References
- Cox J D. Large-dose fractionation (hypofractionation). Cancer 1985; 55: 2105–2111, (Suppl 9)
- Ellis F. Dose, time and fractionation: a clinical hypothesis. Clin Radiol 1969; 20: 1–7
- Thames H D, Jr, Withers H R, Peters L J. Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 1982; 8: 219–226
- Withers H R, Thames HD, Jr, Flow B L. The relationship of acute to late skin injury in 2 and 5 fractionlweek gamma ray therapy. Int J Radiat Oncol Biol Phys 1978; 4: 595–601
- Andrews J R. Dose-time relationships in cancer radiotherapy: a clinical radiobiology study of extremes of dose and time. Am J Roentgenol Radium Ther Nucl Med 1965; 93: 56–74
- Rubenfeld S. Experiences with a rapid irradiation technic in oral carcinoma. Radiology 1953; 60: 724–731
- Atkins H L. Massive dose technique in radiation therapy of inoperable carcinoma of the breast. Am J Roentgenol Radium Ther Nucl Med 1964; 91: 80–89
- Edehan A H, Holtz S, Powers W E. Rapid radiotherapy for inop erable carcinoma of the breast: benefits and complications. Int J Radiat Oncol Biol Phys 1965; 93: 585–599
- Singh K. Two regimes with the same TDF but differing morbidity used in the treatment of stage III carcinoma of the cervix. Br J Radiol 1978; 51: 357–362
- Bennett M B. The treatment of stage III squamous carcinoma of the cervix in air and hyperbaric oxygen. Br J Radiol 1978; 51: 68, (abstract)
- Dische S, Martin W MC, Anderson P. Radiation myelopathy in patients treated for carcinoma of bronchus using a six fraction regime of radiotherapy. Br J Radiol 1981; 54: 29–35
- Handa K, Edoliya T N, Pandey R P. Radiotherapeutic clinical trial of twice per week vs. five times per week in oral cancer. Strahlentherapie 1980; 156: 626–631
- Coutard H. Principles of X-ray therapy of malignant diseases. Lancet 1934; 227: 1–8
- Woodhouse W, Quivey J M, Fu K K. Treatment of carcinoma of the vocal cord a review of 20 years experience. Laryngoscope 1981; 91: 1155–1162
- Buschke F, Vaeth J M. Radiation therapy of carcinoma of the vocal cord without mucosal reaction. Am J Roentgenol Radium Ther Nucl Med 1963; 89: 29–34
- Le Q T, Krieg R M, Quivey J M. Influence of fractionation and time on local control to T1 and T2 glottic carcinoma. Int J Radiat Oncol Biol Phys 1996; 36: 234, Suppl 1(abstract)
- Parsons J T, Bova F J, Million R R. A re-evaluation of split-course technique for squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1980; 6: 1645–1652
- Overgaard J, Hjelm-Hansen M, Johansen L V. Comparison of conventional and split-course. radiotherapy as primary treatment in carcinoma of the larynx. Acta Oncol 1988; 27: 147–152
- Fletcher G H. Keynote address: the scientific basis of the present and future practice of clinical radiotherapy. Int J Radiat Oncol Biol Phys 1983; 9: 1073–1982
- Lipsett J A, Desai K, Pezner R. Acute normal tissue tolerance to 7 day per week accelerated fractionation. Int J Radiat Oncol Biol Phys 1984; 10: 1049–1052
- Coutard H. Roentgen therapy of epitheliomas of the tonsillar region, hypopharynx and larynx from 1920–1926. Am J Roentgenol Radium Ther 1932; 28: 313–331
- Withers H F. Cell renewal system concepts and the radiation response. Front Radiat Ther Oncol 1972; 6: 93–107
- Backstrom A, Jakobsson P A, Littbrand B. Fractionation scheme with low individual doses in irradiation of carcinoma of the mouth. Acta Radiol Ther Phys Biol 1973; 12: 401–406
- Jakobsson A, Littbrand B, Backstrom A. Changed fractionation diagram in the treatment of squamous cell carcinoma in the mouth-cavity. Nord Med 1971; 85: 1253
- Peracchia G, Salti C. Radiotherapy with thrice-a-day fractionation in a short overall time: clinical experiences. Int J Radiat Oncol Biol Phys 1981; 7: 99–104
- Gonzalez D G, Breur K, Schueren E VD. Preliminary results in advanced head and neck cancer with radiotherapy by multiple fractions a day. Clin Radiol 1980; 31: 417–421
- Svohoda V HJ. Further experience with radiotherapy by multiple daily session. Br J Radiol 1978; 51: 363–369
- Olmi P, Cellai E, Chiavacci A. Accelerated fractionation in advanced head and neck cancer: results and analysis of late sequelae. Radiother Oncol 1990; 17: 199–207
- Bourhis J, Fortin A, Dupuis O. Very accelerated radiation therapy: preliminary results in locally unresectable head and neck carcinomas. Int J Radiat Oncol Biol Phys 1995; 32: 747–752
- Gray A J. Treatment of advanced head and neck cancer with accelerated fractionation. Int J Radiat Oncol Biol Phys 1986; 12: 9–12
- Lamb D S, Spry N A, Gray A J. Accelerated fractionation radiotherapy for advanced head and neck cancer. Radiother Oncol 1990; 18: 107–116
- Horiot J C, Le Fur R, Schraub S. Status of the experience of the EORTC cooperative group of radiotherapy with hyperfrac-tionated and accelerated radiotherapy regimes. Semin Radiat Oncol 1992; 2: 34–37
- Wang C C. Local control of oropharyngeal carcinoma after two accelerated hyperfractionation radiation therapy schemes. Int J Radiat Oncol Biol Phys 1988; 14: 1143–1146
- Ang K K, Peters L J. Concomitant boost radiotherapy in the treatment of head and neck cancers. Semin Radiat Oncol 1992; 2: 31–33
- Johnson C R, Schmidt-Ullrich R K, Arthur D W. Standard once-daily versus thrice-daily concomitant boost accelerated superfractionated irradiation for advanced squamous cell carcinoma of the head and neck: preliminary results of a prospective randomized trial. Int J Radiat Oncol Biol Phys 1995; 32: 162, Suppl 1(abstract)
- Kaanders J HAM, Van Daal W AJ, Hoogenraad W J. Accelerated fractionation radiotherapy for laryngeal cancer, acute, and late toxicity. Int J Radiat Oncol Biol Phys 1992; 24: 497–503
- McGinn C J, Harari P M, Fowler J F. Dose intensification in curative head and neck cancer radiotherapy-linear quadratic analysis and preliminary assessment of clinical results. Int J Radiat Oncol Biol Phys 1993; 27: 363–369
- Horiot J C, Le Fur R, Nguyen T. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol 1992; 25: 231–241
- Parsons J T, Mendenhall W M, Stringer S P. Twice-a-day radiotherapy for squamous cell carcinoma of the head and neck: the University of Florida experience. Head Neck 1993; 15: 87–96
- Fu K K, Pajak T F, Marcial V A. Late effects of hyperfractionated radiotherapy for advanced head and neck cancer: long-term follow-up results of RTOG 83–13. Int J Radiat Oncol Biol Phys 1995; 32: 577–588
- Datta N R, Choudhry A D, Gupta S. Twice a day versus once a day radiation therapy in head and neck cancer. Int J Radiat Oncol Biol Phys 1989; 17: 132, Suppl 1(abstract)
- Pinto L HJ, Canary P CV, Araujo C MM. Prospective randomized trial comparing hyperfractionated versus conventional radiotherapy in stages III and IV oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1991; 21: 557–562
- Garden A S, Momson W H, Ang K K. Hyperfractionated radiation in the treatment of squamous cell carcinomas of the head and neck: a comparison of two fractionation schedules. Int J Radiat Oncol Biol Phys 1995; 31: 493–502
- Nguyen T D, Panis X, Froissart D. Analysis of late complications after rapid hyperfractionated radiotherapy in advanced head and neck cancers. Int J Radiat Oncol Biol Phys 1988; 14: 23–25
- Parsons J T, Mendenhall W M. Hyperfractionated or accelerated radiation therapy for squamous cell carcinoma of the head and neck. Advances in Head and Neck Oncology, KD Robbins. Singular Publishing Group, San Diego, CA 1998; 25–36
- Saunders M I, Dische S, Fowler I F. Radiotherapy employing three fractions on each of twelve consecutive days. Acta Oncol 1988; 27: 163–167
- Wang C, Montgomery C. W., Efird J. Local control of oropharyngeal carcinoma by irradiation alone. Laryngoscope 1995; 105: 529–533
- Lievens Y, Vanuytsel L, Rijnders A. The time course of development of late side effects after irradiation of the prostate with multiple fractions per day. Radiother Oncol 1996; 40: 147–152
- Ang K K, Peters L J, Weber R S. Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys 1990; 19: 1339–1345
- Wang C C, Blitzer P H, Suit H D. Twice-a-day radiation therapy for cancer of the head and neck. Cancer 1985; 55: 2100–2104, Suppl 9
- Wang C C. Improved local control of advanced oropharyngeal carcinoma following twice-daily radiation therapy. Am J Clin Oncol 1985; 8: 22
- Wang C C, Suit H D, Blitzer D P. Twice-a-day radiation therapy for supraglottic carcinoma. Int J Radiat Oncol Biol Phys 1986; 12: 3–7
- Wang C C. The enigma of accelerated hyperfractionated radiation therapy for head and neck cancer. Int J Radiat Oncol Biol Phys 1988; 14: 209–210
- Dische S, Saunders M I. Randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer—interim results and implications. Int J Radiat Oncol Biol Phys 1996; 36: 234, Suppl 1(abstract)
- Dische S, Saunders M, Barrett A. A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 1997; 44: 123–136
- Jackson S M, Weir L M, Hay J H. A randomised trial of accelerated versus conventional radiotherapy in head and neck cancer. Radiother Oncol 1997; 43: 39–46
- Horiot J C, Bontemps P, Van den Bogaert W. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial. Radiother Oncol 1997; 44: 111–121
- Parsons I T, Cassisi N J, Million R R. Results of twice-a-day irradiation of squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys 1984; 10: 2041–2051
- Parsons I T, Mendenhall W M, Million R R. Twice-a-day irradiation of squamous cell carcinoma of the head and neck. Semin Radiat Oncol 1992; 2: 29–30
- Fein D A, Lee W R, Amos W R. Oropharyngeal carcinoma treated with radiotherapy: a 30-year experience. Int J Radiat Oncol Biol Phys 1996; 34: 289–296
- Sanchiz F, Milla A, Torner J. Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer. Int J Radiat Oncol Biol Phys 1990; 19: 1347–1350
- Cummings B J, Keane T, Pintilie J. M. A prospective randomized trial of hyperfractionated versus conventional once daily radiation for advanced squamous cell carcinomas of the larynx and pharynx. Int J Radiat Oncol Biol Phys 1996; 36: 235, Suppl 1(abstract)
- Stuschke M, Thames H D. Hyperfractionated radiotherapy of human tumors: overview of the randomized clinical trials. Int J Radiat Oncol Biol Phys 1997; 37: 259–267
- Vanuytsel L, Ang K K, Vandenbussche L. Radiotherapy in multiple fractions per day for prostatic carcinoma: late complications. Int J Radiat Oncol Biol Phys 1986; 12: 1589–1595
- Nguyen T D, Demange L, Froissart D. Rapid hyperfrac-tionationed radiotherapy. Clinical results in 178 advanced squamous cell carcinomas of the head and neck. Cancer 1985; 56: 16–19
- Peters L J, Ang K K, Thames H D, Jr. Accelerated fractionation in the radiation treatment of head and neck cancer. A critical comparison of different strategies. Acta Oncol 1988; 27: 185–194
- Saunders M I, Dische S, Grosch E J. Experience with CHART. Int J Radiat Oncol Biol Phys 1991; 21: 871–878
- Nyman J, Turesson I. Does the interval between fractions matter in the range of 4–8 h in radiotherapy? A study of acute and late human skin reactions. Radiother Oncol 1995; 34: 171–178