Boron Neutron Capture Therapy of Brain Tumors: Past History, Current Status, and Future Potential

References

• Advances in Neutron Capture Therapy, A H Soloway, R F Barth, D E Carpenter. Plenum Press, New York 1994
   Google Scholar
• Boron Neutron Capture Therapy, D Gabel, R Moss. Plenum Press, New York 1992
   Google Scholar
• Cancer Neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996
   Google Scholar
• Barth R F, Soloway A H, Fairchild R G, Brugger R M. Boron neutron capture therapy for cancer: Realities and prospects. Cancer 1992; 70: 2995–3007
   PubMed Web of Science ®Google Scholar
• Hawthorne M F. The role of chemistry in the development of boron neutron capture therapy of cancer. Angew Chem Int Ed Engl 1994; 32: 950–984
   Web of Science ®Google Scholar
• Dorn R V. Boron neutron capture therapy (BNCT): A radiation oncology perspective. Int J Radiat Oncol Biol Phys 1994; 28: 1189–1201
   PubMed Web of Science ®Google Scholar
• Hatanaka H, Kamano S, Amano K, . Clinical experience of boron-neutron capture therapy for glionias:a comparison with conventional chemo-immuno-radio-therapy. Boron Neutron Capture Therapy for Tumors, H Hatanaka, et al. Nishimura Co., Niigata, Japan 1986; 349–378
   Google Scholar
• Hatanaka H. Boron neutron capture therapy for tumors. Glioma, A BMF Karim, E Laws. Springer Verlag, New York 1991; 233–249
   Google Scholar
• Hatanaka H, Nakagawa Y. Clinical results of long-surviving brain tumor patients who underwent boron capture therapy. Int J Radiat Oncol Biol Phys 1994; 28: 1061–1066
   PubMed Web of Science ®Google Scholar
• Mishima Y, Ichihashi M, Tsuji M, et al. Treatment of malignant melanoma by single thermal neutron capture therapy with melanoma-seeking 10B-compound. Lancet 1989; 2: 388–389
   PubMed Web of Science ®Google Scholar
• Mishima Y, Ichihashi M, Hatta S, et al. New thermal neutron capture therapy for malignant melanoma: Melanogenesis-seeking 10B molecule-melanoma cell interaction from in vitro to first clinical trial. Pigment Cell Res 1989; 2: 226–234
   PubMedGoogle Scholar
• Mishima Y, Honda C, Ichihashi M, . Selective melanoma thermal neutron capture therapy for lymph node metastases. Advances in Neutron Capture Therapy, A H Soloway, R F Barth, D E Carpenter, et al. Plenum Press, New York 1993; 705–710
   Google Scholar
• Davis M A, Little J B. Relative biological effectiveness of the 10B(n,α)7Li reaction in HeLa cells. Radiat Res 1970; 43: 534–553
   PubMed Web of Science ®Google Scholar
• Javid M, Brownell G L, Sweet W H. The possible use of neutroncapture isotopes such as boron-10 in the treatment of neoplasms. II. Computation of the radiation energy and estimates of effects in normal and neoplastic brain. J Clin Invest 1952; 31: 603–610
   Web of Science ®Google Scholar
• Tolpin El, Wellum G. R., Dohan F C, Jr, et al. Boron neutron capture therapy of cerebral gliomas. II. Utilization of the blood-brain barrier and tumor-specific antigens for the selective concentration of boron in gliomas. Oncology (Basel) 1975; 32: 223–246
   PubMed Web of Science ®Google Scholar
• Barth R F, Alam F, Soloway A H, . Delivery of boron-10 for neutron capture therapy by means of polyclonal and monoclonal antibodies: Progress and problems. Neutron Capture Therapy, H. Hatanaka, et al. Nishimura, NiigataJapan 1986; 8–16
   Google Scholar
• Gupta N, Gahbauer R A, Blue T E, Wambersie A. Dose prescription in boron neutron capture therapy. Int J Radiat Oncol Biol Phys 1994; 28: 1157–1166
   PubMed Web of Science ®Google Scholar
• Hiratsuka J, Fukuda H, Kobayashi T, et al. The relative biological effectiveness of 10B-neutron capture therapy for early skin reaction in the hamster. Radiat Res 1991; 128: 186–191
   PubMed Web of Science ®Google Scholar
• Fukuda H, Kobayashi T, Matsuzawa T, et al. RBE of a thermal neutron beam and the 10(Bn,α)7Li reaction on cultured B-16 melanoma cells. Int J Radiat Biol 1987; 1: 167–175
   Google Scholar
• Gahbauer R A, Fairchild R G, Goodman J H, Blue T E. RBE in normal tissue studies. Boron. Neutron Capture Therapy, D. Gabel, R. Moss. Plenum Press, New York 1992; 123–128
   Google Scholar
• Solares G R, Guillermo C, Palano J. Zamenhof High resolution quantitative autoradiography and its application to microdosimetry of boron neutron capture therapy. Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy, R G Zamenhof, G R Solares, O K Harling. Advanced Medical Publishing, Madison, WI 1994; 13–27
   Google Scholar
• Ausserer W A, Ling Y -C, Chandra S, Morrison G H. Quantitative imaging of boron, calcium, magnesium, potassium, and sodium distributions in cultured cells with ion microscopy. Anal Chem 1989; 61: 2690–2695
   PubMed Web of Science ®Google Scholar
• Bendayan M, Barth R F, Gingras D, et al. Electron spectroscopic imaging for high resolution immunocytochemistry: Use of boronated protein A. J Histochem Cytochem 1989; 37: 573–580
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Kanda K. Analytical calculation of boron-10 dosage in cell nucleus for neutron capture therapy. Radiat Res 1982; 91: 77–94
   PubMed Web of Science ®Google Scholar
• Gabel D, Fosler S, Fairchild R G. The Monte Carlo simulation of the biological effect of the 10B(n,α)7Li reaction in cells and tissue and its implication for boron neutron capture therapy. Radiat Res 1987; 111: 14–25
   PubMed Web of Science ®Google Scholar
• Charlton D E. Energy deposition in small ellipsoidal volumes by high-LET particles: Application to thermal neutron Dosimetry. Int J Radiat Biol 1991; 59: 827–42
   PubMed Web of Science ®Google Scholar
• Wuu C S, Amols H I, Kliauga P. MicroDosimetry for boron neutron capture therapy. Radiat Res 1992; 130: 355–9
   PubMed Web of Science ®Google Scholar
• Kalend A M, Bloomer W D, Epperly W. Dosimetric consequences of 10B(n,α)Li reaction occurring at the cellular membrane. Int J Radiat Oncol Biol Phys 1995; 31: 171–178
   PubMed Web of Science ®Google Scholar
• Utsumi H, Ichihashi M, Kobayashi T, Elkind M R. Sublethal and potentially lethal damage repair on thermal neutron capture therapy. Pigment Cell Res 1989; 2: 337–42
   PubMedGoogle Scholar
• Rofstad E. Radiation biology of malignant melanoma. Acta Radiol 1986; 15: 1–10
   Google Scholar
• Leibel S A, Sheline G E. Radiation therapy for neoplasms of the brain. J Neurosurg 1987; 66: 1–22
   PubMed Web of Science ®Google Scholar
• Hatanaka H, Masuzawa T, Amano K, et al. Basic and clinical sludies on boroii-neutron capture therapy. Nippon Acta Neuropathol 1968; 9: 37–40
   Google Scholar
• Barth R F. Biologic considerations in targeting brain tumors for boron neutron capture therapy. Cancer neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996; 533–540
   Google Scholar
• Gavin P R, Wheeler F J, Huiskamp R, et al. Large animal normal tissue tolerance using an epithermal neutron beam and borocaptate sodium. Strahlenther Onkol 1993; 169: 48–51
   PubMedGoogle Scholar
• Gabel D. Radiobiological considerations concerning the development of compounds for boron neutron capture therapy. Strahlenther Oncol 1993; 169: 65–70
   PubMedGoogle Scholar
• Allen B J. Maximum therapeutic depth in thermal neutron capture therapy. Strahlenther Onkol 1993; 169: 34–41
   PubMedGoogle Scholar
• Mirkovic N, Meyn R E, Hunter N R, Milas L. Radiation-induced apoptosis in a murine lymphoma in vivo. Radiother Oncol 1994; 33: 11–16
   PubMed Web of Science ®Google Scholar
• Farr L E, Sweet W H, Robertson J S, et al. Neutron capture therapy with boron in the treatment of glioblastoma multiforme. Am J Roentgenol 1954; 71: 279–293
   Web of Science ®Google Scholar
• Asbury A K, Ojemann R G, Nielson S L, Sweet W H. Neuropathologic study of fourteen cases of malignant brain tumor treated by boron-10 slow neutron capture radiation. J Neuropathol Exp Neurol 1972; 31: 278–303
   PubMed Web of Science ®Google Scholar
• Spielvogel B F. Choose a new path: boron biologicals. Biotechnology in the Feed Industry, T D Lyons, K A Jacques. Nottingham University Press, Nottingham, UK 1994; 303–321
   Google Scholar
• Coderre J A, Bergland R, Chadha M, . Boron neutron capture therapy of glioblastoma multiforme using p-boronophenylalanine-fructose complex and epithermal neutrons. Cancer Neutron Capture Therapy, Y. Mishima, et al. Plenum Press, New York 1996; 553–562
   Google Scholar
• Snyder H R, Reedy A J, Lennary W J. Synthesis of aromatic boronic acids: Aldehyde boronic acids and a boronic acid analog of tyrosine. J Am Chem Soc 1958; 80: 835–838
   Web of Science ®Google Scholar
• Belkhou R, Abbé Ch J, Pham P, et al. Uptake and metabolism of boronophenylalanine in human uveal melanoma cells in culture. Relevance to boron neutron capture therapy of cancer cells. Amino Acids 1995; 8: 217–229
   PubMed Web of Science ®Google Scholar
• Zakharkin L I, Grefennikov A V, Luvov A I. Synthesis of some nitrogenous boron derivatives. Izv Akad Nauk SSSR Ser Khim 1970; 1: 106–112
   Google Scholar
• Petterson O -A, Olsson D, Lindström P, et al. Penetration and binding L- and D-carboranylalanine in human melanoma spheroids. Melanoma Res 1993; 3: 369–376
   PubMed Web of Science ®Google Scholar
• Yong J H, Barth R F, Wyzlic I M, et al. In vitro and in vivo evaluation of o-carboranylalanine as a potential boron delivery agent for neutron capture therapy. Anticancer Res 1995; 15: 2039–2044
   PubMedGoogle Scholar
• Fauchere J L, Do K Q, Jow P YC, Hansch C. Universally strong lipophilicity of “fat” or “super” amino acids, including a new reference value for glycine. Experientia 1980; 36: 1203–1204
   PubMedGoogle Scholar
• Wyzlic I M, Beeson J C, Soloway A H, . New unnatural boron-containing amino acids and peptides as potential delivery agents for neutron capture therapy. Cancer Neutron Capture Therapy, Y Mishima, et al. Plenum Press, New York 1966, in press
   Google Scholar
• Schinazi R F, Prusoff W H. Synthesis of 5–(dihydroxyboryl)-2′-deoxyuridine and related boron-containing pyrimidines. J Org Chem 1985; 50: 841–847
   Web of Science ®Google Scholar
• Yamamoto Y, Seko T, Nakamura H, Nemoto H. Synthesis of carborane-containing nucleoside bases. Heteroatom Chem 1992; 3: 239–244
   Web of Science ®Google Scholar
• Tjarks W, Anisuzzaman A KM, Liu L, et al. Synthesis and in vitro evaluation of boronated undine and glucose derivates for neutron capture therapy. J Med Chem 1992; 35: 1628–1633
   PubMed Web of Science ®Google Scholar
• Rong F G, Soloway A H, Ikeda S, Ives D H. Synthesis and biochemical activity of 5-tethered carborane-containing pyrimidine nucleosides as potential agents for DNA incorporation. Nucleosides Nucleotides 1995; 14: 1873–1887
   Google Scholar
• Kahl S B, Koo M S. Synthesis of tetrakis-carborane-carboxylate esters of 2,4-bis-(α,β-dihydroxyethyl)-deuteroporphyrin IX. J Chem Soc Chem Commun 1990; 24: 1769–1771
   Google Scholar
• Lemmen P, Werner B, Streicher B. Ether lipids as potential boron carriers for boron neutron capture therapy: Synthesis of rac-1–(9–0-carboranyl) nonyl-2-methyl-glycero-3-phosphocholine (B-Et-11-OMe). Advances in Neutron Capture Therapy, A H Soloway, R F Barth, D E Carpenter. Plenum Press, New York 1993; 297–300
   Google Scholar
• Scobie M, Threadgill M D. Synthesis of carbonne- containing nitroimidazole compounds via mild 1,3-dipolar cycloaddition. J Chem Soc Chem Commun 1992; 13: 939–941
   Google Scholar
• Fairchild R G, Kahl S B, Laster B H, et al. In vitro determination of uptake, retention, distribution, biological efficacy and toxicity of boronated compounds for neutron capture therapy: A comparison of porphyrins and sulfhydryl boron hydrides. Cancer Res 1990; 51: 4860–4865
   Google Scholar
• Kahl S B, Joel D D, Nawrocky M M, et al. Uptake of a certain nidocarboranyl porphyrins by human glioma xenografts in athymic nude mice and by syngeneic ovarian carcinomas in immunocompetent mice. Proc Natl Acad Sci USA 1990; 87: 7265–7269
   PubMed Web of Science ®Google Scholar
• Hill J S, Kahl S B, Kaye A H, et al. Selective tumor uptake of a boronated porphyrin in an animal model of cerebral glioma. Proc Natl Acad Sci USA 1992; 89: 1785–1789
   PubMed Web of Science ®Google Scholar
• Laster B H, Kahl S B, Warkentien L, Bond V P. In vivo studies in NCT with a boronated porphyrin and tumor growth delay as end point. Advances in Neutron Capture Therapy, A H Soloway, R F Barth, D E Carpenter. Plenum Press, New York 1993; 535–539
   Google Scholar
• Holley J L, Mather A, Wheelhouse R T, et al. Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate. Cancer Res 1992; 52: 4190–4195
   PubMed Web of Science ®Google Scholar
• Yuan Z M, Egorin M J, Rosen D M, et al. Cellular pharmacology of N1 and N8-aziridinyl analogues of spermidine. Cancer Res 1994; 54: 742–748
   PubMed Web of Science ®Google Scholar
• Marton L J, Pegg A E. Polyamines as targets for therapeutic intervention. Annu Rev Pharmacol Toxicol 1995; 35: 55–91
   PubMed Web of Science ®Google Scholar
• Hariharan J R, Wyzlic I M, Soloway A H. Synthesis of novel boron-containing polyamines—Agents for DNA targeting in neutron capture therapy. Polyhedron 1995; 14: 823–825
   Web of Science ®Google Scholar
• Hawthorne M F, Wiersema R J, Takasugi M. Preparation of tumor-specific boron compounds. 1. In vitro studies using boron-labeled antibodies and elemental boron as neutron targets. J Med Chem 1972; 15: 449–453
   PubMed Web of Science ®Google Scholar
• Barth R F, Johnson C W, Wei W -Z, et al. Neutron capture using boronated monoclonal antibody directed against tumor-associated antigens. Cancer Detect Prev 1982; 5: 315–323
   PubMedGoogle Scholar
• Alam F, Soloway A H, Barth R F. Boronation of antibodies with mercaptoundecahydro-c/oso-dodecaborale (2–) anion for potential use in boron neutron capture therapy. Int J Radiat Appl Instrum Part A 1987; 38: 503–506
   PubMedGoogle Scholar
• Barth R F, Alam F, Soloway A H, Adams D M, Steplewski Z. Boronated monocloncal antibody 17–1A for potential neutron capture therapy of colorectal cancer. Hybridoma 1986; 5: S43–S50
   PubMed Web of Science ®Google Scholar
• Barth R F, Adams D M, Soloway A H, et al. Boronated starburst dendrimer-monoclonal antibody as a potential delivery system for neutron capture therapy. Bioconjugate Chem 1994; 5: 58–66
   PubMed Web of Science ®Google Scholar
• Liu L, Barth R F, Adams D M, Soloway A H, Reisfeld R A. Bispecific antibodies as targeting agents for boron neutron capture therapy of brain tumors. J Hematother 1995; 4: 477–483
   PubMedGoogle Scholar
• Pak R H, Primus F J, Rickard-Dickson K J, et al. Preparation and properties of nido-carborane-specific monoclonal antibodies for potential use in boron neutron captures therapy for cancer. Proc Natl Acad Sci USA 1995; 92: 6986–6990
   PubMed Web of Science ®Google Scholar
• Libermann T A, Razon N, Bartal A D, et al. Expressionof epidermal growth factor receptors in human brain tumors. Cancer Res 1984; 44: 753–760
   PubMed Web of Science ®Google Scholar
• Wong A J, Bigner S H, Signer D D, et al. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA 1987; 84: 6899–6903
   PubMed Web of Science ®Google Scholar
• Epenetos A, Courtenay-Luck N, Pickering D, et al. Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen. Br Med J 1985; 280: 1463–1466
   Google Scholar
• Herlyn D, Bender H, Adachi K, . Monoclonal antibody targeting of epidermal growth factor receptor on human malignant gliomas. Monoclonal Antibodies and Applications, A Epenetos, et al. Chapman and Hall Medical, London 1993; 219–226
   Google Scholar
• Kalofonos H P, Pawlikowska T R, Hemingway A, et al. Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antiodies against epidermal growth factor receptor and placental alkaline phosphatase. J Nucl Med 1989; 30: 1636–45
   PubMed Web of Science ®Google Scholar
• Andersson A, Capala J, Carlsson J. Effects of EGF-dextran-tyrosine-131I conjugates on the clonogenic survival of cultured glioma cells. J Neuro-oncol 1992; 14: 213–223
   PubMed Web of Science ®Google Scholar
• Lindström A, Lundqvist H, Carlsson J. Distribution of 125I after administration of 125I-labeled epidermal growth factor-dextran conjugates in mice. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science. Acta Univ Upsaliensis, Uppsala, Sweden 1993; 428
   Google Scholar
• Carlsson J, Gedda L, Grönvik C, et al. Strategy for boron neutron capture therapy against tumor cells with over-expression of the epidermal growth factor-receptor. Int J Radiat Oncol Biol Phys 1994; 30(1)105–115
   PubMed Web of Science ®Google Scholar
• Capala J, Barth R F, Bendayan M, et al. Boronated epidermal growth factor as a potential targeting agent for boron neutron capture therapy of brain tumors. Bioconjugate Chem 1996; 7–15
   PubMed Web of Science ®Google Scholar
• Smith M D, Setiawan Y, Moore D E. Optimisation of drug anchor for ortho-carborane in reconstitution of low density lipoproteins for neutron capture therapy. Cancer Neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996; 143–150
   Google Scholar
• Shelly K, Feakes D A, Hawthorne M F, et al. Model studies directed toward the boron neutron capture therapy of cancer:boron delivery to murine tumors with liposomes. Proc Natl Acad Sci USA 1992; 89: 9039–9043
   PubMed Web of Science ®Google Scholar
• Feakes D A, Shelly K, Hawthorne M. Selective boron delivery to murine tumors by lipophilic species incorporated in the membranes of unilamellar liposomes. Proc Natl Acad Sci USA 1995; 92: 1367–1370
   PubMed Web of Science ®Google Scholar
• Richardson R B, Davies A G, Bourne S P. Radioimmunolocalisation of human brain tumours: Biodistribution of radiolabelled monoclonal antibody UJ13A. Eur J Nucl Med 1986; 12: 313–320
   PubMedGoogle Scholar
• Agamemnon A, Epenetos A, Snook D, et al. Limitations ol radiolabeled monoclonal antibodies for localization of human neoplasms. Cancer Res 1986; 46: 3183–3191
   PubMed Web of Science ®Google Scholar
• Lee Y, Bullard D E, Wikstrand C J, et al. Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration. Cancer Res 1987; 47, 1941–1946
   PubMedGoogle Scholar
• Neuwelt E A, Barnett P A, Hellström I, et al. Delivery of melanomaassocialed immunoglobulin monoclonal antibody and Fab fragments to normal brain utilizing osmotic blood-brain barrier disruption. Cancer Res 1988; 48: 4725–4729
   PubMed Web of Science ®Google Scholar
• Yang W, Barth R F, Carpenter D E, et al. Enhanced delivery of boronophenylalanine to brain tumors for neutron capture therapy by means of carotid injection and blood-brain barrier disruption. Neurosurgery 1996; 38: 985–992
   PubMed Web of Science ®Google Scholar
• Yang W, Barth R F, Rotaru J, et al. Enhanced survival of F98 glioma bearing rats following neutron capture therapy with either sodium borocaptate or boronophenylalanine and osmotic blood brain barrier disruption. Anticancer Res 1995; 15(5A)1659
   Google Scholar
• Yang Y, Barth R F, Rotaru J H, et al. Enhanced survival of F98 glioma bearing rats following boron neutron capture therapy with blood brain barrier disruption and intracarotid injection of boronophenylalanine. J Neuro-oncol 1996, in press
   Web of Science ®Google Scholar
• Barth R F, Rotaru J, Staubus A E, . Sodium borocaptate and boronophenylalanine alone or in combination as capture agents for BNCT of the F98 rat glioma. Cancer Neutron Capture Therapy, Y Mishima, et al. Plenum Press, New York 1996; 553–590
   Google Scholar
• Sweet W H, Soloway A H, Brownell G L. Studies relevant to slow neutron capture therapy of brain tumor. Acta Union Int Cancer 1960; 16: 1216–1219
   PubMedGoogle Scholar
• Sweet W H, Soloway A H, Brownell G L. Boron-slow neutron capture therapy of gliomas. Acta Radiol 1963; 1: 114–121
   Web of Science ®Google Scholar
• Farr L E, Haymaker W, Konikowski T, Lippincott S W. Effects of alpha particles randomly induced in the brain in the neutron-capture treatment of intracramal neoplasms. Int J Neurol 1962; 3: 564–576
   Google Scholar
• Farr L E, Robertson J S. Therapy with neutrons. Handb Med Radiol 1961; XI: 1–23
   Google Scholar
• Slatkin D N. A history of boron neutron capture therapy of brain tumors. Brain 1991; 114: 1609–1629
   PubMed Web of Science ®Google Scholar
• Proceedings of the First International Workshop on Accelerator-based Neutron Sources for Boron Neutron Capture Therapy. US Department of Energy Conference Report CONF-940976, D Nigg. 1994
   Google Scholar
• Fairchild R G, Kalef-Ezra J A, Firaman S, et al. Optimization of an epithermal beam for NCT at the Brookhaven Medical Research Reactor (BMRR). Stralenther Onkol 1989; 165: 84–86
   Web of Science ®Google Scholar
• Brugger R M, Less T D. A progress report. Neutron Capture Therapy, H Hatanaka. Nishimura Co., NiigataJapan 1986; 110–116
   Google Scholar
• Fairchild R F, Kalef-Ezra J A, Saraf S K, . Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR). neutron Beam Design, Devel-opment and Performance for neutron Capture Therapy, O K Harling, J A Bernard, R G Zamenhof, et al. Plenum Press, New York 1990; 185–189
   Google Scholar
• Wheeler F J, Parsons D K, Nigg D W, . Physics design for the Brookhaven Medical Research development and performance for NCT. Neutron Beam Design, Development and Performance for Neutron Capture Therapy, O K Harling, J A Bernard, R G Zamenhof, et al. Plenum Press, New York 1990; 83–95
   Google Scholar
• Choi J R, Clement S D, Harling O K, . neutron capture therapy beams at the MIT research reactor. Neutron Beam Design, Development and Performance for neutron capture Therapy, O K Harling, J A Bernard, R G Zamenhof, et al. Plenum Press, New York 1990; 201–218
   Google Scholar
• Clement S D, Choi J R, Zamenhof R G, . Monte Carlo methods of neutron design for neutron capture therapy at the MIT research reactor (MITR-II). neutron Beam Design, Development and Performance for neutron capture Therapy, O K Harling, J A Bernard, R G Zamenhof, et al. Plenum Press, New York 1990; 51–69
   Google Scholar
• Moss R L. Progress towards boron neutron capture therapy at the high flux reactor Petten. Neutron Beam Design, Development and Performance for Neutron Capture Therapy, O K Harling, J A Bernard, R G Zamenhof. Plenum Press, New York 1990; 169–183
   Google Scholar
• Wheeler F J, Wessol D E, Babcock R. Improvements in patient treatment planning systems. Cancer neutron Capture Therapy, Y Mishima, 1996; 289–294
   Google Scholar
• Wallace S A, Allen B J, Mathur J N. Monte Carlo neutron photon treatment planning calculations: modelling from CT scans with variable voxel size. Cancer Neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996; 295–302
   Google Scholar
• Wierzbicki J G, Maruyama Y. Treatment planning methods with Cf-252 at the University of Kentucky. Nucl Sci Appl 1991; 4: 19–27
   Google Scholar
• Maruyama Y. Clinical radiobiology of Cf-252 for bulky tumor therapy. Nucl Sci Appl 1991; 4: 29–43
   Google Scholar
• Laramore G E (1994) Nonreactor sources of epithermal neutron beams for boron neutron capture therapy (BNCT): A user's perspective. Proceedings of the First International Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy. Sept 11–14, 1994, W Y Jackson. Vol I: 25–33, D Nigg. US Dept of Energy Conference Report CONF-940976
   Google Scholar
• Liu H B, Brugger R M. Upgrades of the epithermal neutron beam at the Brookhaven medical research reactor. Cancer Neutron Capture Therapy, Y Mishima, 1996; 343–356
   Google Scholar
• Harling O K. 1995, personal communication
   Google Scholar
• Joint Research Centre, Petten 1994, Annual Report. Operation of the High Flux Reactor
   Google Scholar
• Brugger R M, Shih J L, Liu H B. An epithermal neutron beam for neutron capture therapy at the Missouri University Research Reactor. Nucl Technol 1992; 98: 322–332
   Web of Science ®Google Scholar
• Less T J, Brugger R M. Reactor moderated intermediate neutron beams for neutron capture therapy. Strahlenther Onkol 1989; 165: 87–90
   PubMed Web of Science ®Google Scholar
• Matsumoto T, Liu H B, Brugger R M. Design of epithermal neutron beams using spent fuel elements at the Mushahi reactor. Cancer Neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996; 419–424
   Google Scholar
• Anterinem I, Hiismaki P. Construction of the epithermal BNCT station at the FIPI. Abstracts of Sixth International Symposium on Cancer neutron Capture Therapy, KobeJapan, Oct 31-Nov. 4, 1994; 64
   Google Scholar
• Su L, Liu Y -WH, Peir J -J, . Epithermal neutron beam design for neutron capture therapy at Tsing Hua open-pool reactor. Cancer neutron Capture Therapy, Y Mishima, et al. Plenum Press, New York 1996; 337–342
   Google Scholar
• Liu H -M. Epithermal-neutron beam design for neutron capture therapy at the Tsing-Hua Open Pool Reactor (THOR). Cancer Neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996; 385–392
   Google Scholar
• Yamada T. 1994, personal communication
   Google Scholar
• Dreweil N H, Lawrence C B, KcKeown J, (1994) 600 kW electron-beam power for boron neutron capture therapy with IMPELA. Proceedings of the First International Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy. Sept. 11–14, 1994, D Nigg, et al. 67–77, Jackson, Wyoming, US Department of Energy Conference Report CONF-940976
   Google Scholar
• Klee K A, Karam R A. Conceptual design for an epithermal neutron beam facility at the Georgia Tech Research Reactor. Cancer Neutron Capture Therapy, Y Mishima. Plenum Press, New York 1996; 357–364
   Google Scholar
• Sweet W H, Soloway A H, Brownell G L. Boron-slow neutron capture therapy of gliomas. Acta Radiologica 1963; 1: 114–121
   Web of Science ®Google Scholar
• Slatkin D N. A history of boron neutron capture therapy of brain tumors. Brain 1991; 114: 1696–1629
   Google Scholar
• Laramore G E, Spence A, Boron M. neutron capture therapy (BNCT) for high grade gliomas of the brain A cautionary note. Int J Radiat Oncol Biol Phys, in press
   Google Scholar
• Curran W J, Jr, Scott C B, Horton J, et al. Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials. J Natl Cancer Inst 1993; 85: 704–710
   PubMed Web of Science ®Google Scholar
• Takagaki M, Oda Y, Koda Y, . Effectiveness of borocaptate sodium for boron neutron capture therapy in malignant brain tumors. Cancer Neutron Capture Therapy, Y. Mishirna, et al. Plenum Press, New York 1996; 571–578
   Google Scholar
• Stragliotto G, Fankhauser H. Biodistribution of boron sulfhydryl for boron neutron capture therapy in patients with intracranial tumors. Neurosurgery 1995; 36: 285–293
   PubMed Web of Science ®Google Scholar
• Haritz D, Gabel D, Huiskamp R. Clinical phase-I study of NA2B12H11SH(BSH) in patients with malignant glioma as precondition for boron neutron capture therapy (BNCT). Int J Radiat Oncol Biol Phys 1994; 28: 1175–1181
   PubMed Web of Science ®Google Scholar
• Haselsberger K, Radner H, Pendl G. Boron neutron capture therapy: Boron biodistribution and pharmacokinetics of Na2,B12H11SH in patients with glioblastoma. Cancer Res 1994; 54: 6318–6320
   PubMed Web of Science ®Google Scholar
• Ceberg C P, Persson A, Brun A, et al. Performance of sulfhydryl boron hydride in patients with grade III and IV astrocytoma: a basis for boron neutron capture therapy. J Neurosurgery 1995; 83: 79–85
   PubMed Web of Science ®Google Scholar
• Watkins P, Harker Y, Amaro C. Nuclear characterization of the HFR Petten BNCT facility. Advances in Neutron Capture Therapy, edited by AH Soloway, R F Barth, D E Carpenter. Plenum Press, New York 1993; 59–65
   Google Scholar
• Coderre J A, Glass J D, Fairchild R G, et al. Selective delivery of boron by the melanin precursor analogue p-boronopheny-lalanine to tumors other than melanoma. Cancer Res 1990; 50: 138–141
   PubMed Web of Science ®Google Scholar
• Coderre J A, Joel D D, Micca P L, et al. Control of intracerebral gliomsarcomas in rats by boron neutron capture therapy with p-boronophenylalanine. Radiat Res 1992; 129: 290–296
   PubMed Web of Science ®Google Scholar
• Saris S C, Solares G R, Wazer D E, et al. Boron neutron capture therapy for murine malignant gliomas. Cancer Res 1992; 52: 4672–4677
   PubMed Web of Science ®Google Scholar
• Matalka K Z, Bailey M Q, Barth R F, et al. Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent. Cancer Res 1993; 53: 3308–3313
   PubMed Web of Science ®Google Scholar
• Matalka K Z, Bailey M Q, Barth R F, et al. Boron neutron capture therapy of a rat glioma using boronphenylalanine as a capture agent. Radiat Res 1994; 137: 44–51
   PubMed Web of Science ®Google Scholar
• Barth R F, Matalka K Z, Bailey M Q, et al. A nude rat model for neutron capture therapy of human inlracerebral melanoma. Int J Radiat Oncol Biol Phys 1994; 28(5)1079–1088
   PubMed Web of Science ®Google Scholar
• Coderre J A, Button T M, Micca P L, et al. Neutron capture therapy of the 9L gliosarcoma using the p-boronophenylalanine-fructose complex. Int J Oncol Biol Phys 1994; 30: 643–652
   PubMed Web of Science ®Google Scholar
• Codcrre J A, Bergland R, Capala J, et al. Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results. J Neuro-oncol 1997, in press
   Google Scholar
• Zamenhof R, Harling O, Wazer D, et al. Proceedings of an invited review panel to comment on the proposed NEMC/MIT clinical protocol for phase-1 BNCT studies. Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy. Advanced Medical Publishing, Madison, WI 1994; 67–79
   Google Scholar
• Nigg D W, Wheeler F J, Wessol D E, et al. Radiation physics and treatment planning for boron neutron capture therapy of glioblastoma multiforme. J Neuro-oncol 1997, in press
   PubMedGoogle Scholar
• Bendel P, Zilberstein J, Salomon Y. In vivo detection of a boron-neutron-capture agent in melanoma by proton observed 1H-10B double resonance. Magn Reson Med 1994; 32: 170–174
   PubMed Web of Science ®Google Scholar
• Bradshaw K M, Schweizer M P, Glover G H. BSH distributions in the canine head and a human patient using 11B MRI. Magn Reson Med 1995; 34: 48–56
   PubMed Web of Science ®Google Scholar
• Harling O K, Rogus R, Choi J R. Dosimetry and dose control for clinical trials of neutron capture therapy at the MITR-II reactor. Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy. Advanced Medical Publishing, Madison, WI 1994; 67–79
   Google Scholar
• Wheeler F J, Nigg D W. Three dimensional radiation distribution analysis for boron neutron capture therapy. Nucl Sci Eng 1992; 110: 16–31
   Web of Science ®Google Scholar