8
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Inhibition of Thymidylatc Synthase After Administration of Doxifluridine in a Transplantable Colon Carcinoma in the Rat

, , , &
Pages 377-383 | Published online: 11 Jun 2009

References

  • Cook A F, Holman M J, Kramer M J, et al. Fluorinated pyrimidine nucleosides. Synthesis and antitumor activity of a series of 5′-deoxy-5-fluoropyrimidine nucleosides. J Med Chem 1979; 22: 1330–1335
  • Armstrong R D, Diasio R B. Selective activation of 5′-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index. Cancer Res 1981; 41: 4891–4894
  • Ishitsuka H, Masanori M, Takemoto, et al. Probable role of uridine phosphorylase for antitumor activity of 5′-deoxy-5-fluorouridine. Gann 1980; 71: 112–123
  • Armstrong R D, Cadman E. 5′-deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. Cancer Res 1983; 43: 2525–2528
  • Alberto P, Mermillod B, Weber W, et al. A randomized comparison of doxifluridine (dFUR) and fluorouracil (FU) in advanced colorectal cancer. Proc ASCO 1986; 5, March
  • Armstrong R D, Diasio R B. Metabolism and biological activity of 5′-deoxy-5-fluorouridine, a novel fluoropyrimidine. Cancer Res 1980; 40: 3333–3338
  • Langenbach R I, Danenberg P V, Heiddberger C. Thymidylate synthetase: Mechanism of inhibition by 5-fluoro-2′-deoxyuridylate. Biochem Biophys Res Commun 1972; 48: 1565–1571
  • Skold O. Enzymes of uracil metabolism in tissues with different growth characteristics. Biochim Biophys Acta 1960; 44: 1–12
  • Moran R G, Spears C P, Heidelberger C. Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5′-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate and thymidylate synthetase. Proc Natl Acad Sci (USA) 1979; 76: 1456–1460
  • Spears C P, Shahinian A H, Moran R G, et al. In vivo kinetics of thymidylate synthetase inhibition in 5-fluorouracil-sensitive and -resistant murine adenocarcinomas. Cancer Res 1982; 42: 450–456
  • Spears C P, Gustavsson B, Spicer D, et al. Thymidylate synthetase inhibition in malignant and normal liver of patients given intravenous 5-fluorouracil. Cancer Res 1984; 44: 4144–4150
  • Beme M HO, Gustavsson B G, Almersjö O, et al. Sequential methotrexate/5-FU, FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma. Cancer Chemother Pharmacol 1986; 16: 237–242
  • Nazar R N, Lawford H G, Wong J TF. An improved procedure for extraction and analysis of cellular nucleotides. Anal Biochem 1970; 35: 305–313
  • Rustum Y, Schwartz H. Methods for the separation and identification of ribonucleotides on DEAE-cellulose. Anal Biochem 1973; 53: 411–419
  • Bollag W, Hartmann H R. Tumor inhibitory effects of a new fluorouracil derivate: 5′-deoxy-5-fluorouridine. Eur J Cancer 1978; 16: 427–432
  • Sommadossi J P, Aubert C, Cano J P, et al. Kinetics and metabolism of a new fluoropyrimidine, 5′-deoxy-5-fluorouridine, in humans. Cancer Res 1983; 43: 930–933
  • de Brujin E A, van Oosterom A T, Tjaden U R, et al. Pharmacology of 5′-deoxy-5-fluorouridine in patients with resistant ovarian cancer. Cancer Res 1985; 45: 5931–5935
  • Suzuki S, Hngu I, Fukazawa H, et al. A new anticancer agent activated selectively in tumor cells Tissue distribution of 5′-dFUR and derived 5-FU in tumor bearing mice and rats. Gann 1980; 71: 238–245
  • Houghton J A, Houghton P J, Wooten R S. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2′-deoxyuridine. Cancer Res 1979; 39: 2406–2413
  • Jenh C-H, Geyer P K, Baskin F, Johnson L F. Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines. Mol Pharmacol 1985; 28: 80–85
  • Washtien W L. Thymidylate synthase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells. Mol Pharmacol 1982; 21: 723–728
  • Houghton J A, Maroda S J, Phillips J O, Houghton P J. Biochemical determinants and responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice. Cancer Res 1981; 41: 144–149
  • Bapat A R, Jarow C, Danenberg P V. Human leucemic cells resistant to 5-fluoro-2′-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J Biol Chem 1983; 258: 4130–4136

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.