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Editorial Article

Comments on the Use of Leukovorin as a Potentiator of 5-Fluorouracil

Pages 233-234 | Published online: 11 Jun 2009

References

  • Bruckner H W, Storch J A, Holland J F. Leucovorin increases the toxicity of 5-fluorouracil: Phase I clinical pharmacological trials. Proc Am Assoc Cancer Res 1981; 22: 192
  • O'Connell M J. Biochemical modulation of 5-fluorouracil by leucovorin. Clinical studies in colon cancer. Mayo Clinic, North Central Cancer Treatment Group. Development of Folates and Folic Acid Antagonists in Cancer Chemotherapy Symposium Abstracts. National Cancer Institute. 1986; 21
  • Ehrlichman C, Fine S, Wong A, et al. A comparison of 5-fluorouracil and folinic acid versus 5-FU in metastatic colorectal carcinoma. Proc Am Soc Clin Oncol 1986; 5: 82
  • Petrelli N, Herrera L, Stulc J, et al. A phase III study of 5-fluorouracil (5-FU) versus 5-FU + methotrexate versus 5-FU + high-dose leucovorin in metastatic colorectal adenocarcinoma. Proc Am Soc din Oncol 1987; 6: 74
  • Bruckner H W, Petrelli N, Stablein D, et al. Comparison of unique leucovorin and 5-fluorouracil dosages and schedules: “Escalating” and “Maximum” dosage strategies. Natl Cancer Inst Monogr 1987, in press
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  • Bruckner H W, Roboz J, Spigelman M, . An efficient leucovorin-5-fluorouracil sequence dosage escalation and pharmacologic monitoring. Advances in Cancer Chemotherapy. The Current Status of 5-Fluorouracil-Leucovorin Calcium Combination, H W Bruckner, Y M Rustum, et al. Park Row Publishers, New York 1984; 49–53
  • Santi D V, McHenry C S, Sommer H. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 1974; 13: 471–481
  • Rustum Y, Trave F, Petrelli N, et al. Modulation of reduced folates in tumor tissue of colon cancer patients. Proc Am Assoc Cancer Res 1987; 28: 229
  • Budd G J, Bukowski R, Fleming T, et al. SWOG 8305: A randomized comparison of two dose schedules of 5-fluorouracil and folinic acid for the treatment of metastatic colorectal cancer. Proc Am Soc Clin Oncol 1985; 4: 82
  • Doroshow J H, Bertrand M, Multhauf P, et al. Prospective randomized trial comparison 5-FU versus 5-FU and high-dose folinic acid for treatment of advanced colorectal cancer. Proc Am Soc Clin Oncol 1987; 6: 96

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