Special Article: Natural Killer Cells: Immunobiology and Clinical Prospects

References

• Maximow A A, Bloom W. A Textbook of Histology4th ed. Saunders, Philadelphia 1947; 43–45
   Google Scholar
• Kay H D, Sinkovics JG. Cytotoxic lymphocytes from normal donors. Lancet 1974; 2: 296–297
   PubMed Web of Science ®Google Scholar
• Kay H D, Bonnard G D, West WH, et al. A functional comparison of human Fc-receptor-bearing lymphocytes active in natural cytotoxicity and antibody dependent cellular cytotoxicity. J Immunol 1977; 118: 2058–2066
   PubMed Web of Science ®Google Scholar
• Rosenberg E B, McCoy J L, Green SS, et al. Destruction of human lymphoid tissues culture cell lines by human peripheral lymphocytes in 51Cr release culture cytotoxicity assays. J Natl Cancer Inst 1974; 52: 345–353
   PubMed Web of Science ®Google Scholar
• Lotzová E, McCredie KB. Natural killer cells in mice and man and their possible biological significance. Cancer Immunol Immunother 1978; 4: 215–221
   Web of Science ®Google Scholar
• Kiessling R, Klein E, Wigzell H. Natural killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol 1975; 5: 112–117
   PubMed Web of Science ®Google Scholar
• Lotzová E. Effector immune mechanisms in cancer. Natl Immun Cell Growth Reg 1985; 4: 293–304
   PubMedGoogle Scholar
• NK Cells and Other Natural Effector Cells, RB Herberman. Academic Press, New York 1982
   Google Scholar
• Immunobiology of Natural Killer Cells, E Lotzová, RB Herberman. CRC Press, Boca Raton, FL 1986; Vol. I and II
   Google Scholar
• Mechanisms of Cytotoxicity by NK Cells, RB Herberman, DM Callewaert. Academic Press, New York 1985
   Google Scholar
• Herberman R B, Ortaldo JR. Natural killer cells: their role in defense against disease. Science 1981; 214: 24–30
   PubMed Web of Science ®Google Scholar
• Welsh RM. Regulation of virus infections by natural killer cells. A review. Natl Immun Cell Growth Reg 1986; 5: 169–199
   PubMedGoogle Scholar
• Lotzová E, Savary CA. Possible involvement of natural killer cells in bone marrow graft rejection. Biomedicine 1978; 27: 341–344
   Google Scholar
• Lotzová E, Savary C A, Pollack SB. Prevention of rejection of allogeneic bone marrow transplants by NK 1.1 antiserum. Transplantation 1983; 35: 490–494
   PubMed Web of Science ®Google Scholar
• Lotzová E. NK cell role in regulation of the growth and functions of hemopoietic and lymphoid cells. Immunobiology of Natural Killer Cells, E Lotzová, RB Herberman. CRC Press, Boca Raton, FL 1986; Vol. II: 89–105
   Google Scholar
• Trinchieri G, Murphy M, Perussia B. Regulaion of hematopoiesis by T lymphocytes and natural killer cells. Review. Crit Rev Oncol Hematol 1987; 7: 219–265
   PubMed Web of Science ®Google Scholar
• Hansson M, Beran M, Andersson B, et al. Inhibition of in vitro granulopoiesis by autologous allogeneic human NK cells. J Immunol 1982; 129: 126–132
   PubMed Web of Science ®Google Scholar
• Scala G, Djeu J Y, Allavena P, . Cytokine secretion and non-cytotoxic functions of human large granular lymphocytes. Immunobiology of Natural Killer Cells, E Lotzová, RB Herberman, et al. CRC Press, Boca Raton, FL 1986; Vol. II: 133–144
   Google Scholar
• Lotzová E, Ades EW. Natural killer cells: Defintion, heterogeneity, lytic mechanism, functions, and clinical application. Natl Immun Cell Growth Reg 1989; 8: 1–9
   PubMedGoogle Scholar
• Lanier L L, Phillips JH. A schema for the classification of cytotoxic lymphocytes based on T cell antigen receptor gene rearrangement and Fc receptor (CD16) or NKH1-/Leu-19 antigen expression. Natural Immunity, Cancer and Biological Response Modification, E Lotzová, RB Herberman. Karger, Basel 1986; 10–18
   Google Scholar
• Lotzová E, Savary C A, Pollock RE, et al. Immunologic and clinical aspects of natural killer cells in human leukemia. Natl Immun Cell Growth Reg 1990; 9: 173–181
   PubMedGoogle Scholar
• Koo G C, Peppard J R, Mark WH. Natural killer cell generated from bone marrow culture. J Immunol 1984; 132: 2300–2304
   PubMed Web of Science ®Google Scholar
• Lotzová E. Role of human circulating and tumor-infiltrating lymphocytes in cancer defense and treatment. Natl Immun Cell Growth Reg 1990; 9: 254–265
   Google Scholar
• Phillips J H, Lanier LL. Dissection of the lymphokine-activated killer cells and T contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis. J Exp Med 1986; 164: 814–825
   PubMed Web of Science ®Google Scholar
• Ortaldo J R, Mason A, Overton R. Heterogeneity of cell populations from human peripheral blood mediating lymphokine-stimulated cytotoxicity. Natural Immunity Cancer and Biological Response Modification, E Lotzová, RB Herberman. Karger, Basel 1986; 114–123
   Google Scholar
• Lotzová E, Savary C A, Freedman RS, et al. Recombinant IL-2 activated NK cells mediate LAK activity against ovarian cancer. Int J Cancer 1988; 42: 225–231
   PubMed Web of Science ®Google Scholar
• Herberman RB. Natural killer cells. Ann Rev Med 1986; 37: 347–352
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Herberman RB. Induction of NK cell activity against fresh human leukemia in culture with interleukin-2. J Immunol 1987; 138: 2718–2727
   PubMed Web of Science ®Google Scholar
• Perussia B, Starr S, Abraham S, et al. Human natural killer cells analyzed by B73.1 monoclonal antibody blocking Fc receptor functions. I. Characterization of lymphocyte subset reactive with B73.1. J Immunol 1983; 130: 2133–2141
   PubMed Web of Science ®Google Scholar
• Knapp W, Rieber P, Dorken B, et al. Towards a better definition of human leucocyte surface molecules. Immunol Today 1989; 10: 253–258
   PubMedGoogle Scholar
• Perussia B, Ramon C, Anegow I, et al. Preferential proliferation of natural killer cells cocultured with B lymphoblastoid cell lines. Natl Immun Cell Growth Reg 1987; 6: 171–188
   PubMedGoogle Scholar
• Lotzová E, Savary CA. Generation of NK cell activity from human bone marrow. J Immunol 1987; 139: 279–284
   PubMed Web of Science ®Google Scholar
• Ortaldo J R, Sharrow S O, Timonen T, et al. Analysis of surface antigens on highly purified human NK cells by flow cytometry with monoclonal antibodies. J Immunol 1981; 126: 2401–2409
   Google Scholar
• Lanier L L, Testi R, Bindl J, et al. Identity of Leu-19 (CD56) leucocyte differentiation antigen and neural cell adhesion molecule. J Exp Med 1989; 169: 2233–2238
   PubMed Web of Science ®Google Scholar
• Nitta T, Yagita H, Sato K, et al. Involvement of CD56 (NKH1/Leu-19 antigen) as an adhesion molecule in natural killertarget interaction. J Exp Med 1989; 170: 1757–1761
   PubMed Web of Science ®Google Scholar
• Abo T, Balch BM. A differentiation antigen of human NK cells and K cells identified by a monoclonal antibody (HNK-1). J Immunol 1981; 127: 1024–1029
   PubMed Web of Science ®Google Scholar
• Trinchieri G, Perussia B. Biology of disease. Human natural killer cells: biologic and pathologic aspects. Lab Invest 1984; 50: 489–513
   PubMed Web of Science ®Google Scholar
• Ng A-K, Induiveri F, Pellegrino MA. Natural cytotoxicity and antibody-dependent cellular cytotoxicity of human lymphocytes depleted of HLA-DR bearing cells with monoclonal HLA-DR antibodies. J Immunol 1980; 124: 2336–2340
   PubMed Web of Science ®Google Scholar
• Brooks C F, Moore M. Presentation of a soluble bacterial antigen and cell surface alloantigens by large granular lymphocytes (LGL) in comparison with monocytes. Immunology 1986; 58: 343–350
   PubMed Web of Science ®Google Scholar
• Herberman RB. Overview and perspective: Natural resistance mechanism. Macrophages and Natural Killer Cells; Regulation and Function, Sorkin Norman. Plenum Press, New York 1982; 799–808
   Google Scholar
• Caligiuri M A, Zmuidzinas A, Manley TJ, et al. Functional consequences of interleukin-2 receptor expression on resting human lymphocytes. J Exp Med 1990; 171: 1509–1526
   PubMed Web of Science ®Google Scholar
• Leung K H, Fischer D G, Koren HS. Erythromyeloid tumor cells (K-562) induce PGE synthesis in human peripheral blood monocytes. J Immunol 1983; 131: 445–449
   PubMed Web of Science ®Google Scholar
• Lotzová E, McCredie K B, Muesse L, . Natural killer cells in man: Their possible involvement in leukemia and bone marrow transplantation. Experimental Hematology Today 1979, SJ Baum, GD Ledney, et al. Springer-Verlag, New York 1979; 207–213
   Google Scholar
• Lotzová E, McCredie K B, Maroun JA, et al. Some studies on natural killer cells in man. Transplant Proc 1979; 11: 1390–1392
   PubMed Web of Science ®Google Scholar
• Rumpold H, Kraft D, Obexer G, et al. A monoclonal antibody against a surface antigen shared by human large granular lymphocytes and granufocytes. J Immunol 1982; 129: 1458–1464
   PubMed Web of Science ®Google Scholar
• Lotzová E. Cytotoxicity and clinical application of activated NK cells. Med Oncol Tumor Pharmacother 1989; 6: 93–98
   PubMedGoogle Scholar
• Shanahan F, Brogan M, Targan S. Human mucosal cytotoxic effector cells. Gastroenterology 1987; 92: 1951–1957
   PubMed Web of Science ®Google Scholar
• Weissler J C, Nicod L P, Lipscomb MR, et al. Natural killer cell function in human lung is compartmentalized. Am Res Respir Dis 1987; 135: 941–949
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Lowlachi M, et al. Cytotoxic and morphologic profile of endogenous and pyrimidinone-activated murine NK cells. J Immunol 1986; 136: 732–740
   PubMed Web of Science ®Google Scholar
• Oldham R K, Forbes J T, Niblach GD. Natural killer activity in human thoracic duct lymphocytes. Proc Am Assoc Cancer Res 1978; 21: 210
   Google Scholar
• Eremin O, Coombs R RA, Plumb D, et al. Characterization of the natural killer (NK) cell in blood and lymphoid organs. Int J Cancer 1978; 21: 41–50
   Google Scholar
• Savary C A, Lotzová E. Phytogeny and ontogeny of NK cells. Immunobiology of Natural Killer Cells, E Lotzová, RB Herberman. CRC Presss, Boca Raton 1986; Vol. I: 45–61
   Google Scholar
• Valembois P, Roch P, Boiledieu D. Natural and induced cytotoxicities in sipunculids and annelids. Phylogeny of Immunological Memory, MJ Manning. Elsevier/North-Holland, New York 1980; 47–55
   Google Scholar
• Decker J M, Elmholt A, Muchmore AV. Spontaneous cytotoxicity mediated by invertebrate mononuclear cells toward normal and malignant vertebrate targets: inhibition by defined mono- and disaccharides. Cell Immunol 1981; 59: 161–170
   PubMed Web of Science ®Google Scholar
• Hostetter R K, Cooper EL. Coelomocyles as effector cells in the earthworm immunity. Immunol Commun 1972; 1: 155–183
   PubMed Web of Science ®Google Scholar
• Pettey C L, McKinney EC. Effect of decreased environmental temperature on spontaneous cytotoxicity in the nurse shark. Fed Proc Am Soc Exp Biol 1980; 39: 934
   Google Scholar
• Roder J C, Karre K, Kiessling R. Natural killer cells. Prog Aller 1981; 28: 66–159
   PubMedGoogle Scholar
• Natural Immunity Cancer and Biological Response Modification, E Lotzová, RB Herberman. Karger, Basel 1986
   Google Scholar
• Interleukin-2 and Killer Cells in Cancer, E Lotzová, RB Herberman. CRC Press, Boca Raton 1990
   Google Scholar
• White J G, Clawson CC. Chediak-Higashi syndrome: variable cytochemical reactivity of giant inclusions in polymorphonuclear leukocytes. Ultrastruct Pathol 1980; 2: 223–236
   Google Scholar
• Argyle J C, Kjeldsberg C R, Marty J, et al. T-cell lymphoma and the Chediak-Higashi syndrome. Blood 1982; 60: 672–676
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Keating MJ, . Defective NK cell mechanism in patients with leukemia. Mechanism for Cytotoxicity by NK Cells, RB Herberman, DM Callewaert, et al. Academic Press, New York 1985; 507–519
   Google Scholar
• Lotzová E, Savary C A, Herberman RB. Impaired NK cell profile in leukemia-diseased patients. Immunobiology of Natural Killer Cells, E Lotzová, RB Herberman. CRC Press, Boca Raton 1986; Vol. II: 163–177
   Google Scholar
• Lotzová E, Savary CA. Function of interleukin-2 activated NK cells in leukemia resistance and treatment. Interleukin-2 and Killer Cells in Cancer, E Lotzová, RB Herberman. CRC Press, Boca Raton 1990; 41–56
   Google Scholar
• Fujimiya Y, Chang W C, Bakke A. Natural killer (NK) cell immunodeficiency in patients with chronic myelogenous leukemia. II. Successful cloning and amplification of natural killer cells. Cancer Immunol Immunother 1987; 24: 213–220
   PubMed Web of Science ®Google Scholar
• Son K, Kew M, Rabson AR. Depressed natural killer cell activity in patients with hepatocellular carcinoma. In vitro effects of interferon and levamisole. Cancer 1982; 50: 2820–2825
   PubMed Web of Science ®Google Scholar
• Pross H F, Herberman RB. Clinical applications of NK cells. Natural Killer Cells and Host Defense, EW Ades, C Lopez. Karger, Basel 1989; 239–241
   Google Scholar
• Schantz S P, Brown B W, Lira E, et al. Evidence for the role of natural immunity in the control of metastatic spread of head and neck cancer. Cancer Immunol Immunother 1987; 25: 141–148
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Freedman RS, et al. Natural killer cell cytotoxic potential of patients with ovarian carcinoma and its modulation with virus-modified tumor cell extract. Cancer Immunol Immunother 1984; 17: 124–129
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Freedman RS, . Natural killer cell antitumor activity in patients with ovarian carcinoma: induction of cytotoxicity by viral oncolysates and interleukin-2. Diagnosis and Treatment Strategies for Gynecological Cancer, FM Rutledfe, RS Freedman, DM Gershenson, et al. University of Texas Press, Austin 1987; 123–126
   Google Scholar
• Strayer D R, Carter W A, Mayberry SD, et al. Low natural cytotoxicity of peripheral blood mononuclear cells in individuals with high familial incidences of cancer. Cancer Res 1984; 44: 370–374
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Herberman RB. Inhibition of clonogenic growth of fresh leukemia cells by unstimulated and IL-2 stimulated NK cells of normal donors. Leukemia Res 1987; 11: 1059–1066
   PubMed Web of Science ®Google Scholar
• Lotzová E. Analysis of effector mechanisms in cancer. Curr Opinion Immunol 1989; 1(5)904–909
   PubMed Web of Science ®Google Scholar
• Lotzová E, Herberman RB. Reassessment of LAK phenomenology—a review. Natl Immun Cell Growth Reg 1987; 6: 109–115
   PubMedGoogle Scholar
• Herberman R B, Balch C, Bolhuis R, et al. Most lymphokine activated killer (LAK) activity mediated by blood and splenic lymphocytes is attributable to stimulation of natural killer (NK) cells by interleukin-2. Immunol Today 1987; 8: 178–181
   PubMedGoogle Scholar
• Ramsdell F, Golub S. IL-2 induced cytotoxic cells from human thymocytes. Interleukin-2 and Killer Cells in Cancer, E Lotzová, RB Herberman. CRC Press, Boca Raton 1989; 97–110
   Google Scholar
• Lotzová E, Savary CA. Growth kinetics, function and characterization of lymphocytes infiltrating ovarian tumors. Interleukin-2 and Killer Cells in Cancer, E Lotzová, RB Herberman. CRC Press, Boca Raton 1990; 153–161
   Google Scholar
• Whiteside TL. Human tumor-infiltrating lymphocytes and their characterization. Interleukin-2 and Killer Cells in Cancer, E Lotzová, RB Herberman. CRC Press, Boca Raton 1989; 133–154
   Google Scholar
• Fleisher G, Koven N, Kamiya H, et al. A non-X-linked syndrome with susceptibility to severe Epstein-Barr virus infections. J Pediatr 1982; 100: 727–730
   PubMed Web of Science ®Google Scholar
• Biron C A, Byron K S, Sullivan JL. Susceptibility to viral infections in an individual with a complete lack of natural killer cells. Natl Immun Cell Growth Reg 1988; 7: 47
   Google Scholar
• Bowden R A, Day L M, Amos DE, et al. Natural cytotoxic activity against cytomegalovirus-infected target cells following marrow transplantation. Transplantation 1987; 44: 504–508
   PubMed Web of Science ®Google Scholar
• Lopez C, Kirkpatrick D, Fitzgerald P. The role of NK (HSV-1) effector cells in the resistance to herpes virus infections in man. NK Cells and Other Natural Effector Cells, RB. Herberman. Academic Press, New York 1982; 1445–1450
   Google Scholar
• Sirianni M C, Soddus S, Malorni W, et al. Mechanism of defective natural killer cell activity in patients with AIDS is associated with defective distribution of tubulin. J Immunol 1988; 140: 2565–2568
   PubMed Web of Science ®Google Scholar
• Fox R I, Pearson G, Vaughn JH. Detection of Epstein-Barr virusassociated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J Immunol 1986; 137: 3162–3168
   PubMed Web of Science ®Google Scholar
• Takeda A, Minato N, Kano S. Selective impairment of alpha interferon-mediated natural killer augmentation in Sjögren's syndrome: Differential effecs of alpha interferon, gamma interferon and interleukin 2 on cytolytic activity. Clin Exp Immunol 1987; 70: 354–363
   PubMed Web of Science ®Google Scholar
• Minato N, Takeda A, Kano S, et al. Studies of the functions of natural killer-interferon system in patients with Sjögren's syndrome. J Clin Invest 1982; 69: 581–588
   PubMed Web of Science ®Google Scholar
• Bartizal K F, Salkowski C, Pleasants JR, et al. The effect of microbial flora, diet, and age on the tumoricidal activity of natural killer cells. J Leuk Biol 1984; 36: 739–750
   PubMed Web of Science ®Google Scholar
• Nabavi N, Murphy JW. In vitro binding of natural killer cells in Cryptococcus neoformans targets. Infect Immunol 1985; 50: 50–57
   PubMed Web of Science ®Google Scholar
• Jimenez B E, Murphy JW. In vitro effects of natural killer cells agains Paracoccidioides brasiliensis yeast phase. Infect Immun 1984; 46: 552–558
   PubMed Web of Science ®Google Scholar
• Petkus A F, Baum LL. Natural killer cell inhibition of young spherules and endospores of Coccidioides immitis. J Immunol 1987; 139: 3107–3111
   PubMed Web of Science ®Google Scholar
• Grimm E A, Mazumder A, Zhang HZ, et al. Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin-2-activated autologous human peripheral blood lymphocytes. J Exp Med 1982; 155: 1823–1841
   PubMed Web of Science ®Google Scholar
• Ramsdell F J, Gray J D, Golub SH. Expression of NKH-1 and CDS on lymphokine-activated killer cells generated from thymocytes. Natl Immun Cell Growth Reg 1988; 7: 36, abstr
   Google Scholar
• Melder R J, Whiteside T L, Vujanovic NL, et al. A new approach to generating antitumor effector cells for adoptive immunotherapy using human adherent lymphokine-activated killer cells. Cancer Res 1988; 48: 3461–3469
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary C A, Schachner JR, et al. Highly cytotoxic adherent killer cells from leukemic patients. Therapeutic possibilities. Proc Am Assoc Cancer Res 1990; 31: 250, abstr
   Google Scholar
• Topalian S L, Muul L M, Solomon D, et al. Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials. J Immunol Methods 1987; 102: 127–141
   PubMed Web of Science ®Google Scholar
• Lotzová E. Ovarian tumor-infiltrating lymphocytes: phenotype and antitumor activity. Natl Immun Cell Growth Reg 1988; 7: 226–229
   PubMedGoogle Scholar
• Whiteside T L, Heo D S, Takagi S, et al. Cytolytic antitumor effector cells in long-term cultures of human tumor-infiltrating lymphocytes in recombinant interleukin-2. Cancer Immunol Immunother 1988; 26: 1–10
   PubMed Web of Science ®Google Scholar
• Muul L M, Spiess P J, Director EP, et al. Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma. J Immunol 1987; 138: 989–995
   PubMed Web of Science ®Google Scholar
• Rosenberg S A, Spiess P, Lafreniere R. A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science 1986; 233: 1318–1321
   PubMed Web of Science ®Google Scholar
• Topalian S L, Solomon D, Avis FP, et al. Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study. J Clin Oncol 1988; 6: 839–853
   PubMed Web of Science ®Google Scholar
• Rosenberg S A, Lotze M T, Muul LM, et al. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 1987; 316: 889–897
   PubMed Web of Science ®Google Scholar
• Lotzová E, Savary CA. Dichotomy in reactivity of IL-2 activated human lymphocyte subsets against normal and malignant hematopoietic cells. Proceedings of 6th International NK Cell Workshop. Karger, Basel 1990
   Google Scholar
• Djeu J Y, Blanchard DK. Lysis of human monocytes by lymphokine-activated killer cells. Cell Immunol 1988; 111: 55–65
   PubMed Web of Science ®Google Scholar
• Sondel P M, Hank J A, Kohler PC, et al. Destruction of autologous human lymphocytes by interleukin-2-activated cytotoxic cells. J Immunol 1986; 137: 502–511
   PubMed Web of Science ®Google Scholar
• Nagler A, Greenberg P L, Lanier LL, et al. The effects of recombinant interleukin-2-activated natural killer cells on autologous peripheral blood hematopoietic progenitors. J Exp Med 1988; 168: 47–54
   PubMed Web of Science ®Google Scholar
• Schwartz R E, Vujanovic L N, Hiserodt JC. Enhanced antimetastatic activity of lymphokine-activated killer cells purified and expanded by their adherence to plastic. Cancer Res 1989; 49: 1441–1446
   PubMed Web of Science ®Google Scholar
• Niederwieser D, Gastl G, Rumpold H, et al. Rapid reappearance of large granular lymphocytes (LGL) with concomitant reconstitution of natural killer (NK) activity after human marrow transplantation (BMT). Br J Heamtol 1987; 65: 301–305
   PubMed Web of Science ®Google Scholar
• Lotzová E. The role of natural killer cells in immune surveillance against malignancies. Cancer Bull 1984; 36: 215–226
   Google Scholar
• Thoen J, Waalen K, Farre O. Natural killer (NK) cells at inflammatory sites of patients with rheumatoid arthritis and IgM rheumatoid factor-positive polyarticular juvenile rheumatoid arthritis. Clin Rheumatol 1987; 6: 215–225
   PubMed Web of Science ®Google Scholar
• Caligiuri M, Murray C, Buchwald D, et al. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol 1987; 139: 3306–3313
   PubMed Web of Science ®Google Scholar
• Levy S M, Herberman R B, Simons A, et al. Persistently low natural killer cell activity in normal adults: immunological, hormonal and mood correlates. Natl Immun Cell Growth Reg 1989; 8: 173–186
   PubMedGoogle Scholar