References
- Taylor W F, Ivins J C, Dahlin D C, et al. Trends and variability in survival from osteosarcoma. Mayo Clin Proc 1978; 53: 695–700
- Taylor W T, Ivins J C, Pritchard D J, et al. Trends and variability in survival among patients with osteo-sarcoma: A seven year study. Mayo Clin Proc 1985; 60: 91–104
- Edmonson J H, Green S J, Ivins J C, et al. A controlled study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 1984; 2: 152–156
- Kolata G B. Dilemma in cancer treatment. Science 1980; 209: 792–794
- Lange B, Levine A S. Is it ethical to conduct a prospectively controlled trial of adjuvant chemotherapy in osteosarcoma. Cancer Treat Rep 1982; 66: 1699–1704
- Carter S K. Adjuvant chemotherapy in osteogenic sarcoma: The triumph that isn't?. J Clin Oncol 1984; 2: 147–148
- Link M P, Goorin A M, Miser A W, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 1986; 314: 1600–1606
- Eilber F R, Guiliano A, Eckardt J, et al. Adjuvant chemotherapy for osteosarcoma: A randomized prospective trial. J Clin Oncol 1987; 5: 21–26
- Jaffe N, Frei E, III. Osteogenic sarcoma: Advances in treatment. CA 1976; 26: 351–359
- Jaffe N, Goorin A, Link M, et al. High-dose methotrexate in osteogenic sarcoma adjuvant chemotherapy and limb salvage results. Cancer Treat Rep 1981; 65(suppl 1)99–106
- Rosen G, Caparros B, Huvos A G, et al. Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoper-tive chemotherapy. Cancer 1982; 49: 1221–1230
- Winkler K, Beron G, Katz R, et al. Neoadjuvant chemotherapy for osteogenic sarcoma: Results of a cooperative German/Austrian study. J Clin Oncol 1984; 2: 617–624
- Weiner M A, Harris M B, Lewis M M, et al. Neoadjuvant high dose methotrexate, cisplatin, and doxorubicin for the management of patients with non-metastatic osteosarcoma. Cancer Treat Rep 1986; 70: 1431–1432
- Jaffe N, Paed D. Recent advances in the chemotherapy of metastatic osteogenic sarcoma. Cancer 1972; 30: 1627–1631
- Jaffe N, Frei E, III, Traggis D, et al. Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N Engl J Med 1974; 291: 994–997
- Waegner D JT, Van Oosterom A T, Mulder J H, et al. Phase II study of low-dose methotrexate in advanced osteosarcoma followed by escalation after disease progression: A study of the Soft Tissue Sarcoma Group of the European Organization for Research of Cancer. Cancer Treat Rep 1986; 70: 615–618
- Krailo M, Ertel I, Makley J, et al. A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvanta chemotherapy in childhood nonmetastatic osteosarcoma: A report from the Children's Cancer Study Group. Med Pediatr Oncol 1987; 15: 69–77
- Picci P, Bacci G, Capanna R, et al. Neoadjuvant chemotherapy for localized osteosarcoma of the extremities. Experience related to 103 cases treated between March 83-March 86. Fifth International Conference on the Adjuvant Therapy of Cancer, Tuscan, Arizona, 1987; 35
- Jaffe N, Fei E, III, Traggis D. Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma: Presurgical treatment of primary tumor and of overt metastases. Cancer 1977; 39: 45–50
- Chabner B A. Methotrexate. Pharmacologic Principles of Cancer Treatment, B A Chabner. WB Saunders, Philadelphia 1982; 229–255
- Kamen B A, Capdevilla A. Receptor mediated folate and methotrexate transport is regulated by the intracellular folate pool. Proc Natl Acad Sci (USA) 1986; 83: 5983–5987
- Winick N J, Kamen B A, Steckfuss A, et al. Methotrexate (MTx) concentration in tumors following low-dose MTx. Cancer Chemother Pharmacol 1987; 20: 78–80
- Samuels L L, Feinberg A, Moccio D M, et al. Detection by high performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue. Biochem Pharmacol 1984; 17: 2711–2714
- Bode U. Methotrexate as relapse therapy rhabdomyosarcoma. Am J Pediatr Hematol Oncol 1986; 8: 70–72
- Grem J L, King S A, Wittes R E, et al. The role of methotrexate in osteosarcoma. J Natl Cancer Inst 1988; 80: 626–656