7
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Dose-Dependent Leucovorin Efficacy with an Intermittent High-Dose 5-Fluorouracil Schedule

, &
Pages 321-326 | Published online: 11 Jun 2009

References

  • Ullman B, Lee M, Martin D W, Jr, et al. Cytotoxicity of 5-fluoro-2′-deoxyuridine: Requirement for reduced folate cofactors and antagonism by methotrexate. Proc Natl Acad Sci (USA) 1978; 75: 980–983
  • Waxman S, Bruckner H W, Wagle A, et al. Potentiation of 5-fluorouracil antimetabolic effect by leucovorin. Proc Am Assoc Cancer Res 1978; 19: 149
  • Bruckner H W, Storch J A, Holland J F. Leucovorin increases the toxicity of 5-fluorouracil. Proc Am Assoc Cancer Res 1981; 22: 192
  • Bruckner H W, Roboz J, Spigelman M, . An efficient leucovorin-5-fluorouracil sequence: Dosage escalation and pharmacologic monitoring. Advances in Cancer Chemotherapy. The Current Status of 5-Fluorouracil-Leucovorin Calcium Combination, H W Bruckner, Y M Rustum, et al. Park Row Publishers, New York 1984; 49–54
  • Bruckner H W, Hart R, Spigelman M, et al. An intermittent leucovorin calcium 5-fluorouracil regimen for advanced adenocarcinoma of the colon. Proc Am Assoc Cancer Res 1987; 28: 202
  • Woolley P V, Ayoob M J, Smith F P, et al. A controlled trial of the effect of 4-hydroxypyrazolopyrimidine (allopurinol) on the toxicity of a single bolus dose of 5-fluorouracil. J Clin Oncol 1985; 1: 103–109
  • Machover D, Timus M, Schwarzenberg L, . Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil combined with high-dose leucovorin: An update. Advances in Cancer Chemotherapy. The Current Status of 5-Fluorouracil-Leucovorin Calcium Combination, H W Bruckner, Y M Rustum, et al. Park Row Publisher, New York 1984; 55–64
  • Bruckner H W, Spigelman M K. Leucovorin as a clinical potentiator of 5-fluorouracil. Toxicity and anti-cancer efficacy. Mt Sinai J Med 1988; 55: 390–394
  • Madajewicz S, Petrelli N, Rustum Y M, et al. Phase I-II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Cancer Res 1984; 44: 4667–4669
  • Rustum Y M, Trave F, Zakrzewski S F, et al. Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin. Natl Cancer Inst Monogr 1987; 5: 165–170
  • Wieand H S, Poon M A, O'Connell M J, Moertel C G. An application of an efficient screening design in an advanced colorectal cancer trial. A North Central Cancer Treatment Group and Mayo Clinic Study. Proc Am Soc Clin Oncol 1988; 7: 96
  • Petrelli N, Stablein D, Bruckner H, et al. A prospective randomized phase III trial of 5-fluorouracil (5FU) versus 5FU + high dose leucovorin versus 5FU + low dose leucovorin in patients with metastatic colorectal adenocarcinoma. A report of a Gastrointestinal Tumor Study Group. Proc Am Soc Clin Oncol 1988; 7: 94
  • Niederhuber J E, Ensminger W, Gyves J, et al. Regional chemotherapy of colorectal cancer metastatic to the liver. Cancer 1984; 53: 1336–1343
  • Kemeny N, Daly J, Reichman B, et al. Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases for colorectal carcinoma. Ann Intern Med 1987; 107: 459–465
  • Schmoll H J, LeBlanc S. Sequential high dose folinic acid and 5-fluorouracil in advanced colorectal cancer with measurable, progressive disease. Proc Am Soc Clin Oncol 1985; 4: 94

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.