353
Views
17
CrossRef citations to date
0
Altmetric
CELLULAR AND MOLECULAR BIOLOGY

Differential Expression and Function of Peroxiredoxin 1 and Peroxiredoxin 6 in Cancerous MCF-7 and Noncancerous MCF-10A Breast Epithelial Cells

, &
Pages 38-47 | Published online: 31 Jan 2012

REFERENCES

  • Halliwell B, Gutteridge J. Free Radicals in Biology and Medicine, 3rd edition. New York: Oxford University Press, 1999.
  • Halliwell B. Oxidative stress and cancer: have we moved forward? Biochem J 2007;401:1–11.
  • Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem-Biol Interact 2006;160:1–40.
  • Fujii J, Ikeda Y. Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep 2002;7(3):123–130.
  • Hofmann B, Hecht HJ, Flohe L. Peroxiredoxins. Biol Chem 2002;383(3–4):347–364.
  • Wood ZA, Schröder E, Harris JR, Poole LB. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci 2003;28(1):32–40.
  • Immenschuh S, Baumgart-Vogt E. Peroxiredoxins, oxidative stress, and cell proliferation. Antioxid Redox Signal 2005;7(5):768–777.
  • Rhee SG, Chae HZ, Kim K. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Rad Biol Med 2005;38:1543–1552.
  • Noh DY, Ahn SJ, Lee RA, Kim SW, Park IA, Chae HZ. Overexpression of peroxiredoxin in human breast cancer. Anticancer Res 2001;21(3B):2085–2090.
  • Kinnula VL, Lehtonen S, Sormunen R, Kaarteenaho-Wiik R, Kang SW, Rhee SG, Soini Y. Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma. J Pathol 2002;196(3):316–323.
  • Karihtala P, Mantyniemi A, Kang SW, Kinnula VL, Soini Y. Peroxiredoxins in breast carcinoma. Clin Cancer Res 2003;15(9):3418–3424.
  • Lehtonen ST, Svensk AM, Soini Y, Paakko P, Hirvikoski P, Kang SW, Saily M. Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer 2004;111(4):514–521.
  • Quan C, Cha EJ, Lee HL, Han KH, Lee KM, Kim WJ. Enhanced expression of peroxiredoxin I and VI correlates with development recurrence and progression of human bladder cancer. J Urolol 2006;175(4):1512–1516.
  • Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ. Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. Breast Cancer Res 2007;9(6):R76.
  • Butterfield LH, Merino A, Golub SH, Shau H. From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. Antioxid Redox Signal 1999;1(4):385–402.
  • Kinnula VL, Paakko P, Soini Y. Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung. FEBS Lett 2004;569(1–3):1–6.
  • Neumann CA, Fang Q. Are peroxiredoxins tumor suppressors? Curr Opin Pharm 2007;7(4):375–380.
  • Li DQ, Wang L, Fei F, Hou YF, Luo JM, Wei-Chen, Zeng R, Wu J, Lu JS, Di GH, Ou ZL, Xia QC, Shen ZZ, Shao ZM. Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry. Proteomics 2006;6(11):3352–3368.
  • Bae J, Ahn S, Han W, Noh D. Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines. J Cell Biochem 2007;101:1038–1045.
  • Chahed K, Kabbage M, Hamrita B, Guillier CL, Trimeche M, Remadi S, Ehret-Sabatier L, Chouchane L. Detection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis. Clin Chim Acta 2008;388(1–2):106–114.
  • Ishii T, Yamada M, Sato H, Matsue M, Taketani S, Nakayama K, Sugita Y, Bannai S. Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J Biol Chem 1993;268(25):18633–18636.
  • Wen ST, Van Etten RA. The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev 1997;11:2456–2467.
  • Berggren MI, Husbeck B, Samulitis B, Baker AF, Gallegos A, Powis G. Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. Arch Biochem Biophys 2001;392(1):103–109.
  • Zhou Y, Zhang W, Easton R, Ray JW, Lampe P, Jiang Z, Brunkan AL, Goate A, Johnson EM, Wu JY. Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. Neurobiol Dis 2002;9(2):126–138.
  • Mu ZM, Yin XY, Prochownik EV. Pag, a putative tumor suppressor, interacts with the Myc box II domain of c-Myc and selectively alters its biological function and target gene expression. J Biol Chem 2002;277:43175–43184.
  • Egler RA, Fernandes E, Rothermund K, Sereika S, de Souza-Pinto N, Jaruga P, Dizdaroglu M, Prochownik EV. Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Oncogene 2005;24(54):8038–8050.
  • Conway JP, Kinter M. Dual role of peroxiredoxin I in macrophage-derived foam cells. J Biol Chem 2006;281(38):27991–28001.
  • Chang R, Wang E. Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. J Cell Biochem 2007;100(2):267–278.
  • Manevich Y, Fisher AB. Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism. Free Rad Biol Med 2005;38:1422–1432.
  • Manevich Y, Sweitzer T, Pak JH, Feinstein SI, Muzykantov V, Fisher AB. 1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage. Proc Natl Acad Sci 2002;99:11599–11604.
  • Phelan SA, Wang X, Wallbrandt P, Forsman-Semb K, Paigen B. Overexpression of peroxiredoxin VI reduces H2O2 but does not prevent diet-induced atherosclerosis. Free Rad Biol Med 2003;35(9):1110–1120.
  • Wang Y, Manevich Y, Feinstein SI, Fisher AB. Adenovirus-mediated transfer of the 1-cys peroxiredoxin gene to mouse lung protects against hyperoxic injury. Amer J Physiol Lung Cell Mol Physiol 2004;286(6):L1188–L1193.
  • Wang Y, Phelan SA, Manevich Y, Feinstein SI, Fisher AB. Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia. Amer J Respir Cell Mol Biol 2006;34(4):481–486.
  • Wang Y, Feinstein S, Fisher A. Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress. J Cell Biochem 2008;104(4):1274–1285.
  • Pak JH, Manevich Y, Kim HS, Feinstein SI, Fisher AB. An antisense oligonucleotide to 1-cys peroxiredoxin causes lipid peroxidation and apoptosis in lung epithelial cells. J Biol Chem 2002;277:49927–49934.
  • Wang X, Phelan SA, Forsman-Semb K, Couturier EF, Brown A, Lerner CP, Paigen B. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem 2003;278(27):25179–25190.
  • Kumin A, Huber C, Rulicke T, Wolf E, Werner S. Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis epithelial and mesenchymal. Cell Biol 2006;169:1194–1205.
  • Wang Y, Feinstein SI, Manevich Y, Ho YS, Fisher AB. Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat induced oxidative stress. Antioxid Redox Signal 2006;8:229–237.
  • Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Meth Enzym 2001;25:402–408.
  • Neumann CA, Krause DS, Carman CV. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defense and tumour suppression. Nature 2003;424:561–565.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.