Targeting of Cytotoxic Cells with Heterocrosslinked Antibodies

References

• Martz E. Mechanism of specific tumor-cell lysis by alloimmune T lymphocytes: resolution and characterization of discrete steps in the cellular interaction. Contemp Top Immunobiol 1977; 7: 301–361
   PubMedGoogle Scholar
• Berke G. Interaction of cytotoxic T lymphocytes and target cells. Prog Allergy 1980; 27: 69–133
   PubMedGoogle Scholar
• Green W R, Henney C S. The mechanism of T cell-mediated cy tolysis. CRC Crit Rev Immunol 1981; 1: 259–286
   Google Scholar
• Bonavida B, Bradley T, Fan J, et al. Molecular interactions in T-cell-mediated cytotoxicity. Immunol Rev 1983; 72: 119–141
   PubMed Web of Science ®Google Scholar
• Lovchik J C, Hong R. Antibody-dependent cell-mediated cytoly-sis (ADCC): analyses and projections. Prog Allergy 1977; 22: 1–44
   PubMedGoogle Scholar
• Herberman R B, Reynolds C W, Ortaldo J R. Mechanism of cytotoxicity by natural killer (NK) cells. Ann Rev Immunol 1986; 4: 651–680
   PubMed Web of Science ®Google Scholar
• Henkart P A. Mechanism of lymphocyte-mediated cytotoxicity. Ann Rev Immunol 1985; 3: 31–58
   PubMed Web of Science ®Google Scholar
• Karpovsky B, Thus J A, Stephany D A, et al. Production of target-specific effector cells using hetero-cross-linked aggregates containing anti-target cell and anti-Fcγ receptor antibodies. J Exp Med 1984; 160: 1686–1701
   PubMed Web of Science ®Google Scholar
• Perez P, Hoffman R W, Shaw S, et al. Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody. Nature 1985; 316: 354–356
   PubMed Web of Science ®Google Scholar
• Staerz U D, Kanagawa O, Bevan M J. Hybrid antibodies can target sites for attack by T cells. Nature 1985; 314: 628–631
   PubMed Web of Science ®Google Scholar
• Zuckerman S H, Douglas S D. The characterization and functional significance of plasma membrane Fc receptors. CRC Crit Rev Microbiol 1978; 7: 1–26
   PubMedGoogle Scholar
• Unkeless J C, Fleit H, Mellman I S. Structural aspects and heterogeneity of immunoglobulin Fc receptors. Adv Immunol 1981; 31: 247–268
   PubMed Web of Science ®Google Scholar
• Unkeless J C. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med 1979; 150: 580–596
   PubMed Web of Science ®Google Scholar
• Holmes K L, Palfree R GE, Hammerling U, et al. Alleles of the Ly-17 alloantigen define polymorphisms of the murine lg Fc receptor. Proc Natl Acad Sci (USA) 1985; 82: 7706–7710
   PubMed Web of Science ®Google Scholar
• Segal D M, Dower S K, Titus J A. The role of non-immune IgG in controlling IgG-mediated effector functions. Mol Immunol 1983; 20: 1177–1189
   PubMed Web of Science ®Google Scholar
• Fleit H B, Wright S D, Unkeless J C. Human neutrophil Fc gamma receptor distribution and structure. Proc Natl Acad Sci (USA) 1982; 79: 3275–3279
   PubMed Web of Science ®Google Scholar
• Perussia B, Starr S, Abraham S, et al. Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1. J Immunol 1983; 130: 2133–2141
   PubMed Web of Science ®Google Scholar
• Lanier L L, Le A M, Phillips J H, et al. Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-U (NK-15) antigens. J Immunol 1983; 131: 1789–1796
   PubMed Web of Science ®Google Scholar
• Phillips J H, Babcock G F. NKP-15: a monoclonal antibody reactive against purified human natural killer cells and granulocytes. Immunol Lett 1983; 6: 143–149
   PubMed Web of Science ®Google Scholar
• Rumpold H, Kraft D, Obexer G, et al. A monoclonal antibody against a surface antigen shared by human large granular lymphocytes and granulocytes. J Immunol 1982; 129: 1458–1464
   PubMed Web of Science ®Google Scholar
• Titus J A, Perez P, Kaubisch A, et al. Human K/natural killer cells targeted with heterocrosslinked antibodies specifically lyse tumor cells in vitro and prevent tumor growth in vivo. J Immunol 1987; 139: 3153–3158
   PubMed Web of Science ®Google Scholar
• Ojo E, Wigzell H. Natural killer cells may be the only cells in normal mouse lymphoid cell populations endowed with cytolytic ability for antibody-coated tumour target cells. Scand J Immunol 1978; 7: 297–306
   PubMed Web of Science ®Google Scholar
• Ortaldo J R, Sharrow S O, Timonen T, et al. Determination of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. J Immunol 1981; 127: 2401–2409
   PubMed Web of Science ®Google Scholar
• Lanier L L, Le A M, Civin C I, et al. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 1986; 136: 4480–4486
   PubMed Web of Science ®Google Scholar
• Perussia B, Trinchieri G, Jackson A, et al. The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. J Immunol 1984; 133: 180–189
   PubMed Web of Science ®Google Scholar
• Looney R J, Abraham G N, Anderson C L. Human monocytes and U937 cells bear two distinct Fc receptors for IgG. J Immunol 1986; 136: 1641–1647
   PubMed Web of Science ®Google Scholar
• Anderson C L, Guyre P M, Whitin J C, et al. Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem 1986; 261: 12856–12864
   Google Scholar
• Shen L, Guyre P M, Anderson C L, et al. Heteroantibody-mediated cytotoxicity: antibody to the high affinity Fc receptor for IgG mediates cytotoxicity by human monocytes that is enhanced by interferon-γ and is not blocked by human IgG. J Immunol 1986; 137: 3378–3382
   PubMed Web of Science ®Google Scholar
• Meuer S C, Acuto O, Hercend T, et al. The human T-cell receptor. Ann Rev Immunol 1984; 2: 23–50
   PubMed Web of Science ®Google Scholar
• Reinherz E L, Meuer S C, Schlossman S F. The human T cell receptor: analysis with cytotoxic T cell clones. Immunol Rev 1983; 74: 83–112
   PubMed Web of Science ®Google Scholar
• Haskins K, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells. Ann Rev Immunol 1984; 2: 51–66
   PubMed Web of Science ®Google Scholar
• Marrack P, Hannum C, Harris M, et al. Antigen-specific, major histocompatibility complex-restricted T cell receptors. Immunol Rev 1983; 76: 131–145
   PubMed Web of Science ®Google Scholar
• Brenner M B, Trowbridge I S, Strominger J L. Cross-linking of human T cell receptor proteins: association between the T cell idio-type beta subunit and the T3 glycoprotein heavy subunit. Cell 1985; 40: 183–190
   PubMed Web of Science ®Google Scholar
• Allison J P, Lanier L L. Identification of antigen receptor-associated structures on murine T cells. Nature 1985; 314: 107–109
   PubMed Web of Science ®Google Scholar
• Dembic Z, Haas W, Weiss S, et al. Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature 1986; 320: 232–238
   PubMed Web of Science ®Google Scholar
• Saito T, Weiss A, Miller J, et al. Specific antigen-la activation of transfected human T cells expressing murine Ti αβ-human T3 receptor complexes. Nature 1987; 325: 125–130
   PubMed Web of Science ®Google Scholar
• Tsoukas C D, Carson D A, Fong S, et al. Molecular interactions in human T cell-mediated cytotoxicity to EBV II Monoclonal antibody OKT3 inhibits a post-killer-target recognition/adhesion step. J Immunol 1982; 129: 1421–1425
   PubMed Web of Science ®Google Scholar
• Landegren U, Ramstedt U, Axberg I, et al. Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies. J Exp Med 1982; 155: 1579–1584
   PubMed Web of Science ®Google Scholar
• Imboden J B, Weiss A, Stobo J D. The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. J Immunol 1985; 134: 663–665
   PubMed Web of Science ®Google Scholar
• Lancki D W, Ma D I, Havran W L, et al. Cell surface structures involved in T cell activation. Immunol Rev 1984; 81: 65–94
   PubMed Web of Science ®Google Scholar
• Hoffman R W, Bluestone J A, Leo O, et al. Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies. J Immunol 1985; 135: 5–8
   PubMed Web of Science ®Google Scholar
• Kranz D M, Tonegawa S, Eisen H N. Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes. Proc Natl Acad Sci (USA) 1984; 81: 7922–7926
   PubMed Web of Science ®Google Scholar
• Spits H, Yssl H, Leeuwenberg J TM, et al. Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3. Eur J Immunol 1985; 15: 88–91
   PubMed Web of Science ®Google Scholar
• Leeuwenberg J TM, Spits H, Tax W JM, et al. Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies. J Immunol 1985; 134: 3770–3775
   PubMed Web of Science ®Google Scholar
• Leo O, Foo M, Sachs D H, et al. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci (USA) 1987; 84: 1374–1378
   PubMed Web of Science ®Google Scholar
• Leo O, Foo M, Henkart P A, et al. Role of accessory molecules in signal transduction of CTL by anti-T cell receptor and anti-Ly-6.2C monoclonal antibodies. J Immunol 1987; 139: 3556–3563
   PubMed Web of Science ®Google Scholar
• Leo O, Foo M, Segal D M, et al. Activation of murine T lymphocytes with monoclonal antibodies: Detection on Lyt2+ cells of an antigen not associated with the T cell receptor complex but involved in T cell activation. J Immunol 1987; 139: 1214–1222
   PubMed Web of Science ®Google Scholar
• Liu M A, Kranz D M, Kurnick J T, et al. Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes. Proc Natl Acad Sci (USA) 1985; 82: 8648–8652
   PubMed Web of Science ®Google Scholar
• Lanzavecchia A, Scheidegger D. The use of hybrid hybridomas to target human cytotoxic T lymphocytes. Eur J Immunol 1987; 17: 105–111
   PubMed Web of Science ®Google Scholar
• Perez P, Hoffman R W, Titus J A, et al. Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies. J Exp Med 1986; 163: 166–178
   PubMed Web of Science ®Google Scholar
• Jung G, Honsik C J, Reisfeld R A, et al. Activation of human peripheral blood mononuclear cells by anti-T3: killing of tumor target cells coated with antitarget-anti-T3 conjugates. Proc Natl Acad Sci (USA) 1986; 83: 4479–4483
   PubMed Web of Science ®Google Scholar
• Segal D M, Perez P, Karpovsky B, et al. Targeting of cytotoxic cells with cross-linked antibody heteroaggregates. Mol Immunol 1986; 23: 1211–1214
   PubMed Web of Science ®Google Scholar
• Frankel A E, Houston L L, Issell B F, et al. Prospects for immunotoxin therapy in cancer. Ann Rev Med 1986; 37: 125–142
   PubMed Web of Science ®Google Scholar
• Schlom J, Colcher D, Hand P H, et al. Monoclonal antibodies reactive with breast tumor-associated antigens. Adv Cancer Res 1985; 43: 143–173
   PubMed Web of Science ®Google Scholar
• Monoclonal Antibodies for Tumour Detection and Drug Targeting, R W Baldwin, V S Byers. Academic Press, London 1985
   Google Scholar
• Perez P, Titus J A, Lotze M T, et al. Specific lysis of human tumor cells by T cells coated with anti-T3 cross-linked to anti-tumor antibody. J Immunol 1986; 137: 2069–2072
   PubMed Web of Science ®Google Scholar
• Carlson J, Drevin H, Aven R. Protein thiolation and reversible protein-protein conjugationN-succinimidyl 3-(2-pyridyldithiol) propionate, a new heterobifunctional reagent. Biochem J 1978; 173: 723–737
   PubMedGoogle Scholar
• Staerz U D, Bevan M J. Use of anti-receptor antibodies to focus T cell activity. Immunol Today 1986; 7: 241–245
   PubMedGoogle Scholar
• Staerz U D, Bevan M J. Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc Natl Acad Sci (USA) 1986; 83: 1453–1457
   PubMed Web of Science ®Google Scholar
• Winn H J. Immune mechanisms in homotransplantation II Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts. J Immunol 1961; 86: 228–237
   PubMed Web of Science ®Google Scholar
• Shin H S, Kaliss N, Borenstein D, et al. Antibody-mediated suppression of grafted lymphoma cells II. Participation of macrophages. J Exp Med 1972; 136: 375–380
   PubMed Web of Science ®Google Scholar
• Schulz G, Staffileno L K, Reisfeld R A, et al. Eradication of established human melanoma tumors in nude mice by antibody-directed effector cells. J Exp Med 1985; 161: 1315–1325
   PubMed Web of Science ®Google Scholar
• Titus J A, Garrido M A, Hecht T T, et al. Human T cells targeted with anti-T3 crosslinked to anti-tumor antibody prevent tumor growth in nude mice. J Immunol 1987; 138: 4018–4022
   PubMed Web of Science ®Google Scholar
• Teh J G, Stacker S A, Thompson C H, et al. The diagnosis of human tumours with monoclonal antibodies. Cancer Surv 1985; 4: 149–184
   PubMedGoogle Scholar
• Greiner J W, Guadagni F, Noguchi P, et al. Use of recombinant interferon to enhance monoclonal antibody-targeting of carcinoma lesions in vivo. Science 1987; 149–184
   Google Scholar