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Original Article

Effect of Ornithine in Parenteral Nutrition Regimens on Difluoromethylornithine-Induced Platelet Suppression and Changes in Tumor Polyamine Content

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Pages 160-165 | Published online: 11 Jun 2009

References

  • Pegg AE. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res 1988; 48: 759–774
  • Tabor CW, Tabor H. Polyamines. Annu Rev Biochem 1984; 53: 749–790
  • Ajani JA, Ota DM, Grossie VB, Jr, Levin B, Nishioka K. Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine: Correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels. Cancer Res 1989; 49: 5761–5765
  • Grossie VB, Jr, Ota DM, Ajani JA, Chang T-H, Patenia D, Nishioka K. Reduction of difluoromethylornithine induced thrombocytopenia with ornithine while maintaining antitumor activity. Cancer Res 1989; 49: 4159–4162
  • Grossie VB, Jr, Ota DM, Ajani JA, Nishioka K. Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose DFMO. Invest New Drugs 1991; 9: 321–326
  • O'Brien TG, Madara T, Pyle JA, Holmes M. Ornithine decarboxylase from mouse epidermis and epidermal papillomas: Differences in enzymatic properties and structure. Proc Natl Acad Sci USA 1986; 83: 9448–9456
  • O'Brien TG, Hietala O, O'Donnell K, Holmes M. Activation of mouse epidermal tumor ornithine decarboxylase by GTP: Evidence for different catalytic forms of the enzyme. Proc Natl Acad Sci USA 1987; 84: 8927–8931
  • Grossie VB, Jr, Nishioka K. Nutritional modifications, polyamines, and cancer. Critical Roles of Polyamines in Cancer: Basic Mechanisms and Clinical Approaches, K. Nishioka. RG Landes Co., Georgetown, TX 1996
  • Nishioka K, Grossie VB, Jr, Ajani JA, Patenia D, Chang T-H, Ota D. Polyamine directed preferential nutritional repletion of normal tissues in tumor-bearing hosts. Int J Cancer 1988; 42: 744–747
  • Grossie VB, Jr, Nishioka K, Ajani JA, Ota DM. Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. J Surg Oncol 1992; 50: 161–167
  • Grove J, Gozard JR, Mamont PS. Assay of α-difluoromethyor-nithine in body fluids and tissues by automatic amino-acid analyzer. J Chromatogr 1981; 223: 409–416
  • Ota DM, Grossie VB, Jr, Ajani JA, Stephens LC, Nishioka K. Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion. Int J Cancer 1986; 38: 245–249
  • Sjoholm A, Bucht E, Theodorsson E, Larsson R, Nygren P. Polyamines regulate human medullary thyroid carcinoma T-cell proliferation and secretion of calcitonin and calcitonin gene-related peptide. Mol Cell Endocrinol 1994; 103: 89–94

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