Biochemical Modulation of Tumor Cell Energy in Vivo: II. A Lower Dose of Adriamycin is Required and a Greater Antitumor Activity is Induced when Cellular Energy is Depressed

References

• Stolfi RL, Colofiore JR, Nord LD, Koutcher JA, Martin DS. Biochemical modulation of tumor cell energy. I. Regression of advanced, spontaneous murine breast tumors with a 5-fluorouracilcontaining drug combination. Cancer Res 1992; 52: 4074–4081
   PubMed Web of Science ®Google Scholar
• Martin DS, Stolfi RL, Sawyer RC, Spiegelman S, Casper ES, Young CW. Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: A murine study with clinical relevance. Cancer Res 1983; 43: 2317–2321
   PubMed Web of Science ®Google Scholar
• Martin DS, Stolfi RL, Sawyer RC, Nayak R, Spiegelman S, Young C, Woodcock T. An overview of thymidine. Cancer 1980; 45: 1117–1128
   PubMed Web of Science ®Google Scholar
• Martin DS, Stolfi RL, Sawyer RC, Nayak R, Spiegelman S, Schmid F, Heimer R, Cadman E. Biochemical modulation of 5-fluorouracil and cytosine arabinoside with emphasis on thymidine, PALA and 6-methylmercaptopurine riboside. Nucleosides and Cancer Treatment, NHN Tattersall, RM Fox. Academic Press, SydneyAustralia 1981; 339–382
   Google Scholar
• Ardalan B, Singh G, Silberman H. A randomized phase I and II study of fluorouracil with or without N- (phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers. J Clin Oncol 1988; 6: 1053–1058
   PubMed Web of Science ®Google Scholar
• O'Dwyer PJ, Paul AR, Walczak J, Weiner LM, Litwin S, Comis RL. Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer. J Clin Oncol 1990; 8: 1497–1500
   PubMed Web of Science ®Google Scholar
• Barry MA, Behnke CA, Eastman A. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 1990; 40: 2353–2362
   PubMed Web of Science ®Google Scholar
• Kyprianou N, Isaacs JT. “Thymineless” death in androgen-independent prostatic cancer cells. Biochem Biophys Res Commun 1989; 165: 73–81
   PubMed Web of Science ®Google Scholar
• Hyslop PA, Hinslaw DB, Halsey WA, Jr, Schraufstatter IU, Sauerheber RD, Spragg RG, Jackson JH, Cochrane CG. Mechanisms of oxidant-mediated injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem 1988; 263: 1665–1675
   PubMed Web of Science ®Google Scholar
• Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RH, Cocrane CG. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 1986; 77: 1312–1320
   PubMed Web of Science ®Google Scholar
• Boobis AR, Fawthrop DJ, Davies DS. Mechanism of cell death. Trends in Pharmacological Sciences 1989; 10: 275–280
   PubMed Web of Science ®Google Scholar
• Berger NA, Berger SJ, Gerson SL. DNA repair, ADP ribosylation and pyridine nucleotide metabolism as targets for cancer chemotherapy. Anti-cancer Drug Design 1987; 2: 203–210
   PubMedGoogle Scholar
• Schraufstatter IU, Hinshaw PA, Hyslop RG, Spragg RG, Cochrane CG. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells. J Clin Invest 1985; 76: 1471–1476
   PubMedGoogle Scholar
• Orrenius S, McConkey DJ, Bellomo G, Nicotera P. Role of Ca2+ in toxic cell killing. Trends in Pharmacological Sciences 1989; 10: 281–285
   PubMed Web of Science ®Google Scholar
• Missiaen L, Wuytack F, Raeymaekers L, De Smedt H, Droogmans G, Declerck I, Casteels R. Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores. Pharmacol Ther 1991; 50: 191–232
   PubMed Web of Science ®Google Scholar
• Wielckins K, Delfs T. Glucocorticoid-induced cell death and poly adenosine diphosphate (ADP-ribosyl)ation: Increased toxicity of dexamethasone on mouse S491 lymphoma cells with the poly(ADP-ribosyl)ation inhibitor benzamide. Endocrinology 1986; 119: 2383–2392
   PubMed Web of Science ®Google Scholar
• McConkey DJ, Hartzell P, Orrenius S. Rapid turnover of endogenous activity in thymocytes. Effects of inhibitors of macromolecular synthesis. Arch Biochem Biophys 1990; 278: 284–287
   PubMed Web of Science ®Google Scholar
• Wyllie AH, Kerr J FR, Currie AR. Cell death: The significance of apoptosis. Int Rev Cytol 1980; 68: 251–306
   PubMedGoogle Scholar
• Arends MJ, Morris RG, Wyllie AH. Apoptosis: The role of the endonuclease. Am J Pathol 1990; 136: 593–608
   PubMed Web of Science ®Google Scholar
• Kaufmann SH. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res 1989; 49: 5870–5878
   PubMed Web of Science ®Google Scholar
• Tanizawa A, Kubota M, Hashimoto H. VP-16-induced nucleotide pool changes and poly (ADP-ribose) synthesis: The role of VP-16 in interphase death. Exp Cell Res 1989; 185: 237–246
   PubMed Web of Science ®Google Scholar
• Marks DI, Fox RM. DNA damage, poly (ADP-ribosyl)ation and apoptotic cell death as a potential common pathway of cytotoxic drug action. Biochem Pharmacol 1990; 42: 1859–1867
   Web of Science ®Google Scholar
• Stolfi RL, Martin DS, Fugmann RA. Spontaneous murine mammary adenocarcinoma: Model system for evaluation of combined methods of therapy. Cancer Chemother Rep 1971; 55: 239–251
   PubMedGoogle Scholar
• Martin DS, Fugmann RA, Stolfi RL, Hayworth PE. Solid tumor animal model therapeutically predictive for human breast cancer. Cancer Chemother Rep 1975; 5: 89–109, Part 2
   Google Scholar
• Goldin A, Venditti JM, MacDonald JS, Muggia F, Henney J, DeVita VT, Jr. Current results of the screening program at the Division of Cancer Treatment, National Cancer Institute. Eur J Cancer 1981; 17: 129–142
   PubMed Web of Science ®Google Scholar
• Nelson JA, Parks RE, Jr. Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto) purine riboside in sarcoma 180 cells. Cancer Res 1972; 32: 2034–2041
   PubMed Web of Science ®Google Scholar
• Scholar EM, Brown PR, Parks RE, Jr. Synergistic effect of 6-mercaptopurine and 6-methylmercapto-purine ribonucleoside on the levels of adenine nucleotides of sarcoma 180 cells. Cancer Res 1972; 32: 259–269
   PubMed Web of Science ®Google Scholar
• Warnick CT, Patterson A RP. Effect of methylthioinosine on nucleotide concentration in L5178 Y cells. Cancer Res 1973; 33: 1711–1715
   PubMed Web of Science ®Google Scholar
• Woods RA, Henderson RM, Henderson JF. Consequences of inhibition of purine biosynthesis de novo by 6-methylmercaptopurine ribonucleoside in cultured lymphoma L5178 cells. Eur J Cancer 1978; 14: 765–770
   PubMed Web of Science ®Google Scholar
• Atkinson DE (1969) Regulation of energy metabolism: Exploitable molecular mechanisms and neoplasia. The University of Texas MD Anderson Hospital and Tumor Institute at Houston, 22nd Annual Symposium on Fundamental Cancer Research. 1968. Williams & Wilkins, Baltimore, 397–413
   Google Scholar
• Dietrich LS, Kaplan LA, Friedland IM, Martin DS. Quantitative differences between tumor and host. VI. 6-Aminonicotinamide antagonism of DPN-dependent enzymatic systems. Cancer Res 1958; 18: 1272–1280
   PubMed Web of Science ®Google Scholar
• Martin DS, Dietrich LS, Shils ME. Quantitative biochemical differences between tumor and host as a basis for cancer chemotherapy. V. Niacin and 6-aminonicotinamide. Cancer Res 1957; 17: 600–604
   PubMed Web of Science ®Google Scholar
• Hunting D, Gowans B, Henderson JF. Effects of 6-aminonicotinamide on cell growth. Poly (ADP) ribose synthesis and nucleotide metabolism. Biochem Pharmacol 1985; 34: 3999–4003
   PubMed Web of Science ®Google Scholar
• Glock GE, McLean P. Levels of oxidized and reduced diphosphopyridine nucleotide and triphosphopyridine nucleotide in tumors. Biochem J 1957; 65: 413–416
   PubMed Web of Science ®Google Scholar
• Jedkien LA, Weinhouse S. Metabolism of neoplastic tissue. VI. Assay of oxidized and reduced diphosphopyridine nucleotide in normal and neoplastic tissues. J Biol Chem 1955; 213: 271–280
   PubMed Web of Science ®Google Scholar
• Morton RK. Enzymatic synthesis of coenzyme I in relation to chemical control of cell growth. Nature 1958; 18: 540–542
   Google Scholar
• Ackerman WW, Potter VR. Enzyme inhibition in relation to chemotherapy. Proc Soc Biol Med 1949; 72: 1–9
   PubMed Web of Science ®Google Scholar
• Gerlach JH, Kartner N, Bell DR, Ling V. Multidrug resistance. Cancer Surv 1986; 5: 26–46
   Google Scholar
• Versantvoort C HM, Broxterman HJ, Pinedo HM. Energy-dependent processes involved in reduced drug accumulation in multi-drug resistant human lung cancer cell lines without p-glycoprotein expression. Cancer Res 1992; 52: 17–23
   PubMed Web of Science ®Google Scholar
• Dano K. Active outward transport of daunorubicin in resistant Ehrlich ascites tumor cells. Biochim Biophys Acta 1973; 323: 466–483
   PubMed Web of Science ®Google Scholar
• Stolfi RL, Stolfi LM, Sawyer RC, Martin DS. Chemotherapeutic evaluation using clinical criteria in spontaneous, autochthonous murine breast tumors. J Natl Cancer Inst 1988; 80: 52–55
   PubMed Web of Science ®Google Scholar
• Lindahl T. DNA glycosylase, endonucleases for apurinic/apyrimidinic sites and base excision repair. Prog Nucleic Acids Res Mol Biol 1979; 22: 135–142
   PubMedGoogle Scholar
• Imlay J, Linn S. DNA damage and oxygen radical toxicity. Science 1988; 240: 1302–1309
   PubMed Web of Science ®Google Scholar
• Richter C, Park J, Ames B. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 1988; 85: 6465–6467
   PubMed Web of Science ®Google Scholar
• Sancar A, Sancar G. DNA repair enzymes. Annu Rev Biochem 1988; 57: 29–67
   PubMed Web of Science ®Google Scholar
• Kunkel TA, Loeb LA. Fidelity of mammalian DNA polymerases. Science 1981; 213: 765–767
   PubMed Web of Science ®Google Scholar
• Epstein RJ. Drug-induced DNA damage and tumor chemosensitivity. J Clin Oncol 1990; 8: 2062–2084
   PubMed Web of Science ®Google Scholar
• Lonn U, Lonn S. DNA lesions in human neoplastic cells and cytotoxicity of 5-fluoropyrimidines. Cancer Res 1986; 46: 3866–3870
   PubMed Web of Science ®Google Scholar
• Lonn U, Lonn S. Progressive formation of DNA lesions during treatment with antimetabolites without incorporation of the drugs into DNA. Mutat Res 1988; 200: 243–247
   PubMed Web of Science ®Google Scholar
• Hunting D, Hordern J, Henderson JF. Effects of altered ribonucleotide concentrations on ribonucleotide reduction in intact Chinese hamster ovary cells. Can J Biochem 1981; 59: 821–829
   PubMedGoogle Scholar
• Rosbe KW, Brann TW, Holden SA, Teicher BA, Frei E. Effect of lonidamine in the cytotoxicity of four alkylating agents in vitro. Cancer Chemother Pharmacol 1989; 25: 32–36
   PubMed Web of Science ®Google Scholar
• Cummings J, Anderson L, Willmott N, Smyth JF. The molecular pharmacology of doxorubicin in vivo. Eur J Cancer 1991; 27: 532–535
   PubMed Web of Science ®Google Scholar
• Long BH, Musial ST, Brattain MG. Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16–213 and UM26: A quantitative structure-activity relationship. Biochemistry 1984; 23: 1183–1188
   PubMed Web of Science ®Google Scholar
• Loike JD, Horwitz SB. Effect of VP16–213 on the intracellular degradation of DNA in HeLa cells. Biochemistry 1976; 15: 5443–5448
   PubMed Web of Science ®Google Scholar
• Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF, Sikorska M. Topoisomerase II-reactive chemotherapeutic drugs induced apoptosis in thymocytes. Cancer Res 1991; 51: 1078–1085
   PubMed Web of Science ®Google Scholar
• Ross G, Brown R. The role of DNA repair processes in determining response to cancer therapy. Eur J Cancer 1992; 28: 281–285
   PubMedGoogle Scholar
• Whitaker SJ. DNA damage by drugs and radiation: What is important and how is it measured. Eur J Cancer 1992; 28: 273–276
   PubMedGoogle Scholar
• Rubin E, Kharbanda S, Gunji H, Weichselbaum R, Kufe D. Cis-diammine dichloroplatinum (II) induces c-jun expression in human myeloid leukemia cells: Potential involvement of a protein kinase C-dependent signaling pathway. Cancer Res. 1992; 52: 878–882
   PubMed Web of Science ®Google Scholar
• Hayaishi O, Veda K. Poly- and mono (ADP-ribosyl)ation reactions. Their significance in molecular biology. ADP-Ribosylation Reactions. Biology and Medicine, O Hayaishi, K Veda. Academic Press, New York 1982; 3–16
   Google Scholar
• Martin SJ, Cotter TG. Disruption of microtubules induces an endogenous suicide pathway in human leukemia HL-60 cells. Cell Tissue Kinet 1990; 23: 545–559
   PubMedGoogle Scholar
• Gunj H, Kharbanda S, Kufe D. Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by I-B-D-arabinofuranosylcytosine. Cancer Res 1991; 51: 741–743
   PubMed Web of Science ®Google Scholar
• Fornace A, Nebert D, Hollnader M EA. Mammalian genes regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol 1989; 9: 4196–4203
   PubMed Web of Science ®Google Scholar
• Sherman M, Datta R, Hallohan D EA. Ionizing radiation regulates the expression of the c-jun proto oncogene. Proc Natl Acad Sci USA 1990; 87: 5663–5666
   PubMed Web of Science ®Google Scholar
• Hollander MC, Fornace AJ, Jr. Induction of fos RNA by DNA-damaging agents. Cancer Res 1989; 49: 1687–1692
   PubMed Web of Science ®Google Scholar
• Alnemri ES, Fernandes TF, Haldar S, Croce CM, Litwack G. Involvement of BCl-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias. Cancer Res 1992; 52: 491–495
   PubMed Web of Science ®Google Scholar
• McConkey DJ, Orrenius S, Johndal M. Cellular signalling in programmed cell death (apoptosis). Immunol Today 1990; II(4)120–121
   Google Scholar
• Lennon SV, Martin SJ, Cotter TG. Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif 1991; 24: 203–214
   PubMed Web of Science ®Google Scholar
• Bursch W, Paffe B, Putz G, Schulte-Hermann R. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 1990; 11: 847–856
   PubMed Web of Science ®Google Scholar
• O'Connor PM, Wassermann K, Sarong M, Magrath I, Bohr VA, Kohn KW. Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard. Cancer Res 1991; 51: 6550–6557
   PubMed Web of Science ®Google Scholar
• Kuo MT, Hsu TC. Bleomycin causes release of nucleosomes from chromatin and chromosomes. Nature 1978; 271: 83–34
   PubMed Web of Science ®Google Scholar
• Berger NA, Catino DM, Vietti TJ. Synergistic antileukemic effect of 6-aminonicotinamide and 1,3-bis (2-chloroethyl)-l-nitrosourea on L1210 cells in vitro and in vivo. Cancer Res 1982; 42: 4382–4386
   PubMed Web of Science ®Google Scholar
• Piacentini M, Fesus L, Farrace MG, Ghiubelli L, Piredda L, Melino G. The expression of “tissue” transglutaminase in two human cancer cell lines is related with the programmed cell death (apoptosis). Eur J Cell Biol 1991; 54: 246–254
   PubMed Web of Science ®Google Scholar
• Brune B, Hartzell P, Nicotera P, Orrenius S. Spermine prevents endonuclease activation and apoptosis in thymocytes. Exp Cell Res 1991; 195(2)323–329
   PubMed Web of Science ®Google Scholar
• Warters RL. Radiation-induced apoptosis in a murine T-cell hybridoma. Cancer Res 1992; 52: 883–890
   PubMed Web of Science ®Google Scholar
• Duvall E, Wyllie AH. Death and the cell. Immunol Today 1986; 7(4)115–119
   PubMedGoogle Scholar
• Kerr J FR, Harmon BV. Definition and incidence of apoptosis: An historical perspective. Apoptosis: The Molecular Basis of Cell Death, LD Tomei, FO Cope. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 1991; 5–29
   Google Scholar
• Szende B, Schally AV, Conaru-Schally AM. Cellular and molecular aspects of apoptosis in experimental tumors of animals treated with analogs of LHRH and somatostatin. Apoptosis: The Molecular Basis of Cell Death, LD Tomei, FO Cope. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 1991; 139–155
   Google Scholar
• Iversen OH. Kinetics of cellular proliferation and cell loss in human carcinomas. A discussion of methods available for in vivo studies. Eur J Cancer 1967; 3: 389–394
   PubMedGoogle Scholar
• Refsum SB, Berdal P. Cell loss in malignant tumors in man. Eur J Cancer 1967; 3: 235–236
   PubMedGoogle Scholar
• Steel GG. Cell loss as a factor in the growth rate of human tumors. Eur J Cancer 1967; 3: 381–387
   PubMedGoogle Scholar
• Frindel E, Malaise E, Tubiana M. Cell proliferation kenetics in five human solid tumors. Cancer 1968; 22: 611–620
   PubMed Web of Science ®Google Scholar
• Laird AK. Dynamics of growth in tumors and in normal organisms. Human Tumor Cell Kinetics National Cancer Institute Monograph 30, S Perry. National Cancer Institute, Bethesda, MD 1969; 15–28
   Google Scholar
• Lala PK. Evaluation of the mode of cell death in Ehrlich ascites tumor. Cancer 1972; 29: 261–266
   PubMed Web of Science ®Google Scholar
• Kerr JF, Bishop CJ, Searle J. Apoptosis. Recent Adv Histopathol 1984; 12: 1–16
   Google Scholar