External Beam Radiotherapy ± Chemotherapy in the Treatment of Anal Canal Cancer: A Single-Institute Long-Term Experience on 100 Patients

REFERENCES

• Ryan DP, Compton CC, Mayer RJ. Carcinoma of the anal canal. N Engl J Med 2000;342(11):792–800.
   PubMed Web of Science ®Google Scholar
• Uronis HE, Bendell JC. Anal cancer: an overview. Oncologist 2007;12(5):524–534.
   PubMed Web of Science ®Google Scholar
• Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR anal cancer trial working party. UK Co-ordinating committee on cancer research. Lancet 1996:348;1049–1054.
   PubMedGoogle Scholar
• Fesneau M, Champeaux-Orange É, Hennequin C. Anal cancer. Cancer Radiothérapie 2010;14(Suppl. 1):S120–S126.
   Google Scholar
• Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, Peiffert D, van Glabbeke M, Pierart M. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European organization for research and treatment of cancer radiotherapy and gastrointestinal cooperative groups. J Clin Oncol 1997;15:2040–2049.
   PubMed Web of Science ®Google Scholar
• Flam M, John M, Pajak TF, Petrelli N, Myerson R, Doggett S, Quivey J, Rotman M, Kerman H, Coia L, Murray K. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 1996;14: 2527–2539.
   PubMed Web of Science ®Google Scholar
• http://www.nccn.org/professionals/physician_gls/f_guidelines.asp #anal.
   Google Scholar
• http://cancer.gov/cancertopics/pdq/treatment/anal/HealthProfe ssional/page7
   Google Scholar
• Svensson C, Goldman S, Friberg B, Glimelius B. Induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 1998;41:863–867.
   PubMed Web of Science ®Google Scholar
• Cummings BJ, Keane TJ, O'Sullivan B, Wong CS, Catton CN. Epidermoid anal cancer: treatment by radiation alone or by radiation and 5-fluorouracil with or without mitomycin C. Int J Radiat Oncol Biol Phys 1991;21:1115–1125.
   PubMed Web of Science ®Google Scholar
• James RD, Glynne-Jones R, Meadows HM, Cunningham D, Myint AS, Saunders MP, Maughan T, McDonald A, Essapen S, Leslie M, Falk S, Wilson C, Gollins S, Begum R, Ledermann J, Kadalayil L, Sebag-Montefiore D. Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 × 2 factorial trial. Lancet Oncol 2013;14(6):516–524.
   PubMed Web of Science ®Google Scholar
• Mitchell SE, Mendenhall WM, Zlotecki RA, Carroll RR. Squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 2001;49:1007–1013.
   PubMed Web of Science ®Google Scholar
• Ferrigno R, Nakamura RA, Dos Santos Novaes PE, Pellizzon AC, Maia MA, Fogarolli RC, Salvajoli JV, Filho WJ, Lopes A. Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of results and radiation dose effectiveness. Int J Radiat Oncol Biol Phys 2005;61(4):1136–1142.
   PubMed Web of Science ®Google Scholar
• Huang K, Haas-Kogan D, Weinberg V, Krieg R. Higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canal. World J Gastroenterol 2007;13(6):895–900.
   PubMed Web of Science ®Google Scholar
• Zilli T, Schick U, Ozsahin M, Gervaz P, Roth AD, Allal AS. Node-negative T1-T2 anal cancer: radiotherapy alone or concomitant chemoradiotherapy? Radiother Oncol 2012;102(1):62–67.
   PubMed Web of Science ®Google Scholar
• Lestrade L, De Bari B, Montbarbon X, Pommier P, Carrie C. Radiochemotherapy and brachytherapy could be the standard treatment for anal canal cancer in elderly patients? A retrospective single-centre analysis. Med Oncol 2013;30(1):402.
   PubMedGoogle Scholar
• De Bari B, Lestrade L, Chekrine T, Shakir Shakir I, Ardiet JM, Chapet O, Mornex F. Should the treatment of anal carcinoma be adapted in the elderly? A retrospective analysis of acute toxicities in a French centre and a review of the literature. Cancer Radiother 2012;16(1):52–57.
   PubMed Web of Science ®Google Scholar
• Sobin LH, Wittekind C. TNM Classification of Malignant Tumors, 6th edition. New York: Wiley-Liss, 2002.
   Google Scholar
• Moreau-Claeys MV, Peiffert D. Normal tissue tolerance to external beam radiation therapy: anal canal. Cancer Radioth 2010;14:359–362.
   PubMed Web of Science ®Google Scholar
• National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. 2009 May. http://evs.nci. nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_ 5×7.pdf
   Google Scholar
• Womack NR, Morrison JF, Williams NS. Prospective study of the effects of postanal repair in neurogenic faecal incontinence. Br J Surg 1988;75(1):48–52.
   PubMed Web of Science ®Google Scholar
• Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994;47: 1245–1251.
   PubMed Web of Science ®Google Scholar
• Bentzen AG, Guren MG, Wanderås EH, Frykholm G, Tveit KM, Wilsgaard T, Dahl O, Balteskard L. Chemoradiotherapy of anal carcinoma: survival and recurrence in an unselected national cohort. Int J Radiat Oncol Biol Phys 2012;83(2):e173–e180.
   PubMed Web of Science ®Google Scholar
• Deniaud-Alexandre E, Touboul E, Tiret E, Sezeur A, Houry S, Gallot D, Parc R, Huang R, Qu SH, Huart J, Pène F, Schlienger M. Results of definitive irradiation in a series of 305 epidermoid carcinomas of the anal canal. Int J Radiat Oncol Biol Phys 2003;56(5):1259–1273.
   PubMed Web of Science ®Google Scholar
• Deniaud-Alexandre E, Touboul E, Tiret E, Sezeur A, Houry S, Gallot D, Parc R, Huang R, Qu SH, Pène F, Schlienger M. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients. Cancer Radiother 2003;7(4):237–253.
   PubMedGoogle Scholar
• Tomaszewski JM, Link E, Leong T, Heriot A, Vazquez M, Chander S, Chu J, Foo M, Lee MT, Lynch CA, Mackay J, Michael M, Tran P, Ngan SY. Twenty-five-year experience with radical chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys 2012;83(2):552–558.
   PubMed Web of Science ®Google Scholar
• Olivatto LO, Cabral V, Rosa A, Bezerra M, Santarem E, Fassizoli A, Castro L, Simões JH, Small IA, Ferreira CG. Mitomycin-C- or cisplatin-based chemoradiotherapy for anal canal carcinoma: long-term results. Int J Radiat Oncol Biol Phys 2011;79(2):490–495.
   PubMed Web of Science ®Google Scholar
• Salmon RJ, Fenton J, Asselain B, Mathieu G, Girodet J, Durand JC, Decroix Y, Pilleron JP, Rousseau J. Treatment of epidermoid anal cancer. Am J Surg 1984;147:43–48.
   PubMed Web of Science ®Google Scholar
• Myerson RJ, Kong F, Birnbaum EH Radiation therapy for epidermoid carcinoma of anal canal, clinical and treatment factors associated with outcome. Radiother Oncol 2001;61(1): 15–22.
   PubMed Web of Science ®Google Scholar
• Das P, Bhatia S, Eng C, Fleshman JW, Kodner IJ, Picus J, Ratkin GA, Read TE, Walz BJ. Predictors and patterns of recurrence after definitive chemoradiation for anal cancer. Int J Radiat Oncol Biol Phys 2007;68(3):794–800.
   PubMed Web of Science ®Google Scholar
• Widder J, Kastenberger R, Fercher E, Schmid R, Langendijk JA, Dobrowsky W, Pötter R. Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients. Radiother Oncol 2008;87:367–375.
   PubMed Web of Science ®Google Scholar
• Touboul E, Schlienger M, Buffat L, Lefkopoulos D, Pène F, Parc R, Tiret E, Gallot D, Malafosse M, Laugier A. Epidermoid carcinoma of the anal canal. Results of curative-intent radiation therapy in a series of 270 patients. Cancer 1994;73(6):1569–1579.
   PubMed Web of Science ®Google Scholar
• Coquard R, Cenni JC, Artru P, Chalabreysse P, Queneau PE, Taieb S, Alessio A, Lledo G. Definitive treatment of anal canal carcinoma with radiotherapy: Adverse impact of a pre-radiation resection. A retrospective study of 57 patients treated with curative intent. Cancer Radioth 2009;13:715–720.
   PubMed Web of Science ®Google Scholar
• Tournier-Rangeard L, Peiffert D, Lafond C, Mege A, Metayer Y, Marchesi V, Buchheit I, Uwer L, Conroy T, Kaminsky MC. Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation. Cancer Radioth 2007;11:169–177.
   PubMed Web of Science ®Google Scholar
• John M, Pajac T, Flam M, Hoffman J, Markoe A, Wolkov H, Paris K. Dose escalation in chemoradiation for anal cancer: preliminary results of RTOG 92–08. Cancer J Sci Am 1996;2:205–211.
   PubMedGoogle Scholar
• Peiffert D, Tournier-Rangeard L, Gérard JP, Lemanski C, François E, Giovannini M, Cvitkovic F, Mirabel X, Bouché O, Luporsi E, Conroy T, Montoto-Grillot C, Mornex F, Lusinchi A, Hannoun-Lévi JM, Seitz JF, Adenis A, Hennequin C, Denis B, Ducreux M. Induction chemotherapy and dose intensification of the radiation boost in locally advanced anal canal carcinoma: final analysis of the randomized UNICANCER ACCORD 03 trial. J Clin Oncol 2012;30(16):1941–1948. doi: 10.1200/JCO.2011.35.4837.
   PubMed Web of Science ®Google Scholar
• Chapet O, Gerard JP, Riche B, Alessio A, Mornex F, Romestaing P. Prognostic value of tumor regression evaluated after first course of radiotherapy for anal canal cancer. Int J Radiat Oncol Biol Phys 2005;63(5):1316–1324.
   PubMed Web of Science ®Google Scholar
• Papillon J, Montbarbon JF, Gerard JP, Chassard JL, Ardiet JM. Interstitial curietherapy in the conservative treatment of anal and rectal cancers. Int J Radiat Oncol Biol Phys 1989;17(6):1161–1169.
   PubMed Web of Science ®Google Scholar
• Tournier-Rangeard L, Peiffert D, Lafond C, Mege A, Metayer Y, Marchesi V, Buchheit I, Uwer L, Conroy T, Kaminsky MC. Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation. Cancer Radiother 2007; 11(4):169–177.
   PubMed Web of Science ®Google Scholar
• Dewas CV, Maingon P, Dalban C, Petitfils A, Peignaux K, Truc G, Martin E, Khoury C, Dewas S, Créhange G. Does gap-free intensity modulated chemoradiation therapy provide a greater clinical benefit than 3D conformal chemoradiation in patients with anal cancer? Radiat Oncol 2012;7(1):201.
   PubMedGoogle Scholar
• Brooks CJ, Lee YK, Aitken K, Hansen VN, Tait DM, Hawkins MA. Organ-sparing intensity-modulated radiotherapy for anal cancer using the ACTII schedule: a comparison of conventional and intensity-modulated radiotherapy plans. Clin Oncol (R Coll Radiol) 2013;25(3):155–161.
   PubMed Web of Science ®Google Scholar
• Ortholan C, Resbeut M, Hannoun-Levi JM, Teissier E, Gerard JP, Ronchin P, Zaccariotto A, Minsat M, Benezery K, François E, Salem N, Ellis S, Azria D, Champetier C, Gross E, Cowen D. Anal canal cancer: management of inguinal nodes and benefit of prophylactic inguinal irradiation (CORS-03 Study). Int J Radiat Oncol Biol Phys. 2012;82(5):1988–1995.
   PubMed Web of Science ®Google Scholar