References
- Yarosh D. The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis. Mutat Res 1985; 145: 1–16
- Pegg A. Mammalian O6-alkylguanine-DNA alkytransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 1990; 50: 6119–6129
- Aida T, Bodell W. Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum (II) in human glial-derived cell lines. Cancer Res 1987; 47: 1361–1366
- Fornace A, Papathanasiou M, Hollander M. Expression of the O6methylguanine-DNA methyltransferase gene MGMT in Mer + and Mer-human tumor cells. Cancer Res 1990; 50: 7908–7911
- Watatani M, Lkenage M, Hatanaka T. Analysis of MNNG induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer-xeno-grafts in athymic nude mice. Carcinogenesis (Lond) 1985; 6: 549–553
- Brent T, Houghton P, Houghton J. O6-alkylguanine-DNA alkyl-transferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to CNNU. Proc Natl Acad Sci USA 1985; 82: 2985–2989
- Fujio C, Chang H, Tsujimura T. Hypersensitivity of human tumor xenografts lacking O6-alkylguanine-DNA alkyltransferase to the antitumor agent ACNU. Carcinogenesis (Lond) 1989; 10: 351–356
- Peters W P, Shpall E J, Jones R B. High dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer. J Clin Oncol 1988; 6: 1368–1376
- Rudiger Schwartz H. U, Serrand E. Reduced O-methyl-guanine repair in fibroblast cultures from patients with lung cancer. Cancer Res 1989; 49: 5623–5626
- Belinsky S A, Foley J F, White C M. Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4–(methylnitro-samino)-l-(3-pyridyl)-1-butanone. Cancer Res 1990; 50: 3772–3780
- Citron M, Decker S, Chen S. O6-Methylguanine-DNA-methyltransferase in human normal and tumor tissue from brain, lung, and ovary. Cancer Res 1991; 51: 4131–4134
- Grafstrom R C, Pegg A E, Trump B F. O6-Alkylguanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res 1984; 44: 2855–2857
- Selawry O S. Chemotherapy in lung cancer. Lung Cancer, M Straus. Crune & Stratton, New York 1977; 199–221
- Myrnes B, Norstrand K, Giercksky K E. A simplified assay for O6-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues. Car-cinogenesis 1984; 5: 1061–1064
- Redmond S, Joncourt F, Buser K. Assessment of P-gly-coprotein, glutathione-based detoxifying enzymes and O6-alkyl-guanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors. Cancer Res 1991; 51: 2092–2097
- Sagher D, Kamson T, Schwartz J. Low O6-alkyIguanine-DNA alkyltransferase activity in the peripheral blood lymphocytes of patients with therapy-related acute nonlymphocytic leukemia. Cancer Res 1988; 48: 3084–2089
- Yarosh D B, Scudiero D, Yai A. T. Human tumor cell strains both unable to repair O6-methylguanine and hypersensitive to killing by human alpha and beta interferons. Carcinogenesis 1985; 6: 883–886
- Panella T I, Schold S C, Winer E P. Modulation of O6-kylguanine-DNA alkyltransferase (O6-AGAT) mediated BCNU resistance using streptozotocin: A phase I study. Proc Am Soc Clin Oncol 1991; 10: 96
- Dolan M E, Mitchell R B, Mumment C. Effect of O6-ben-zylguanine analogs on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res 1991; 51: 3367–3372