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Miscellaneous Article

Interleukin-4 and Cancer Therapy

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Pages 473-486 | Published online: 11 Jun 2009

References

  • Howard M., Farrar J., Hilfiker M., et al. Identification of a T cell-derived B cell stimulatory factor distinct from IL-2. J Exp Med 1982; 155: 914–923
  • Isakson P. C., Pure E., Vitetta S., et al. T cell-derived B cell differentiation factor (s). Effect on the isotype switch of munne B cells. J Exp Med 1982; 155: 734–748
  • Noma Y., Sideras P., Naito T., et al. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature 1986; 319: 640–646
  • Lee F., Yokoda T., Otsuka T., et al. Isolation and characterization of a mouse interleukin cDNA that expresses B-cell stimulatory factor 1 activities, and T cell and mast cell stimulating activities. Proc Natl Acad Sci USA 1986; 83: 2061–2065
  • Yokoda T., Otsuka T., Mosman T., et al. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, and that expresses B-cell and T cell stimulatory activities. Proc Natl Acad Sci USA 1986; 83: 5894–5898
  • Kuhn R., Rajewsky K., Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991; 254: 707–710
  • Tepper R. I., Levinson D. A., Stanger B. Z., et al. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 1990; 62: 457–466
  • Burnstein H. J., Tepper R. I., Leder P., et al. Humoral immune functions in IL-4 transgenic mice. J Immunol 1991; 147: 2950–2956
  • Brown M., Hu-Li J., Paul W. E. II-4/B-cell stimulatory factor-1 stimulates T cell growth by an IL-2 independent mechanism. J Immunol 1988; 131: 504–541
  • Spits H., Yssel H., Takebe Y., et al. Recominant IL-4 promotes the growth of human T cells. J Immunol 1987; 139: 1142–1147
  • Martinez O. M., Gibbons R. S., Garovoy M. R., et al. IL-4 inhibits IL-2 receptor and IL-2 dependent proliferation of human T cells. J Immunol 1990; 144: 2211–2215
  • Kawakami Y., Rosenberg S. A., Lotze M. T. Interleukin 4 promotes the growth of tumor infiltrating lymphocytes cytotoxic for human autologous melanoma. J Exp Med 1989; 168: 2183
  • Horohov D. W., Crim J. A., Smith P. J., et al. IL-4 (B cell-stimulatory factor 1) regulates multiple aspects of influenza virus-specific cell mediated immunity. J. Immunol 1988; 141: 4217–4223
  • Spits H., Yssel H., Takebe Y., et al. IL-4 inhibits IL-2-mediated induction of human lymphokine activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed lymphocyte cultures. J Immunol 1988; 141: 29–36
  • Yamashita U., Tanaka Y. Suppressive activity of intereleukin 4 on the induction of antigen-specific cytotoxic T cells in humans. Jpn J Cancer Res 1991; 82: 585–592
  • Vercelli D., Jabara H. H., Lauener R. P., et al. IL-4 inhibits synthesis of IFN-γ and induces the synthesis of IgE in human mixed lymphocyte cultures. J Immunol 1990; 144: 570–573
  • Kawakami Y., Custer M. C., Rosenberg S. A., et al. IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes. J Immunol 1989; 142: 3452–3461
  • Defrance T., Vandervliet B., Aubry J-P, et al. B cell growth promoting activity of recombinant human interleukin 4. J Immunol 1987; 139: 1135–1141
  • Banchereau J., DePaoli P., Valle A., et al. Long-term human B-cell lines dependent on interleukin-4 and antibody to CD40. Science 1991; 251: 70–72
  • Llorente L., Mitjavila F., Crevon M-C, et al. Dual effects of interleukin 4 on antigen activated human B cell: Induction of proliferation and inhibition of interleukin 2-dependent differentiation. Eur J Immunol 1990; 20: 1887–1892
  • Noelle R. J., Krammer P. H., Ohara J., et al. Increased expression of la antigens on resting B cells: An additional role for B cell growth factor. Proc Natl Acad Sci USA 1984; 81: 6149–6155
  • Lee H-K, Xia X., Choi Y. S. IL-4 blocks the up-regulation of IL-2 receptors induced by IL-2 in normal human B cells. J Immunol 1990; 69: 57–64
  • Karray S., Dautry-Varsat A., Tsudo M., et al. IL-4 inhibits the expression of high affinity IL-2 receptors on monoclonal human B cells. J Immunol 1990; 145: 1152–1158
  • DeFrance T., Vandervliet B., Pene J., et al. Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM. J Immunol 1988; 141: 2000–2005
  • Jelinek D. F., Lipsky P. Inhibitory influence of IL-4 on human B cell responsiveness. J Immunol 1988; 141: 164–173
  • Karray S., DeFrance T., Merle-Beral H., et al. Interleukin 4 counteracts the IL-2 induced proliferation of monoclonal B cells. J Exp Med 1988; 168: 85–94
  • Gascan H., Gauchat J-F, Roncarolo M-G, et al. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J Exp Med 1991; 173: 747–750
  • Shields J. G., Armitage R. J., Jamieson B. N., et al. Increased expression of surface IgM but not IgD or IgG on human B cells in response to IL-4. Immunology 1989; 66: 224–227
  • DeFrance T., Aubry J. PL, Rousset F., et al. Human recombinant IL-4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. J Exp Med 1987; 165: 1459–1467
  • Butcher R. DJ, McGarvie G. M., Cushley W. Recombinant interleukin 4 promotes the expression of CD25 (tac) antigen at the plasma membrane of high density human tonsillar B lymphocytes. Immunology 1990; 144: 3431–3436
  • Rousset F., Billaud M., Blanchard D., et al. IL-4 induces LFA-1 and LFA-3 on Burkitt's lymphoma cell lines. J Immunol 1989; 143: 1490–1498
  • Te Velde A. A., Klomp J. PG, Yard B. A., et al. Modulation of phe-notypic and functional properties of human peripheral blood monocytes by IL-4. J Immunol 1988; 140: 1548–1554
  • Essner R., Rhoades K., Me Bride W. H., et al. IL-4 down-regulates IL-2 and TNF gene expression in human monocytes. J Immunol 1989; 142: 3857–3861
  • Hart P. H., Vitti G. F., Burgess D. R., et al. Potential antiinflamma-tory effects of IL-4: Suppression of human monocyte TNF, IL-1 and PGE2. Proc Natl Acad Sci USA 1989; 86: 3803–3807
  • Standiford T. J., Strieter R. M., Chensue S. W., et al. IL-4 inhibits the expression of IL-8 from stimulated human monocytes. J Immunol 1990; 145: 1435–1439
  • Cheung D. L., Hart P. H., Vitti G. F., et al. Contrasting effects of interferon-gamma and interleukin-4 on the IL-6 activity of stimulated human monocytes. Immunology 1990; 71: 70–75
  • Weiser M., Bonifer R., Roster W., Lindemann A., Meltelsmann R., Hermann F. Interleukin 4 induces secretion of CSF for granulo-cytes and CSF for macrophages by peripheral blood monocytes. Blood 1989; 73: 1105–1108
  • Broxmeyer H. E., Lu L., Cooper S., Tushinski R., Mochizuki D., Rubin B. Y., Gillis S., Williams D. E. Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. J Immunol 1988; 141: 3852–3862
  • TeVelde A. A., Huijbens R. JF, DeVries J. E., Figdor C. G. IL-4 decreased FcγR membrane expression and FcγR-mediated cytotoxic activity of human monocytes. J Immunol 1990; 144: 3046–3051
  • Hudson M. M., Markowitz A. B., Gutterman J. U., Knowles R. D., Sny-Der J. S., Kleinerman E. S. Effect of recombinant human IL-4 on human monocyte activity. Cancer Res 1990; 50: 3154–3158
  • Te Velde A. A., Klomp J. PG, Yard B. A., de Vries J. E., Figdor C. G. Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4. J Immunol 1988; 140: 1548–1554
  • Vercelli D., Jabara H. H., Lee B-W, Woodland N., Geha R. S., Leung D. YM. Human recombinant IL-4 induces FceR2/CD23 on normal human monocytes. J Exp Med 1988; 167: 1406–1416
  • Wong H. L., Lotze M. T., Wahl L. M., et al. Administration of recombinant IL-4 to humans regulates gene expression, phenotype, and function in circulating monocytes. J Immunol 1992; 148: 2118–2125
  • Hart P. H., Burggess D. R., Vitti G. F., Hamilton J. A. IL-4 stimulates human monocytes to produce tissue-plasminogen activator. Blood 1989; 74: 1222–1225
  • Lewis D. B., Yu C. C., Forbush K. A., et al. Interleukin 4 expressed in-situ selectively alters thymocyte development. J Exp Med 1991; 62: 457–467
  • Valenga E., de Wolf J. ThM, Baentjes J. AM, Esselink M. T., Smit J. W., Halie M. R. Divergent effects of IL-4 on the granulocye colony-stimulating factor and IL-3 supported myeloid colony formation from normal and leukemic bone marrow cells. Blood 1990; 75: 633–637
  • Jansen J. H., Wientjens G. JHM, Fibbe W. E., Willemze R., Kluin-Nelemans J. C. Inhibition of human macrophage-colony formation by IL-4. J Exp Med 1989; 170: 577–582
  • Mosman T. R., Bond M. W., Coffman R. L., Ohara J., Paul W. E. T cell and mast cell lines respond to B-cell stimulatory factor-1. Proc Natl Acad Sci USA 1986; 83: 5654–5658
  • Valent T., Bevec D., Maurer D., et al. IL-4 promotes expression of mast cell ICAM-1 antigen. Proc Natl Acad Sci USA 1991; 88: 339–342
  • Howells G., Pham P., Taylor D., Foxwell B., Feldman M. IL-4 induces IL-6 production by endothelial cells: Synergy with interferon-γ. Eur J Immunol 1991; 21: 97–101
  • Thomhill M. H., Kyan-Aung U., Haskard D. O. IL-4 increased human endothelial cell adhesiveness for T cells but not for neutro-phils. J Immunol 1990; 144: 3060–3065
  • Thornhill M. H., Haskard D. O. IL-4 regulates endothelial cell activation by IL-1, TNF, of IFN-γ. J Immunol 1990; 145: 865–872
  • Masinovsky B., Urdal D., Gallatin W. M. IL-4 acts synergistically with IL-1 to promote lymphocyte adhesion to microvascular en-dothelium by induction of vascular cell adhesion molecule-1. J Immunol 1990; 145: 2886–2895
  • Toi M., Harris A. L., Bicknell R. IL-4 is a potent mitogen for capillary endothelium. Biochem Biophys Res Commun 1991; 174: 1287–1293
  • Boey H., Rosenbaum R., Jon Castracane B. A., et al. Interleukin 4 is a neutrophil activator. J Allergy Clin Immunol 1989; 83: 978–984
  • Fabre C., Saeland S., Caux C., et al. InterIeukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cells. Blood 1990; 75: 67–73
  • White M. V., Igarashi Y., Emergy B. E., et al. Effects of in vivo administration of IL-2 and IL-4, alone and in combination, on ex vivo human basophil histamine release. Blood 1992; 79: 1491–1495
  • Paul W. E. Interleukin-4: A prototypic immunoregulatory lym-phokine. Blood 1990; 77: 1859–1870
  • Ohara J., Coligan J., Koon K., et al. High efficiency purification and chemical characterization of B cell stimulatory factor 1/IL-4. J Immunol 1987; 139: 1127–1138
  • Grabstein K., Eiseman J., Mochizuki D., et al. Purification to homogeneity of B cell stimulating factor. J Exp Med 1986; 163: 1405–1414
  • Arai N., Nomura D., Villaret D., et al. Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. J Immunol 1989; 142: 274–282
  • Mosman T. R., Yokota T., Kastelein R., et al. Species-specificity of T-cell stimulating activities of IL-2, BSF-1 (IL-4): Comparison of normal and recombinant, mouse and human IL-2 and BSF-1 (IL-4). J Immunol 1897; 138: 1813–1816
  • Ohara J., Paul W. E. Receptors for B-cell stimulatory factor-1 expressed on cells of hematopoeitic lineage. Nature 1987; 325: 537–540
  • Park L. S., Friend D., Sassenfeld H. M., et al. Characterization of the human B cell stimulatory factor 1 receptor. J Exp Med 1987; 166: 476–488
  • Idzerda R. L., March C. J., Mosley B., et al. Human Interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 1990; 171: 861–873
  • Le H. V., Ramanathan L., Labdon J. E., et al. Isolation and characterization of multiple variants of recombinant human interleukin-4 expressed in mammalian cells. J Biol Chem 1988; 263: 10817–10823
  • Le Beau M. M., Lemons R. S., Espinoza R., III, et al. Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors are deleted in myeloid leu-kemias with del (5q). Blood 1989; 73: 647–650
  • Takahashi M., Yoshida M. C., Satosh H., et al. Chromosomal mapping of the mouse IL-4 and human IL-5 genes. Genomics 1989; 4: 47–56
  • Van leeuween B. H., Martinson M. E., Wee G. C., et al. Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5. Blood 1990; 73: 350–356
  • Otsuka T., Villaret D., Yokota T., et al. Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities. Nucleic Acids Res 1987; 14: 333–244
  • Eder A., Krafft-Czepa H., Krammer P. H. The 5′ region of the human interleukin 4 gene: structure and potential regulatory elements. Nucleic Acids Res 1988; 16: 772–779
  • Mossmann T. R., Cherwinski H., Bond M. W., et al. Two types of murine helper T cell clones. Definition according to profiles of lympokines activities and secreted proteins. J Immunol 1986; 136: 2348–2357
  • Howard M., Farrar J., Hilfiker M., et al. Identification of a T cell derived B cell growth factor distinct from interleukin 2. J Exp Med 1982; 155: 914–923
  • Milanese C., Richardson N. ER, Reinherz E. L. Identification of T helper cell-derived lymphokine that activates resting T lymphocytes. Science 1986; 231: 1118–1122
  • Plaut M., Pierce J. H., Watson C. J., et al. Mast cell lines produce lymphokines in response to cross lineage of FCεRI or to calcium ionophores. Nature 1989; 6219: 64–67
  • Swain S. L., Zlotnik A., Woodward J. G. Characterization of T helper I and 2 cell subsets in normal mice. J Immunol 1988; 141: 3445–3455
  • Sideras P., Funa K., Zalcberg-Quintana I., et al. Analysis by in-situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and in peripheral lymphocytes from mice. Proc Natl Acad Sci USA 1988; 85: 218–221
  • Ben-Sasson S. Z., Gros G. L., Conrad D. H., et al. IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. J Immunol 1990; 145: 1127–1136
  • Seder R. A., Boulay J-L, Finkelman F., et al. CDS+ T cells can be primed in vitro to produce IL-4. J Immunol 1992; 148: 1652–1656
  • O'Garra A., Barbis D., Hirada N., et al. Constitutive production of lymphokines by cloned murine B-cell lymphomas:CH12 B lym-phoma produces interleukin 4. J Mol Cell Immunol 1989; 4: 149–158
  • Paliard X., De Waal M. R., Yssel H., et al. Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD+ and CD+ T cell clones. J Immunol 1988; 141: 849–855
  • Wierenga E. A., Snoek M., de Groot C., et al. Evidence for com-partmentalization of functional subsets of CD2+ T lymphocytes in atopic patients. J Immunol 1990; 144: 4651–4658
  • Tanaka Y., Saito K., Shirakawa F., et al. Production of B-cell stimulating factors by B cells in patients with systemic lupus erythe-matosus. J Immunol 1988; 141: 3043–3049
  • Chretien I., Van Kimmenade A., Pearce M. K., et al. Development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin 4. J Immunol Methods 1989; 117: 67–81
  • Horohov D. W., Crira J. A., Smith P., Siegel J. P. IL-4 (B-cell stimulatory factor-1) regulates multiple aspects of influenza virus-specific cell mediated immunity. J Immunol 1988; 141: 4217–4223
  • Lewis D. B., Prickett K. S., Larsen A., et al. Restricted production of interleukin 4 by activated human T cells. Proc Natl Acad Sci USA 1988; 85: 9743–9747
  • van der Heijden F. L., Wierenga E. A., Bos J. D., et al. High frequency of IL-4-producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 1991; 97: 389–394
  • Salmon M., Kitas C. D., Bacon P. A. Production of lymphokine mRNA by CD45RA+ and CF45RA-helper T cells from human peripheral blood and by human CD4+ T cell clone. J Immunol 1989; 143: 907–912
  • Idzerda R. L., March C. J., Mosley B., et al. Human Interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 1990; 171: 861–873
  • Lowenthal J. W., Castle B. E., Christiansen J., et al. Expression of high affinity receptors for murine interleukin 4 (BSF-I) on he-matopoietic and nonhematopoietic cells. J Immunol 1988; 140: 456–464
  • Park L. S., Friend D., Sassenfeld H. M., et al. Characterization of the high affinity cell surface receptor for murine B cell stimulatory factor-1. Proc Natl Acad Sci USA 1987; 84: 1669–1673
  • Ohara J., Paul W. E. Upregulation of Interleukin 4/B cell stimulatory factor-1 receptor expression. Proc Natl Acad Sci USA 1988; 85: 8221–8225
  • Puri R. K., Finbloom D. S., Leland P., et al. Expression of high affinity IL4 receptors on murine tumor infiltrating lymphocytes and their upregulation by IL2. Immunology 1990; 70: 492–497
  • Puri R. K., Aggarwal B. B. Human immunodeficiency virus type I tat gene up-regulates interleukin 4 receptors on a human B-lymphoblastoid cell line. Cancer Res 1992; 52: 3787–3790
  • Foxwell B. MJ, Woerly G., Ruffel B. Identification of Interleukin 4 receptor-associated proteins and expression of both high and low-affinity binding on human lymphoid cells. Eur J Immunol 1989; 19: 1637–1641
  • Armitage R. J., Beckmann M. P., Idzerda R. L., et al. Regulation of interleukin 4 receptors on human T cells. Int Immunol 1990; 2: 1039–1045
  • Zuber C., Galizzi J. P., Valle A., et al. Interleukin 4 receptors in normal human B lymphocytes: Characterization and regulation. Eur J Immunol 1990; 20: 551–555
  • Wagteveld A. J., Zanten A. KV, Esselink M. T., et al. Expression and regulation of IL-4 receptors on human monocytes and acute myeloblastic leukemia cells. Leukemia 1991; 5: 782–788
  • Feldman G. M., Finbloom D. S. Induction and regulation of IL-4 receptor expression on murine macrophage cell lines and bone marrow-derived macrophages by IFN-γ. J Immunol 1990; 145: 854–859
  • Feldman G. M., Ruhl S., Bickel M., et al. Regulation of interleukin-4 receptor on murine myeloid progenitor cells by interleukin-6. Blood 1991; 78: 1678–1684
  • Cabrillat H., Galizzi J-P, Djossou O., et al. High affinity binding of human interleukin 4 to cell lines. Biochem Biophys Res Commun 1987; 149: 995–1001
  • Okabe M., Kuni-Eda Y., Sugiwura T., et al. Inhibitory effects of IL-4 on the in vitro growth of Ph'-positive acute lymphoblastic leukemia cells. Blood, 78: 1574–1580
  • Puri R. K., Ogata M., Leland P., et al. Expression of high affinity IL4 receptors on murine sarcoma cells and receptor mediated cytotoxicity of tumor cells to chimeric protein between IL-4 and Pseudomonas exotoxin. Cancer Res 1991; 51: 3011–3017
  • Obiri N. I., Siegel J. P., Puri R. K. Expression of high affinity interleukin-4 receptors on human melanoma, ovarian and breast carcinoma cells, (submitted)
  • Obiri N. I., Hillman G., Haas G., Sud S., Puri R. K. Expression of high affinity interleukin 4 receptors on human renal carcinoma cells and inhibition of tumor cell growth in vitro by IL-4. J Clin Invest 1993; 91: 88–93
  • Tüngekar M. F., Turley H., Dunnill M. S., et al. Interleukin-4 receptor expression on human lung tumors and normal lung. Cancer Res 1991; 51: 261–265
  • Galizzi J. P., Zuber C. E., Cabrillat H., et al. Internalization of human interleukin 4 receptor and transient downregulation of its receptor in the CD23-inducible jijoye cells. J Biol Chem 1989; 264: 6984–6989
  • Keegan A. D., Beckmann M. P., Park L. S., et al. The IL-4 receptor: Biochemical characterization of IL-4-binding molecules in a T cell line expressing large numbers of receptors. J Immunol 1991; 146: 2272–2279
  • Mosley B., Beckmann M. P., Park L. S., et al. The murine IL-4 receptor: Molecular cloning and characterization of secreted and membrane forms. Cell 1989; 59: 335–348
  • Harada N., Castle B. E., Gorman D. M., et al. Expression cloning of a cDNA encoding the murine IL-4 receptor based on ligand binding. Proc Natl Acad Sci USA 1990; 87: 857–861
  • Galizzi J-P, Zuber C. E., Harada N., et al. Molecular cloning of a cDNA encoding the human IL-4 receptor. Int Immunol 1990; 2: 669–675
  • Bazan J. F. Haemopoietic receptors and helical cytokines. Immunol Today 1990; 11: 350–356
  • Ruhl S., Feldman G. M., Akahane K., et al. Soluble IL-4 receptor production by murine myeloid cells: Induction by IL-6 and IFN-γ. Cytokine 1993, (in press)
  • Fernandez-Botran R., Vitetta E. S. A soluble, high affinity, interleukin-4-binding protein is present in the biological fluids of mice. Proc Natl Acad Sci USA 1990; 87: 4202–4206
  • Fanslow W. C., Clifford K., Vanden Box T., et al. A soluble form of the IL-4 receptor in biological fluids. Cytokine 1990; 2: 298–301
  • Jacobs C. A., Lynch D. H., Roux E. R., et al. Characterization and pharmacokinetics parameters of soluble Interleukin 4 receptor. Blood 1991; 7: 2396–2403
  • Fanslow W. C., Clifford K. N., Rubin A. S., et al. Regulation of al-loreactivity in vivo by IL-4 and the soluble IL-4 receptor. J Immunol 1991; 147: 535–540
  • Bosco M., Giovarelli M., Forni M., et al. Low doses of IL4 injected perilymphatically in tumor-bearing mice inhibit the growth of poorly and apparently nonimmunogenic tumors and induce a tumor-specific immune memory. J Immunol 1990; 145: 3136–3143
  • Tepper R. I., Pattengale P. K., Leder P. Murine Interleukin 4 displays potent antitumor activity in vivo. Cell 1989; 57: 503–512
  • Li W., Diamantstein T., Blakenstein T. Lack of tumorigenicity of intereleukin 4 autocrine growing cells seems related to the anti-tumor function of interleukin 4. Mol Immunol 1990; 27: 1331–1337
  • Golumbek P. T., Lazenby J. A., Levitsky H. I., et al. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 1991; 254: 713–716
  • Akashi K., Shibuya T., Harada M., et al. Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells. J Clin Invest 1991; 88: 223–230
  • Luo H., Rubio M., Biron G., et al. Antiproliferative effect of interleukin-4 in B chronic lymhocytic leukemia. J Immunother 1991; 10: 418–425
  • Carlsson M., Sundstrom C., Bentsson M., et al. IL-4 strongly augments or inhibits DNA synthesis and differentiation of B-type chronic lymphocytic leukemia cells depending on the co-stimulatory activation and progression signals. Eur J Immunol 1989; 19: 913–21
  • Mahar D. W., Pike B. L., Boyd A. W. The response of human B cells to interleukin 4 is determined by their stage of activation and differentiation. Scand J Immunol 1990; 32: 631–640
  • Andreef F. HM, Gruss H-J, Brach M. A., et al. Interleukin-4 inhibits growth of multiple myelomas by suppressing IL-6 expression. Blood 1991; 78: 2070–2074
  • Taylor C. W., Grogan T. M., Salmon S. E. Effects of Interleukin-4 on the in vitro growth of human lymphoid and plasma cell neoplasms. Blood 1990; 75: 1114–1118
  • Defrance T., Fluciger A-C, Rossi J-F, et al. Antiproliferative effects of IL-4 on freshly isolated non-Hodgkin malignant B-lymphoma cells. Blood 1992; 79: 990–996
  • Tony H-P, Lehrnbecher T., Merz H., et al. Regulation of IL-4 responsiveness in lymphoma B cells. Leukemia Res 1991; 15: 911–919
  • Totpal K., Aggarwal B. B. Interleukin 4 potentiates the antipro-liferative effects of tumor necrosis factor on various tumor cell lines. Cancer Res 1991; 51: 4266–4270
  • Imai Y., Nara N., Tohda S., et al. Antiproliferative and differentiative effects of recombinant interleukin-4 on a G-CSF-stimulating-dependent tnyeloblastic leukemic cell line. Blood 1991; 78: 471–478
  • Al Jabaari B., Ladyman H. M., Larche M., et al. Elevated expression of the interleukin 4 receptor in carcinoma: A target for immunotherapy. Br J Cancer 1989; 59: 910–914
  • Hoon D. SB, Banex M., Okun E., et al. Modulation of human melanoma cells by interleukin-4 and in combination with γ-interferon or α-tumor necrosis factor. Cancer Res 1991; 51: 2002–2008
  • Hoon D. SB, Okun E., Banez M., et al. Interleukin 4 alone and with γ-interferon or tumor necrosis factor inhibits cell growth and modulates cell surface antigens on human renal cell carcinomas. Cancer Res 1991; 51: 5687–5693
  • Toi M., Bicknel R., Harris A. L. Inhibition of colon and breast carcinoma cell growth by interleukin-4. Cancer Res 1992; 52: 275–279
  • Ohara J. Interleukin 4: Molecular structure and biochemical characteristics, biological function and receptor expression. The Year in Immunology. Immunoregulatory Cytokines and Cell Growth, Vol 5, J. M. Cruse, R. E. Lewis, Jr. Karger, Basel 1989; 126–159
  • Lotze M. T. In vivo administration of recombinant human interleukin 4 to patients with cancer. J Cell Biochem 1991; 33(Suppl F), (abstract)
  • Markowitz A., Kleinerman E., Hudson M., et al. Phase I study of recombinant IL-4 in patients with advanced cancer. Blood 1989; 74(Suppl)146a, (abstract)
  • Taylor C. W., Hultquist K. E., Taylo A. M., et al. Immunopharmacology of recombinant human interleukin-4 administered by the subcutaneous route in patients with malignancy. Blood 1992; 76(Suppl)221a, (abstract)
  • Sosman J. A., Ellis T., Bodner B., et al. A phase IA/1B trial of continuous infusion interleukin-4 alone and following interleukin-2 in cancer patients. Proc Am Assoc Cancer Res 1992; 33: 2070, (abstract)
  • Netaji B., Murphy S., Budd G. T., et al. Phase IA/IB trial of rIL-2 and rhuIL-4 in refractory malignancy. Proc Am Assoc Cancer Res 1991; 32: 1152, (abstract)
  • Whitehead R. P., Friedman K. D., Clark D. A. A phase I trial of subcutaneous interleukin 2 and interleukin 4. Proc Am Assoc Cancer Res 1992; 33: 1381, (abstract)
  • Freimann J., Estrov Z., Itoh K., et al. Phase I studies of recombinant interleukin-4 in patients with hematologic malignancies. Blood 1990; 76(Suppl)93a, (abstract)
  • Maher D., Boyd A., McKendrick J., et al. Rapid response of B cell malignancies induced by interleukin 4. Blood 1990; 76(Suppl)152a, (abstract)

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