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Original Article

Present Status of Serum Tumor Markers in Diagnosis, Prognosis, and Evaluation of Therapy

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Pages 305-327 | Published online: 11 Jun 2009

References

  • Gold P, Freedman S O. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965; 121: 439–459
  • Slayter H S, Coligan J E. Electron microscopy and physical characterization of the carcinoembryonic antigen. Biochemistry 1975; 14: 2323–2330
  • VonKleist S, Chavanel G, Burtin P. Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen. Proc Natl Acad Sci USA 1972; 69: 2492–2494
  • Mach J P, Pusztaszeri G. Carcinoembryonic antigen (CEA): Demonstration of a partial identity between CEA and a normal glycoprotein. Immunochemistry 1972; 9: 1031–1034
  • LoGerfo P, Krupey J, Hansen H J. Demonstration of an antigen common to several varieties of neoplasia—assay using zirconyl phosphate gel. N Engl J Med 1971; 285: 138–141
  • Moore T L, Kantrowitz P A, Zamcheck N. Carcinoembryonic antigen (CEA) in inflammatory bowel disease. JAMA 1972; 222: 944–947
  • Thompson D MP, Krupey J, Freedman S O, et al. The radio-immunoassay of circulatory carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci USA 1969; 64: 161–167
  • Fleisher M, Nisselbaum S S, Loftin L, et al. Roche RIA and Abbott EIA carcinoembryonic antigen assays compared. Clin Chem 1984; 30: 200–205
  • Kuroki M, Kuroki M, Koga Y, et al. Monoclonal antibodies to carcinoembryonic antigen: A systemic analysis of antibody specificities by using related normal antigens and evidence for allotypic determinants on carcinoembryonic antigen. J Immunol 1984; 133: 2090–2097
  • Hedin A, Carlsson L, Berglund A, et al. A monoclonal antibody-enzyme immunoassay for serum carcinoembryonic antigen with increased specificity for carcinomas. Proc Natl Acad Sci 1983; 80: 3470–3474
  • Lokich J J, Ellenberg S, Gerson B. Criteria for monitoring carcinoembryonic antigen: Variability of sequential assays at elevated levels. J Clin Oncol 1984; 2: 181–185
  • Ravry M, Moertel C G, Schutt A J, et al. Usefulness of serial serum carcinoembryonic antigen (CEA) determinations during anti-cancer therapy or long-term follow-up of gastrointestinal carcinoma. Cancer 1974; 34: 1230–1234
  • Hansen H J, Snyder Miller J J, et al. Carcinoembryonic antigen (CEA) assay, a laboratory adjunct in the diagnosis and management of cancer. J Hum Pathol 1974; 5: 139–147
  • Dykes P W, King J. Progress report: Carcinoembryonic antigen (CEA). Gut 1974; 13: 1000–1013
  • Costanza M E, Saroj D, Nathanson L, et al. Carcinoembryonic antigen: Report of a screening study. Cancer 1974; 33: 583–590
  • Dhar P, Moore T, Zamcheck N, et al. Carcinoembryonic antigen (CEA) in colonic cancer—use in preoperative and postoperative diagnosis and prognosis. JAMA 1972; 221: 31–35
  • LoGerfo P, LoGerfo F F, Barker H G, et al. Tumor-associated antigen in patients with carcinoma of the colon. Am J Surg 1972; 123: 127–131
  • Cullen K J, Stevens D P, Frost M A, et al. Carcinoembryonic antigen (CEA), smoking and cancer in a longitudinal population study. Aust NZ J Med 1976; 6: 279–283
  • Alexander J C, Jr, Silverman N A, Chretien P B. Effect of age and cigarette smoking on carcinoembryonic antigen levels. JAMA 1976; 235: 1975–1979
  • Mach J P, Jaeger P H, Bertholet M M, et al. Detection of recurrence of large bowel carcinoma by radioimmunoassay of circulating carcinoembryonic antigen (CEA). Lancet 1974; 2: 535–540
  • Holyoke D, Reynoso T, Chut M. Carcinoembryonic antigen (CEA) in patients with carcinoma of the digestive tract. Ann Surg 1972; 176: 559–564
  • Zamcheck N. The present status of CEA in diagnosis, prognosis, and evaluation of therapy. Cancer 1975; 36: 2460–2470
  • Wanebo H J, Rao B, Pinsky C M, et al. Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer. N Engl J Med 1978; 299: 448–451
  • Holyoke E D, Chu T M, Evans J T, . Carcinoembryonic antigen as a tumor marker. Biochemical Markers for Cancer, T M Chu, et al. Marcel Dekker, Inc., New York and Basel 1982; 68–69
  • Herrera M A, Chu T M, Holyoke E D. Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma. Ann Surg 1970; 183: 5–9
  • Minton J P, Hoehn J L, Gerber D M, et al. Results of a 400-patient carcinoembryonic antigen second-look colorectal cancer study. Cancer 1985; 55: 1284–1290
  • Holyoke E D, Chu T M, Evans J T, . Carcinoembryonic antigen as a tumor marker. Biochemical Markers for Cancer, T M Chu, et al. Marcel Dekker, Inc., New York and Basel 1982; 70
  • Shani A, O'Connell M J, Moertel C G, et al. Serial plasma carcinoembryonic antigen measurements in the management of metastatic colorectal carcinoma. Ann Intern Med 1978; 88: 627–630
  • Goslin R, O'Brien M S, Steele G, et al. Correlation of plasma CEA and CEA tissue staining in poorly differentiated colorectal cancer. Am J Med 1981; 71: 246–253
  • Gitlin D, Boesman M. Sites of serum a-fetoprotein synthesis in the human and in the rat. J Clin Invest 1967; 46: 1010–1016
  • Abelev G I. Alpha-protein in oncogenesis and its association with malignant tumors. Adv Cancer Res 1971; 14: 295–358
  • Gitlin D, Boesman M. Serum a-fetoprotein, albumin, and G-globulin in the human conceptus. J Clin Invest 1966; 45: 1826–1838
  • Abelev G I, Perova S D, Khramkova N I, et al. Production of embryonal a-globulin by transplantable mouse hepatomas. Transplantation 1963; 1: 174–180
  • Tatarinov Y S. Detection of embryo-specific a-globulin in the blood sera of patients with primary liver tumor. Vopr Med Khim 1964; 10: 90–91
  • Anderson T, Waldman T A, Javadpour N, et al. Testicular germ-cell neoplasms: Recent advances in diagnosis and therapy. Ann Intern Med 1979; 90: 373–385
  • Bloomer J R, Waldman T A, McLntire K R, et al. Alphafetoprotein in non-neoplastic hepatic disorders. JAMA 1975; 233: 38–41
  • Hirai H. Alpha fetoprotein. Biochemical Markers for Cancer, T M Chu. Marcel Dekker, Inc., New York and Basel 1982; 29
  • Yachnin S, Hus R, Heinrikson R, et al. Comparison of the physical properties and imunosuppressive effects of hepatoma and fetal human alpha-fetoprotein. Clin Res 1976; 24: 483A
  • Gold P, Labitan A, Wong H CG, et al. Physicochemical approach to the purification of human a-fetoprotein from the ascites fluid of a hepatoma-bearing patient. Cancer Res 1978; 38: 6–12
  • Vessela R L, Santrach M A, Bronson D, et al. Evaluation of AFP glycosylation heterogeneity in cancer patients with AFP-producing tumors. Int J Cancer 1984; 34: 309–314
  • Ishiguro T, Sugitachi I, Sakaguchi H, et al. Serum alpha-fetoprotein subtractions in patients with primary hepatoma or hepatic metastasis of gastric cancer. Cancer 1985; 55: 156–159
  • A Manual of Quantitative Immunoelectrophoresis, N H Axelsen, J Kroll, B Weeks. Universitetsforla-get, Oslo-Bergen-Tromso 1973
  • Ruoslahti E, Seppala M. Studies of carcinofetal protein. III. Development of a radioimmunoassay for a-fetoprotein in serum of healthy human adults. Int J Cancer 1971; 8: 374–383
  • Purvis L R, Purvis M. Serum alpha-fetoprotein. VI. The radioimmunoassay. Evidence for the presence of AFP in the serum of normal people and during pregnancy. S Afr Med J 1972; 46: 1290–1297
  • Nichi S, Hirai H. Radioimmunoassay of carcinoembryonic antigen and its related antigen by the sandwich method. Onco-developmental Gene Expression, W H Fishman, S Sell. Academic Press, New York 1976; 567–572
  • Bellet D H, Wand J R, Isselbacher K J, et al. Serum alpha-fetoprotein levels in human disease: Perspective from a highly specific monoclonal radioimmunoassay. Proc Natl Acad Sci USA 1974; 81: 3869–3873
  • Waldmann T A, McLntire K R. The use of a radioimmunoassay for alpha-fetoprotein in the diagnosis of malignancy. Cancer 1974; 34: 1510–1520
  • Kurman R J, Norris H J. Endodermal sinus tumor of the ovary: A clinical and pathologic analysis of 71 cases. Cancer 1976; 38: 2404–2419
  • Tsukada Y, Hirai H. Alpha-fetoprotein and albumin synthesis during the cell cycle. Ann NY Acad Sci 1975; 259: 37–46
  • Massayeff R F. Factors influencing alpha-fetoprotein biosynthesis in patients with primary liver cancer and other diseases. Alpha-fetoprotein and Hepatoma, H Hirai, T Miyaji. Tokyo University Press, Tokyo 1973; 3–18
  • Lehman F G. Prognostic significance of alpha-fetoprotein in liver cirrhosis: Five-year prospective study. Onco-developmental Gene Expression, W H Fishman, S Sills. Academic Press, New York 1976; 407–415
  • Okuda K, Kotoda K, Obatu H, et al. Clinical observations during a relatively early stage of hepatocellular carcinoma with special reference to serum alpha-fetoprotein levels. Gastroenterology 1977; 69: 226–234
  • Matsumoto Y, Suzuki T, Asada I, et al. Clinical classification of hepatoma in Japan according to serial changes in serum alpha-fetoprotein levels. Cancer 1982; 49: 354–560
  • Purves L R, Bershon I, Path F C, et al. Serum alpha-fetoprotein and primary cancer of the liver in man. Cancer 1970; 25: 1261–1270
  • Chen D, Sung J, Shen J, et al. Serum alpha-fetoprotein in the early stage of human hepatocellular carcinoma. Gastroenterology 1984; 86: 1404–1409
  • Thompson D, Haddow J. Serial monitoring of serum alpha-fetoprotein and chorionic gonadotropin in males with germ cell tumors. Cancer 1979; 43: 1820–1829
  • Lange P H, McLntire K R, Waldman T A, et al. Serum alpha-fetoprotein and human chorionic gonadotropin in the diagnosis and management of non-seminomatous germ cell testicular cancer. N Engl J Med 1976; 295: 1237–1240
  • Lange P H, McLntire K R, Waldman T A, et al. Alpha-fetoprotein and human chorionic gonadotropin in the management of testicular tumors. J Urol 1977; 118: 593–596
  • Talerman A, Haige W G, Baggerman L. Serum alpha-fetoprotein in diagnosis and management of endodermal sinus tumor and mixed germ cell tumor of the ovary. Cancer 1977; 41: 272–278
  • Vogelzang N S, Lange P H, Goldman A, et al. Acute changes of alpha-fetoprotein and human chorionic gonadotropin during induction chemotherapy of germ cell tumors. Cancer Res 1982; 42: 4855–4861
  • Borkowski A, Muquardt C. Human chorionic gonadotropin in the plasma of normal non-pregnant subjects. N Engl J Med 1979; 301: 298–302
  • Hussa R, Cole L A. New horizons in HCG detection. Advances in Experimental Medicine and Biology, R A Patillo, R O Hussa. Plenum Press, New York and London 1984; 217–243, No. 176
  • Pierce G B, Dixon F J, Verney E. Endocrine function of a hetero-transplantable human embryonal carcinoma. Arch Pathol 1959; 67: 204–210
  • Pierce G B, Midgley A R, Verney E L. Therapy of heterotransplanted choriocarcinoma. Cancer Res 1962; 22: 563–567
  • Lewis J L, Davis R C, Ross G T, et al. Hormonal, immunologic and chemotherapeutic studies of transplantable human choriocarcinoma. Am J Obstet Gynecol 1969; 104: 472–478
  • Hayashi H, Kamlyn T, Shimosato Y, et al. Chemotherapy of human choriocarcinoma transplanted to nude mice. Am J Obstet Gynecol 1978; 131: 548–554
  • Morgan F S, Berkin S, Canfield R E. The amino acid sequence of human chorionic gonadotropin. J Biol Chem 1975; 250: 5247–5288
  • Vaitukaitis J L, Braunstein G D, Ross G T. A radioimmunoassay which specifically measures human gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol 1972; 113: 751–758
  • Braunstein G D, Vaitukaitis J L, Carbone P, et al. Ectopic production of human chorionic gonadotropin by neoplasms. Ann Intern Med 1973; 78: 39–45
  • Navarro C, Corretger S M, Sancho A, et al. Paraneoplastic precocious puberty: Report of a new case with hepatoblastoma and review of the literature. Cancer 1985; 56: 1725–1729
  • Bagshawe K D. Risk and prognostic factors in trophoblastic neoplasms. Cancer 1976; 38: 1373–1375
  • Jones W B. Human chorionic gonadotropin—the ideal tumor marker?. Controversies in Gynecological Oncology, S C Ballen. Hull, Boston 1981; 367–375
  • Bagshawe K D. Clinical applications of HCG. Human Trophoblast Neoplasms, R A Pattillo, R O Hussa. Plenum Press, New York 1984; 313–324
  • Hussa R O. Clinical utility of HCG and alpha subunit measurement. Obstet Gynecol 1982; 60: 1–12
  • Bagshawe K D, Wilson H, Dublon P, et al. Follow-up after hydatidiform mole: Studies using radioimmunoassay for urinary human chorionic gonadotropin (HCG). J Obstet Gynecol Br Comm 1973; 80: 461–468
  • Anderson T, Waldmann T A, Javadpour N, et al. Testicular germ-cell neoplasm: Recent advances in diagnosis and therapy. Ann Intern Med 1979; 90: 373–385
  • Scardino P T, Cox H D, Waldmann T A, et al. The value of serum tumor markers in the staging and prognosis of germ cell tumors of the testis. J Urol 1977; 118: 994–999
  • Braunstein G D, McLntire K R, Waldman T A. Discordance of human chorionic gonadotropin and AFP in testicular teratocarcinoma. Cancer 1973; 31: 1065–1068
  • Perlin E, Engeler J E, Jr, Edsen M, et al. The value of serial measurement of both human chorionic gonadotropin and alpha-fetoprotein for monitoring germinal tumors. Cancer 1976; 37: 215–219
  • Picozzi V J, Freiha F S, Hannigan J F, et al. Prognostic significance of a decline in serum human chorionic gonadotropin levels after initial chemotherapy for advanced germ-cell carcinoma. Ann Intern Med 1984; 100: 183–186
  • Richardson R L, Schoumacher R A, Per M F, et al. The unrecognized extragonadal germ cell cancer syndrome. Ann Intern Med 1981; 94: 181–186
  • Potts J T, Jr, Reisfeld R A, Hirsch P F, et al. Purification of porcine thyrocalcitonin. Proc Natl Acad Sci USA 1967; 58: 328–335
  • Deftos L J, Lee M R, Potts J T, Jr. A radioimmunoassay for thyrocalcitonin. Proc Acad Sci USA 1968; 60: 293–299
  • Hirsch P F, Voelkel E F, Munson P L. Thyrocalcitonin: Hypo-calcemic hypophosphatemic principle of the thyroid gland. Science 1964; 146: 412–413
  • Tashjian A H, Wolfe H F, Voelkel E F. Human calcitonin. Immunologic assay, cytologic localization and studies on medullary thyroid carcinoma. Am J Med 1974; 56: 840–849
  • Hennessey J F, Wells S A, Ontjes D A, et al. A comparison of pen-tagastrin injection and calcium infusion as provocative agents for the detection of medullary carcinoma of the thyroid. J Clin Endocrinol Metab 1974; 39: 487–495
  • Wells S A, Baylin S B, Lineham W M, et al. Provocative agents and the diagnosis of medullary carcinoma of the thyroid gland. Ann Surg 1978; 188: 139–141
  • Hirsch P F, Munson P L. Thyrocalcitonin. Physiol Rev 1969; 49: 548–622
  • Tashjian A H, Jr, Howland B G, Melvin K EW, et al. Immunoassay of human calcitonin. Clinical measurement, relationship to serum calcium and studies in patients with medullary carcinoma. N Engl J Med 1970; 283: 890–895
  • Melvin K EW, Tashjian A H, Jr, Miller H H. Studies in familial (medullary) thyroid carcinoma. Rec Progr Horm Res 1972; 28: 399–470
  • Wolfe H F, Melvin K EW, Cervi-Skinner S, et al. C-cell hyperplasia preceding medullary thyroid carcinoma. N Engl J Med 1973; 289: 437–441
  • Graze K, Spiler I J, Tashjian A H, Jr, et al. natural history of familial medullary thyroid carcinoma: Effect of a program for early diagnosis. N Engl J Med 1978; 299: 980–985
  • Leape L L, Miller H H, Graze K, et al. Total thyroidectomy for occult familial medullary carcinoma of the thyroid in children. J Pediatr Surg 1976; 11: 831–837
  • Gagel R F, Jackson C E, Block M A, et al. Age-related probability of development of hereditary medullary thyroid carcinoma. J. Pediatr 1982; 101: 941–946
  • Vindelov L L, Hansen H H, Christensen I J, et al. Clonal heterogeneity of small cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis. Cancer Res 1980; 40: 4295–4300
  • Coombes R C, Hillyard C, Greenberg P B, et al. Plasma-immunoreactive-calcitonin in patients with non-thyroid tumors. Lancet 1974; 1: 1080–1083
  • Cate C C, Douple E B, Andrews K M, et al. Calcitonin as an indicator of the response of human small cell carcinoma of the lung cells to drugs and radiation. Cancer Res 1984; 44: 949–954
  • Bock E, Dissing J. Demonstration of enolase activity connected to the brain specific protein 14–3–2. Scand J Immunol 1975; 4: 31–36, (Suppl 2)
  • Hullin D A, Brown K, Kynoch P AM, et al. Purification, radioimmunoassay, and distribution of human brain 14–3–2 protein (nervous system-specific enolase) in human tissues. Biochem Biophys Acta 1980; 628: 98–108
  • Moore B W. Chemistry and biology of two proteins, S-100 and 14–3–2, specific to the nervous system. International Review of Neurobiology, Volume 15, C C Pfeiffer, J R Smythies. Academic Press, New York 1972; 215–225
  • Schmechel D, Marangos P J, Zis A P, et al. Brain enolases as specific markers of neuronal and glial cells. Science 1978; 199: 313–315
  • Marangos P J, Schmechel D E, Parma A M, et al. Measurement of neuron-specific (NSE) and non-neuronal (NNE) isoenzymes of enolase in rat, monkey and human nervous tissue. J Neurochem 1979; 33: 319–329
  • Marangos P J, Polak J M, Pearse A GE. Neuron-specific enolase: A probe for neurons and neuroendocrine cells. Trends Neurosci 1982; 5: 193–195
  • Royds J A, Parson M A, Taylor C B, et al. Enolase isoenzyme distribution in the human brain and its tumors. J Pathol 1982; 137: 37–9
  • Schmechel D, Marangos P J, Brightman M. Neuron-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature 1978; 273: 834–836
  • Kato K, Ishiguro Y, Suzuki F, et al. Distribution of nervous system-specific forms of enolase in peripheral tissues. Brain Res 1982; 237: 441–448
  • Tapia F J, Polak J M, Barbosa A JA, et al. Neuron-specific enolase is produced by neuroendocrine tumors. Lancet 1981; 1: 808–811
  • Ishiguro Y, Kato K, Ito T, et al. Determination of three enolase isozymes and S-100 protein in various tumors in children. Cancer Res 1983; 43: 6080–6084
  • Gu J, Polak J M, Van Noorden S, et al. Immunostaining of neuron-specific enolase as a diagnostic tool for Merkel cell tumors. Cancer 1983; 52: 1039–1043
  • Prinz R A, Bermes E W, Kimmel J R, et al. Serum markers for pancreatic islet cell and intestinal carcinoid tumors: A comparison of neuron-specific enolase, B-human chorionic gonadotropin and pancreatic polypeptide. Surgery 1983; 94: 1019–1023
  • Oskam R, Rijksen G, Lips C JM, et al. Enolase isoenzymes in differentiated and undifferentiated medullary thyroid carcinomas. Cancer 1985; 55: 394–399
  • Inoue M, Ueda G, Nakajima T. Immunohistochemical demonstration of neuron-specific enolase in gynecologic malignant tumors. Cancer 1985; 55: 1686–1690
  • Haimoto H, Takahashi Y, Koshikawa T, et al. Immunohistochemical localization of γ-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab Invest 1985; 52: 257–263
  • Marangos P J, Goodwin F K, Parma A, et al. Neuron specific protein (NSP) in neuroblastoma cells: Relation to differentiation. Brain Res 1978; 145: 49–58
  • Schmechel D E, Brightman M W, Marangos P J. Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation. Brain Res 1980; 190: 195–214
  • Wevers R A, Jacobs A AC, Hommes O R. A bioluminescent assay for enolase (EC 4.2.1.11) activity in human serum and cerebrospinal fluid. Clin Chim Acta 1983; 135: 159–168
  • Gerbitz K-D, Summer J, Thallemer J. Brain-specific proteins: Solid-phase immunobioluminescence assay for neuron-specific enolase in human plasma. Clin Chem 1984; 30: 382–386
  • Carney D N, Marangos P J, Ihde D C, et al. Seram neuron-specific enolase: A marker for disease extent and response to therapy of small-cell lung cancer. Lancet 1982; 1: 583–585
  • Ishiguro Y, Kato K, Ito T, et al. Nervous system-specific enolase in serum as a marker for neuroblastoma. Pediatrics 1983; 72: 696–700
  • Johnson D H, Marangos P J, Forbes J T, et al. Potential utility of serum neuron-specific enolase levels in small cell carcinoma of the lung. Cancer Res 1984; 44: 5409–5419
  • Esscher T, Steinholtz L, Bergh J, et al. Neuron specific enolase: A useful diagnostic serum marker for small cell carcinoma of the lung. Thorax 1985; 40: 85–90
  • Marangos P J, Parma A M, Goodwin F K. Functional properties of neuronal and glial isoenzymes of brain enolase. J Neurochem 1978; 31: 727–732
  • Kato K, Asai R, Shimizu F, et al. Immunoassay of three enolase isozymes in human serum and in blood cells. Clin Chim Acta 1983; 127: 353–363
  • Zeltzer P M, Marangos P J, Sather H, et al. Prognostic importance of serum neuron specific enolase in local and widespread neuroblastoma. Progr Clin Biol Res 1984; 17: 319–329
  • Prinz R A, Marangos P J. Use of neuro-specific enolase as a serum marker for neuroendocrine neoplasms. Surgery 1982; 97: 887–889
  • Prinz R A, Marangos P J. Serum neuron-specific enolase: A serum marker for non-functioning pancreatic islet cell carcinoma. Am J Surg 1983; 145: 77–81
  • Wacker W EC, Ulmer D D, Vallee B L. Metalloenzymes and myocardial infarction, II. Malic and lactic dehydrogenase activities and zinc concentrations in serum. N Engl J Med 1956; 255: 449–456
  • Goldman R, Kaplan N O, Hall T C. Lactic dehydrogenase in human neoplastic tissues. Cancer Res 1964; 24: 389–399
  • Wroblewski F, LaDue J S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med 1955; 90: 210–213
  • Peake M J, Pejakovic M, Alderman M J, et al. Mechanism of platelet interference with measurement of lactate dehydrogenase activity in plasma. Clin Chem 1984; 30: 518–520
  • Chainurati T, Harinasuta U, Zimmerman H J. Spurious elevation of apparent lactate dehydrogenase activity caused by triamterene. Clin Chem 1973; 19: 1202–1204
  • Acheampong-Mensah D. Persistent increase of serum lactate dehydrogenase activity related to enzyme IgG (lambda) immunoglobulin complex. Clin Chem 1980; 26: 789–790
  • Nagamine M. Serum inactivator to M subunit of lactate dehydrogenase isoenzymes. Clin Chim Acta 1974; 50: 173–179
  • Jacobs D S, Robinson R A, Clark G M, et al. Clinical significance of the isomorphic pattern of the isoenzymes of serum lactate dehydrogenase. Ann Clin Lab Sci 1977; 7: 411–421
  • Vanderlinde R E. Measurement of total lactate dehydrogenase activity. Ann Clin Lab Sci 1985; 15: 13–31
  • Hill B R, Levi C. Elevation of a serum component in neoplastic disease. Cancer Res 1954; 14: 513–515
  • Zondag H A, Klein F. Clinical applications of lactate dehydrogenase isozymes: Alterations in malignancy. Ann NY Acad Sci 1968; 151: 578–586
  • Bierman H R, Hill B R, Reinhardt L, et al. Correlation of serum lactic dehydrogenase activity with the clinical status of patients with cancer lymphomas and leukemias. Cancer Res 1957; 17: 660–677
  • Ratcliff C R, Culp T W, Hall F F. Serum lactic dehydrogenase and other enzymes in malignant disease: Comparison with an immunodiagnostic test for cancer. Am J Gastroenterol 1971; 56: 199–208
  • Wood D C, Varela V, Palmquist M, et al. Serum lactic dehydrogenase and isoenzymes in clinical cancer. J Surg Oncol 1973; 5: 251–257
  • Singh R, Rohatgi A K, Shukla P K. Lactate dehydrogenase activity in ocular tumors. Ann Ophthalmol 1983; 15: 317–319
  • O'Connor D T, Gochman N. Lactic dehydrogenase activity in human pheochromocytoma. JAMA 1983; 249: 383–385
  • Cori C F, Cori G T. The carbohydrate metabolism of tumors. II. Changes in the sugar, lactic acid, and CO2-combining power of blood passing through a tumor. J Biol Chem 1925; 65: 397–405
  • Boxer G E, Devlin T M. Pathways of intracellular hydrogen transport. Science 1961; 134: 1495–1501
  • Brindley C O, Francis F L. Serum lactic dehydrogenase and glutamic-oxaloacetic transaminase correlations with measurements of tumor masses during therapy. Cancer Res 1963; 23: 112–117
  • Shapira F. Isoenzymes and cancer. Adv Cancer Res 1973; 18: 77–153
  • Vesell E S, Beam A G. Localization of lactic acid dehydrogenase activity in serum fractions. Proc Soc Exp Biol Med 1957; 94: 96–99
  • von Eyben F E. Biochemical markers in advanced testicular tumors: Serum lactate dehydrogenase, urinary chorionic gonadotropin and total urinary estrogens. Cancer 1978; 41: 648–652
  • Lieskovsky G, Skinner D G. Significance of serum lactic dehydrogenase in stages B and C non-seminomatous testis tumors. J Urol 1980; 123: 516–517
  • Lippert M, Papadopoulos N, Javadpour N. Role of lactate dehydrogenase isoenzymes in testicular cancer. Urology 1981; 18: 50–53
  • Lippert M C, Javadpour N. Lactic dehydrogenase in the monitoring and prognosis of testicular cancer. Cancer 1981; 48: 2274–2278
  • Sheiko M C, Hart W R. Ovarian germinoma (dysgerminoma) with elevated serum lactic dehydrogenase: Case report and review of literature. Cancer 1982; 49: 994–998
  • Brereton H D, Simon R, Pomeroy T C. Pretreatment serum lactate dehydrogenase predicting metastatic spread in Ewing's sarcoma. Ann Intern Med 1975; 83: 352–354
  • Glaubiger D, Makuch R, Schwartz J, et al. Determination of prognostic factors and their influence on therapeutic results in patients with Ewing's sarcoma. Cancer 1980; 45: 2213–2219
  • Blatt J, Reaman G, Poplack D G. Biochemical markers in lymphoid malignancy. N Engl J Med 1980; 303: 918–922
  • Anderson T, Magrath I, Brereton H, et al. Burkitt's lymphomas: Prediction of early relapse and metabolic complications of therapy. Proc Am Assoc Cancer Res 1974; 15: 169
  • Arseneau J C, Canellos G P, Banks P M, et al. American Burkitt's lymphoma: A clinicopathologic study of 30 cases. I. Clinical factors relating to prolonged survival. Am J Med 1975; 58: 314–321
  • Magrath I, Lee Anderson Y J, et al. Prognostic factors in Burkitt's lymphoma. Importance of total tumor burden. Cancer 1980; 45: 1507–1515
  • Schneider R J, Seibert K, Passe S, et al. Prognostic significance of serum lactate dehydrogenase in malignant lymphoma. Cancer 1980; 46: 139–143
  • Ferraris A M, Guintini P, Gaetani G F. Serum lactic dehydrogenase as a prognostic tool for non-Hodgkin's lymphomas. Blood 1979; 54: 928–932
  • Rubery E D, Doran J F, Thompson R J. Brain-type creatine kinase BB as a potential tumor marker: Serum levels measured by radioimmunoassay in 1015 patients with histologically confirmed malignancies. Eur J Cancer Clin Oncol 1982; 18: 951–956
  • Carney D N, Zweig M H, Ihde D C, et al. Elevated serum creatine kinase BB levels in patients with small cell lung cancer. Cancer Res 1984; 44: 5399–5403
  • Gazdar A F, Zweig M H, Carney D N, et al. Levels of creatine kinase and its BB isoenzyme in lung cancer specimens and cultures. Cancer Res 1981; 41: 2773–2777
  • Berggard I, Beam A C. Isolation and properties of low molecular weight β2-globulin occurring in human biological fluids. J Biol Chem 1968; 243: 4095–403
  • Cresswell P, Springer T, Strominger J L, et al. Immunological identity of the small subunit of HLA antigens and β2 microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci 1974; 71: 2123–2127
  • Grey H M, Kubo R T, Colon S M, et al. The small subunit of HLA antigens is β2 microglobulin. J Exp Med 1973; 138: 1608–1612
  • Cunningham B A, Berggard I. Structure, evolution and significance of β2 microglobulin. Transplant Rev 1974; 21: 3–14
  • Bernier G M, Cohen R J, Conrad M E. Microglobulinemia in renal failure. Nature 1968; 218: 598–599
  • Wibell L, Evrin P E, Berggard I. Serum β2 microglobulin in renal disease. Nephron 1973; 10: 320–331
  • Karlsson F A, Wibell L, Evrin P E. β2 microglobulin in clinical medicine. Scand J Clin Lab Invest 1980; 40: 27–37
  • Michalski J P, Daniels R E, Talal M, et al. β2 microglobulin and lymphocytic infiltration in Sjogren's syndrome. N Engl J Med 1975; 293: 1228–1231
  • Mornex J F, Revillard J P, Vincent C, et al. Elevated serum β2 microglobulin levels and Ciq-binding immune complexes in sarcoidosis. Biomedicine 1979; 31: 210–213
  • Descos L, Andre C, Beorchia S, et al. Serum levels of β2 microglobulin. A new marker of activity in Crohn's disease. N Engl J Med 1979; 301: 440–441
  • Teasdal C, Mander A M, Fifield R, et al. Serum β2 microglobulin in controls and cancer patients. Clin Chem 1973; 78: 135–143
  • Hallgren R, Nou E, Lundquist G. Serum β2 microglobulin in patients with bronchial carcinoma and controls. Cancer 1980; 45: 780–785
  • Rashid S A, Cooper E H, Axon A TR, et al. Serum β2 microglobulin in malignant and benign diseases of the stomach and pancreas. Biomedicine 1980; 33: 112–116
  • Amplot P L, Adinolfi M. Serum β2 microglobulin and its prognostic value in lymphomas. Eur J Cancer 1978; 15: 791–796
  • Cassuto J P, Krebs B P, Viot G, et al. β2 microglobulin, a tumour marker of lymphoproliferative disorders. Lancet 1978; 2: 108–109
  • Norfolk O, Child J A, Cooper E H, et al. Serum β2 microglobulin in myetomatosis: Potential value in stratification and monitoring. Br J Cancer 1979; 39: 510–515
  • Child J A, Spati B, Illingworth S, et al. Serum β2 microglobulin and C-reactive protein in the monitoring of lymphomas. Cancer 1980; 45: 318–326
  • Simonsson B, Wibell L, Nilsson K. β2 microglobulin in chronic lymphocytic leukemia. Scand J Haematol 1980; 24: 174–180
  • Bataille R, Magub M, Grenier J, et al. Serum beta-2-microglobulin in multiple myeloma: Relation to presenting features and clinical status. Eur J Cancer Clin Oncol 1982; 18: 59–66
  • Anderson H, Scarffe J H, Swindell R, et al. Serum β2 microglobulin in patients with non-Hodgkin's lymphoma. Eur J Cancer Clin Oncol 1983; 19: 327–331
  • Bataille R, Durie B G, Grenier J. Serum β2 microglobulin and survival duration in multiple myeloma: A simple reliable marker for staging. Br J Haematol 1983; 55: 439–447
  • Hagberg J, Killander A, Simonsson B. Serum β2 microglobulin in malignant lymphoma. Cancer 1982; 51: 2220–2225
  • Norfolk D R, Child J A, Roberts B E, et al. Serum beta-2-microglobulin in disorders of myeloid proliferation. Acta Haemat 1983; 69: 361–368
  • Bataille R, Grenier J, Sany J. Beta-2-microglobulin in myeloma: Optimal use for staging, prognosis, and treatment. A prospective study of 160 patients. Blood 1984; 63: 468–476
  • Constantinides I P, Pathouli C, Karvountzis G, et al. Serum β2 microglobulin in malignant lymphoproliferative disorders. Cancer 1985; 55: 2384–2389
  • Swanson R A, Tracy R P, Katzmnan J A, et al. β2 microglobulin determined by radioimmunoassay with monoclonal antibody. Clin Chem 1982; 28: 2033–2039
  • Playford R J, Dawnay A, Cattell W R, et al. The development of a fluoroimunoassay for β2 microglobulin in serum. Ann Clin Biochem 1985; 22: 166–170
  • Hazkomori S-I. Glycolipids of tumor cell membrane. Adv Cancer Res 1974; 18: 265–315
  • Nigam V N, Cantero A. Polysaccharides in cancer: Glycoproteins and glycolipids. Adv Cancer Res 1973; 17: 1–80
  • Winzler R J. Determinations of serum glycoproteins. Methods of Biochemical Analysis, Vol. 2, W Click. Interscience Publishers, New York 1955; 279–311
  • Silver H KB, Rangel D M, Morton D L. Serum sialic acid elevations in malignant melanoma patients. Cancer 1978; 4: 1497–1499
  • Moss A J, Bissada N K, Boyd M C, et al. Significance of protein-bound neuraminic acid levels in patients with prostatic and bladder carcinoma. Urology 1979; 13: 182–184
  • Silver H K, Kanin K A, Archibald E L, et al. Serum sialic acid elevation in malignant melanoma patients. Cancer Res 1979; 39: 5036–5042
  • Hogan-Ryan A, Fennelly J J, Jones J, et al. Serum sialic acid and CEA concentrations in human breast cancer. Br J Cancer 1980; 41: 587–592
  • Dnistrian A M, Schwartz M K. Plasma lipid-bound sialic acid and carcinoembryonic antigen in cancer patients. Clin Chem 1981; 27: 1737–1739
  • Dnistrian A M, Schwartz M K, Katopodis N, et al. Serum lipid-bound sialic acid as a marker in breast cancer. Cancer 1982; 50: 1815–1819
  • Horgan E I. Total and lipid-bound sialic acid levels in sera from patients with cancer. Clin Chem Acta 1982; 118: 327–331
  • Katopodis N, Hirshaut Y, Geller N L. Lipid associated sialic acid test for the detection of human cancer. Cancer Res 1981; 42: 1737–1739
  • Erbil K M, Jones J D, Klee G G. Use and limitation of serum total and lipid bound sialic acid concentration as markers for colorectal cancer. Cancer 1985; 55: 404–409
  • Koprowski H, Steplewski Z, Mitchell K, et al. Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genetics 1979; 5: 957–972
  • Koprowski H, Herlyn M, Steplewski Z, et al. Specific antigen in serum of patients with colon carcinoma. Science 1981; 212: 53–55
  • Herlyn M, Sears H F, Steplewski Z, et al. Monoclonal antibody detection of a circulating tumor associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric and pancreatic carcinoma. J Clin Immunol 1982; 2: 135–140
  • Silverman B A, Rubinstein A. Serum lactate dehydrogenase levels in adults and children with acquired immune deficiency syndrome (AIDS) and AIDS-related complex: Possible indicator of B-cell proliferation and disease activity. Am J Med 1985; 78: 728–736
  • Gutman A B, Gutman E B. An “acid” phosphatase occurring in the serum of patients with metastasizing carcinoma of the prostate gland. J Clin Invest 1938; 17: 473–478
  • Shulman S, Mamrod L, Gonder M J, et al. The detection of prostatic acid phosphatase by antibody reactions in gel diffusion. J Immunol 1964; 93: 474–480
  • Choe B K, Lillehoj H S, Dong M K, et al. Characterization of anti-genie sites of human prostatic acid phosphatase. Ann NY Acad Sci 1982; 390: 16–26
  • Maatman T J, Gupta M K, Montie J E. The role of serum prostatic acid phosphatase as a tumor marker in men with advanced adenocarcinoma of the prostate. J Urol 1984; 132: 58–60
  • Pappad A A, Gadsden R H. Prostatic acid phosphatase: Clinical utility in detection, assessment and monitoring carcinoma of the prostate. Ann Clin Lab Sci 1984; 14: 285–291
  • Schadt M J, Garnett J E, Grayhack J T. Biochemical markers in prostatic cancer. Urol Clin North Am 1984; 11: 253–267
  • Cooper J F, Foti A G. A radioimmunoassay for prostatic acid phosphatase. I. Methodology and range of normal male serum values. Invest Urol 1974; 12: 98–102
  • Foti A G, Cooper J F, Herschman H, et al. Detection of prostatic cancer by solid-phase radioimmunoassay of serum prostatic acid phosphatase. N Engl J Med 1977; 297: 1357–1361
  • Chu T M, Wang M C, Scott W W, et al. Immunochemical detection of serum prostatic acid phosphatase. Methodology and clinical evaluation. Invest Urol 1978; 15: 319–323
  • Killian C S, Varga F P, Lee C L, et al. Quantitative counter-immunoelectrophoresis assay for prostatic acid phosphatase. Invest Urol 1980; 18: 219–224
  • Lee C L, Wang M C, Murphy G P, et al. A solid-phase fluorescent immunoassay for human prostatic acid phosphatase. Cancer Res 1978; 38: 2871–2878
  • Lee C L, Killian C S, Murphy G P, et al. A solid-phase immuno-absorbent assay for serum prostatic acid phosphatase. Clin Chim Acta 1980; 101: 209–216
  • Kuriyama M, Wang M C, Lee C L, et al. Multiple marker evaluation in human prostate cancer with the use of tissue-specific antigens. J Natl Cancer Inst 1982; 68: 99–105
  • Lee C L, Li C Y, Jou Y H, et al. Immunochemical characterization of prostatic acid phosphatase with monoclonal antibodies. Ann NY Acad Sci 1982; 390: 52–61
  • Foti A G, Heschman H, Cooper J F. Comparison of human prostatic acid phosphatase by measurement of enzymatic activity and by radioimmunoassay. Clin Chem 1977; 23: 95–99
  • Wajsman Z, Chu T M, Saroff J, et al. Two new, direct and specific methods of acid phosphatase determination. National Field Trial. Urol 1979; 13: 8–11
  • Romas N A, Shaw L M, Hsu K C, et al. Clinical comparison of immunologic assays for determining prostatic acid phosphatase. Ann NY Acad Sci 1982; 390: 140–109
  • Bruce A W, Mahan D E. The role of prostatic acid phosphatase in the investigation and treatment of adenocarcinoma of the prostate. Ann NY Acad Sci 1982; 390: 110–121
  • Vihko F, Kontturi M, Lukkarinen O, et al. Screening for carcinoma of the prostate. Rectal examination, and enzymatic and radioimmunologic measurements of serum acid phosphatase compared. Cancer 1985; 56: 173–177
  • Guinan P, Bush I, Ray V, et al. The accuracy of the rectal examination in the diagnosis of prostate carcinoma. N Engl J Med 1980; 303: 499–503
  • Lee C L, Chu T M, Wajsman L Z, et al. Value of new fluorescent immunoassay for human prostatic acid phosphatase in prostate cancer. Urology 1980; 15: 338–341
  • Griffiths J C. Prostate-specific acid phosphatase: Re-evaluation of radioimmunoassay in diagnosing prostate disease. Clin Chem 1980; 26: 433–436
  • Griffiths J. The appropriate uses of prostatic acid phosphatase determination in the diagnosis of adenocarcinoma of the prostate. Ann NY Acad Sci 1982; 390: 100–103
  • Whitesel J A, Donohue R E, Mani J H, et al. Acid phosphatase: Its influence on the management of carcinoma of the prostate. J Urol 1984; 131: 70–71
  • Vihko P, Kontturi M, Lukkarinen O, et al. Immunoreactive prostatic acid phosphatase in prostatic cancer: Diagnosis and followup of patients. J Urol 1985; 133: 979–982
  • Killian C S, Vargas F P, Slack N H, et al. Prostatic-specific acid phosphatase versus acid phosphatase in monitoring patients with prostate cancer. Ann NY Acad Sci 1982; 390: 122–132
  • Tsung S W. Creatine kinase isoenzyme patterns in human tissues obtained at surgery. Clin Chem 1976; 22: 173–175
  • Van Steirteghem A C, Robertson E A, Zweig M H. Distribution of serum concentrations of creatine kinase MM and BB isoenzymes measured by radioimmunoassay. Clin Chim Acta 1979; 93: 25–28
  • Zweig M H, Van Steirteghem A C, Schecter A. Radioimmunoassay of creatine kinase isoenzymes in human serum: Isoenzyme BB. Clin Chem 1978; 24: 422–428
  • Zweig M H, Van Steirteghem A C. Assessment by radioimmunoassay of serum creatine kinase BB (CK-BB) as a tumor marker: Studies in patients with various cancers and a comparison of CK-BB concentrations to prostate acid phosphatase concentrations. J Natl Cancer Inst 1981; 66: 859–862
  • Abbott L B, Lott J A. Reactivation of serum creatine kinase isoenzyme BB in patients with malignancies. Clin Chem 1984; 30: 1861–1863
  • Lederer W H, Gerstbrein H L. Creatine kinase isoenzyme BB activity in serum of a patient with gastric cancer. Clin Chem 1976; 22: 1748–1749
  • Hoag G, Franks C, De Coteau W. Creatine kinase isoenzymes in serum of patients with cancer of various organs. Clin Chem 1978; 24: 1654
  • Coolen R B, Propay D A, Nosanchuk J S, et al. Elevation of brain-type creatine kinase from patients with carcinoma. Cancer 1979; 44: 1414–1418
  • Forman D L. The significance of creatine kinase (CK-BB) in metastatic cancer of the prostate. Ann Clin Lab Sci 1979; 9: 333–338
  • Silverman L M, Dermer G B, Zweig M H, et al. Creatine kinase BB: A new tumor-associated marker. Clin Chem 1979; 25: 1432–1435
  • Aleyassine H, Maclsaac S G. The diagnostic significance of serum creatine kinase-BB isoenzyme in adenocarcinoma of the prostate. Clin Biochem 1980; 13: 109–112
  • Cornbleet P S, Evans M D. Creatine kinase BB isoenzyme activity in patients with hematologic disorders. Clin Chem 1980; 26: 1635–1636
  • Thompson R J, Rubery E D, Jones H M. Radioimmunoassay of serum creatine kinase-BB as a tumor marker in breast cancer. Lancet 1980; 2: 673–675
  • Magnani J L, Nilsson B, Brockhaus M, et al. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialyated lacto-N-fucopentaose II. J Biol Chem 1982; 257: 14365–14369
  • Magnani J L, Steplewski Z, Koprowski H, et al. Identification of the gastrointestinal and pancreatic cancer associated antigen detected by monoclonal antibody 19–9 in the sera of patients as a mucin. Cancer Res 1983; 43: 5489–5492
  • Atkinson B F, Ernst C S, Herlyn M, et al. Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res 1982; 42: 4820–4823
  • Sears H F, Herlyn M, Del Villano B C, et al. Monoclonal antibody detection of a circulating tumor associated antigen II. A longitudinal evaluation of patients with colorectal cancer. J. Clin Immunol 1982; 2: 141–149
  • Ritts R E, Del Villano B C, Go V LW, et al. Initial clinical evaluation of immunoradiometric assay for CA 19–9 using the NCI serum bank. Int J Cancer 1984; 33: 339–345
  • Satake K, Kanazawa G, Kho I, et al. A clinical evaluation of carbohydrate antigen 19–9 and carcinoembryonic antigen in patients with pancreatic carcinoma. J Surg Oncol 1985; 29: 15–21
  • Tatsuta M, Yamakura H, Iishi H, et al. Values of CA 19–9 in the serum, pure pancreatic juice, and aspirated pancreatic material in the diagnosis of malignant pancreatic tumor. Cancer 1985; 56: 2669–2673
  • Gupta M K, Arciapa R, Bocci L, et al. Measurement of a monoclonal-antibody-defined antigen (CA 19–9) in the sera of patients with malignant and nonmalignant diseases. Cancer 1985; 56: 277–283
  • Jalanko H, Kuusela P, Roberts P, et al. Comparison of a new tumour marker, CA 19–9 (TM), with alpha-fetoprotein and carcinoembryonic antigen in patients with upper gastrointestinal disease. J Clin Pathol 1984; 37: 218–222
  • Kuusela P, Jalanko H, Roberts P, et al. Comparison of CA 19–9 and carcinoembryonic antigen (CEA) levels in serum of patients with colorectal diseases. Br J Cancer 1984; 49: 135–138
  • Yoshikawa T, Tishida K, Tanigawa M, et al. Carbohydrate anti-genie determinant (CA 19–9) and other tumor markers in gastrointestinal malignancies. Digest 1985; 31: 67–76
  • Bast R C, Jr, Feeney M, Lazarus H, et al. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 1981; 68: 1331–1337
  • Kabawat S E, Bast R C, Jr, Welch W R, et al. Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometroid, and clear cell type. Am J Clin Pathol 1983; 79: 98–104
  • Masuho Y, Zalutsky M, Knapp R C, et al. Interaction of monoclonal antibodies with cell surface antigens of human ovarian carcinomas. Cancer Res 1984; 44: 2813–2819
  • Klug T L, Bast R C, Jr, Niloff J M, et al. A monoclonal antibody immunoradiometric assay for an antigenic determinant (CA 125) associated with human epithelial ovarian carcinomas. Cancer Res 1984; 44: 1048–1053
  • Bast R C, Jr, Klug T L, St John E, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983; 309: 883–887
  • Bast R C, Jr, Klug T L, Schaetzl E, et al. Monitoring human ovarian carcinoma with a combination of CA 125, CA 19–9, and carcinoembryonic antigen. Am J Obstet Gynecol 1984; 149: 553–559
  • Canney P A, Moore M, Wilkinson P M, et al. Ovarian cancer antigen CA 125: A prospective clinical assessment of its role as a tumor marker. Br J Cancer 1984; 50: 765–769
  • Heinonen P K, Tontti K, Koivula T, et al. Tumor-associated antigen CA 125 in patients with ovarian cancer. Br J Obstet Gynecol 1985; 92: 528–531
  • Ricolleau G, Chatal J, Fumoleau P, et al. Radioimmunoassay of the CA 125 antigen in ovarian carcinomas: Advantages compared to CA 19–9 and CEA. Tumour Biol 1984; 5: 151–159
  • Niloff J M, Klug T L, Schaetzl E, et al. Elevation of serum CA 125 in carcinomas of the fallopian tube, endometrium and endo-cervix. Am J Obstet Gynecol 1984; 148: 1057–1058
  • Niloff J M, Bast R C, Jr, Schaetzl E, et al. Predictive value of CA 125 antigen levels in second-look procedures for ovarian cancer. Am J Obstet Gynecol 1985; 151: 981–986

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