References
- Topal MD, Baker MS. DNA precursor pool: A significant target for N-methyl-N-nitrosourea in C34/10Tl/2 clone 8 cells. Proc Natl Acad Sci USA 1982; 79: 2211–2215
- Ronen A. 2-Aminopurine. Mutat Res 1979; 75: 1–47
- Lasken RS, Goodman MF. The biochemical basis of 5-bromouracil-induced mutagenesis. J Biol Chem 1984; 259: 11491–11495
- Coulondre C, Miller JH. Genetic studies of the lac repressor. IV. Mutagenic specificity in the lac I gene of Escherichia coli. J Molec Biol 1977; 117: 577–606
- Miller W, Weber H, Meyer F. Site-directed mutagenesis in DNA: Generation of point mutations in cloned β-globin complementary DNA at the positions corresponding to amino acids 121 to 123. J Molec Biol 1978; 124: 343–358
- Miller EC, Miller JA. Mechanisms of chemical carcinogenesis. Cancer 1981; 47: 1055–1064
- Miyaki M, Suzuki K, Aihara M. Misincorporation in DNA synthesis after modification of template or polymerase by MNNG, MMS and UV radiation. Mutat Res 1983; 107: 203–218
- Singer B, Grunberger D. Molecular Biology of Mutagens and Carcinogens. Plenum Press, New York 1982; 56
- Farmer PB, Foster AB, Jarman M. The alkylation of 2 ′-deoxyguanosine and of thymidine with diazoalkanes. Biochem J 1973; 135: 203–213
- Loveless A. Possible relevance of 0–6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides. Nature 1969; 233: 206–207
- Doniger J, Day RS, DiPaolo JA. Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents. Proc Natl Acad Sci USA 1985; 82: 421–425
- Richardson FC, Dyroff MC, Boucheron JA. Differential repair of 04-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens. Carcinogenesis 1985; 6: 625–629
- Pegg AE. Methylation of the 06 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents. Cancer Invest 1984; 2: 223–231
- Singer B. Alkylation of the 06 of guanine is only one of many chemical events that may initiate carcinogenesis. Cancer Invest 1984; 2: 233–238
- Snow ET, Foote RS, Mitra S. Kinetics of incorporation of O-methyldeoxyguanosine monophosphate during in vitro DNA synthesis. Biochemistry 1984; 23: 4289–4294
- Dodson LA, Foote RS, Mitra S. Mutagenesis of bacteriophage T7 in vitro by incorporation of 06-methylguanine during DNA synthesis. Proc Natl Acad Sci USA 1982; 79: 7440–7444
- Eadie JS, Conrad M, Toorchen D. Mechanism of mutagenesis by 06-methylguanine. Nature 1984; 308: 201–203
- Toorchen D, Topal MD. Mechanisms of chemical mutagenesis and carcinogenesis: Effects of DNA replication of methylation at the 06-guanine position of dGTP. Carcinogenesis 1983; 4: 1591–1597
- Hall JA, Saffhill R. The incorporation of 06-methyldeoxyguanosine and 04-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and α. Nucl Acids Res 1983; 11: 4185–4193
- Hopkins RL, Goodman MF. Ribonucleoside and deoxyribonucleoside triphosphate pools during 2-aminopurine mutagenesis in T4 mutator-, wild type-, and antimutator-infected Escherichia coli. J Biol Chem 1985; 260: 6618–6622
- Bessman MJ, Muzyczka N, Goodman MF. Studies on the biochemical basis of spontaneous mutation, II. The incorporation of a base and its analogue into DNA by wild-type, mutator and antimutator DNA polymerases. J Mol Biol 1974; 88: 409–421
- Ball JC, McCormick JJ, Maher VM. Biological effects of incorporation of 06-methyldeoxyguanosine into Chinese hamster V79 cells. Mutat Res 1983; 110: 423–433
- Hsie AW, Stankowski LF, Schenley RL. An analysis of alkylating mutagenesis in CHO cells. Intematiowl symposium on Recent Trends in Medical Genetics, Advances in Bio-sciences, KM Marimuphu, PM Gopinath. Pergamon Press, Oxford 1986; Vol. 56
- Pegg AE, Swann PF. Metabolism of 06-alkyldeoxyguanosines and their effect of removal of 06-methylguanine from rat liver DNA. Biochem Biophys Acta 1979; 565: 241–252
- Goodman MF, Watanabe SM, Branscomb EW. Passive polymerase control of DNA replication fidelity: evidence against unfavored tautomer involvement in 2-aminopurine-induced base transition mutations. Basic Life Sci 1982; 20: 213–229
- Watanabe SM, Goodman MF. Kinetic measurement of 2-aminopurine·cytosine and 2-aminopurine·thymine base pairs as a test of DNA polymerase fidelity mechanisms. Proc Natl Acad Sci USA 1982; 79: 6429–6433
- Klopman G, Ray A. Selective alkylation of nucleic acids by car-cinogens may cause miscoding in DNA. A theoretical study. Cancer Biochem Biophys 1982; 6: 31–35
- Nagata C, Takeda E, Aida M. Why 06-alkylguanine is specifically promutagenic? Ab initio molecular orbital consideration. Mutat Res 1982; 105: 1–8
- Hopkins RL, Goodman MF. Deoxyribonucleotide pools, base pairing, and sequence configuration affecting bromodeoxyuridine-and 2-aminopurine-induced mutagenesis. Proc Natl Acad Sci USA 1980; 77: 1801–1805
- Fersht AR. Fidelity of replication of phage øX174 DNA by DNA polymerase III holoenzyme: Spontaneous mutation by misincorporation. Proc Natl Acad Sci, US 1979; 76: 4946–4950
- Wang MJ, Stellwagen RR, Goodman MF. Evidence for the absence of DNA proofreading in HeLa cell nuclei. J Biol Chem 1981; 256: 7097–7100
- Karran P, Marinus MG. Mismatch correction at O-methylguanine residues in E. coli DNA. Nature 1982; 296: 868–869
- Snow ET, Foote RS, Mitra S. Base-pairing properties of 06-methylguanine in template DNA during in vitro DNA replication. J Biol Chem 1984; 259: 8095–8100
- Foote RS, Mitra S, Pal BC. Demethylation of O-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. Biochem Biophys Res Commun 1980; 97: 654–659
- Olsson M, Lindahl T. Repair of Alkylated DNA in Escherichia coli. J Biol Chem 1980; 255: 10569–10571
- Loechler EL, Green CL, Essigmann JM. L In vivo mutagenesis by O-methylguanine built into a unique site in a viral genome. Proc Natl Acad Sci USA 1984; 81: 6271–6275
- Foote RS, Pal BC, Mitra S. Quantitation of 06-methylguaiüne-DNA methyltransferase in HeLa cells. Mutat Res 1983; 119: 221–228
- Day RS, III., Ziolkowskj JH, Scudiero DA. Defective repair of alkylated DNA by human tumor and SV40-transformed human cell strains. Nature 1980; 288: 724–727
- Sklar R, Strauss B. Removal of O-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Nature 1981; 289: 417–420
- Yarosh DB. The role of 06-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis. Mutat Res 1985; 145: 1–16
- Brennand J, Saffhill R, Fox M. The effects of methylated thymidines upon cultures of V79 cells and the mechanism of incorporation of 04-methylthymidine into their DNA. Carcinogenesis 1982; 3: 219–222
- Veer Reddy GP, Pardee AB. Inhibitor evidence for allosteric interaction in the replitase multienzyme complex. Nature 1983; 304: 86–88
- Nicander B, Reichard P. Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts. J Biol Chem 1985; 260: 5376–5381
- Bochner BR, Ames BN. Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography. J Biol Chem 1982; 257: 9759–9769
- Loeb LA, Kunkel TA. Fidelity of DNA synthesis. Ann Rev Biochem 1982; 51: 429–457
- Volkin E, Boling ME, Lee WH. The effect of chemical mutagens on purine and pyrimidine nucleotide biosynthesis. Biochem Biophys Acta 1983; 755: 217–224
- Das SK, Benditt EP, Loeb LA. Rapid changes in deoxynucleoside triphosphate pools in mammalian cells treated with mutagens. Biochem Biophys Res Commun 1983; 114: 458–464
- Meuth M. The genetic consequences of nucleotide precursor pool imbalance in mammalian cells. Mutat Res 1984; 126: 107–112
- Volkin E, Boling ME, Jones MH. Suppression of the biosynthesis of guanosine triphosphate by protein synthesis inhibitors. J Biol Chem 1980; 255: 9105–9109
- Karran P, Williams SA. The cytotoxic and mutagenic effects of alkylating agents on human lymphoid cells are caused by different DNA lesions. Carcinogenesis 1985; 6: 789–792