6
Views
11
CrossRef citations to date
0
Altmetric
Original Article

A Phase II Study of Continuous Infusion of Trimetrexate in Patients with Refractory Acute Leukemia

, , , , &
Pages 36-40 | Published online: 11 Jun 2009

References

  • Bertino J R, Sawicki W L, Moroson B A. 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino) methyl) quinazoline (TMQ), a potent non-classical folate antagonist inhibitor-1. Biochem Pharmacol 1979; 28: 1983–1987
  • Lin J T, Bertino J R. Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties. Cancer Invest 1991; 9(2)159–172
  • Kamen B A, Eibl B, Cashmore A R. Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5 methyl-6-((3,4,5-trimethoxy-anilino) methyl] quinazoline), a non-classical antifolate in meth-otrexate-resistant leukemia cells, in vitro. Biochem Pharmacol 1985; 33: 1697–1699
  • Fry D W, Besserer V A. Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates. Cancer Res 1988; 48: 6986–6991
  • Rodenhuis S, McGuine J J, Sawake W L, Bertino J R. Effect of methotrexate and of the “non classical” folate antagonist trimetrexate on human leukemia cells. Leukemia 1987; 1: 116–120
  • Mini E, Moroson B A, Franco C T, Bertino J R. Cytotoxic effects of folate antagonists against methotrexate-resistant human leuke-mic lymphoblast CCRF-CEM cell lines. Cancer Res 1985; 45: 325–330
  • Lin J, Tong W P, Trippett T M, Niedzwiecki D. Basis for natural resistance to methotrexate in human acute non-lympho-cytic leukemia. Cancer Res 1991; 15: 1191–1196
  • Ohnoshi T, Ohnuma T, Takahaashi I, Scanlon K. Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists. Cancer Res 1982; 42: 1655–1660
  • Balis F M, Lester C M, Poplack D G. Pharmacokinetics of trimetrexate (NSC352122) in monkeys. Cancer Res 1986; 46: 169–174
  • Balis F M, Patel R, Luks E, Doherty K M. Pediatric phase I trial and pharmacokinetic study of trimetrexate. Cancer Res 1987; 47: 4973–4976
  • Fanucchi M P, Walsh T D, Fleisher M, Lokos G. Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks. Cancer Res 1987; 47: 3303–3308
  • Stewart J A, McCormack J J, Tong W P, Low J B. Phase I clinical and pharmacokinetic study of trimetrexate using a daily X5 schedule. Cancer Res 1988; 48: 5029–5035
  • Sanders J, Ducore J, Kamen B. A pediatric phase I trial of trimetrexate (TMTX) in children with acute leukemia and solid tumors. Proc Am SOC Clin Oncol 1987; 644, (abstract)
  • Rosen M, Ohnuma T, Zimet A. Phase I study of trimetrexate (TMTX, TMQ. JB-11) glucuronate in a 5 day infusion schedule. Proc Am Assoc Cancer Res 1986; 27: 172, (abstract)
  • Bishop J F, Raghavan D, Olver I N, Reece P. A phase I study of trimetrexate (NSC 352122) administered by 5-day continuous intravenous infusion. Cancer Chemother Pharmacol 1989; 24: 246–250
  • Pappo A, Dubowy R, Ravindranath Y, Alvarado C. Phase II trial of trimetrexate in the treatment of recurrent childhood acute lymphoblastic leukemia: A Pediatric Oncology Group study. J Natl Cancer Inst 1990; 82(20)164–1642
  • Ackerly C C, Hartshorn J, Tong W P, McCormack J. A rapid and sensitive method for determination of TMTX from biological fluid. J Liquid Chromatogr 1985; 125–134
  • Trippett T, Schlemmer S, Elisseyeff Y, Goker E. Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia. Blood 1992; 1158–1162
  • Allegra C J, Chabner B A, Tuzan C V, Araakaki D O. Trimetrexate for the treatment of pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. N Engl JMed 1987; 317: 978–985
  • Armstrong R D, Vera R, Snyder L, Cadman E. Enhancement of 6-thioguanine cytotoxic activity with methotrexate. Biochem Biophys Res Commun 1982; 109: 595–601
  • Bokkemik J PM, Bakker M AH, Hulscher T W, Abrev R A. Sequence time and dose dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts. Biochem Pharmacol 1986; 35: 3549–3555
  • Conti J A, Kemeny N, Goker E, Tong W. A phase I trial of sequential trimetrexate, fluorouracil and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma. Proc Am SOC Clin Oncol 1993; 12: 567, (abstract)
  • Tan C, Trippett T, Tong W, Vansyckle K. A pharmacologic guided trial of sequential methotrexate (MTX) and 6-thioguanine (6-TC). Proc Am Assoc Cancer Res 1992; 33: 209
  • Camitta B, Leventbal B, Lauer S, Shuster J J. Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: A Pediatric Oncology Group study. J Clin Oncol 1989; 7: 1539–1544

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.