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Article

Betulinic Acid-Induced Cytotoxicity in Human Breast Tumor Cell Lines MCF-7 and T47D and its Modification by Tocopherol

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Pages 402-408 | Received 03 Oct 2013, Accepted 06 Jun 2014, Published online: 14 Jul 2014

REFERENCES

  • Pisha E, Chai H, Lee SI, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CWW, Fong HHS, Kinghorn AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Das Gupta TK, Pezzuto JM. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1995;1:1046–1051.
  • Wick W, Grimmel C, Wagenknecht B, Dichgans J, Weller M. Betulinic acid induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Experim Ther 1999;289:1306–1312.
  • Schmidt ML, Kuzmanoff KL, Ling-indeck L, Pezzuto JM. Betulinic acid induces apoptosis in human neuroblastoma cell lines. European J Cancer 1997;33:2007–2010.
  • Fulda S, Jeremias I, Pietsch T, Debatin KM. Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors. Klin Padiatr 1999a, 211:319–322.
  • Fulda S, Debatin KM. Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. Med Pediatr Oncol 2000;35:616–618.
  • Hashimoto F, Kashiwada Y, Cosentino LM, Chen CH, Garrett PE, Lee KH. Anti-AIDS agents—XXVII Synthesis and anti-HIV activity of betulinic acid and di hydro betulinic acid derivatives. Bioorg Med Chem 1997;5:2133–2143.
  • Vlietinck AJ, De Bruyne T, Apers S, Pieters LA. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med 1998;64:97–109.
  • Smith H, Sun SL, Jin L, Matthews TJ, Lee KH, Chen CH. Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative. Antimicrob Agents Chemother 2001;45:60–66.
  • Hanne LZ, Henrik F, Majid S, Mehrnoush T, Mahboubeh D, Tehrani KB, Henry HG, Dan S, Jerzy WJ. Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: Structure–activity relationships for betulinic acid analogues. Bioorg Med Chem 2004;12:119–127.
  • Hata K, Hori K, Ogasawara H, Takahashi H. Antileukemic activity of Lup-28al-20(29)-en-3-one, a lupane triterpenoid. Toxocol Lett 2003;143:1–7.
  • Recio MC, Gnier RM, Manez S, Gueho J, Julien HS, Hoskettman K. Investigations on steroidal anti-inflammatory activity of Triterpenoids from Diospyros Leucomelas. Planta Med 1995;61:9–12.
  • Mukherjee PK, Saha K, Das J, Pal M, Saha BP. Studies on anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Med 1997;63:367–369.
  • De Clercq E. Antiviral therapy for human immunodeficiency virus infections. Clin Microbiol Rev 1995;8:200–239.
  • De Clercq E. New developments in anti-HIV chemotherapy. Curr Med Chem 2001;8:1543–1572.
  • Zuco V, Rhigetti SC, Cleris E, Marchesi L, Passserini CG, Formelli F. Selective cytotoxicity of betulinic acid on tumor cell lines but not on normal cells. Cancer Lett 2002;10:17–25.
  • Raghuvar Gopal DV, Narkar AA, Badrinath Y, Mishra KP, Joshi DS. Betulinic acid induces apoptosis in human chronic myelogenous leukemia (CML) cell line K-562 without altering the levels of Bcr-Abl. Toxicol Lett 2005;155:343–351.
  • Fernandes J, Castilho RO, Da Costa MR. Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxicity on multidrug resistant and sensitive leukemia cell lines. Cancer Lett 2003;190(2):165–169.
  • Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME, Debatin KM. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 1998;273:33942–33948.
  • Kumar B, Joshi J, Kumar A, Pandey BN, Hazra B, Mishra KP. Radiosensitization by diospyrin diethylether in MCF-7 breast carcinoma cell line. Mol Cell Biochem 2007;304:287–296.
  • Kumar B, Kumar A, Pandey BN, Hazra B, Mishra KP. Enhancement of radiation-induced cytotoxicity in fibrosarcoma tumor in murine models, as well as in a human cell line, by diospyrin diethylether. Int J Radiat Biol 2008;84:429–440.
  • Pandey BN, Mishra KP. In vitro studies on radiation induced membrane oxidative damage in apoptotic death in mouse thymocytes. Int J Low Radiat 2003;1:113–119.
  • Doroshow JH. Prevention of doxorubicin induced killing of MCF7 human breast cancer cells by oxygen radical scavengers and iron chelating agents. Biochem Biophys Res Comm 1986;135:330–335.
  • Delia D, Aiello A, Meroni L, Nicolim M, Reed JC, Pierotli MA. Role of antioxidants and intracellular free radicals in retinamide induced cell death. Carcinogenesis 1997;18:943–948.
  • Kamarova EA, Gudkov AV. Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry (Moscow) 2000;65:41–48.
  • Komarov PG, Komarova EA, Kondratov RV, Christov- Tselkov K, Coon JS, Chernov MV, Gudkov AV. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999;285:1733–1737.
  • Zhang M, Liu W, Ding D, Salvi R. Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis. Neuroscience 2003;120:191–205.
  • Sandhya T, Mishra KP. Cytotoxic response of breast cancer cell lines, MCF 7 and T 47 D to triphala and its modification by antioxidants. Cancer Lett 2006;238:304–313.
  • Ziegler HL, Franzyk H, Sairafianpour M, Tabatabai M, Tehrani MD, Bagherzadeh K, Hagerstrand H, Staerk D, Jaroszewski JW. Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth, structure-activity relationships for betulinic acid analogues. Bioorg Med Chem 2004;2:119–127.
  • Azam S, Hadi N, Khan NU, Hadi SM. Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties. Toxicol In Vitro 2004;18:555–561.
  • Raghuvar Gopal DV, Narkar AA, Badrinath Y, Mishra KP, Joshi DS. Protection of Ewing's sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by α-dl-tocopherol. Toxicol Lett 2004;153:201–212.

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