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Cancer Investigation Volume 6, 1988 - Issue 2
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Original Article

Continuous Infusion 5-Fluorouracil and Folinic Acid in Disseminated Colorectal Cancer

Joanne E. Mortimer University of Washington Administration Hospital, Seattle, Washington, 98195
&
Celestia Higano University of Veterans Administration Hospital, Seattle, Washington, 98195
Pages 129-132 | Published online: 11 Jun 2009

References

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  • Waxma S, Bruckner H, Wagle A, Schreiber C. Potentiation of 5 fluorouracil (5FU) antimetabolic effect by leucovorin (LV). Proc Natl Acad Sci (USA) 1978; 75: 980–983
  • Machover D, Goldschmidt E, Chollet P, et al. Treatment of advanced colorectal and gastric adenocarcinoma with 5 FU and high-dose folinic acid: a pilot study. J Clin Oncol 1986; 4: 685–696
  • Bukowski R M, Cunningham J. Efficacy of 5 fluorouracil in combination with leucovorin in patients with colorectal carcinoma: continuous infusion of low dose. Advances in Cancer Chemotherapy. The Current Status of 5 FluorouracU-Leukovorin Calcium Combination, H W Bruckner, Y M Rustum. John Wiley and Sons, New York 1984; 69–72
  • Mehta B M, Gisolfi A L, et al. Serum distribution of citrovorum factor and 5-methylenetetrahydrofolate following oral and IM administration of calcium leucovorin in normal adults. Cancer Treat Rep 1978; 62: 345–350
  • Nixon F F. Folinic acid: pharmacokinetics and pharmacodynamics. Clin Exp Pharmacol Physiol 1979; 5(suppl)35–41
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  • Byrne P J, Treat J, McFadde M. Therapeutic efficacy of the combination of 5 fluorouracil and high-dose leukovorin in patients with advanced colorectal carcinoma: single daily intravenous dose for five days. Advances in Cancer Chemotherapy. The Current Status of 5 Fluorouracil-Leukovorin Calcium Combination, H W Bruckner, Y M Rustum. John Wiley and Sons, New York 1984; 65–67
  • Zakem M, Hines J D, Adelstein D J, Rustum Y M. High-dose leukovorin and 5-fluorouracil in refractory and relapsed colorectal carcinoma. Prcc Am Soc Clin Oncol 1986; 5: 81
  • Erlichman C, Fine Wong S., Elhakim A. A comparison of 5-fluorouracil and folinic acid versus 5 FU in metastatic colorectal carcinoma. Proc Am Soc Clin Oncol 1986; 5: 82

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