106
Views
31
CrossRef citations to date
0
Altmetric
Original Article

Recent Advances in Understanding the Molecular Mechanisms of Tamoxifen Action

Pages 391-396 | Published online: 11 Jun 2009

References

  • Butta A, MacLennan K, Flanders K C, et al. Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment. Cancer Res 1992; 52: 4261–4264
  • Charlier C, Colin C, Merville M P, et al. [Tamoxifen in the treatment of breast cancer]. J Gynecol Obstet Biol Reprod (Paris) 1994; 23: 751–756
  • Gagliardi A, Collins D C. Inhibition of angiogenesis by antiestrogens. Cancer Res 1993; 53: 533–535
  • Jordan V C. Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer. Br J Pharmacol 1993; 110: 507–517
  • Jordan V C. A current view of tamoxifen for the treatment and prevention of breast cancer. (Gaddum Memorial Lecture). Br J Pharmacol 1993; 110: 507–517
  • Jordan V C. Third annual William L. McGuire Memorial Lecture. Studies on the estrogen receptor in breast cancer–20 years as a target for the treatment and prevention of cancer. Breast Cancer Res Treat 1995; 36: 267–285
  • Mulshine J L, Jett M, Cuttita F, et al. Scientific basis for cancer prevention. Intermediate cancer markers. Cancer 1993; 72(Suppl 3)978–983
  • Nayfield S G. Tamoxifen's role in chemoprevention of breast can-Molecular Mechanisms of Tamoxifen Action cer: An update. J Cell Biochem 1995; 22(Suppl)42–50
  • Baral E, Nagy E, Berczi I. Modulation of natural killer cell-mediated cytotoxicity by tamoxifen and estradiol. Cancer 1995; 75: 591–599
  • Charlier C, Chariot A, Antoine N, et al. Tamoxifen and its active metabolite inhibit growth of estrogen receptor-negative MDA-MB-435 cells. Biochem Pharmacol 1995; 49: 351–358
  • Croxtall J D, Emmas C, White J O, et al. Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells. Biochem Pharmacol 1994; 47: 197–202
  • Grenman S E, Worsham M J, Van D D, et al. Establishment and characterization of UM-EC-2, a tamoxifen-sensitive, estrogen receptor-negative human endometrial carcinoma cell line. Gynecol Oncol 1990; 37: 188–199
  • Howe S R, Pass H I, Ethier S P, et al. Presence of an insulin-like growth factor I autocrine loop predicts uterine fibroid responsiveness to tamoxifen. Cancer Res 1996; 56: 4049–41055
  • Zajchowski D A, Sager R, Webster L. Estrogen inhibits the growth of estrogen receptor-negative, but not estrogen receptor-positive, human mammary epithelial cells expressing a recombinant estrogen receptor. Cancer Res 1993; 53: 5004–5011
  • Chakravarty N. The roles of calmodulin and protein kinase C in histamine secretion from mast cells. Agents Actions 1992; 36: 183–191
  • Colletta A A, Benson J R, Baum M. Alternative mechanisms of action of anti-oestrogens. Breast Cancer Res Treat 1994; 31: 5–9
  • Lam H Y. Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase. Biochem Biophys Res Commun 1984; 118: 27–32
  • Lopes M C, Vale M G, Carvalho A P. Ca2+-dependent binding of tamoxifen to calmodulin isolated from bovine brain. Cancer Res 1990; 50: 2753–2758
  • Mac N S, Wagner M, Kirkham P R, et al. Inhibition of melanoma cell/matrix interaction by tamoxifen. Melanoma Res 1993; 3: 67–74
  • Mac N S, Dawson R A, Crocker G, et al. Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity. Br J Dermatol 1993; 128: 143–150
  • Pan Z, Radding W, Zhou T, et al. Role of calmodulin in HIV-potentiated Fas-mediated apoptosis. Am J Pathol 1996; 149: 903–910
  • Sutherland R L, Watts C K, Hall R E, et al. Mechanisms of growth inhibition by nonsteroidal antioestrogens in human breast cancer cells. J Steroid Biochem 1987; 27: 891–897
  • Wiseman H. Tamoxifen:new membrane-mediated mechanisms of action and therapeutic advances. Trends Pharmacol Sci 1994; 15: 83–89
  • Colletta A A, Wakefield L M, Howell F V, et al. Anti-oestrogens induce the secretion of active transforming factor beta from human fetal fibroblasts. Br J Cancer 1990; 62: 405–4109
  • Knabbe C, Zugmaier G, Schmahl M, et al. Induction to transforming growth factor beta by the antiestrogens droloxifene, tamoxifen, and toremifene in MCF-7 cells. Am J Clin Oncol 1991; 14(Suppl2)S15–20
  • Knabbe C, Kopp A, Hilgers W, et al. Regulation and role of TGF beta production in breast cancer. Ann NY Acad Sci 1996; 784: 263–276
  • Kang Y, Cortina R, Perry R R. Role of c-myc in tamoxifen-induced apoptosis estrogen-independent breast cancer cells. J Natl Cancer Inst 1996; 88: 279–284
  • Rochefort H. Oestrogen- and anti-oestrogen-regulated genes in human breast cancer. Ciba Found Symp 1995; 191: 254–265
  • Laurence J, Cooke H, Sikder S K. Effect of tamoxifen on regulation of viral replication and human immunodeficiency virus (HIV) long terminal repeat-directed transcription in cells chronically infected with HIV-1. Blood 1990; 75: 696–703
  • Lim J S, Frenkel K, Troll W. Tamoxifen suppresses tumor promoter-induced hydrogen peroxide formation by human neutrophils. Cancer Res 1992; 52: 4969–4972
  • Moraru I I, Laky M, Stanescu T, et al. Protein kinase C controls Fc gamma receptor-mediated endocytosis in human neutrophils. FEBS Lett 1990; 274: 93–95
  • Pollack I F, Randall M S, Kristofik M P, et al. Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. Cancer Res 1990; 50: 7134–7138
  • O'Brian C A, Ward N E, Anderson B W. Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme. J Natl Cancer Inst 1988; 80: 1628–1633
  • O'Brian C A, Liskamp R M, Solomon D H, et al. Triphenylethylenes: a new class of protein kinase C inhibitors. J Natl Cancer Inst 1986; 76: 1243–1246
  • Friedman Z Y. The anti-tumor agent tamoxifen inhibits breakdown of polyphosphoinositides in GH4Cj cells. J Pharmacol Exp Ther 1994; 271: 238–245
  • Friedman Z Y. Tamoxifen and vanadate synergize in causing accumulation of polyphosphoinositides in GH4C, membranes. J Pharmacol Exp Ther 1993; 267: 617–623
  • Berridge M J. Inositol lipids and cell proliferation. Biochim Biophys Acta 1987; 907: 33–45
  • McDonald C C, Stewart H J. Fatal myocardial infarction in the Scottish adjuvant tamoxifen trial. The Scottish Breast Cancer Committee. BMJ 1991; 303: 435–437
  • Wiseman H, Quinn P, Halliwell B. Tamoxifen and related compounds decrease membrane fluidity in liposomes. Mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?. FEBS Lett 1993; 330: 53–56
  • Wiseman H, Paganga G, Rice E C, et al. Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: A mechanism accounting for the cardioprotective action of tamoxifen. Biochem J 1993; 292: 635–638
  • Wiseman H, Quinn P. The antioxidant action of synthetic oestro-gens involves decreased membrane fluidity: relevance to their potential use as anticancer and cardioprotective agents compared to tamoxifen. Free Radic Res 1994; 21: 187–194
  • Love R R, Wiebe D A, Newcomb P A, et al. Effects of tamoxifen on cardiovascular risk factors in postmenopausal women. Ann Intern Med 1991; 115: 860–864
  • Berridge M J. Inositol triphosphate and diacylglycerol: Two interacting second messengers. Annu Rev Biochem 1987; 56: 159–193
  • Cockroft S. Phosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein Gp. Trends Biochem Sci 1987; 12: 75–78
  • Boyer J L, Hepler J R, Harden T K. Hormone and growth factor-mediated regulation of phospholipase C activity. Trends Pharmacol Sci 1989; 10: 360–364
  • Margolis B, Rhee S G, Felder S, et al. EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling. Cell 1989; 57: 1101–1107
  • Meisenhelder J, Suh P-G, Rhee S G, et al. Phosphlipase C-gamma is a substrate for the PDGF and EGF receptor protein kinases in vivo and in vitro. Cell 1989; 57: 1109–1122
  • Wahl M I, Nishibe S, Suh P-G, et al. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium. Proc Natl Acad Sci USA 1989; 86: 1568–1572
  • Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203–212
  • Smith M R, Ryu S H, Suh P-G, et al. S-phase induction and transformation of quiescent NIH3T3 cells by micrinjection of phos-pholipase C. Proc Natl Acad Sci USA 1989; 86: 3659–3663
  • Gorga F R, Riney C E, Benjamin T L. Inositol triphosphate levels in cells expressing wild-type and mutant polyomavirus middle T antigens: Evidence for activation of phospholipase C via activation of pp60c-src. J Virol 1990; 64: 105–112
  • Sesko A, Cabot M, Mossman B. Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells. Proc Natl Acad Sci USA 1990; 87: 7385–7389
  • Talwar H S, Fisher G J, Voorhees J J. Bradykinin induces phospho-inositide turnover, 1,2-diacylglyceride formation and growth in cultured adult keratinocytes. J Invest Dermatol 1990; 95: 705–710
  • Tilly B C, Tertoolen L G, Remorie R, et al. Histamine as a growth factor an chemoattractant for human carcinoma and melanoma cells: action through Ca2+-mobilizing HI receptors. J Cell Biol 1990; 110: 1211–1215
  • Lucas D O, Bajjalieh S M, Kowalchyk J A, et al. Direct stimulation by thyrotropin-releasing hormone (TRH) of polyphosphoinositide hydrolysis in GH3 cell membranes by a guanine nucleotide-modulated mechanism. Biochem Biophys Res Commun 1985; 132: 721–728
  • Martin T FJ, Bajjalieh S M, Lucas D O, et al. Thyrotopin-releasing hormone stimulation of polyphosphoinositdes hydrolysis in GH3 cell membranes is GTP dependent but insensitive to cholera or pertussis toxin. J Biol Chem 1986; 261: 10141–10149
  • Straub R E, Gershengorn M C. Thyrotopin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells. J Biol Chem 1986; 261: 2712–2717
  • Martin T FJ, Kowalchyk J A. Reconstruction of a solubilized membrane but not cytosolic phospholipase C with membrane-associated Gp from GH3 cells. J Biol Chem 1989; 264: 20917–20922
  • Pachter J A, Law G J, Dannies P S. Bombesin stimulates inositol polyphosphate production in GH4C[ rat pituitary cells: Demonstration of guanyl nucleotide sensitivity. Biochem Biophys Res Commun 1988; 154: 654–659
  • Fischer J B, Schonbrunn A. The bombesin receptor is coupled to a guanyl nucleotide binding protein which is insensitive to pertussis and cholera toxins. J Biol Chem 1988; 263: 2808–2816
  • Allan D, Michell R H. Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Biochem J 1974; 142: 591–597
  • Harwood J L, Hawthorne J N. The properties and subcellular distribution of phosphatidylinositol kinases in mammalian tissues. Biochim Biophys Acta 1969; 171: 75–88
  • Endemann G, Dunn S N, Cantley L C. Bovine brain contains two types of phosphatidylinositol kinase. Biochemistry 1987; 26: 6845–6852
  • Whitman M, Kaplan D, Roberts T, et al. Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Biochem J 1987; 247: 165–174
  • Kai M, Salway J G, Hawthorne J N. The diphosphoinositide kinase of rat brain. Biochem J 1968; 106: 791–797
  • Cochet C, Chambaz E M. Catalytic properties of a purified phos-phatidylinositol-4-phosphate kinase from rat brain. Biochem J 1986; 237: 25–31
  • Ling L E, Schulz J T, Cantley L C. Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells. J Biol Chem 1989; 264: 1580–5088
  • Van Dongen C J, Zwiers H, Gipsen W H. Purification and partial characterization of the phosphatidylinositol 4-phosphate kinase from rat brain. Biochem J 1984; 223: 197–203
  • Jarvis W D, Judd A M, MacLeod R M. Attenuation of anterior pituitary phosphoinositide phosphorylase activity by the D2 dopamine receptor. Endocrinology 1988; 123: 2793–2799
  • Urumow T, Wieland O H. Evidence for a cholera-toxin-sensitive G-protein involved in the regulation of phosphatidylinositol-4-phosphate kinase of rat liver membranes. Biochim Biophys Acta 1988; 972: 232–238
  • Urumow T, Wieland O H. A small G-protein involved in phos-phatidylinositol-4-phosphate kinase activation. FEBS Lett 1990; 263: 15–17
  • Smith C D, Chang K J. Regulation of brain phosphatidylinositol-4-phosphate kinase by GTP analogues. A potential role for guanine nucleotide regulatory proteins. J Biol Chem 1989; 264: 3206–3210
  • Pike M C, Costello K M, Lamb K A. IL-8 stimulates phos-phatidylinostitol-4-phosphate kinase in human polymorphonuclear leukocytes. J Immunol 1992; 148: 3158–3164
  • Pike M C, Costello K, Southwick F S. Stimulation of human polymorphonuclear leukocytes phosphatidylinositol-4-kinase by con-canavalin A and formyl-methionyl-leucyl-phenylalanine is calcium-independent. Correlation with maintenance of actin assembly. J Immunol 1991; 147: 2270–2275
  • Suzuki Y, Ohsugi K, Ono Y. EB V increases phosphoinositide kinase activities in human B cells. J Immunol 1992; 149: 207–213
  • Ballou L R, Barker S C, Postlethwaite A E, et al. Interleukin-1 stimulates phosphatidylinositol kinase activity in human fibroblasts. J Clin Invest 1991; 87: 299–304
  • Cochet C, Filhol O, Parastre B, et al. Interaction between the epidermal growth factor receptor and phosphoinositide kinases. J Biol Chem 1991; 266: 637–644
  • Michell R H, Harwood J L, Coleman R, et al. Characteristics of rat liver phosphatidylinositol kinase and its presence in the plasma membrane. Biochim Biophys Acta 1967; 144: 649–658
  • MacDonald M L, Kuenzel E A, Glomset J A, et al. Evidence from two transformed cell lines that the phosphorylations of peptide tyrosine and phosphatidylinositol are catalysed by different proteins. Proc Natl Acad Sci USA 1985; 82: 3993–3997
  • van Rooijen L LA, Rossovska M, Bazan N G. Inhibition of phos-phatidylinositol-4-phosphate kinase by its product phosphatidyli-nositol-4,5-bisphosphate. Biochem Biophys Res Commun 1985; 126: 150–155
  • Rao U S, Fine R L, Scarborough G A. Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol 1994; 48: 287–292
  • Callaghan R, Higgins C F. Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br J Cancer 1995; 71: 294–299

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.