9
Views
16
CrossRef citations to date
0
Altmetric
Review Article

Tuftsin: An Immunomodulating Peptide Hormone and Its Clinical Potential as a Natural Biological Response Modifier

, , , &
Pages 39-49 | Published online: 11 Jun 2009

References

  • James K, McBride B, Stuart A. The Macrophage and Cancer. University of Edinburgh, Edinburgh 1977
  • Haberman R B. Natural Cell-Mediated Immunity Against Tumors. Academic Press, New York 1980
  • Klebanoff S J, Clark R A. The Neutrophil: Function and Clinical Disorders. North-Holland Publishing Co, New York 1978
  • Chirigos M A. Immune Modulation and Control of Neoplasia by Adjuvant Therapy. Raven Press, New York 1978
  • Hersh E M, Chirigos M A, Mastrangelo M J. Augmenting Agents in Cancer Therapy. Raven Press, New York 1981
  • Oldham R K. Biological response modifiers program. J Biol Resp Modif 1982; 1: 81–100
  • Nishioka K, Amoscato A A, Babcock G F. Minireview: Tuftsin: A hormone-like tetrapeptide with antimicrobial and antitumor activities. Life Sci 1981; 28: 1081–1090
  • Goldstein A L, Low T LK, Thurman G B, Zatz M M, Hall N, Chen J, Hu S-K, Naylor P B, McClure J E. Current status of thymosin and other hormones of the thymus gland. Recent Progress in Hormone Research, R O Greep. Academic Press, New York 1981; Vol 37: 369–415
  • Pestka S. The human interferons-From protein purification and sequence to cloning and expression in bacteria: Before, between, and beyond. Arch Biochem Biophys 1983; 221: 1–37
  • Najjar V A, Nishioka K. 'Tuftsin': A physiological phagocytosis stimulating peptide. Nature (London) 1970; 228: 672–673
  • Najjar V A, Fidalgo B V, Stitt E. The physiological role of the lymphoid system. VII. The disappearance of leucokinin activity following splenectomy. Biochemistry 1968; 7: 2376–2379
  • Nishioka K, Constantopoulos A, Statoh P S, Najjar V A. The characteristics, isolation and synthesis of the phagocytosis stimulating peptide tuftsin. Biochem Biophys Res Commun 1972; 47: 172–179
  • Nishioka K, Constantopoulos A, Satoh P S, Mitchell W M, Najjar V A. Characteristics and isolation of the phagocytosis-stimulating peptide tuftsin. Biochim Biophys Acta 1973; 310: 217–229
  • Nishioka K, Satoh P S, Constantopoulos A, Najjar V A. The chemical synthesis of the phagocytosis-stimulating tetrapeptide tuftsin (Thr-Lys-Pro-Arg) and its biological properties. Biochim Biophys Acta 1973; 310: 230–237
  • Edelman G F, Cunningham B A, Gall W E, Gottlieb P D, Rutishauser U, Waxdal M J. The covalent structure of an entire γG immunoglobulin molecule. Proc Natl Acad Sci USA 1969; 63: 78–85
  • Najjar V A, Constantopoulos A. A new phagocytosis-stimulating tetrapeptide hormone, tuftsin, and its role in disease. J Reticuloendothel Soc 1972; 12: 197–215
  • Constantopoulos A, Najjar V A. Tuftsin deficiency syndrome. Acta Paediatr Scand 1973; 62: 645–648
  • Inada K, Nemoto N, Nishijima A, Wada S, Hirata M, Yoshida M. A suspected case of tuftsin deficiency. Phagocytosis: Its Physiology and Pathology, Y Kokubun, N Kobayashi. University Park Press, Baltimore 1979; 101–108
  • Najjar V A, Chaudhuri M K, Konopinska D, Beck B D, Layne P P, Linehan L. Tuftsin (Thr-Lys-Pro-Arg) a physiological activator of phagocytic cells: A possible role in cancer suppression and therapy. Augmenting Agents of Cancer Therapy, E M Hersh, A Ghirigos, M Mastrangelo. Raven Press, New York 1980; 459–478
  • Konopinska D, Najjar V A, Callery M. Solid phase synthesis of L-threonyl-L-glutamyl-L-prolyl-L-arginine, as the mutant analog of tuftsin. Arch Immunol Ther Exp 1981; 29: 851–856
  • Likhite V V. Opsonin and leucophilic γ-globulin in chronically splenectomized rat with and without heterotropic auto-transplanted splenic tissue. Nature (London) 1975; 253: 742–744
  • Spirer Z, Zakuth V, Bogair N, Fridkin M. Radioimmunoassay of the phagocytosis-stimulating peptide tuftsin in normal and splenectomized subjects. Eur J Immunol 1977; 7: 69–74
  • Pearson H A, Johnston D, Smith K A, Touloukian R J. The born-again spleen: Return of splenic function after splenectomy for trauma. N Engl J Med 1978; 298: 1389–1392
  • Singer D B. Postsplenectomy sepsis. Perspect Pediatr Pathol 1973; 1: 285–305
  • Balfanz J R, Nesbit M E, Jr, Jarvis C, Krivit W. Overwhelming sepsis following splenectomy for trauma. J Pediatr 1976; 88: 458–460
  • Aigner K, Dobroschke J, Weber E G, Schwemmle K, Bauer M, Teuber J, Helmke K. Successful reimplantation of splenic tissue after neonatal abdominal trauma. Lancet 1980; 1: 360–361
  • Patel J, Williams J S, Shmigel B, Hinshaw R. Preservation of splenic function by autotransplantation of traumatized spleen in man. Surgery 1981; 90: 683–688
  • Millikan J S, Moore E E, Moore G E, Stevens R E. Alternative to splenectomy in adults after trauma, repair, partial resection, and reimplantation of splenic tissue. Am J Surgery 1982; 144: 711–716
  • Constantopoulos A, Likhite V, Crosby W H, Najjar V A. Phagocytic activity of the leukemic cells and its response to the phagocytosis-stimulating tetrapeptide, tuftsin. Cancer Res 1973; 33: 1230–1234
  • Spirer Z, Weisman Y, Zakuth V, Fridkin M, Bogair N. Decreased serum tuftsin concentrations in sickle cell disease. Arch Dis Child 1980; 55: 566–567
  • Fridkin M, Gottlieb P. Tuftsin, Thr-Lys-Pro-Arg: Anatomy of an immunologically active peptide. Mol Cell Biochem 1981; 41: 73–97
  • Siemion I Z, Konopinska D. Tuftsin analogs and their biological activity. Mol Cell Biochem 1981; 41: 13–18
  • Amoscato A A, Babcock G F, Nishioka K. Analysis of contaminants in commercial preparations of the tetrapeptide tuftsin by high-performance liquid chromatography. J Chromatogr 1981; 205: 179–184
  • Constantopoulos A, Najjar V A. The requirement for membrane sialic acid in the stimulation of phagocytosis by the natural tetrapeptide, tuftsin. J Biol Chem 1973; 248: 3819–3822
  • Stabinsky Y, Gottlieb P, Zakuth V, Spirer Z, Fridkin M. Specific binding sites for the phagocytosis stimulating peptide tuftsin on human polymorphonuclear leukcocytes and monocytes. Biochem Biophys Res Commun 1978; 83: 599–606
  • Nair R MG, Ponce B, Fudenberg H H. Interactions of radiolabeled tuftsin with human neutrophils. Immunochemistry 1978; 15: 901–907
  • Bar-Shavit Z, Stabinsky Y, Fridkin M, Goldman R. Tuftsin-macrophage interaction: Specific binding and augmentation of phagocytosis. J Cell Physiol 1979; 100: 55–62
  • Constantopoulos A, Najjar V A. Tuftsin, a natural and general phagocytosis stimulating peptide affecting macrophages and polymorphonuclear granulocytes. Cytobios 1972; 6: 97–100
  • Bar-Shavit Z, Bursuker I, Goldman R. Functional tuftsin binding sites on macrophage-like tumor line P388D1 and on bone marrow cells differentiated in vitro into mononuclear phagocytes. Mol Cell Biochem 1980; 30: 151–155
  • Amoscato A A, Davies P JA, Babcock G F, Nishioka K. Receptor-mediated internalization of tuftsin by human polymorphonuclear leukocytes. J Reticuloendothel Soc 1983; 34: 53–67
  • Amoscato A A, Davies P JA, Babcock G F, Nishioka K. Receptor-mediated internalization of tuftsin. Ann NY Acad Sci, in press
  • Middlebrook J L, Kohn L D. Receptor-Mediated Binding and Internalized of Toxins and Hormones. Academic Press, New York 1981
  • Goldstein J L, Anderson R OW, Brown M S. Coated pits, coated vesicles, and recepter-mediated endocytosis. Nature (London) 1979; 279: 679–685
  • Niedel J E, Kahane I, Cuatrecasas P. Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils. Science 1979; 205: 1412–1414
  • Blumenstein M, Layne P P, Najjar V A. Nuclear magnetic resonance studies on the structure of the tetrapeptide tuftsin, L-threonyl-L-lysyl-L-prolyl-L-arginine, and its pentapeptide analogue L-threonyl-L-lysyl-L-prolyl-L-prolyl-L-arginine. Biochem 1979; 18: 5247–5253
  • Spirer Z, Zakuth V, Golander A, Bogair N, Fridkin M. The effect of tuftsin on the nitrous blue tetrazolium reduction of normal human polymorphonuclear leukocytes. J Clin Invest 1975; 55: 198–200
  • Tritsch G L, Niswander P W. Positive correlation between superoxide release and intracellular adenosine deaminase activity during macrophage membrane perturbation regardless of nature or magnitude of stimulus. Mol Cell Biochem 1982; 49: 49–51
  • Hartung H P, Toyka K V. Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. Immunol Lett 1983; 6: 1–6
  • Stabinsky Y, Bar-Shavit Z, Fridkin M, Goldman R. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem 1980; 30: 71–77
  • Rauner R A, Schmidt J J, Najjar V A. Proline endopeptidase and exopeptidase activity in polymorphonuclear granulocytes. Mol Cell Biochem 1976; 10: 77–80
  • Nagaoka I, Yamashita T. Inactivation of phagocytosis-stimulating activity of tuftsin by polymorphonuclear neutrophils: A possible role of leucine aminopeptidase as an ecto-enzyme. Biochim Biophys Acta 1981; 675: 85–93
  • Phillips J H, Babcock G F, Nishioka K. Tuftsin: A naturally occurring immunopotentiating factor I. In vitro enhancement of murine natural cell-mediated cytotoxicity. J Immunol 1981; 126: 915–921
  • Martinez J, Winternitz F, Videl J. Nouvelles syntheses et proprietes de la tuftsine. Eur J Med Chem Chim Ther 1977; 12: 511–516
  • Franke E L, Neu H C. Postsplenectomy infection. Surg Clin North Am 1981; 61: 135–155
  • Chilcote R R, Baehner R L, Hammond D. Septicemia and meningitis in children splenectomized for Hodgkin's disease. N Engl J Med 1976; 295: 798–800
  • Rosner F, Zarrabi M H. Late infections following splenectomy in Hodgkin's disease. Cancer Invest 1983; 1: 57–65
  • Mikulski S M, Von Hoff D D, Rozencweig M, Muggia F M. Tuftsin—Unimportant or forgotten?. N Engl J Med 1977; 296: 454
  • Hisatsune K, Nozaki S, Ishikawa T, Hayashi M, Nagaki K, Ogawa H. Biochemical study of phagocytic activities of tuftsin and its analogues. Ann NY Acad Sci, in press
  • Nishioka K. Anti-tumor effect of the physiological tetrapeptide, tuftsin. Br J Cancer 1979; 39: 342–345
  • Nishioka K. Migration enhancement by tuftsin of human mononuclear cells and its effect on the migration inhibition factor test with tumor antigens. Gann 1978; 69: 569–572
  • Babcock G F, Amoscato A A, Nishioka K. Effect of tuftsin on the migration, chemotaxis and differentiation of macrophages and granulocytes. Ann NY Acad Sci, in press
  • Goetzl E J. Plasma and cell-derived inhibitors of human neutrophil chemotaxis. Ann NY Acad Sci 1975; 256: 210–221
  • Goetzl E J. Modulation of human eosinophil polymorphonuclear leukocyte migration and function. Am J Pathol 1976; 85: 419–435
  • Horsmanheimo A, Horsmanheimo M, Fudenberg H H. Effect of tuftsin on migration of polymorphonuclear and mononuclear human leukocytes in leukocyte migration agarose test. Clin Immunol Immunopathol 1978; 11: 251–255
  • Yamanaka N, Fukushima M, Matsuoka H, Nishida K, Ota K. Effect of tuftsin on polymorphonuclear leukocyte metabolism. Phagocytosis: Its Physiology and Pathology, Y Kokubun, N Kobayashi. University Park Press, Baltimore 1979; 93–100
  • Giroud J P, Roch-Arveiller M, Muntaner O, Bradshaw D. Action comparee et de la tuftsine sur le chimiotactisme des polynucleaires de rat. Nouv Rev Fr Hematol 1980; 22: 69–76
  • Kavai M, Lukacs K, Szegedi G, Szekerke M, Erchegyi J. Chemotactic and stimulating effect of tuftsin and its analogues en human monycytes. Immunol Lett 1981; 2: 219–224
  • Florentin I, Bruley-Rosset M, Kiger N, Imbach J L, Winternitz F, Mathe G. In vivo immunostimulation by tuftsin. Cancer Immunol Immunother 1978; 5: 211–216
  • Tzehoval E, Segal S, Stabinsky Y, Fridkin M, Spirer Z, Feldman M. Tuftsin (an Ig-associated tetrapeptide) triggers the immunogenic function of macrophages: Implications for activation of programmed cells. Proc Natl Acad Sci USA 1978; 75: 3400–3404
  • Luftig R B, Yoshinaka Y, Oroszlan S. Sequence relationship between Rauscher Leukemia virus (RLV) p 65-70 (gag gene product) and tuftsin as monitored by the p 65-70 proteolytic factor. J Cell Biol 1977; 25: 397a
  • Oroszlan S, Henderson L W, Stephenson J R, Copeland T D, Long C W, Ihle J N, Gilden R V. Amino-and carboxy-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus. Proc Natl Acad Sci USA 1978; 75: 1404–1408
  • Bar-Shavit Z, Goldman R, Stabinsky Y, Gottlieb P, Fridkin M, Teichberg V I, Blumberg S. Enhancement of phagocytosis—A newly found activity of substance P residing in its N-terminal tetrapeptide sequence. Biochem Biophys Res Commun 1980; 94: 1445–1451
  • Bar-Shavit Z, Goldman R. Tuftsin and substance P as modulators of phagocyte functions. Adv Exp Med Biol 1982; 141: 549–558
  • Herman Z S, Stachura Z, Siemion I Z, Nawrocka E. Analgesic activity of tuftsin analogs. Naturwissenschaften 1980; 67: 613–614
  • Kamenskii A A, Antonova L V, Samoilova N A, Galkin O M, Andreev S M, Ashmarin I P. Excitatory action of the tetrapeptide tuftsin on activity of albino rats. Bull Exp Biol Med 1980; 89: 911–914
  • Val'dman A V, Kozlovskaya M M, Ashmarin I P, Mineeva M F, Anokhin K V. Central effects of the tetrapeptide tuftsin. Bull Exp Biol Med 1981; 92: 890–892
  • Nishioka K, Babcock G F, Phillips J H, Noyes R D. Antitumor effect of tuftsin. Mol Cell Biochem 1981; 41: 13–18
  • Takami H, Nishioka K. Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. Br J Cancer 1980; 41: 751–756
  • Nishioka K, Takami H, Noyes R D, Babcock G F. Cloudman S-91 melanoma colony assay in the lungs of mice and profiles of the biochemical tumor markers, tyrosinase and polyamines. Pigment Cell 1981, Phenotypic Expression in Pigment Cell, M Seiji. University of Tokyo Press, Tokyo 1981; 617–621
  • Noyes R D, Babcock G F, Nishioka K. Antitumor activity of tuftsin on murine melanoma in vivo. Cancer Treat Rep 1981; 65: 673–675
  • Babcock G F, Noyes R D, Nishioka K. The effect of tuftsin, an immunopotentiating peptide, on Cloudman S-91 melanoma in vivo. Pigment Cell 1981, Phenotypic Expression in Pigment Cell, M Seiji. University of Tokyo Press, Tokyo 1981; 623–628
  • Nishioka K, Babcock G F, Phillips J H, Banks R A, Amoscato A A. In vivo and in vitro antitumor activities of tuftsin. Ann NY Acad Sci, in press
  • Banks R A, Babcock G F, Nishioka K. Effect of tuftsin on in vivo murine oncogenesis. Proc Am Assoc Cancer Res 1983; 24: 1994
  • Babcock G F, Phillips J H, Nishioka K. The immunotherapeutic effect of the peptide tuftsin on the B cell lymphoma, CHI. B and T Cell Tumors: Biological and Clinical Aspects, E Vitetta, C F Fox. Academic Press, New York 1982; 481–485
  • Catanzaro P J, Schwartz H J, Graham R C. Spectrum and possible mechanism of carrageenan cytotoxicity. Am J Pathol 1971; 64: 387–404
  • Quan P-C, Kolb J-P, Lespinats G. NK activity in carrageenantreated mice. Immunology 1980; 40: 495–503
  • Sunkara P S, Prakash N J, Nichioka K. Potentiation of antitumor activity of α-difluoromethyl ornithine by immunomodulating peptide tuftsin. Ann NY Acad Sci, in press
  • Metcalf B W, Bey P, Danzin C, Jung M J, Casara P, Vevert J P. Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C. 4.1.1.17) by substrate and product analogues. J Am Chem Soc 1978; 100: 2551–2553
  • Nishioka K. In vitro induction of human granulocyte cytotoxicity by tuftsin. Gann 1979; 70: 845–846
  • Phillips J H, Nishioka K, Babcock G F. Tuftsin-induced enhancement of murine and human natural cell-mediated cytotoxicity. Ann NY Acad Sci, in press
  • Bruley-Rosset M, Hercend T, Martinez J, Rappaport H, Mathe G. Prevention of spontaneous tumors of aged mice by immunopharmacologic manipulation: Study of immune antitumor mechanisms. J Natl Cancer Inst 1981; 66: 1113–1119
  • Bruley-Rosset M, Florentin I, Mathe G. Macrophage activation by tuftsin and muramy 1-dipeptide. Mol Cell Biochem 1981; 41: 113–118
  • Najjar V A, Konopinska D, Chaudhuri M K, Schmidt D E, Linehan Tuftsin L. a natural activator of phagocytic functions including tumoricidal activity. Mol Cell Biochem 1981; 41: 3, 12
  • Catane R, Schlanger S, Weiss L, Penchas S, Fuks Z, Treves A J, Fridkin M. Toxicology and antitumor activity of tuftsin. Ann NY Acad Sci, in press
  • Mathe G, Bruley-Rosset M, Rappaport H. Spontaneous development of tumors in C57BL/6 mice associated with aging. Ann NY Acad Sci, in press

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.