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Original Article

Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs

, &
Pages 509-527 | Published online: 11 Jun 2009

References

  • Smith P K. Certain aspects of Ihe pharmacology of the salicylates. Pharmacol Rev 1949; 1: 353–382
  • Lewis A J, Furst D W. Steroid Anti-inflammatory Drugs. Mechanism and Clinical Use. Marcel Dekker, New York 1987
  • Laska E M, Sunshine A, Mueller F, et al. Caffeine as an analgesic adjuvant. JAMA 1984; 251: 1711–1718
  • Gotzsche P C. Review of dose-response studies of NSAIDs in rheumatoid arthritis. Dan Med Bull 1989; 36: 395–399
  • Foley K M. The treatment of cancer pain. N Engl J Med 1985; 313: 84–95
  • Takeda F. WHO cancer pain relief programme. Pain Res Clin Manage 1991; 4: 467–474
  • Kantor T G. Current modalities in arthritic diseases. Am J Med 1987; 83: 2–5
  • Jacobs J, Keyserling J A, Britton M, et al. The total cost of care and the use of pharmaceuticals in the management of rheumatoid arthritis: the Medi-Cal program. J Clin Epidemiol 1988; 41: 215–223
  • Preston S J, Arnold M H, Belter E M, et al. Comparative analgesic and anti-inflammatory properties of sodium salicylate and ace-tylsalicylic acid (aspirin) in rheumatoid arthritis. Br J Clin Pharmacol 1989; 27: 607–611
  • Gracely R H. Studies of pain in normal man. Textbook of Pain, P D Wall, R Melzack. Churchill Livingstone, Edinburgh 1994; 315–336
  • Raja S N, Meyer R A, Campbell J N. Peripheral mechanisms of somatic pain. Anesthesiology 1988; 168: 571–590
  • Dray A, Perkins M. Bradykinin and inflammatory pain [see comments]. Trends Neurosci 1993; 16: 99–104
  • Dickenson A H, Sullivan A F. Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain 1987; 30: 349–360
  • Neugebauer V, Schaible H G. Peripheral and spinal components of the sensitization of spinal neurons during an acute experimental arthritis. Agents Actions 1988; 25: 234–236
  • Woolf C J. Evidence for a central component of post-injury pain hypersensitivity. Nature 1983; 306: 686–688
  • Mendell L M, Wall P D. Response of single dorsal cord cells to peripheral cutaneous unmyelinated fibres. Nature 1965; 206: 97–99
  • Wheeler-Aceto H, Porreca F, Cowan A. The rat paw formalin test: comparison of noxious agents. Pain 1990; 40: 223–238
  • Puig S, Sorkin L S. Formalin-evoked activity in identified primary afferent fibers: systematic lidocaine suppresses phase 2 activity. Pain 1996; 64: 345–355
  • LaMotte R H, Thalhammer J G, Torebjork H E, et al. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J Neurosci 1982; 2: 765–781
  • Torebjork H E, Lundberg L E, LaMotte R H. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. J Physiol 1992; 448: 765–780
  • LaMotte R H, Shain C N, Simone D A, et al. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neu-rophysiol 1991; 66: 190–211
  • Bonica J J. Clinical importance of hyperalgesia. Hyperalgesia and Allodynia, W D Willis. Raven, New York 1992; 17–43
  • Levine J D, Taiwo Y O. Hyperalgesic pain: a review. Anesth Prog 1990; 37: 133–135
  • Yaksh T L, Malmberg A B. Central pharmacology of nociceptive processing. Textbook of Pain, P D Wall, R Melzack. Churchill Livingstone, Edinburgh 1994; 165–200
  • Chapman V, Dickenson A H. The effect of intrathecal administration of RP67580, a potent neurokinin 1 antagonist on nociceptive transmission in the rat spinal cord. Neurosci Lett 1993; 157: 149–152
  • Yashpal K, Radhaknshnan V, Coderre T J, et al. CP-96,345. but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat. Neuroscience 1993; 52: 1039–1047
  • Neugebauer V, Lucke T, Grubb B, et al. The involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle. Neurosci Lett 1994; 170: 237–240
  • Yamamoto T, Yaksh T L. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 1992; 77: 757–763
  • Coderre T J, Melzack R. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci 1992; 12: 3665–3670
  • Mayer M L, Westbrook G L. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neu-robiol 1987; 28: 197–276
  • Hunter J C, Goedert M, Pinnock R D. Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices. Biochem Biophys Res Commun 1985; 127: 616–622
  • Rusin K J, Bleakman D, Chard P S, et al. Tachykinins potentiate N-methyl-D-aspartate responses in acutely isolated neurons from the dorsal horn. J Neurochem 1993; 60: 952–960
  • Rusin K I, Jiang M C, Cerne R, Randic M. Interactions between excitatory amino acids and tachykinins in the rat spinal dorsal horn. Brain Res Bull 1993; 30: 329–338
  • Yaksh T L. The spinal actions of opioids. Handbook Pharmacol 1993; 104: 53–89
  • Yaksh T L, Jage J, Takano Y. Pharmacokinetics and pharmacodynamics of medullar agents, c. The spinal actions of a,-adrener-gic agonists as analgesics. Bailliere's Clinical Anaesthesiol-ogy, A R Aitkenhead, G Benad, B R Brown, et al. Bailliere Tindall, London 1993; 597–614
  • Spector W G. Substances which affect capillary permeability. Pharmacol Rev 1958; 10: 475–512
  • Roche-y-Silva M, Rosenthal S R. Release of pharmacologically active substances from the rat skin in vivo following thermal injury. J Pharmacol Exp Ther 1961; 132: 110–123
  • Lewis G P. Active polypeptides derived from plasma proteins. Physiol Rev 1960; 40: 647–679
  • Armstrong D, Dry R ML, Keele C A, et al. Observations on chemical excitants of cutaneous pain in man. J Physiol 1953; 120: 326–336
  • Armstrong D., Jepson J B, Keele C A, et al. Pain producing substance in the human inflammatory exudates and plasma. J Physiol 1957; 135: 350–369
  • Lim R K. Pain. Annu Rev Physiol 1970; 32: 269–288
  • Meyer R A, Campbell J N. Myelinated nociceptive aflerents account for the hyperalgesia that follows a burn to the hand. Science 1981; 213: 1527–1529
  • Taber R I. Predictive value of analgesic assays in mice and rats. Adv Biochem Psychopharmacol 1973; 8: 191–211
  • O'Callaghan J P, Holtzman S G. Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J Pharmacol Exp Ther 1975; 192: 497–505
  • Vinegar R., Truax J F, Selph J L. Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenace-tin and acetaminophen in rodents. Eur J Pharmacol 1976; 37: 23–30
  • Pearl J, Aceto M D, Hams L S. Prevention of writhing and other Mechanism of Action of NSAIDs effects of narcotics and narcotic antagonists in mice. J Pharmacol ExpTher 1968; 160: 217–230
  • Lim R KS, Guzman F, Rodgers D W, et al. Site of action of narcotic and non-narcotic analgesics determined by blocking brady-kinin-evoked visceral pain. Arch Int Pharmacodyn 1964; 152: 25–58
  • Lim R K, Miller D G, Guzman F, et al. Pain and analgesia evaluated by the intraperitoneal bradykinin-evoked pain method in man. Clin Pharmacol Ther 1967; 8: 521–542
  • Yaksh T L. Central and peripheral mechanism for the antialgesic action of acetylsalicylic acid. Acetylsalicylic Acid: New Uses for an Old Drug, J M Barnet, J Hirsh, J F Mustard. Raven Press, New York 1982; 137–152
  • Smith J B, Willis A L. Aspirin selectively inhibits prostaglandin production in human platelets. Nature (New Biol) 1971; 231: 235–237
  • Vane J R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol) 1971; 231: 232–235
  • Ferreira S H. Prostaglandins, aspirin-like drugs and analgesia. Nature (New Biol) 1972; 240: 200–203
  • Moncada S, FeiTeira S H, Vane J R. Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint. Eur J Pharmacol 1975; 31: 250–260
  • Woodbury D M. Analgesic and antipyretics. The Pharmacological Basis of Therapeutics, L S Goodman, A Oilman. MacMillian, New York 1965; 314
  • Flower R J, Moncada S, Vane J R. Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of gout. The Pharmacological Basis of Therapeutics, A G Oilman, L S Goodman, A Gilman. Macmillian, New York 1980; 314
  • Insel P A. Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of rheumatoid arthritis and gout. The Pharmacological Basis of Therapeutics, A G Gilman, T W Rail, A S Nies, P Taylor. Macmillian, New York 1990; 640
  • Kujubu D A, Fletcher B S, Varnum B C, et al. TIS10. a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homo-logue. J Biol Chem 1991; 266: 12866–12872
  • DeWitt D L, Smith W L. Cloning of sheep and mouse prostaglandin endoperoxide synthases. Methods Enzymol 1990; 187: 469–479
  • Xie W L, Chipman J G, Robertson D L, et al. Expression of a mi-togen-responsivc gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991; 88: 2692–2696
  • Picot D, Loll P J, Garavito R M. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 [see commentsj. Nature 1994; 367: 243–249
  • Kurumbail R G, Stevens A M, Gierse J K, et al. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature 1996; 384: 644–648
  • Smith W L, DeWitt D L. Prostaglandin Endoperoxide H Synthases-1 and -2. Adv Immunol 1996; 62: 167–215
  • Harris R C, McKanna J A, Akai Y, et al. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest 1994; 94: 2504–2510
  • Sirois J, Richards J S. Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. J Biol Chem 1992; 267: 6382–6388
  • Sirois J. Induction of prostaglandin endoperoxide synthase-2 by human chorionic gonadotropin in bovine preovulatory follicles in vivo. Endocrinology 1994; 135: 841–848
  • Meade E A, Smith W L, DeWitt D L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993; 268: 6610–6614
  • Gierse J K, McDonald J J, Hauser S D, et al. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem 1996; 271: 15810–15814
  • Seibert K, Zhang Y, Leahy K, et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 1994; 91: 12013–12017
  • Iseki S. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. Histochem J 1995; 27: 323–328
  • Masferrer J L, Zweifel B S, Manning P T, et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 1994; 91: 3228–3232
  • Mehlisch D R, Hubbard R C, Isakson P C, et al. A single-blind, placebo controlled comparison of the analgesic efficacy of a highly selective inhibitor of COX-2 (SC-58635) versus aspirin 650 mg in patients with post-surgical dental pain. International Association for the Study of pain Vancouver. 1996; 234, (poster)
  • Mehlisch D R. Review of the comparative analgesic efficacy of salicylates, acetaminophen, and pyrazolones. Am J Med 1983; 75: 47–52
  • McCormack K, Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs 1991; 41: 533–547
  • Ferreira S H, Lorenzetti B B, Correa F M. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol 1978; 53: 39–48
  • Attal N, Kayser V., Eschalier A, et al. Behavioural and electrophysiological evidence for an analgesic effect of a non-steroidal anti-inflammatory agent, sodium diclofenac. Pain 1988; 35: 341–348
  • Braga P C, Biella G, Tiengo M, Fraschini F. Depressant effects of suprofen. a new non-steroidal anti-inflammatory drug on thalamic evoked neuronal firing in arthritic rats. Neuropharmacology 1986; 25: 1055–1062
  • Braga P C, Biella G, Tiengo M. Effects of tenoxicam on nociceptive thalamic neuronal firing in arthritic rats. Drugs Exp Clin Res 1987; 13: 389–398
  • Okuyama S., Aihara H. The site of action of morphine and indo-methacin differs with electrical stimulation of cutaneous or tibial nerves in normal and adjuvant arthritic rats. Arch hit Pharmacodyn Ther 1985; 276: 133–141
  • Carlsson K H, Monzel W, Jurna I. Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone). lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain 1988; 32: 313–326
  • Groppetti A, Braga P C, Biella G, et al. Effect of aspirin on serotonin and met-enkephalin in brain: correlation with the antinociceptive activity of the drag. Neuropharmacology 1988; 27: 499–505
  • Jurna I, Brane K. Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen. and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus. Pain 1990; 41: 71–80
  • Okuyama S, Aihara H. The mode of action of analgesic drugs in adjuvant arthritic rats as an experimental model of chronic inflammatory pain: possible central analgesic action of acidic nonsteroidal anti-inflammatory drags. Jpn J Pharmacol 1994; 35: 95–103
  • Okuyama S, Aihara H. Hyperalgesic action in rats of intracere-broventricularly administered arachidonic acid, PG E2 and PG F2 alpha: effects of analgesic drugs on hyperalgesia. Arch Int Pharmacodyn Ther 1985; 278: 13–22
  • Malmberg A B, Yaksh T L. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formal in test in the rat. J Pharmacol Exp Ther 1992; 263: 136–146
  • Malmberg A B, Yaksh T L. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test. Eur J Pharmacol 1994; 256: 205–209
  • Bannwarth B, Netter P, Lapicque F, et al. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br J Clin Pharmacol 1992; 34: 79–81
  • Bannwarth B, Netter P, Lapicque F, et al. Plasma and cerebrospinal fluid concentrations of indomethacin in humans. Relationship to analgesic activity. Eur J Clin Pharmacol 1990; 38: 343–346
  • Rice A S, Lloyd J, Bullingham R E, et al. Ketorolac penetration into the cerebrospinal fluid of humans. J Clin Anesth 1993; 5: 459–462
  • Adams S S, Bresloff P, Mason C G. Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of me (-)-isomer. J Pharm Pharmacol 1976; 28: 256–257
  • Garcia-Rafanell J, Forn J. Correlation between antiinflammatory activity and inhibition of prostaglandin biosynthesis induced by various non-steroidal antiinflammatory agents. Arzneimittel-forschung 1979; 29: 630–633
  • Pruss T P, Gardocki J F, Taylor R J, et al. Evaluation of the analgesic properties of zomepirac. J Clin Pharmacol 1980; 20: 216–222
  • Shen T Y. Prostaglandin synthetase inhibitor. Handbook of Experimental Pharmacology, Part II: Anti-inflammatory Drugs, J R Vane, S H Ferreira. Springer-Verlag, Berlin 1979; 307–347
  • Ferrari R A, Ward S J, Zobre C M, et al. Estimation of the in vivo effect of cyclooxygenase inhibitors on prostaglandin E2 levels in mouse brain. Eur J Pharmacol 1990; 179: 25–34
  • Malmberg A B, Yaksh T L. Hyperalgesia mediated by spinal glu-tamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992; 257: 1276–2179
  • Brune K, Beck W S, Geisslinger G, et al. Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experientia 1991; 47: 257–261
  • Peskar B M, Kluge S, Peskar B A, et al. Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eico-sanoid release from various rat organs ex vivo. Prostaglandins 1991; 42: 515–531
  • Malmberg A B, Yaksh T L. Capsaicin-evoked prostaglandin E2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors. Eur J Pharmacol 1994; 271: 293–299
  • Flower R J, Vane I R. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acet-amidophenol). Nature 1972; 240: 410–411
  • Abdel-Halim M S, Sjoquist B, Anggard E. Inhibition of prostaglandin synthesis in rat brain. Acta Pharmacol Toxicol 1978; 43: 266–272
  • Wolfe L S, Rostworowski K, Pappius H M. The endogenous biosynthesis of prostaglandins by brain tissue in vitro. Can J Bio-chem 1976; 54: 629–640
  • Malmberg A B, Yaksh T L. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J Neurosci 1995; 15: 2768–2776
  • Uphouse L A, Welch S P, Ward C R, et al. Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine. Eur J Pharmacol 1993; 242: 53–58
  • Bjorkman R, Hedner J, Hedner T, et al. Central, naloxone-re-versible antinociception by diclofenac in the rat. Naunyn Schmiedebergs Arch Pharmacol 1990; 342: 171–176
  • Bjorkman R, Hallman K M, Hedner J, et al. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain 1994; 57: 259–264
  • Breder C D, Smith W L, Raz A, et al. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J Comp Neurol 1992; 322: 409–438
  • Breder C D, Dewitt D, Kraig R P. Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 1995; 355: 296–315
  • Beiche F, Scheuerer S, Brune K, et al. Up-regulation of cyclo-oxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett 1996; 390: 165–169
  • Yamagata K, Andieasson K I, Kaufmann W E, et al. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 1993; 11: 371–386
  • Dirig D M, Isakson P C, Yaksh T L. Effects of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther 1998; 285: 1031–1038
  • Yamamoto T, Yaksh T L. Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. Life Sci 1991; 49: 1955–1963
  • Chapman V, Dickenson A H. The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. Eur J Pharmacol 1992; 219: 427–433
  • Yasphal K, Wright D M, Henry J L. Substance P reduces tail-flick latency: implications for chronic pain syndromes. Pain 1982; 14: 155–167
  • Hunskaar S, Fasmer O B, Hole K. Acetylsalicylic acid, paracetamol and morphine inhibit behavioral responses to intrathecally administered substance P or capsaicin. Life Sci 1985; 37: 1835–1841
  • MacDermott A B, Mayer M L, Westbrook G L, et al. NMDA-re-ceptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones [published erratum appears in Nature 1986 2;321(6073):888]. Nature 1986; 321: 519–522
  • Ramwell P W, Shaw J E, Jessup R. Spontaneous and evoked release of prostaglandins from frog spinal cord. Am J Physiol 1966; 211: 998–1004
  • Coderre T J, Gonzales R, Goldyne M E, et al. Noxious stimulus-induced increase in spinal prostaglandin E2 is noradrenergic terminal-dependent. Neurosci Lett 1990; 115: 253–258
  • Sorkin L S, Moore J H. Evoked release of amino acids and prostanoids in spinal cords of anethesized rats: Changes during peripheral inflammation and hyperlagesia. Am J Ther 1996; 3: 268–275
  • Malmberg A B, Hamberger A, Hedner T. Effects of prostaglandin E2 and capsaicin on behavior and cerebrospinal fluid amino acid concentrations of unanesthetized rats: A microdialysis study. J Neurochem 1995; 65: 2185–2193
  • Marriott D R, Wilkin G P, Wood J N. Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism. J Neurochem 1991; 56: 259–265
  • Urban L, Dray A. Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro. Neurosci Lett 1991; 134: 9–11
  • Bevan S, Hothi S, Hughes G, et al. Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol 1992; 107: 544–552
  • Dirig D M, Hua X-Y, Yaksh T L. Temperature-dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord. J Neurosci 1997; 17: 4406–4414
  • Nicholls D, Attwell D. The release and uptake of excitatory amino acids [see comments]. Trends Pharmacol Sci 1990; 11: 462–468
  • Vasko M R, Campbell W B, Waite K J. Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. J Neurosci 1994; 14: 4987–4997
  • Minami T, Nishihara I, Uda R, et al. Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice. Pain 1994; 57: 225–231
  • Minami T, Uda R, Horiguchi S, et al. Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. Pain 1994; 57: 217–223
  • Taiwo Y O, Levine J D. Indomethacin blocks central nociceptive effects of PGF, alpha. Brain Res 1986; 373: 81–84
  • Uda R., Horiguchi S, Ito S, et al. Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2 alpha to conscious mice. Brain Res 1990; 510: 26–32
  • Malmberg A B, Rafferty M F, Yaksh T L. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci Lett 1994; 173: 193–196
  • Nicol G D, Klingberg D K, Vasko M R. Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons. J Neurosci 1992; 12: 1917–1927
  • Geppetti P, Del Bianco E, Tramontana M, et al. Arachidonic acid and bradykinin share a common pathway to release neuropeptide from capsaicin-sensitive sensory nerve fibers of the guinea pig heart. J Pharmacol Exp Ther 1991; 259: 759–765
  • Hingtgen C M, Vasko M R. Prostacyclin enhances the evoked-release of substance P and calcitonin gene-related peptide from rat sensory neurons. Brain Res 1994; 655: 51–60
  • Andreeva L, Rang H P. Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunore-activity from the rat spinal cord in vitro. Br J Pharmacol 1993; 108: 185–190
  • Vasko M R, Zirkelbach S L, Waite K J. Prostaglandins stimulate the release of substance P from rat spinal cord slices. Progress in Pharmacology and Clinical Pharmacology, I Jurna, T L Yaksh. Gustav Fischers Verlag, Stuttgart, New York 1993; 69–89
  • Matsumura K, Watanabe Y, Imai-Matsumura K. Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography. Brain Res 1992; 581: 292–298
  • Coleman R A, Smith W L, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 1994; 46: 205–229
  • Taiwo Y O, Levine J D. Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J Neurosci 1988; 8: 1346–1349
  • Hedqvist P. Autonomic neurotransmission. The Prostaglandins, P W Ramwell. Plenum, New York 1973; 101–131
  • Catania A, Arnold J, Macaluso A, et al. Inhibition of acute inflammation in the periphery by central action of salicylates. Proc Natl Acad Sci USA 1991; 88: 8544–8547
  • de Beaurepaire R, Suaudeau C, Chait A, et al. Anatomical mapping of brain sites involved in the antinociceptive effects of keto-profen. Brain Res 1990; 536: 201–206
  • Gelgor L, Cartmell S, Mitchell D. Intracerebroventricular microinjections of non-steroidal anti-inflammatory drugs abolish re-perfusion hyperalgesia in the rat's tail. Pain 1992; 50: 323–329
  • Braga P C. Ketoprofen: i.e.v. injection and electrophysiological aspects of antinociceptive effect. Eur J Pharmacol 1990; 184: 273–280
  • Bjorkman R L, Hedner T, Hallman K M, et al. Localization of the central antinociceptive effects of diclofenac in the rat. Brain Res 1992; 590: 66–73
  • Okuyama S., Aihara H. Hyperalgesic action in mice of intracere-broventricularly administered arachidonic acid. PG E2. PG F2 alpha and PG D2: Effects of analgesic drugs on hyperalgesia. J Pharmacobiodyn 1986; 9: 902–908
  • Horiguchi S, Ueno R, Hyodo M, Hayaishi O. Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2 alpha to conscious mice. Eur J Pharmacol 1986; 122: 173–179
  • Navarro E, Romero S D, Yaksh T L. Release of prostaglandin E2 from brain of cat: II. In vivo studies on the effects of adrenergic, cholinergic and dopaminergic agonists and antagonists. Neuropharmacology 1988; 27: 1067–1072
  • Navarro E, Romero S D, Yaksh T L. CNS stimulation and PGE, release. III. Pentamethylenetetrazole-induced seizures. J Cereb Blood Flow Metab 1989; 9: 180–186
  • Schady W, Torebjork H E. Central effects of zomepirac on pain evoked by intraneural stimulation in man. J Clin Pharmacol 1984; 24: 429–435
  • Guieu R, Blin O, Pouget J, Serratrice G. Analgesic effect of indomethacin shown using the nociceptive flexion reflex in humans. Ann Rheum Dis 1992; 51: 391–393
  • Piletta P, Porchet H C, Dayer P. Central analgesic effect of acetaminophen but not of aspirin. Clin Pharmacol Ther 1991; 49: 350–354
  • Wilier J C, De Broucker T, Bussel B, et al. Central analgesic-effect of ketoprofen in humans: electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over study. Pain 1989; 38: 1–7
  • Fabbri A, Cruccu G, Sperti P, et al. Piroxicam-induced analgesia: evidence for a central component which is not opioid mediated. Experientia 1992; 48: 1139–1142
  • Devoghel J C. Small intrathecal doses of lysine-acetylsalicylate relieve intractable pain in man. J Int Med Res 1983; 11: 90–91
  • Pellerin M, Hardy F, Abergel A, et al. Chronic refractory pain in cancer patients. Value of the spinal injection of lysine acetyl-salicylate. 60 cases. Presse Med 1987; 16: 1465–1468

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