Investigation of Epothilone B-Induced Cell Death Mechanisms in Human Epithelial Cancer Cells –in Consideration of Combined Treatment With Ionizing Radiation

REFERENCES

• Bentzen SM, Harari PM, Bernier J. Exploitable mechanisms for combining drugs with radiation: concepts, achievements and future directions. Nat Clin Pract Oncol 2007;4(3):172–180.
   PubMedGoogle Scholar
• Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity. Int J Radiat Oncol Biol Phys 1979;5(1):85–91.
   PubMed Web of Science ®Google Scholar
• Seiwert TY, Salama JK, Vokes EE. The concurrent chemoradiation paradigm –general principles. Nat Clin Pract Oncol 2007;4(2):86–100.
   PubMedGoogle Scholar
• Higgins GS, O'Cathail SM, Muschel RJ, et al. Drug radiotherapy combinations: Review of previous failures and reasons for future optimism. Cancer Treat Rev 2015; pii: S0305-7372(14)00217-5.
   PubMed Web of Science ®Google Scholar
• Liebmann J, Cook JA, Fisher J, et al. In vitro studies of taxol as a radiation sensitizer in human tumor cells. J Natl Cancer Inst 1994;86:441–446.
   PubMed Web of Science ®Google Scholar
• Choe KS, Salama JK, Stenson KM, et al. Adjuvant chemotherapy prior to postoperative concurrent chemoradiotherapy for locoregionally advanced head and neck cancer. Radiother Oncol 2010;97:318–321.
   PubMed Web of Science ®Google Scholar
• Piccart M. The role of taxanes in the adjuvant treatment of early stage breast cancer. Breast Cancer Res Treat 2003;79(Suppl 1):S25–S34.
   PubMedGoogle Scholar
• Donehower RC, Rowinsky EK. An overview of experience with Taxol (paclitaxel) in the U.S.A. Cancer Treat Rev 1993;19(Suppl C):63–78.
   PubMed Web of Science ®Google Scholar
• Bollag DM, McQueney PA, Zhu J, et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995;55:2325–2333.
   PubMed Web of Science ®Google Scholar
• Kowalski RJ, Giannakakou P, Hamel E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®). J Biol Chem 1997;272:2534–2541.
   PubMed Web of Science ®Google Scholar
• Agrawal NR, Ganapathi R, Mekhail T. Tubulin interacting agents: novel taxanes and epothilones. Curr Oncol Rep 2003;5: 89–98.
   PubMedGoogle Scholar
• Argyriou AA, Marmiroli P, Cavaletti G, et al. Epothilone-induced peripheral neuropathy: a review of current knowledge. J Pain Symptom Manage 2011;42:931–940.
   PubMed Web of Science ®Google Scholar
• Rothermel J, Wartmann M, Chen T, et al. EPO906 (epothilone B): a promising novel microtubule stabilizer. Semin Oncol 2003;30(Suppl 6):51–55.
   PubMedGoogle Scholar
• Larkin JMG. Patupilone. Antimitotic drug, microtubule-stabilizing agent, oncolytic. Drugs Future 2007;32:323–336.
   Web of Science ®Google Scholar
• Hofstetter B, Voung V, Broggini-Tenzer A, et al. Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo. Clin Cancer Res 2005;11:1588–1596.
   PubMed Web of Science ®Google Scholar
• Bley CR, Jochum W, Orlowski K, et al. Role of the microenvironment for radiosensitization by patupilone. Clin Cancer Res 2009;15:1335–1342.
   PubMed Web of Science ®Google Scholar
• Baumgart T, Klautke G, Kriesen S, et al. Radiosensitizing effect of epothilone B on human epithelial cancer cells. Strahlenther Onkol 2012;188:177–184.
   PubMed Web of Science ®Google Scholar
• Baumgart T, Kriesen S, Hildebrandt G, et al. Effect of epothilone B on cell cycle, metabolic activity, and apoptosis induction on human epithelial cancer cells - under special attention of combined treatment with ionizing radiation. Cancer Invest 2012;30(8):593–603.
   PubMed Web of Science ®Google Scholar
• Furmanova-Hollenstein P, Broggini-Tenzer A, Eggel M, et al. The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion Radiat Oncol 2013;8:105.
   PubMed Web of Science ®Google Scholar
• Fogh S, Machtay M, Werner-Wasik M, et al. Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies. Int J Radiat Oncol Biol Phys 2010;77:1009–1016.
   PubMed Web of Science ®Google Scholar
• Oehler C, von Bueren AO, Furmanova P, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol 2011;13:1000–1010.
   PubMed Web of Science ®Google Scholar
• Pentenero M, Donadini A, Di Nallo E, et al. Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high-resolution DNA flow cytometry. Cancer 2011;117(22):5052–5057.
   PubMed Web of Science ®Google Scholar
• Swanton C, Nicke B, Schuett M, et al. Chromosomal instability determines taxane response. Proc Natl Acad Sci USA 2009;106(21):8671–8676.
   PubMed Web of Science ®Google Scholar
• Mansilla S, Llovera L, Portugal J. Chemotherapeutic targeting of cell death pathways. Anticancer Agents Med Chem 2012;12(3):226–238.
   PubMed Web of Science ®Google Scholar
• Stalder MW, Anthony CT, Woltering EA. Metronomic dosing enhances the anti-angiogenic effect of epothilone B. J Surg Res 2011;169:247–256.
   PubMed Web of Science ®Google Scholar
• Beswick RW, Ambrose HE, Wagner SD. Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res 2006;30:427–436.
   PubMed Web of Science ®Google Scholar
• Kallas A, Pook M, Maimets M, et al. Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells. PLoS One 2011;6:e19114.
   PubMed Web of Science ®Google Scholar
• Reiss M, Brash DE, Munoz-Antonia T, et al. Status of the p53 tumor suppressor gene inhuman squamous carcinoma cell lines. Oncology Res 1992;4:349–357.
   PubMed Web of Science ®Google Scholar
• Oliver FJ, de la Rubia G, Rolli V, et al. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J Biol Chem 1998;273:33533–33539.
   PubMed Web of Science ®Google Scholar
• Pendergrass W, Wolf N, Poot M. Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues. Cytometry A 2004;61(2):162–169.
   PubMed Web of Science ®Google Scholar
• Haga N, Fujita N, Tsuruo T. Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis. Oncogene 2003;22(36):5579–5585.
   PubMed Web of Science ®Google Scholar
• Zanet J, Freije A, Ruiz M, et al. A mitosis block links active cell cycle with human epidermal differentiation and results in endoreplication. PLoS One 2010;5(12):e15701.
   PubMed Web of Science ®Google Scholar
• Chiu WH, Luo SJ, Chen CL, et al. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochem Pharmacol 2012;83(9):1159–1171.
   PubMed Web of Science ®Google Scholar
• Wolanin K, Magalska A, Mosieniak G, et al. Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-Expressing cells. Mol Cancer Res 2006;4(7):457–469.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Xue J, Semizarov D, et al. Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics. Int J Cancer 2005;115(4):528–538.
   PubMed Web of Science ®Google Scholar
• Countryman PI, Heddle JA. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat Res 1976;41(2–3):321–332.
   PubMed Web of Science ®Google Scholar
• Weaver BA, Cleveland DW. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 2005;8(1):7–12.
   PubMed Web of Science ®Google Scholar
• Portugal J, Bataller M, Mansilla S. Cell death pathways in response to antitumor therapy. Tumori 2009;95:409–421.
   PubMed Web of Science ®Google Scholar
• Pellicciotta I, Yang CP, Venditti CA, et al. Response to microtubule-interacting agents in primary epithelial ovarian cancer cells. Cancer Cell Int 2013;10;13(1):33.
   Web of Science ®Google Scholar
• May P, May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 1999;18(53):7621–7636.
   PubMed Web of Science ®Google Scholar
• Weller M. Predicting response to cancer chemotherapy: the role of p53. Cell Tissue Res 1998;292(3):435–445.
   PubMed Web of Science ®Google Scholar
• Tokalov SV, Abolmaali N. Radiosensitization of p53-deficient lung cancer cells by pre-treatment with cytostatic compounds. Anticancer Res 2012;32:1239–1244.
   PubMed Web of Science ®Google Scholar
• Nur-E-Kamal A, Gross SR, Pan Z, et al. Nuclear translocation of cytochrome c during apoptosis. J Biol Chem 2004;279(24):24911–24914.
   PubMed Web of Science ®Google Scholar
• Khawaja NR, Carré M, Kovacic H, et al. Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria. Mol Pharmacol 2008;74(4):1072–1083.
   PubMed Web of Science ®Google Scholar
• Ricci MS, Zong WX. Chemotherapeutic approaches for targeting cell death pathways. Oncologist 2006;11(4):342–357.
   PubMed Web of Science ®Google Scholar
• Ha GH, Baek KH, Kim HS, et al. P53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Res 2007;67(15):7155–7164.
   PubMed Web of Science ®Google Scholar
• D'Amours D, Sallmann FR, Dixit VM, et al. Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J Cell Sci 2001;114(Pt 20):3771–3778.
   PubMed Web of Science ®Google Scholar
• Chen JG, Yang CP, Cammer M, et al. Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res 2003;63:7891–7899.
   PubMed Web of Science ®Google Scholar
• Lee SH, Son SM, Son DJ, et al. Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization-independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. Mol Cancer Ther 2007;6(10):2786–2797.
   PubMed Web of Science ®Google Scholar
• Lin B, Catley L, LeBlanc R, et al. Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo. Blood 2005;105:350–357.
   PubMed Web of Science ®Google Scholar
• Wang M, Wu W, Wu W, et al. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 2006;34(21):6170–6182.
   PubMed Web of Science ®Google Scholar
• Bröker LE, Huisman C, Ferreira CG, et al. Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells. Cancer Res 2002;62:4081–4088.
   PubMed Web of Science ®Google Scholar
• Rogalska A, Gajek A, Marczak A. Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. Toxicol In Vitro 2014;28(4):675–683.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Abrams JM, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012;19(1): 107–120.
   PubMed Web of Science ®Google Scholar
• Winsel S, Sommer A, Eschenbrenner J, et al. Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells. PLoS One 2011;6(4):e19273.
   PubMed Web of Science ®Google Scholar
• Bekier ME, Fischbach R, Lee J, et al. Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. Mol Cancer Ther 2009;8(6):1646–1654.
   Google Scholar
• Zhang C, Zhao L, Qi W, et al. Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877(29):3748–3752.
   PubMed Web of Science ®Google Scholar
• Fenech M. The in vitro micronucleus technique. Mutat Res 2000;455(1–2):81–95.
   PubMed Web of Science ®Google Scholar
• Lichtner RB, Rotgeri A, Bunte T, et al. Subcellular distribution of epothilones in human tumor cells. Proc Natl Acad Sci USA 2001;98(20):11743–11748.
   PubMed Web of Science ®Google Scholar
• Swanton C, Nicke B, Schuett M, et al. Chromosomal instability determines taxane response. Proc Natl Acad Sci USA 2009;106(21):8671–8676.
   PubMed Web of Science ®Google Scholar