4
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Radioantibodies for the Diagnosis and Treatment of Cancer; Radioimmunoimaging (RAI) and Radioimmunotherapy (RAT)

, &
Pages 381-405 | Published online: 11 Jun 2009

References

  • Rubin P X. Statement of the Clinical Oncologic Problem. Clinical Oncology, a Multidisciplinary Approach, P Rubin. American Cancer Society, New York 1983
  • DeLand F H, Goldenberg D M. Radiolabeled antibodies: Radiochemistry and clinical applications. Clinical Radionuclide Imaging, L M Freeman. Grune and Stratton, Inc., New York 1986; Vol. 3: 1915–1992
  • Barnier G M. Antibody and immunoglobulins: structure and function. Immunology III, J A Bellant. W.B. Saunders, Philadelphia 1985; 89–105
  • Keenan A M. Radiolabeled monoclonal antibodies: Current status and future outlook. Nuclear Medicine Annual 1988, L M Freeman, H S Weissman. Raven Press, New York 1988; 171–207
  • Zalutsky M R. Antibody-mediated radiotherapy: Future prospects. Antibodies in Radiodiagnosis and Therapy, M R Zalutky. CRC Press, Inc., Boca Raton, FL 1989; 213–235
  • Haber E, Katus H A, Hunell J G, et al. Detection and quantification of myocardial cell death: Applications of monoclonal antibodies specific for cardiac myosin. J Mol Cell Cardiol 1982; 14(Suppl. 3)139–146
  • Sfakianakis G, Scoles P. Type specific radioimmunoimaging of experimental type-B influenza osteomyelitis abstract. J Nucl Med 1985; 24: 64
  • Fischman A J, Wilkinson R, Khaw B A, et al. Imaging of localized bacterial infections with radiolabeled nonspecific antibody fragments. J Nucl Med 1988; 29: 887
  • Oster Z H, Som P, Zamora P O, et al. The diagnosis of mesenteric thrombosis with Tc-99m 50H. 19: A monoclonal antiplatelet antibody (abstr). J Nucl Med 1988; 29: 886
  • Alavi A., Gupta N, Berger H, et al. Indium-111 antifibrin antibody imaging in the detection of venous thrombosis. Proceedings of the Second Conference on Radioimmunodetection and Radioimmunotherapy of Cancer, , New Jersey, 1988, 65
  • Von Behring E. Untersuchungen uber das Zustande-kommen der Diphtherie-Immunitat bei Theiren. Dtsh Med Wochenschr 1890; 16: 1145
  • Wainwright J M. Tetanus: its incidence and treatment. Arch Surg 1926; 12: 1062
  • Hericourt J, Richet C. De la serotherapie dans la traitement du cancer. Cr Hebd Seances Head Sci 1985; 121: 567
  • Witebsky E. Disponibilitat, und Spezifitat alkohollslicher Strukturen von Organen un Bosartigen geschwulstn. Z Immunitaetsforsch 1929; 62: 35
  • Hirzfeld L, Halber W, Laskowski J. Untersuchungen uber die serologischen Eigenschaften der Gewebe; uber serologische Eigenschaften der Neubildungen. Z Immunotaetsforsch 1929; 64: 81
  • Pressman D, Korngold L. The in vivo localization of anti-Wagnerosteogenic sarcoma antibodies. Cancer 1953; 6: 619
  • Bale W, Spar I. Studies directed toward the use of antibodies as carriers of radioactivity for therapy. Adv Biol Med Phys 1957; 5: 825
  • Izzo M, Bale W. Preferential localization and rate of loss of labeled alloantibody from rat tumors and skin transplants carrying the corresponding alloantigen. Cancer Res 1976; 36: 2868
  • Pressman D. The development and use of radiolabeled antitumor antibodies. Cancer Res 1980; 40: 2960
  • Sfakianakis G, DeLand F. Radioimmunodiagnosis and radioimmunotherapy. J Nucl Med 1982; 23: 840
  • Larson S, Carasquillo J, Krohn K, et al. Imaging of melanoma with 131I-labeled antibody. J Clin Invest 1983; 24: 123
  • Wahl R, Parker C, Philpott G. Improved radioimmunoimaging and tumor localization with monoclonal F(ab')2. J Nucl Med 1983; 24: 316
  • Wright T, Sinanan M, Harrington D, et al. Immunoglobulins: applications to scanning and treatment. Appl Radiol/NM 1979; 120
  • Ballou B, Levine G, Hakala T, et al. Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy. Science 1979; 206: 844
  • Keenan A, Harber J, Larson S. Monoclonal antibodies in nuclear medicine. J Nucl Med 1985; 26: 531
  • Larson S, Carasquillo J, Reynolds J C. Radioimmunodetection and radioimmunotherapy. Cancer Invest 1984; 2: 363
  • Milstein C. Monoclonal antibodies. Sci Am 1980; 243: 66
  • Bartal A H, Hirshaut Y. Current methodologies in hybridoma formation. Methods of Hybridoma Formation, A H Bartal, Y Hirshaut. Humana Press, Clifton, NJ 1987; 1–70
  • Gold P, Freedman S. Demonstration of tumor specific antigen in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965; 121: 439
  • Abelev G. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv Cancer Res 1971; 14: 295
  • Goldenberg D, Sharkey R, Primus E. Carcinoembryonic antigen in histopathology. Immunoperoxidase staining of conventional tissue sections. J Natl Cancer Inst 1976; 57: 11
  • Khoo S, Warner N, Lie J, et al. Carcinoembryonic antigenic activity of tissue extracts: A quantitative study of malignant and benign neoplasms, cirrhotic liver, normal adult and fetal organs. Int J Cancer 1973; 11: 681
  • Martin E, Kibbey E, DiVecchia L, et al. Carcinoembryonic antigen. Clinical and historical aspects. Cancer 1976; 37: 62
  • Goldenberg D. Oncofetal and other tumor associated antigens of the human digestive system. Curr Top Pathol 1976; 63: 289
  • Hansen H, Snyder J, Miller E, et al. Carcinoembryonic antigen (CEA) assay. A laboratory adjunct in the diagnosis and management of cancer. Hum Pathol 1974; 5: 139–147
  • Aburano T, Tonami N, Nisada K. Radioimmunoassay for Carcinoembryonic antigen as and adjunct to liver scan in the detection of liver metastases from digestive-tract cancer. J Nucl Med 1979; 20: 232
  • Martin E J, James K, Hurtwbise P, et al. The of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures. Cancer 1977; 39: 440
  • Martin E, Cooperman M, King G, et al. A retrospective and prospective study of serial CEA determinations in the early detection of recurrent colon cancer. Am J Surg 1979; 137: 167
  • Zamcheck N. The present status of CEA in diagnosis, prognosis, and evaluation of therapy. Cancer 1975; 36: 2460
  • Bashawe K, Searle F, Lewis J, et al. Preliminary therapeutic and localization studies with human chorionic gonatropin. Cancer Res 1980; 40: 3016
  • Larson S. Radiolabeled monoclonal and anti-tumor antibodies in diagnosis and therapy. J Nucl Med 1985; 26–538
  • Hayes D F, Friedman E L, Kufe D W, . Radioimmunoscintigraphy of human carcinoma: Characterization of monoclonal antibodies. Antibodies in Radiodiagnosis and Therapy, M R Zalutsky, et al. CRC Press, Inc., Boca Raton, FL 1989; 57–82
  • Garty I, Serafini A N, Ardalan B, et al. Scintigraphic detection of colorectal carcinoma with 1–123 labeled Fab and F(ab)2 fragments of anti-carcinoembryonic antigen antibodies NP-4. Radiology 1988; 169: 391
  • Delaloye B, Bischof-Delaloye A, Buchegger F, et al. Detection of colorectal carcinoma by emission computed tomography after injection of 123I-labeled Fab or F(ab')2 fragments from monoclonal anti-carcinoembryonic antibodies. J Clin Invest 1986; 77: 301–311
  • Garty I, Serafini A N, Fayad F, et al. Radioimmunodetection of colorectal carcinoma with 1–123 labeled anti-CEA monoclonal antibody fragments. Cancer Res 1989, (in press)
  • Serafini A N, Friden A. Monoclonal antibody imaging, clinical and technical perspectives. Current Clinical Role of Nuclear Medicine: Comparison with Other Modalities, W H McCartney. Southeastern Chapter of the Society of Nuclear Medicine, Charleston, SC 1988; XXII, (1–2)
  • Garty I, Serafini A N, Sfakianakis G N. Radioimmunoscintigraphy (RIS) and radioimmunotherapy (RIT): General principles, current status and future perspectives. Diagnos Imag 1989; 11: 84–93
  • Primus F, Bennett S, Kim E, et al. Circulating immune complexes in cancer patients receiving goat radiolocalizing antibodies to Carcinoembryonic antigen. Cancer Res 1980; 40: 447
  • Larson S, Carasguillo J, Krohn K, et al. Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy. J Clin Invest 1983; 72: 2101
  • Goldenberg D, Primus F, DeLand F. Tumor detection and localization with purified antibodies to Carcinoembryonic antigen. Immunodiagnosis of Cancer, R B Herberman, K R McIntyre. Marcel Dekker, New York 1979; 303
  • Schlom J, Weeks M. Potential clinical utility of monoclonal antibodies in the management of human carcinomas. Important Advances in Oncology, V T DeVita, S Hellman, S A Rosenberg. J.B. Lippincott Co., Philadelphia 1985
  • DeNardo G, Raventos A, Hine H, et al. Requirements for a treatment planning system for radioimmunotherapy. Int J Radial Oncol Biol Phys 1985; 11: 335
  • O'Brien H A, Jr. Overview of radionuclides useful for radioimmunoimaging/radioimmunotherapy and current status of preparing radiolabeled antibodies. Radioimmunoimaging and Radioimmunotherapy, S W Bruchiel, B A Rhodes. Elsevier, New York 1983; 161–169
  • Kalnickis Bloomer W D. Antibody Radiodiagnosis and Therapy, M R Zalutsky. CRC Press, Inc., Boca Raton, FL 1989; 199–212
  • Ghose T, Tai J, Guclu A, et al. Antibodies as carriers of radionuclides and cytotoxic drugs in the treatment and diagnosis of cancer. Ann NY Acad Sci 1976; 277: 671
  • Day E, Planinsed J, Pressman D. Localization of radioiodinated rat fibrinogen in transplanted rat tumors. J Natl Cancer Inst 1959; 23: 799
  • Mahaley M, Mahaley J, Day E. The localization of radioantibodies in human brain tumors II. Radioautography. Cancer Res 1965; 25: 779
  • Spar I, Bale W, Marrrack D, et al. I-131 labeled antibodies to human fibrinogen. Diagnostic studies and therapeutic trials. Cancer 1967; 20: 865
  • Order S, Colgan J, Hellamn S. Distribution of fast and slow migrating Hodgkin's tumor associated antigens. Cancer Res 1974; 34: 1182
  • Order S, Bloomer W, Jones A, et al. Radionuclide immunoglobulin lymphangiography. A case report. Cancer 1975; 35: 1487
  • Goldenberg D, DeLand F, Kim E, et al. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med 1978; 298: 1384
  • DeLand F, Kim E, Goldenberg D. Lymphoscintigraphy with radionuclide-labeled antibodies to carcinoembryonic antigen. Cancer Res 1980; 40: 299
  • DeLand F, Kim E, Corgan R, et al. Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer. J Nucl Med 1979; 20: 1243
  • Goldenberg D, Kim E, DeLand F, et al. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res 1980; 40: 2984
  • Hine K, Bradwell A, Reeder T, et al. Radioimmunodetection of gastrointestinal neoplasms with antibodies to carcinoembryonic antigen. Cancer Res 1980; 40: 2993
  • Mach J, Carrel S, Forni M, et al. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma. N Engl J Med 1980; 303: 5
  • Reif A, Curtis L, Duffiels R, et al. Trial of radiolabeled antibody localization in metastases of a patient with a tumor containing carcinoembryonic antigen (CEA). J Surg Oncol 1974; 6: 133
  • Deland F, Kim E, Simmons G, et al. Imaging approach in radioimmunodetection. Cancer Res 1980; 40: 3046
  • Kim E, Deland F, Nelson M, et al. Radioimmunodetection of cancer with radiolabeled antibodies to alphafetoprotein. Cancer Res 1980; 40: 3008
  • Koji T, Ishii H, Munehisa T, et al. Localization of radioiodinated antibody to alphafetoprotein in hepatoma transplanted in rats and a case report of alpha-fetoprotein antibody treatment of a hepatoma patient. Cancer Res 1980; 40: 3013
  • Ghose T, Norvell S T, Aquino J, et al. Localization of I-131-labeled antibodies in human renal cell carcinomas and in a mouse hepatoma and correlation with tumor detection by photoscanning. Cancer Res. 1980; 40: 3018
  • Order S, Kein J, Ettinger D, et al. Phase I-II study of radiolabeled antibody integrated in the treatment of primary hepatic malignancies. Int J Radial Oncol Biol Phys 1980; 6: 703
  • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495
  • Serafini A N, Kotler L, Feun L, et al. Technetium-99m labeled monoclonal antibodies in the detection of metastatic melanoma. Clin Nucl Med 1989; 14: 580–587
  • Salk D. A multicenter clinical study using technetium-labeled monoclonal antibodies for imaging metastatic melanoma. Sem Oncol 1988; 15: 608–618
  • Mach J, Buchegger F, Forni M, et al. Use of radio-labeled monoclonal anticarcinoembryonic antigen antibodies for the detection of human carcinomas by external photoscaning and tomoscintigraphy. Immunol Today 1981; 2: 239
  • Moldofsky P, Power J, Mulhern C, Jr, et al. Metastatic colon carcinoma detected with radiolabeled F[ab]2 monoclonal antibody fragments. Radiology 1983; 149: 549
  • Serafini A N, Garry I, Dewanjee M, et al. Colorectal carcinoma detected by 123I labeled anti-CEA monoclonal antibody fragments: correlation of planar and SPECT scintigraphy. Proceeding of the Fourth International Conference in Monoclonal Antibody Immunoconjugates for Cancer, San Diego, 1989
  • Berche C, Mach J, Lumbroso J, et al. Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers. First clinical results using radiolabeled monoclonal antibodies against carcinoembryonic antigen. Br Med J 1982; 285: 1447
  • Farrands O, Perkins A, Pimm M, et al. Radioimmunodetection of human colorectal cancers by an antitumor monoclonal antibody. Lancet 1982; 11: 397
  • Mach J, Chatal J, Lumbroso J, et al. Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma. Cancer Res 1983; 43: 5593
  • Chatal J, Saccavini J, Douillard J, et al. Comparison of SPECT imaging using monoclonal antibodies with computed tomography (CT) and ultrasonography (US) for detection of recurrences of colorectal carcinoma. A prospective clinical study. J Nucl Med 1985; 10: 15, (abstract)
  • Epenetos A, Britton K, Mather S, et al. Targeting of iodine-123-labeled tumor associated monoclonal antibodies to tumor patients with ovarian breast and gastrointestinal tumors. Lancet 1982; II: 999
  • Rainsbury R, Ott R, Westwood J. Localization of metastatic breast carcinoma by a monoclonal antibody chelate labeled with Indium-Ill. Lancet 1984; 2: 934
  • Thompson C, Lichenstein M, Stacker S, et al. Immunoscintigraphy for detection of lymph node metastases from breast cancer. Lancet 1984; 2: 1245
  • Epenetos A, Sheperd J, Britton K, et al. 123I radioiodinated antibody imaging of occult ovarian cancer. Cancer 1985; 55: 984
  • Farrands P, Perkins A, Sully L, et al. Localization of human osteosarcoma by antitumour monoclonal antibody. J Bone-Joint-Surg 1983; 65: 638
  • Goldman A, Vivian G, Gordon I, et al. Immunolocalization of neuroblastoma using radiolabeled monoclonal antibody UJ13A. J Pediatr 1984; 105: 252
  • Rosenblum M, Murray J, Haynie T, et al. Pharmacokinetics of 111-In-labeled Anti-P97 monoclonal antibody in patients with metastatic malignant melanoma. Cancer Res 1985; 45: 2382
  • Smedley H, Finan P, Lenox E, et al. Localization of metastatic carcinoma by a radiolabeled monoclonal antibody. Br J Cancer 1983; 478: 253
  • Moldofsky P, Sears H, Mulhearn C J, et al. Detection of metastatic tumor in normal sized retroperitoneal lymph nodes by monoclonal antibody imaging. N Engl J Med 1984; 311: 106
  • Eary F J, Robert W S, Abrams P G, et al. Successful imaging of malignant melanoma with technetium-99m labeled monoclonal antibodies. J Nucl Med 1989; 30: 25–32
  • Carrasquillo J, Bunn P J, Keenan A, et al. Radioimmunodetection of cutaneous T-cell lymphoma with In-111-labeled T101 monoclonal antibody. N Engl J Med 1986; 315: 673
  • Order S. The history and progress of serologic immunotherapy of radiodiagnosis. Radiology 1976; 118: 219
  • Ettinger D, Dragon L, Kein J, et al. Isotopic immunoglobulin in an integrated multimodal treatment program for a primary liver cancer. A case report. Cancer Treat Rep 1979; 63: 131
  • Order S, Leibel S. Radiolabeled antibodies in the treatment of primary liver cancer. Appl Radiol Sept. Oct., 1984
  • Carrasquillo J, Krohn K, Beaumier P, et al. Diagnosis of and therapy for solid tumors with radiolabeled antibodies and immune fragments. Cancer Treat Rep 1984; 68: 317
  • Order S, Donahue V, Knapp R. Immunotherapy of ovarian carcinoma. Cancer 1973; 32: 573
  • Order S, Kirkman R, Knapp R. Serological immunotherapy. Results and probable mechanism of action. Cancer 1974; 34: 175
  • Order S, Thurston J, Knapp R. Ovarian tumor antigens. A new potential for therapy. Natl Cancer Inst Monogr 1975; 42: 33
  • Order S, Kein J, Ettinger D, et al. Use of isotopic immunoglobulin in therapy. Cancer Res 1980; 40: 3001
  • Bloomer W, Lipstein R, Dal ton J. Antibody mediated radiotherapy. Cancer 1985; 55(Suppl)2229
  • Kemshead J, Goldman A, Jones D, et al. Therapeutic applications of radiolabeled monoclonal antibody UJ13A in children with disseminated neuroblastoma—A Phase I study. Prog Clin Biol Res 1985; 175: 533
  • Kizumi K, DeNardo G, Denardo S, et al. Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer. J Nucl Med 1986; 27: 1243
  • Garty I, Friedman A, Kedar A, et al. Neuroblastoma: The role of 1–131 MIBG, Tc-99m MDP and Ga-67 citrate in diagnosis. Clin Nucl Med 1989, (in press)
  • Yashgh D, Coons A. Stimulation of immunoglobulin and an amnestic antibody in vitro. J Immunol 1969; 102: 306
  • Cuatrecasas P. Protein purification by affinity chromatography. J Biol Chem 1970; 245: 3059
  • Eshar Z, Order S, Katz D. Ferritin. A Hodgkin's disease associated antigen. Proc Natl Acad Sci (USA) 1974; 71: 3956
  • Nisonoff A. Resynthesis of precipitating antibody from univalent fragments. Biochem Biophys Res Comm 1960; 3: 466
  • Nisonoff A, Wissler F, Lipman L. Properties of the major component of a peptic digest of rabbit antibody. Science 1960; 132: 1770
  • Nisonoff A, Wissler F, Lipman I, et al. Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds. Arch Biochem Biophys 1960; 89: 230
  • Structure and Biosynthesis of Antibodies; Studies in Soviet Science. Consultants Bureau, New York 1977; 106
  • Weir D. Experimental Immunology. FA Davis Co., Philadelphia 1967; 258
  • Primus F, Newman E, Hansen H. Affinity in radioimmunoassay of antibody crossreactive with carcinoembryonic antigen (CEA) and colon carcinoma antigen-III (CCA-II). J Immunol 1977; 118: 55
  • Primus F, Goldenberg D. Immunological considerations in the use of goat antibodies to carcinoembryonic antigen for the radioimmunodetection of cancer. Cancer Res 1980; 40: 2979
  • McConahey P, Dixon F. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy 1966; 29: 185
  • Marchalonis J. An enzymic method for the trace iodination of immunoglobulins and other proteins. Biochem J 1969; 113: 2999
  • Eckelman W, Paik C, Reba R. Radiolabeling of antibodies. Cancer Res 1980; 40: 3036
  • Petit W, DeLand F, Bennett S, et al. Radioiabeling of affinity-purified goat anti-carcinoembryonic antigen immunoglobulin G with technetium-99m. Cancer Res 1980; 40: 3043
  • Petit W, DeLand F, Bennet S, et al. Improved protein labeling by stanous tartrate reduction of pertechnetate. J Nucl Med 1979; 21: 59
  • Hnatowich D, Virzi F, Doherty P. DTPA-coupled antibodies labeled with Yttrium-90. J Nucl Med 1985; 26: 503
  • Deshpand S V, DeNardo S J, Meares C R, et al. Copper-67 labeled monoclonal antibody Lym-1 a potential radiopharmaceutical for cancer therapy: labeling and biodistribution of RAJI rumored mice. J Nucl Med 1988; 29: 217–225
  • Pan Y Z, Lamki L M, Haymie T P, et al. Improved tumor localization with increased dose of Indium-111-labeled anticarcinoembryonic antigen, monoclonal antibody 2CE-025 in metastatic colorectal cancer. J Clin Oncol 1988; 6: 1220–1230
  • Cornelius E A, Neumann R D, Zaghbi S S, et al. Intrapatient and interpatient comparison of tumor size and monoclonal antibody uptake in melanoma. Clin Nucl Med 1988; 13: 243–249
  • Van Heertum R L, Yudd A P, Kowalsky W P, . Current status of SPECT abdominal imaging. Nuclear Medicine Annual, L M Freeman, H S Weissman, et al. Raven Press, New York 1988; 39–77
  • Pinsky C. Editorial. Monoclonal antibodies. Progress is slow but sure. N Engl J Med 1986; 315: 7704
  • Haller D G. Monoclonal antibody imaging of patients with colorectal cancer (Editorial). J Clin Oncol 1988; 6: 1213–1215

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.