Melanoma Res 2006, 16, 223–234.
  • Buscher, K.; Trefzer, U.; Hofmann, M.; Sterry, W.; Kurth, R.; Denner, J. Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res 2005, 65, 4172–4180.
  • Romano, C.M.; Ramalho, R.F.; Zanotto, P.M. Tempo and mode of ERV-K evolution in human and chimpanzee genomes. Arch Virol 2006, 151, 2215–2228.
  • Hirschl, S.; Schanab, O.; Seppele, H.; Waltenberger, A.; Humer, J.; Wolff, K.; Pehamberger, H.; Muster, T. Sequence variability of retroviral particles derived from human melanoma cells melanoma-associated retrovirus. Virus Res 2007, 123, 211–215.
  • Taruscio, D.; Mantovani, A. Factors regulating endogenous retroviral sequences in human and mouse. Cytogenet Genome Res 2004, 105, 351–362.
  • Lavie, L.; Kitova, M.; Maldener, E.; Meese, E.; Mayer, J. CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K(HML-2). J Virol 2005, 79, 876–883.
  • Montoya-Durango, D.E.; Liu, Y.; Teneng, I.; Kalbfleisch, T.; Lacy, M.E.; Steffen, M.C.; Ramos, K.S. Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins. Mutat Res 2009, 665, 20–28.
  • Cui, Y.; Borysova, M.K.; Johnson, J.O.; Guadagno, T.M. Oncogenic B-Raf (V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. Cancer Res 2010, 70, 675–684.
  • Henkel, J. Attacking AIDS with a ‘cocktail’ therapy? FDA Consum 1999, 33, 12–17.

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