8
Views
9
CrossRef citations to date
0
Altmetric
Original Article

The Retinoblastoma Gene: Its Role in Human Malignancies

, &
Pages 535-540 | Published online: 11 Jun 2009

References

  • Murphree A L, Benedict W F. Retinoblastoma: Clues for human oncogenesis. Science 1984; 223: 1028–1033
  • Knudson A G. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 1985; 45: 1437–1443
  • Knudson A G. Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci (USA) 1971; 68: 820–823
  • Sparkes R S, Murphree A L, Lingua R W, et al. Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D. Science 1983; 219: 917–979
  • Benedict W F, Banerjee A, Mark C, et al. Non-random chromosomal changes in direct preparations of primary retinoblastoma. Cancer Genet Cytogenet 1983; 10: 311–333
  • Benedict W F, Murphree A L, Banerjee A, et al. Evidence from a patient with the deletion form of retinoblastoma that the retinoblastoma gene is a recessive cancer gene. Science 1983; 219: 973–975
  • Cavenee W K, Dryja T P, Phillips R A, et al. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 1983; 305: 779–784
  • Dryja T P, Cavenee W, White R, et al. Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med 1984; 310: 550–552
  • Friend S H, Bernards R, Rogelj S, et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323: 643–646
  • Lee W-H, Bookstein R, Hong F, et al. Human retinoblastoma susceptibility gene: Cloning, identification and sequence. Science 1987; 235: 1394–1399
  • Fung Y-K T, Murphree A L, T'Ang A, et al. Structural evidence for the authenticity of the human retinoblastoma gene. Science 1984; 236: 1657–1661
  • Abramson D H, Ellsworth R M, Kitchin F D, et al. Second mononuclear tumors in retinoblastoma survivors. Ophthalmology 1984; 91: 1351–1355
  • T'Ang A, Varley J M, Chakraborty S, et al. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 1988; 242: 263–266
  • Lee E Y-H, To H, Shew J-Y, et al. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 1988; 241: 218–221
  • Harbour J W, Lai S-L, Whang-Peng J, et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 1988; 353–357
  • Yokota J, Akiyama T, Fung Y-K T, et al. Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene 1988; 3: 471–475
  • Lalande M, Dryja T P, Schreck R R, et al. Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus. Cancer Genet Cytogenet 1984; 13: 283–295
  • Dryja T, Rapaport J M, Joyce J M, et al. Molecular detection of deletions involving band 14q of chromosome 13 in retinoblastomas. Proc Natl Acad Sci (USA) 1986; 83: 7391–7394
  • Friend S H, Horowitz J M, Gerber M R, et al. Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein. Proc Natl Acad Sci (USA) 1987; 84: 9059–9063
  • Canning S, Dryja T P. Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene. Proc Natl Acad Sci (USA) 1989; 86: 5044–5048
  • Yandell D W, Dayton S H, Campbell T A, et al. Detection of point mutations in the human retinoblastoma gene by direct genomic sequencing. N Engl J Med 1989; 32: 1689–1695
  • Dunn J M, Phillips R A, Becker A J, et al. Identification of germline and somatic mutations affecting the retinoblastoma gene. Science 1988; 241: 1797–1800
  • Huang H-J, Yee S, Shew J-Y, et al. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 1988; 242: 1563–1566
  • Hansen M F, Koufos A, Gallie B L, et al. Osteosarcoma and retinoblastoma: A shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci (USA) 1985; 82: 6216–6220
  • Weichselbaum R, Beckett M, Diamond A. Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. Proc Natl Acad Sci (USA) 1988; 85: 2106–2109
  • Reissman P T, Simon M A, Lee W-H, et al. Studies of the retinoblastoma gene in human sarcomas. Oncogene 1989; 4: 839–843
  • Toguchida J, Ishizaki K, Sasaki M S, et al. Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. Cancer Res 1988; 48: 3939–3943
  • Xu H-J, Hu S-X, Hashimoto T, et al. The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells. Oncogene 1989; 4: 807–812
  • Benedict W F, Fung Y-K T. Structural and expressional changes of the retinoblastoma susceptibility gene in various human cancers. Proceedings of the Retina Research Foundation Symposium, D. M-K. Lam. Portfolio Publishing Co., The Woodlands, TX 1988; Vol I.: 108–112
  • Sanders B M, Jay M, Draper G J, et al. Non-ocular cancer in relatives of retinoblastoma patients. Br J Cancer 1989; 60: 358–365
  • Horowitz J M, Yandell D W, Park S-H, et al. Point mutational inactivation of the retinoblastoma antioncogene. Science 1989; 243: 937–940
  • Motomura K, Nishisho I, Takai S-I, et al. Loss of alleles at loci on chromosome 13 in human primary gastric cancers. Genomics 1988; 2: 180–184
  • Wang H P, Rogler C E. Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas. Cytogenetic Cell Genet 1988; 48: 72–78
  • Lee W-H, Shew J-Y, Hond F D, et al. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 1987; 329: 642–645
  • Varley J M, Armour J, Swallow J E, et al. The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumors. Oncogene 1989; 4: 725–729

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.