Biotechnological approaches for the value addition of whey

References

• Abou-Zeid AA, Baghlaf AO, Khan JA, Makhashin SS. 1983. Utilization of date seeds and cheese whey in production of citric acid by Candida lipolytica. Agric Wastes 8: 131–142.
   Google Scholar
• Aeschlimann A, Von Stockar U. 1990a. Continuous production of lactic acid from whey permeate by Lactobacillus helveticus in a cell recycle reactor. Enzyme Microb Technol 13: 811–816.
   Google Scholar
• Aeschlimann A, Von Stockar U. 1990b. The effect of yeast extract supplementation on the production of lactic acid from whey permeate by Lactobacillus helveticus. Appl Microbiol Biotechnol 32: 398–402.
   Web of Science ®Google Scholar
• Alonso S, Herrero M, Rendueles M, Díaz M. 2010. Residual yoghurt whey for lactic acid production. Biomass Bioenergy 34: 931–938.
   Google Scholar
• Alvarez DC, Pérez VH, Justo OR, Alegre RM. 2006. Effect of the extremely low frequency magnetic field on nisin production by Lactococcus lactis subsp. lactis using cheese whey permeate. Process Biochem 41: 1967–1973.
   Web of Science ®Google Scholar
• Alvarez MM, Aguirre-Ezkauriatza EJ, Ramírez-Medrano A, Rodríguez-Sánchez A. 2010. Kinetic analysis and mathematical modeling of growth and lactic acid production of Lactobacillus casei var. rhamnosus in milk whey. J Dairy Sci 93: 5552–5560.
   Google Scholar
• Amrane A. 2003. Seed culture and its effect on the growth and lactic acid production of Lactobacillus helveticus. J Gen Appl Microbiol 49: 21–27.
   Google Scholar
• Amrane A. 2005. Analysis of the kinetics of growth and lactic acid production for Lactobacillus helveticus growing on supplemented whey permeate. J Chem Technol Biotechnol 80: 345–352.
   Google Scholar
• Amrane A, Prigent Y. 1993. Influence of media composition on lactic acid production rate from whey by Lactobacillus helveticus. Biotechnol Letts 15: 239–244.
   Google Scholar
• Ananou S, Muñoz A, Gálvez A, Martínez-Bueno M, Maqueda M, Valdivia E. 2008. Optimization of enterocin AS-48 production on a whey-based substrate. Intl Dairy J 18: 923–927.
   Web of Science ®Google Scholar
• Ansari SA, Qayyum H. 2010. Lactose hydrolysis by β-galactosidase immobilized on concanavalin A-cellulose in batch and continuous mode. J Mol Catal B: Enzym 63: 68–74.
   Google Scholar
• Anvari M, Khayati G. 2011. Submerged yeast fermentation of cheese whey for protein production and nutritional profile analysis. Adv J Food Sci Technol 3: 122–126.
   Google Scholar
• Arasaratnam V, Senthuran A, Balasubramaniam K. 1996. Supplementation of whey with glucose and different nitrogen sources for lactic acid production by Lactobacillus delbrueckii. Enzyme Microb Technol 19: 482–486.
   Google Scholar
• Arnaud M, Malige B, Galzy P, Moulin G. 1978. Perfectionnement a la fabrication de levure lactique. French Patent 7830229.
   Google Scholar
• Ashour SA, el-Shora HM, Metwally M, Habib SA. 1996. Fungal fermentation of whey incorporated with certain supplements for the production of proteases. Microbios 86: 59–69.
   Google Scholar
• Athanasiadis I, Boskou D, Kanellaki M, Kiosseoglou V, Koutinas AA. 2002. Whey liquid waste of the dairy industry as raw material for potable alcohol production by kefir granules. J Agric Food Chem 50: 7231–7234.
   Google Scholar
• Axelsson A, Nilsson M, Zacchi G, Hahn-Hagerdal B. 1991. Performance of batch and continuous reactors with co-immobilized yeast and β-galactosidase. J Chem Technol Biotechnol 52: 227–241.
   Web of Science ®Google Scholar
• Axelsson L. 2004. Lactic acid bacteria: classification and physiology. In: Salminen S, von Wright A, Ouwehand A, Marcel Dekker eds. Lactic Acid Bacteria: Microbiological and Functional Aspects. New York, Marcel Dekker, 1–66.
   Google Scholar
• Azbar N, Dokgöz FTÇ, Keskin T, Korkmaz KS, Syed HM. 2009. Continuous fermentative hydrogen production from cheese whey wastewater under thermophilic anaerobic conditions. Int J Hydrogen Energy 34: 7441–7447.
   Web of Science ®Google Scholar
• Babu PS, Vaidya AN, Bal AS, Kapur R, Juwarkar A, Khanna P. 1996. Kinetics of biosurfactant production by Pseudomonas aeruginosa strain BS2 from industrial wastes. Biotechnol Letts 18: 263–268.
   Web of Science ®Google Scholar
• Bachhawat N, Gowda LR, Bhat SG. 1996. Single step method of preparation of detergent permeabilized Kluyveromyces fragilis for lactose hydrolysis. Process Biochem 31: 21–25.
   Google Scholar
• Baig S, Qadeer MA, Akhtar MS, Ahmed T. 1990. Utilization of unhydrolyzed cheese whey for the production of extracellular polysaccharide by Xanthomonas cucurbitae PCSIR B-52. J Ferment Bioengg 69: 345–349.
   Google Scholar
• Bailey RB, Benitez T, Woodward A. 1982. Saccharomyces cerevisiae Mutants Resistant to Catabolite Repression: Use in Cheese Whey Hydrolysate Fermentation. Appl Environ Microbiol 44: 631–639.
   Web of Science ®Google Scholar
• Bajpai P, Gera RK, Bajpai PK. 1992. Optimization studies for the production of α-amylase using cheese whey medium. Enzyme Microbial Technol 14: 679–683.
   Google Scholar
• Bajpai P, Verma N, Neer J, Bajpai PK. 1991. Utilization of cheese whey for production of α-amylase enzyme. J Biotechnol 18: 265–270.
   Google Scholar
• Bansal S, Oberoi HS, Dhillon GS, Patil RT. 2008. Production of β-galactosidase by Kluyveromyces marxianus MTCC 1388 using whey and effect of four different methods of enzyme extraction on β-galactosidase activity. Indian J Microbiol 48: 337–341.
   Web of Science ®Google Scholar
• Becerra M, Baroli B, Fadda AM, Méndez JB, González Siso MI. 2001. Lactose bioconversion by calcium-alginate immobilization of Kluyveromyces lactis cells. Enzyme Microb Technol 29: 506–512.
   Web of Science ®Google Scholar
• Begin A, Beaulieu Y, Goulet J, Castaigne F. 1992. Production of propionic acid and utilization of lactic acid and lactose by Propionibacterium shermanii immobilized in alginate gels. J Dairy Sci 75: 138–141.
   Google Scholar
• Ben-Hassan RM, Ghaly AE, Ben-Abdallah N. 1993. Heat generation during batch and continuous production of single cell protein from cheese whey. Biomass Bioenergy 4: 213–225.
   Google Scholar
• Bergmaier D, Champagne CP, Lacroix C. 2003. Exopolysaccharide production during batch cultures with free and immobilized Lactobacillus rhamnosus RW-9595M. J Appl Microbiol 95: 1049–1057.
   PubMedGoogle Scholar
• Bergmaier D, Champagne CP, Lacroix C. 2005. Growth and exopolysaccharide production during free and immobilized cell chemostat culture of Lactobacillus rhamnosus RW-9595M. J Appl Microbiol 98: 272–284.
   PubMed Web of Science ®Google Scholar
• Bernstein S, Tzeng CH, Sisson D. 1977. The commercial fermentation of cheese whey for the production of protein and/or alcohol. Biotechnol Bioeng 7: 1–9.
   Google Scholar
• Bodalo A, Gomez E, Gomez JL, Bastida J, Maximo MF, Diaz F. 1991. A comparison of different methods of β-galactosidase immobilization. Process Biochem 26: 349–353.
   Web of Science ®Google Scholar
• Boyaval P, Goulet J. 1988. Optimal conditions for production of lactic acid from cheese whey permeate by Ca-alginate-entrapped Lactobacillus helveticus. Enzyme Microb Technol 10: 725–728.
   Web of Science ®Google Scholar
• Boze H, Moulin G, Galzy P. 1995. Production of microbial biomass. In: Rehm HJ, Reed G, eds. Biotechnology. Weinheim, Germany: VCH Verlagsgesellschaft mbH, 9, 167–220.
   Google Scholar
• Buchta K. 1983. Lactic acid. In: Rehm HJ, Reed G, eds. Biotechnology. Weinheim, Germany: VCH Verlagsgesellschaft mbH, 3, 409–417.
   Google Scholar
• Burgess K, Shaw M. 1983. Dairy. In: Godfrey T, Reichlet J, eds. Industrial Enzymology, Surrey, England: Mcmillan Publishers Ltd, 221–259.
   Google Scholar
• Buyukgungor H. 1987. Co-immobilization of yeast and β-galactosidase for ethanol formation from cheese-whey. Proc 4th European Congress on Biotechnol 60–63.
   Google Scholar
• Büyükkileci AO, Harsa S. 2004. Batch production of L (+) lactic acid from whey by Lactobacillus casei (NRRL B-441). J Chem Technol Biotechnol 79: 1036–1040.
   Web of Science ®Google Scholar
• Castelló E, García Y Santos C, Iglesias T, Paolino G, Wenzel J, Borzacconi L, Etchebehere C. 2009. Feasibility of biohydrogen production from cheese whey using a UASB reactor: Links between microbial community and reactor performance. Biotechnol Appl Biochem 42: 17–23.
   Google Scholar
• Castillo E, Casas LT. 1990. In: de Bont JAM, Visser J, Mattiasson B, Tramper J (eds), Amsterdam, Netherlands: Elsevier Science Publs, 213–218.
   Google Scholar
• Castillo FJ. 1990. Lactose metabolism by yeasts. In: Verachtert H, De Mot R, eds. Yeast Biotechnology and Biocatalysis. New York: Marcel Dekker, 297–320.
   Google Scholar
• Castillo FJ, de Sánchez SB. 1978. Studies on the growth of Kluyveromyces fragilis in whey for the production of yeast protein. Acta Cient Venez 29: 113–118.
   Google Scholar
• Champagne CP, Girard F, Rodrigue N. 1993. Production of concentrated suspensions of thermophilic lactic acid bacteria in calcium-alginate beads. Intl Dairy J 3: 257–275.
   Web of Science ®Google Scholar
• Champagne CP, Goulet J, Lachance RA. 1990. Production of bakers’ yeast in cheese whey ultrafiltrate. Appl Environ Microbiol 56: 425–430.
   PubMed Web of Science ®Google Scholar
• Champluvier B, Kamp B, Rouxhet PG. 1988. Preparation and properties of β-galactosidase confined in cells of Kluyveromyces sp. Enzyme Microb Technol 10: 611–617.
   Google Scholar
• Chiarini L, Mara L. 1990. Lactic acid production from whey or ultrafiltrate by Lactobacillus helveticus. Food Biotechnol 4: 101–105.
   Google Scholar
• Chiarini, L, Mara, L, Tabacchioni S. 1992. Influence of growth supplements on lactic acid production in whey ultrafiltrate by Lactobacillus helveticus. Appl Microbiol Biotechnol 36: 461–464.
   Web of Science ®Google Scholar
• Chiu CP, Kosikowski FV. 1985. Hydrolyzed lactose syrup from concentrated sweet whey permeate. J Dairy Sci 68: 16–22.
   Google Scholar
• Cladera-Olivera F, Caron GR, Brandelli A. 2004. Bacteriocin production by Bacillus licheniformis strain P40 in cheese whey using response surface methodology. Biochem Engg J 21: 53–58.
   Web of Science ®Google Scholar
• Colomban A, Roger L, Boyaval P. 1993. Production of propionic acid from whey permeate by sequential fermentation, ultrafiltration, and cell recycling. Biotechnol Bioeng 42: 1091–1098.
   PubMed Web of Science ®Google Scholar
• Compagno C, Porro D, Smeraldi C, Ranzi BM. 1995. Fermentation of whey and starch by transformed Saccharomyces cerevisiae cells. Appl Microbiol Biotechnol 43: 822–825.
   PubMed Web of Science ®Google Scholar
• Coughlin RW, Charles M. 1980. Applications of lactase and immobilized lactase. In: Pitcher WH, ed. Immobilized Enzymes for Food Processing. Florida: CRC Press, 153–179.
   Google Scholar
• Cox GC, Macbean RD. 1977. Lactic acid production by Lactobacillus bulgaricus in supplemented whey ultrafilterate. Aust J Dairy Technol 32: 19–22.
   Google Scholar
• Dale MC, Eagger A, Okos MR. 1994. Osmotic inhibition of free and immobilized K. marxianus anaerobic growth and ethanol productivity in whey permeate concentrate. Process Biochem 29: 535–544.
   Web of Science ®Google Scholar
• Davila-Vazquez G, Alatriste-Mondragón F, de León-Rodríguez A, Razo-Flores E. 2008. Fermentative hydrogen production in batch experiments using lactose, cheese whey and glucose: Influence of initial substrate concentration and pH. Intl J Hydrogen Energy 33: 4989–4997.
   Web of Science ®Google Scholar
• Davila-Vazquez G, Cota-Navarro CB, Rosales-Colunga LM, de León-Rodríguez A, Razo-Flores E. 2009. Continuous biohydrogen production using cheese whey: Improving the hydrogen production rate. Intl J Hydrogen Energy 34 4296–4304.
   Web of Science ®Google Scholar
• Decleire M, De-Cat W, Van-Huynh N. 1987. Comparison of various permeabilization treatments on Kluyveromyces by determining in situ β-galactosidase activity. Enzyme Microb Technol 9: 300–302.
   Google Scholar
• Decleire M, Van-Huynh N, Motte JC. 1985. Hydrolysis of lactose solutions and wheys by cells of Kluyveromyces bulgaricus. Appl Microbiol Biotechnol 21 103–107.
   Google Scholar
• Delaney RAM. 1981. Recent developments in the utilization of whey. Cult Dairy Prod J 16: 11–14.
   Google Scholar
• De León-Rodríguez A, Rivera-Pastrana D, Medina-Rivero E, Flores-Flores JL, Estrada-Baltazar A, Ordóñez-Acevedo LG, de la Rosa AP. 2006. Production of penicillin acylase by a recombinant Escherichia coli using cheese whey as substrate and inducer. Biomol Eng 23: 299–305.
   Google Scholar
• de Lima CJB, Coelho LF, Contiero J. (2010). The use of response surface methodology in optimization of lactic acid production: focus on medium supplementation, temperature and pH control. Food Technol Biotechnol 48: 175–181.
   Web of Science ®Google Scholar
• Demirhan E, Apar DK, Ozbek B. 2008. Effect of hydrolysis products and Mg2+ Mn2+ and Ca2+ ions on whey lactose hydrolysis and β-galactosidase stability. J Chem Technol Biotechnol 83: 625–636.
   Google Scholar
• Desai M, Madamwar D. 1994. Anaerobic digestion of a mixture of cheese whey, poultry waste and cattle dung: a study of the use of adsorbents to improve digester performance. Environ Pollut 86: 337–340.
   Google Scholar
• de Sánchez SB, Castillo FJ. 1980. Effect of pH on the growth of Kluyveromyces fragilis on deproteinized whey. Acta Cient Venez 31: 24–26.
   Google Scholar
• Domingues L, Lima N, Teixeira JA. 2001. Alcohol production from cheese whey permeate using genetically modified flocculent yeast cells. Biotechnol Bioeng 72: 507–514.
   PubMed Web of Science ®Google Scholar
• Donaghy JA, McKay AM. 1994. Pectin extraction from citrus peel by polygalacturonase produced on whey. Bioresource Technol 47: 25–28.
   Web of Science ®Google Scholar
• Dragone G, Mussatto SI, Almeida e Silva JB, Teixeira JA. 2011. Optimal fermentation conditions for maximizing the ethanol production by Kluyveromyces fragilis from cheese whey powder. Biomass Bioenergy 35: 1977–1982.
   Google Scholar
• Dragone G, Mussatto SI, Oliveira JM, Teixeira JA. 2009. Characterisation of volatile compounds in an alcoholic beverage produced by whey fermentation. Food Chem 112 929–935.
   Web of Science ®Google Scholar
• Dwevedi A, Kayastha AM. 2009. Optimal immobilization of beta-galactosidase from Pea (PsBGAL) onto Sephadex and chitosan beads using response surface methodology and its applications. Bioresour Technol 100: 2667–2675.
   PubMed Web of Science ®Google Scholar
• Elezi O, Kourkoutas Y, Koutinas AA, Kanellaki M, Bezirtzoglou E, Barnett YA, Nigam P. 2003. Food additive lactic acid production by immobilized cells of Lactobacillus brevis on delignified cellulosic material. J Agric Food Chem 51: 5285–5289.
   Google Scholar
• el-Gindy A. 2003. Production, partial purification and some properties of beta-galactosidase from Aspergillus carbonarius. Folia Microbiol (Praha) 48: 581–584.
   PubMed Web of Science ®Google Scholar
• El-Holi MA, Al-Delaimy KS. 2003. Citric acid production from whey with sugars and additives by Aspergillus niger. African J Biotechnol 2: 356–359.
   Google Scholar
• el-Sabaeny AH. 1996. Influence of medium composition on lactic acid production from dried whey by Lactobacillus delbrueckii. Microbiologia 12: 411–416.
   Google Scholar
• el-Samragy YA, Khorshid MA, Foda MI, Shehata AE. 1996. Effect of fermentation conditions on the production of citric acid from cheese whey by Aspergillus niger. Int J Food Microbiol 29: 411–416.
   PubMed Web of Science ®Google Scholar
• El-Samragy YA, Shehata AE, Foda MI, Khorshid MA. 1993. Suitability of strains and mutants of Aspergillus niger for the production of citric acid from cheese whey. Milchwissenschaft 48: 498–501.
   Google Scholar
• Ergüder TH, Tezel U, Güven E, Demirer GN. 2001. Anaerobic biotransformation and methane generation potential of cheese whey in batch and UASB reactors. Waste Manag 21: 643–650.
   PubMed Web of Science ®Google Scholar
• Estrada-Baltazar A, Ordóñez-Acevedo LG, Barba de la Rosa AP. 2006. Production of penicillin acylase by a recombinant Escherichia coli using cheese whey as substrate and inducer. Biomol Engg 23: 299–305.
   Google Scholar
• Feijoo G, Moreira M, Roca E, Lema J. 1999. Use of cheese whey as a substrate to produce manganese peroxidase by Bjerkandera sp BOS55. J Ind Microbiol Biotechnol 23: 86–90.
   PubMed Web of Science ®Google Scholar
• Ferrari MD, Loperena L, Varela H. 1994. Ethanol production from concentrated whey permeate using a fed-batch culture of Kluyveromyces fragilis. Biotechnol Letts 16: 205–210.
   Google Scholar
• Fialho AM, Martins LO, Donval ML, Leitao JH, Ridout MJ, Jay AJ, Morris VJ, Sa-Correia I I. 1999. Structures and properties of gellan polymers produced by sphingomonas paucimobilis ATCC 31461 from lactose compared with those produced from glucose and from cheese whey. Appl Environ Microbiol 65: 2485–2491.
   PubMed Web of Science ®Google Scholar
• Finocchiaro T, Olson NF, Richardson T. 1980. Use of immobilized lactase in milk systems. Adv Biochem Engg 15: 71–88.
   Google Scholar
• Flores MV, Voget CE, Ertola RJJ. 1994. Permeabilization of yeast cells (Kluyveromyces lactis) with organic solvents. Enzyme Microb Technol 16: 340–346.
   Web of Science ®Google Scholar
• Foda MI, Dong H, Li Y. 2010. Study the suitability of cheese whey for bio-butanol production by clostridia. J Am Sci 6: 39–46.
   Google Scholar
• Fox PF, Guinee TP, Cogan TM, McSweeney PLH. 2000. Fundamentals of cheese science. Gaithersburg, Maryland: Aspen publishers Inc.
   Google Scholar
• Frengova GI, Emilina SD, Beshkova DM. 2003. Carotenoid production by lactoso-negative yeasts co-cultivated with lactic acid bacteria in whey ultrafiltrate. Z Naturforsch, C, J Biosci 58: 562–567.
   PubMedGoogle Scholar
• Frengova G, Simova E, Beshkova D. 2004. Use of whey ultrafiltrate as a substrate for production of carotenoids by the yeast Rhodotorula rubra. Appl Biochem Biotechnol 112: 133–141.
   Google Scholar
• Gandhi DN. 1989. Production of some useful products of industrial importance through microbial fermentation of whey. Indian Dairyman 45: 182–184.
   Google Scholar
• Gekas V, Lopez-Leiva M. 1985. Hydrolysis of lactose: A literature review. Process Biochem 20: 2–12.
   Web of Science ®Google Scholar
• Ghaly AE, Ben-Hassan RM, Ben-Abdallah N. 1992. Effect of ambient temperature on the heating/cooling requirement of a single cell protein batch reactor operating on cheese whey. Biomass Bioenergy 3: 335–344.
   Google Scholar
• Ghaly AE, El-Taweel AA. 1995. Effect of micro-aeration on the growth of Candida pseudotropicalis and production of ethanol during batch fermentation of cheese whey. Biores Technol 52: 203–217.
   Web of Science ®Google Scholar
• Ghaly AE, El-Taweel AA. 1997. Kinetic modelling of continuous production of ethanol from cheese whey. Biomass Bioenergy 12: 461–472.
   Web of Science ®Google Scholar
• Ghaly AE, Kamal M, Correia LR. 2005. Kinetic modelling of continuous submerged fermentation of cheese whey for single cell protein production. Bioresour Technol 96: 1143–1152.
   PubMed Web of Science ®Google Scholar
• Ghaly AE, Kamal MA. 2004. Submerged yeast fermentation of acid cheese whey for protein production and pollution potential reduction. Water Res 38: 631–644.
   PubMed Web of Science ®Google Scholar
• Ghasemi M, Najafpour G, Rahimnejad M, Beigi PA, Sedighi M, Hashemiyeh B. 2009. Effect of different media on production of lactic acid from whey by Lactobacillus bulgaricus. African J Biotechnol 8: 81–84.
   Google Scholar
• Giec A, Kosikowski FV. 1982. Activity of lactose fermenting yeasts in producing biomass from concentrated whey permeates. J Food Sci 47: 1892–1907.
   Google Scholar
• Gohlwar CS, Sethi RP, Marwaha SS, Sehgal VK, Kennedy JF. 1984. Gibberellic acid biosynthesis from whey and simulation of cultural conditions. Enzyme Microb Technol 6: 312–316.
   Web of Science ®Google Scholar
• Göksungur Y, Gündüz M, Harsa S. 2005. Optimization of lactic acid production from whey by L.casei NRRL B-441 immobilized in chitosan stabilized Ca-alginate beads. J Chem Technol Biotechnol 80: 1282–1290.
   Web of Science ®Google Scholar
• González MI, Álvarez S, Riera F, Álvarez R. 2007. Economic evaluation of an integrated process for lactic acid production from ultrafiltered whey. J Food Engg 80: 553–561.
   Web of Science ®Google Scholar
• Gonzalez-Siso MI. 1994. β-galactosidase production by Kluyveromyces lactis on milk whey: batch versus fed-batch cultures. Process Biochem 29 565–568.
   Web of Science ®Google Scholar
• Gonzalez-Siso MI, Suarez-Doval S. 1994. Kluyveromyces lactis immobilization on corn grits for milk whey lactose hydrolysis. Enzyme Microb Technol 16: 303–310.
   Google Scholar
• Gonzalez-Siso MI. 1996. The biotechnological utilization of cheese whey: A review. Biores Technol 57: 1–17.
   Web of Science ®Google Scholar
• Gowda LR, Joshi MS, Bhat SG. 1988. In situ assay of intracellular enzymes of yeast (Kluyveromyces fragilis) by digitonin permeabilization of cell membrane. Anal Biochem 175: 531–536.
   Google Scholar
• Guerra NP, Castro LP. 2003. Enhancement of nisin production by Lactococcus lactis in periodically re-alkalized cultures. Biotechnol Appl Biochem 38: 157–167.
   PubMed Web of Science ®Google Scholar
• Guerra NP, Rua ML, Pastrana L. 2001. Nutritional factors affecting the production of two bacteriocins from lactic acid bacteria on whey. Int J Food Microbiol 70: 267–281.
   PubMed Web of Science ®Google Scholar
• Guerra NP, Bernárdez PF, Castro LP. 2007. Fed-batch pediocin production on whey using different feeding media. Enzyme Microb Technol 41: 397–406.
   Web of Science ®Google Scholar
• Haider T, Husain Q. 2009. Hydrolysis of milk/whey lactose by β-galactosidase: A comparative study of stirred batch process and packed bed reactor prepared with calcium alginate entrapped enzyme. Chem Engg Process: Process Intesification 48: 576–580.
   Web of Science ®Google Scholar
• Harju M, Heikkonen M, Kreula M. 1976. Nutrient supplementation of swiss cheese whey for the production of feed yeast. Milchiwssenschaft 31: 530–534.
   Google Scholar
• Hossain M, Brooks JD, Maddox IS. 1983. Production of citric acid from whey permeate by fermentation using Aspergillus niger. NZJ Dairy Sci Technol 18: 161–168.
   Google Scholar
• Iliev I, Radoilska E, Ivanova I, Enikova R. 2001. Biosynthesis of exopolysaccharides by two strains of Lactobacillus bulgaricus in whey-based media. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 66: 511–516.
   Google Scholar
• Jelen P. 2003. Whey processing In: Roginski H, Fuquay JW, Fox PF, eds. Encylcopedia of dairy sciences. London: Academic press, 2739–2751.
   Google Scholar
• Jeong YS, Vieth WR, Matsuura T. 1991. Fermentation of lactose to ethanol with recombinant yeast in an immobilized yeast membrane bioreactor. Biotechnol Bioeng 37: 587–590.
   PubMed Web of Science ®Google Scholar
• Joshi MS, Gowda LR, Katwa LC, Bhat SG. 1987. Permeabilization of yeast cells (Kluyveromyces fragilis) to lactose by cetyltrimethylammonium bromide. Biotechnol Letts 9: 549–554.
   Web of Science ®Google Scholar
• Joshi MS, Gowda LR, Katwa LC, Bhat SG. 1989. Permeabilization of yeast cells (Kluyveromyces fragilis) to lactose by digitonin. Enzyme Microb Technol 11: 439–443.
   Google Scholar
• Joshi S, Bharucha C, Jha S, Yadav S, Nerurkar A, Desai AJ. 2008. Biosurfactant production using molasses and whey under thermophilic conditions. Bioresour Technol 99: 195–199.
   PubMed Web of Science ®Google Scholar
• Kahlon SS, Malhotra S. 1986. Production of gibberellic acid by fungal mycelium immobilized in sodium alginate. Enzyme Microb Technol 8: 613–616.
   Web of Science ®Google Scholar
• Kallel-Mhiri H, Valance C, Engasser JM, Miclo A. 1994. Yeast continuous mixed cultures on whey permeate and hydrolysed starch. Process Biochem 29: 381–386.
   Google Scholar
• Kargi F, Ozmıhc S. 2006. Utilization of cheese whey powder (CWP) for ethanol fermentations: Effects of operating parameters. Enzyme Microb Technol 38: 711–718.
   Web of Science ®Google Scholar
• Kaur G, Panesar PS, Bera MB, Kumar H. 2009. Hydrolysis of whey lactose using CTAB-permeabilized yeast cells. Bioprocess Biosyst Eng 32: 63–67.
   PubMed Web of Science ®Google Scholar
• Kitamoto HK, Nakahara T. 1994. Isolation of L-methionine-enriched mutant of Kluyveromyces lactis grown on whey permeate. Process Biochem 29 127–131.
   Web of Science ®Google Scholar
• Koller M, Bona R, Chiellini E, Fernandes EG, Horvat P, Kutschera C, Hesse P, Braunegg G. 2008. Polyhydroxyalkanoate production from whey by Pseudomonas hydrogenovora. Bioresour Technol 99: 4854–4863.
   PubMed Web of Science ®Google Scholar
• Kosikowski FV. 1979. Whey utilization and whey products. J Dairy Sci 62: 1149–1160.
   Web of Science ®Google Scholar
• Kourkoutas Y, Psarianos C, Koutinas AA, Kanellaki M, Banat IM, Marchant R. 2002. Continuous whey fermentation using kefir yeast immobilized on delignified cellulosic material. J Agric Food Chem 50: 2543–2547.
   Google Scholar
• Kourkoutas Y, Xolias V, Kallis M, Bezirtzoglou E, Kanellaki M. 2005. Lactobacillus casei cell immobilization on fruit pieces for probiotic additive, fermented milk and lactic acid production. Process Biochem 40: 411–416.
   Web of Science ®Google Scholar
• Kozhucharova A, Baztosolova K, Papova Y, Kirova N, Klysursky D, Simeonov, T. 1990. Properties and employment of β-galactosidase immobilized on hydrogel from silica. Bioteknologiya 1: 61–64.
   Google Scholar
• Krischke W, Schroder M, Trosch W. 1991. Continuous production of L-lactic acid from whey permeate by immobilized Lactobacillus casei subsp. casei. Appl Microbiol Biotechnol 34: 573–578.
   Web of Science ®Google Scholar
• Kulozik U, Wilde J. 1999. Rapid lactic acid production at high cell concentrations in whey ultrafiltrate by Lactobacillus helveticus. Enzyme Microb Technol 24: 297–302.
   Web of Science ®Google Scholar
• Kumari S, Panesar PS, Bera MB, Singh B. 2011a. Permeabilization of yeast cells for β-galactosidase activity using mixture organic solvents: A response surface methodology approach. Asian J Biotechnol 3: 406–411.
   Google Scholar
• Kumari S, Panesar PS, Panesar R. 2011b. Production of β-galactosidase using novel yeast isolate from whey. Intl J Dairy Sci 6: 150–156.
   Google Scholar
• Lefrancois L. 1964. Problemes de l’aeration et de la circulation dans les curve de fermentations aerobies. Ind Alim Agric 1: 3–18.
   Google Scholar
• Linko YY, Jalanka H, Linko P. 1981. Ethanol production from whey with immobilized living yeast. Biotechnol Letts 3: 263–268.
   Web of Science ®Google Scholar
• Liu C, Liu Y, Liao W, Wen Z, Chen S. 2004. Simultaneous production of nisin and lactic acid from cheese whey: optimization of fermentation conditions through statistically based experimental designs. Appl Biochem Biotechnol 113-116: 627–638.
   Google Scholar
• Liu X, Chung Y-K, Yang S-T, Yousef AE. 2005. Continuous nisin production in laboratory media and whey permeate by immobilized Lactococcus lactis. Process Biochem 40: 13–24.
   Web of Science ®Google Scholar
• Lo KV, Liao PH. 1988. Laboratory scale studies on the mesophilic anaerobic digestion of cheese whey in different digester configurations. J Agri Engg Res 39: 99–105.
   Google Scholar
• Lund B, Norddahl B, Ahring B. 1992. Production of lactic acid from whey using immobilized whey protein as nitrogen source. Biotechnol Letts 14: 851–856.
   Web of Science ®Google Scholar
• Macedo MG, Lacroix C, Champagne CP. 2002. Combined effects of temperature and medium composition on exopolysaccharide production by Lactobacillus rhamnosus RW-9595M in a whey permeate based medium. Biotechnol Prog 18: 167–173.
   Google Scholar
• Magalhães KT, Dragone G, de Melo Pereira GV, Oliveira JM, Domingues L, Teixeira JA, Almeida e Silva JB, Schwan RF. 2011. Comparative study of the biochemical changes and volatile compound formations during the production of novel whey-based kefir beverages and traditional milk kefir. Food Chem 126: 249–253.
   Google Scholar
• Mahmood MM, Kosikowaski FV. 1982. Alcohol and single cell protein protein production by Kluyveromyces in concentrated whey permeate with reduced ash. J Dairy Sci 65: 2082–2087.
   Google Scholar
• Marcoux V, Beaulieu Y, Champagne CP, Goulet J. 1992. Production of Propionibacterium freudenreichii subsp. shermanii in whey-based media. J Ferment Bioengg 74: 95–99.
   Google Scholar
• Mariotti MP, Yamanaka H, Araujo AR, Trevisan HC. 2008. Hydrolysis of whey lactose by immobilized β-Galactosidase. Braz Arch Biol Technol 51: 1233–1240.
   Google Scholar
• Marwaha SS, Kennedy JF. 1984a. Alcohol production from whey permeate by immobilized and free cells of Kluyveromyces marxianus NCYC 179. Process Biochem 19: 79–84.
   Google Scholar
• Marwaha SS, Kennedy JF. 1984b. Ethanol production from whey permeate by immobilized yeast cells. Enzyme Microb Technol 6: 18–22.
   Google Scholar
• Marwaha SS, Kennedy JF. 1988. Review: whey pollution problem and potential utilization. Int J Food Sci Technol 23: 323–336.
   Google Scholar
• Marwaha SS, Sethi RP. 1983. Utilization of dairy waste for vitamin B12 fermentation. Agric Wastes 9: 111–130.
   Google Scholar
• Marwaha SS, Sethi RP, Kennedy JF. 1983a. Influence of 5,6-dimethylbenzimidazole (DMB) on vitamin B12 biosynthesis by strains of Propionibacterium. Enzyme Microb Technol 5: 361–364.
   Web of Science ®Google Scholar
• Marwaha SS, Sethi RP, Kennedy JF. 1983b. Role of amino acids, betaine and choline on vitamin B12 biosynthesis by strains of Propionibacterium. Enzyme Microb Technol 5: 454–464.
   Google Scholar
• Mawson AJ. 1994. Bioconversions for whey utilization and waste abatement. Bioresource Technol 47: 195–203.
   Web of Science ®Google Scholar
• Mehaia MA, Cheryan M. 1986. Lactic acid from acid whey permeate in a membrane recycle bioreactor. Enzyme Microb Technol 8: 289–292.
   Web of Science ®Google Scholar
• Mehyar GF, Delaimy KS, Ibrahim SA. 2005. Citric acid production by Aspergillus niger using date base medium fortified with whey, methanol and tricalcium phosphate. Food Biotechnol 19: 137–144.
   Web of Science ®Google Scholar
• Mendez R, Blazquez R. 1989. Anaerobic treatment of cheese whey: start-up and operation. Water Sci Technol 21: 1857–1860.
   Google Scholar
• Meyrath J, Bayer K. 1979. Biomass from whey. In: Rose AH, ed. Economic Microbiology. London: Academic Press, 4, 207–269.
   Google Scholar
• Mistry VV, Kosikowski FV, Bellam WD. 1987. Improvement of lactic acid production in ultrafiltered milk by the addition of nutrients. J Dairy Sci 70: 2220–2225.
   Google Scholar
• Moebus O, Kiesbye P. 1975. Continuous process for producing yeast protein and baker’s yeast. G.F.R. Patent Application 2410349.
   Google Scholar
• Mostafa NA. 1996. Production of lactic acid from whey with agar immobilized cells in a continuous packed tubular reactor. Energy Conver Manag 37: 253–260.
   Google Scholar
• Mostafa NA. 2001. Production of acetic acid and glycerol from salted and dried whey in a membrane cell recycle bioreactor. Energy Conver Manag 42: 1133–1142.
   Web of Science ®Google Scholar
• Moulin G, Galzy P. 1984. Whey, a potential substrate for biotechnology. Biotechnol Genet Engg Rev 1: 347–374.
   Web of Science ®Google Scholar
• Moulin G, Legrand M, Galzy P. 1983. The importance of residual aerobic fermentation in aerated medium for the production of yeast from glucidic substrates. Process Biochem 18: 5–17.
   Google Scholar
• Mukherjee S, Das P, Sen R. 2006. Towards commercial production of microbial surfactants. Trends Biotechnol 24: 509–515.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay R, Chatterjee S, Chatterjee BP, Banerjee PC, Guha AK. 2005. Production of gluconic acid from whey by free and immobilized Aspergillus niger. Intl Dairy J 15: 299–303.
   Web of Science ®Google Scholar
• Murad HA, Abd El-Ghani S, Effat BA. 1992. Utilization of some dairy and food industry wastes in the production of lactic acid. Egyptian J Dairy Sci 20 83–90.
   Google Scholar
• Murad HA, Foda MS. 1992. Utilization of some dairy and food industry wastes in the production of lactic acid. Bioresource Technol 41: 247–250.
   Google Scholar
• Najafpour GD, Rahimnejad M, Mokhtarian N, Daud WRW and Ghoreyshi AA. 2010. Bioconversion of whey to electrical energy in a biofuel cell using Saccharomyces cerevisiae. World Appl Sci J 8: 1–5.
   Google Scholar
• Nunes MFA, Massaguer S, Alegra RM. 1983. Production and properties of β-galactosidase of Kluyveromyces fragilis NRRL Y-2415. Rev Farm Bioquim Univ Sao-Paulo 29: 25–30.
   Google Scholar
• O’Leary VS, Green R, Sullivan BC, Holsinger VH. 1977. Alcohol production by selected yeast strains in lactase hydrolyzed acid whey. Biotechnol Bioeng 19: 1019–1035.
   Web of Science ®Google Scholar
• Omar S, Sabry S. 1991. Microbial biomass and protein production from whey. J Islamic Acad Sci 4: 170–172.
   Google Scholar
• Ozmıhci S, Kargi F. 2007a. Ethanol fermentation of cheese whey powder solution by repeated fed-batch operation. Enzyme Microb Technol 41: 169–174.
   Web of Science ®Google Scholar
• Ozmıhci S, Kargi F. 2007b. Effects of feed sugar concentration on continuous ethanol fermentation of cheese whey powder solution (CWP). Enzyme Microb Technol 41: 876–880.
   Web of Science ®Google Scholar
• Ozmıhci, S., and Kargi, F. 2008. Ethanol production from cheese whey powder solution in a packed column bioreactor at different hydraulic residence times. Biochemical Engg J 42: 180–185.
   Web of Science ®Google Scholar
• Panesar PS. 2008a. Application of response surface methodology in the permeabilization of yeast cells for lactose hydrolysis. Biochem Eng J 39: 91–96.
   Web of Science ®Google Scholar
• Panesar PS. 2008b. Production of β-D-glactosidase from whey using Kluyveromyces marxianus. Research J Microbiol 3: 24–29.
   Google Scholar
• Panesar PS, Kennedy JF, Gandhi DN, Bunko K. 2007a. Bioutilisation of whey for lactic acid production. Food Chem 105: 1–14.
   Web of Science ®Google Scholar
• Panesar PS, Kennedy JF, Knill CJ, Kosseva MR. 2010a. Optimization of process parameters for the production of L(+) lactic acid by Lactobacillus casei from whey. Braz Arch Biol Technol 53: 219–226.
   Google Scholar
• Panesar R, Panesar PS, Kumar N, Bera MB. 2010b. Evaluation of bacterial strains for biosurfactant production from agro-industrial waste. Asian J Microbiol Biotechnol Environ 12: 33–38.
   Google Scholar
• Panesar R, Panesar PS, Singh RS, Bera MB. 2007b. Applicability of alginate entrapped yeast cells for the production of lactose hydrolyzed milk. J Food Process Eng 30: 472–484.
   Google Scholar
• Panesar PS, Panesar R, Singh RS, Kennedy JF. 2006. Microbial production, immobilization and applications of β-D-galactosidase. J Chemical Technol Biotechnol 81: 530–543.
   Web of Science ®Google Scholar
• Pantazaki AA, Papaneophytou CP, Pritsa AG, Liakopoulou-Kyriakides M, Kyriakidis DA. 2009. Production of polyhydroxyalkanoates from whey by Thermus thermophilus HB8. Process Biochem 44: 847–853.
   Web of Science ®Google Scholar
• Paraskevopoulou A, Athanasiadis I, Kanellaki M, Bekatorou A, Blekas G, Kiosseoglou V. 2003. Functional properties of single cell protein produced by kefir microflora. Food Res Intl 36: 431–438.
   Web of Science ®Google Scholar
• Patel P, Datta M. 1998. Surfactants in anaerobic digestion of salty cheese whey using upflow fixed film reactor for improved biomethanation. Process Biochem 33: 199–203.
   Google Scholar
• Patel P, Desai M, Datta M. 1995. Biomethanation of cheese whey using anaerobic upflow fixed film reactor. J Ferm Bioengg 79: 398–399.
   Google Scholar
• Pauli T, Fitzpatrick JJ. 2002. Malt combing nuts as a nutrient supplement to whey permeate for producing lactic by fermentation with Lactobacillus casei Process Biochem 38: 1–6.
   Web of Science ®Google Scholar
• Pérez Guerra N, Bernárdez PF, Agrasar AT, López Macías C, Castro LP. 2005. Fed-batch pediocin production by Pediococcus acidilactici NRRL B-5627 on whey. Biotechnol Appl Biochem 42: 17–23.
   Google Scholar
• Plainer H, Sprossler BG, Uhlig H. 1984. Technical application of immobilized lactase and amino acid acylase (Plexazym). Hoppe-Seyler-Z Physiol Chem 365: 1043–1047.
   Google Scholar
• Pooro D, Martegani E, Ranza BM, Alberghina L. 1992. Development of high cell density cultures of engineered Saccharomyces cerevisiae cells able to grow on lactose. Biotechnol Letts 14: 1085–1088.
   Google Scholar
• Qureshi N, Maddox IS. 1995. Continuous production of acetone-butanol-ethanol using immobilized cells of Clostridium acetobutylicum and integration with product removal by liquid-liquid extraction. J Ferment Bioengg 80: 185–189.
   Google Scholar
• Ramakrishnan S, Hartley BS. 1993. Fermentation of lactose by yeast cells secreting recombinant fungal lactase. Appl Environ Microbiol 59: 4230–4235.
   PubMed Web of Science ®Google Scholar
• Ramírez Matheus AO, Rivas N. 2003. [Production and partial characterization of beta-galactosidase from Kluyveromyces lactis grown in deproteinized whey]. Arch Latinoam Nutr 53: 194–201.
   Google Scholar
• Rapin JD, Marison IW, Von Stockar U, Reilly PJ. 1994. Glycerol production by yeast fermentation of whey permeate. Enzyme Microb Technol 16: 143–150.
   Google Scholar
• Rech R, Ayub MAZ. 2007. Simplified feeding strategies for fed-batch cultivation of Kluyveromyces marxianus in cheese whey. Process Biochem 42: 873–877.
   Web of Science ®Google Scholar
• Rech R, Cassini C, Secchi A, Ayub M. 1999. Utilization of protein-hydrolyzed cheese whey for production of beta-galactosidase by Kluyveromyces marxianus. J Ind Microbiol Biotechnol 23: 91–96.
   PubMed Web of Science ®Google Scholar
• Rhimi M, Boisson A, Dejob M, Boudebouze S, Maguin E, Haser R, Aghajari N. 2010. Efficient bioconversion of lactose in milk and whey: immobilization and biochemical characterization of a beta-galactosidase from the dairy Streptococcus thermophilus LMD9 strain. Res Microbiol 161: 515–525.
   PubMed Web of Science ®Google Scholar
• Rodrigues L, Teixeira JA, Oliveira R. 2006. Response surface optimization of the medium components for production of biosurfactants by probiotic bacteria. Process Biochem 41: 1–10.
   Web of Science ®Google Scholar
• Rogosa M, Browne HN, Whittier EO. 1947. Ethyl alcohol from whey. J Dairy Sci 30: 263–269.
   Google Scholar
• Romero FJ, García LA, Salas JA, Díaz M, Quirós LM. 2001. Production, purification and partial characterization of two extracellular proteases from Serratia marcescens grown in whey. Process Biochem 36: 507–515.
   Google Scholar
• Roukas T. 1999. Pullulan production from deproteinized whey by Aureobasidium pullulans. J Ind Microbiol Biotechnol 22: 617–621.
   Google Scholar
• Roukas T, Kotzekidou P. 1991. Production of lactic acid from deproteinized whey by coimmobilized Lactobacillus casei and Lactococcus lactis cells. Enzyme Microb Technol 13: 33–38.
   Web of Science ®Google Scholar
• Roy D, Goulet J, LeDuy A. 1986. Batch fermentation of whey ultrafilterate by Lactobacillus helveticus for lactic acid production. Appl Microbiol Biotechnol 24: 206–213.
   Web of Science ®Google Scholar
• Roy D, Goulet J, LeDuy A. 1987. Continuous production of lactic acid by free and calcium alginate entrapped Lactobacillus helveticus. J Dairy Sci 70: 506–513.
   Web of Science ®Google Scholar
• Roy I, Gupta MN. 2003. Lactose hydrolysis by Lactozym™ immobilized on cellulose beads in batch and fluidized bed modes. Process Biochem 39: 325–332.
   Web of Science ®Google Scholar
• Russel I. 1986. DNA yeast be able to solve whey disposal problems? Trends Biotechnol 4: 107–108.
   Google Scholar
• Saddoud A, Hassaïri I, Sayadi S. 2007. Anaerobic membrane reactor with phase separation for the treatment of cheese whey. Bioresour Technol 98: 2102–2108.
   PubMed Web of Science ®Google Scholar
• Sandhu DK, Waraich MK. 1983. Conversion of cheese whey to single-cell protein. Biotechnol Bioeng 25: 797–808.
   PubMed Web of Science ®Google Scholar
• Sansonetti, S, Curcio, S, Calabrò, V, Iorio, G. 2009. Bio-ethanol production by fermentation of ricotta cheese whey as an effective alternative non-vegetable source. Biomass Bioenergy 33: 1687–1692.
   Web of Science ®Google Scholar
• Sansonetti S, Curcio S, Calabrò V, Iorio G. 2010. Optimization of ricotta cheese whey (RCW) fermentation by response surface methodology. Bioresour Technol 101: 9156–9162.
   PubMed Web of Science ®Google Scholar
• Sansonetti S, Curcio S, Calabrò V, Iorio G. 2010b. A hybrid neural approach to model batch fermentation of “ricotta cheese whey” to ethanol. Computers Chem Eng 34: 1590–1596.
   Google Scholar
• Schepers AW, Thibault J, Lacroix C. 2002. Lactobacillus helveticus growth and lactic acid production during pH-controlled batch cultures in whey permeate/yeast extract medium. Part I. multiple factor kinetic analysis. Enzyme Microb Technol 30: 176–186.
   Web of Science ®Google Scholar
• Schepers AW, Thibault J, Lacroix, C. 2006. Continuous lactic acid production in whey permeate/yeast extract medium with immobilized Lactobacillus helveticus in a two-stage process: Model and experiments. Enzyme Microb Technol 38: 324–337.
   Web of Science ®Google Scholar
• Schultz N, Chang L, Hauck A, Reuss M, Syldatk C. 2006. Microbial production of single-cell protein from deproteinized whey concentrates. Appl Microbiol Biotechnol 69: 515–520.
   PubMed Web of Science ®Google Scholar
• Senthuran A, Senthuran V, Hatti-Kaul R, Mattiasson B. 1999. Lactic acid production by immobilized Lactobacillus casei in recycle batch reactor: a step towards optimization. J Biotechnol 73: 61–70.
   Google Scholar
• Shahbazi A, Mims MR, Li Y, Shirley V, Ibrahim SA, Morris A. 2005. Lactic acid production from cheese whey by immobilized bacteria. Appl Biochem Biotechnol 121-124: 529–540.
   Google Scholar
• Shene C, Bravo S. 2007. Whey fermentation by Lactobacillus delbrueckii subsp. bulgaricus for exopolysaccharide production in continuous culture. Enzyme Microb Technol 40: 1578–1584.
   Web of Science ®Google Scholar
• Shukla TP. 1975. Beta-galactosidase technology: A solution to the lactose problem. Crit Rev Food Technol 5: 325–356.
   Google Scholar
• Silva EM, Yang S-T. 1995. Kinetics and stability of a fibrous-bed bioreactor for continuous production of lactic acid from unsupplemented acid whey. J Biotechnol 41: 59–70.
   Google Scholar
• Silva MF, Fornari RCG, Mazutti MA, de Oliveira D, Padilha FF, Cichoski AJ, Cansian RL, Luccio MD, Treichel H. 2009. Production and characterization of xantham gum by Xanthomonas campestris using cheese whey as sole carbon source. J Food Engg 90: 119–123.
   Web of Science ®Google Scholar
• Silveira WB, Passos FJV, Mantovani HC, Passos FML. 2005. Ethanol production from cheese whey permeate by Kluyveromyces marxianus UFV-3: A flux analysis of oxido-reductive metabolism as a function of lactose concentration and oxygen levels. Enzyme Microb Technol 36: 930–936.
   Web of Science ®Google Scholar
• Singh RS, Sooch BS, Kaur K, Kennedy JF. 2004. Optimization of parameters for citric acid production from cheddar cheese whey using Metschnikowia pulcherrima NCIM 3108. J Biol Sci 4: 700–705.
   Google Scholar
• Siso MIG, Cerdan E, Freire MA, Ramil E, Belmonte ER, Torres AMR. 1992. Permeabilization of Kluyveromyces lactis cells for milk whey saccharification: A comparison of different treatments. Biotechnol Technol 6: 289–292.
   Google Scholar
• Siso MIG, Freire MA, Ramil E, Belmonte ER, Torres AR, Cerdan E. 1994. Covalent immobilization of β-galactosidase on corn grits: A system for lactose hydrolysis without diffusional resistance. Process Biochem 29: 7–12.
   Google Scholar
• Somkuti GA, Bencivengo MM. 1981. Citric acid fermentation in whey permeate. Dev Ind Microbiol 22: 557–563.
   Google Scholar
• Somkuti GA, Dominiecki ME, Steinberg DH. 1998. Permeabilization of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus with ethanol. Curr Microbiol 36: 202–206.
   PubMed Web of Science ®Google Scholar
• Somkuti GA, Steinberg DH. 1994. Permeabilization of Streptococcus thermophilus and the expression of beta-galactosidase. Enzyme Microb Technol 16: 573–576.
   Web of Science ®Google Scholar
• Somkuti GA, Steinberg DH. 2003. Pediocin production by recombinant lactic acid bacteria. Biotechnol Lett 25: 473–477.
   PubMed Web of Science ®Google Scholar
• Sreekrishna K, Dickson RC. 1985. Construction of strains of Saccharomyces cerevisiae that grow on lactose. Proc Natl Acad Sci USA 82: 7909–7913.
   PubMed Web of Science ®Google Scholar
• Szczodrak J. 2000. Hydrolysis of lactose in whey permeate by immobilized β-galactosidase from Kluyveromyces fragilis. J Mol Cat B Enz 10: 631–637.
   Web of Science ®Google Scholar
• Tango MSA, Ghaly AE. 1999. Effect of temperature on lactic acid production from cheese whey using Lactobacillus helvetics under batch conditions. Biomass Bioenergy 16: 61–78.
   Web of Science ®Google Scholar
• Thigiel AA, Deak T. 1989. Selection of strains and extraction procedures for optimum production of β-galactosidase from Kluyveromyces strains. Zbl Mikrobiol 144: 465–471.
   Google Scholar
• Tuli A, Sethi RP, Khanna PK, Marwaha SS, Kennedy JF. 1985. Lactic acid production from whey permeate by immobilized Lactobacillus casei. Enzyme Microb Technol 7: 164–168.
   Web of Science ®Google Scholar
• Varela H, Ferrari MD, Loperena L, Lareo C. 1992. Effect of aeration rate on the alcoholic fermentation of whey by Kluyveromyces fragilis. Microbiologia 8: 14–20.
   Google Scholar
• Vasala A, Panula J, Neubauer P. 2005. Efficient lactic acid production from high salt containing dairy by-products by Lactobacillus salivarius ssp. salicinius with pre-treatment by proteolytic microorganisms. J Biotechnol 117: 421–431.
   PubMed Web of Science ®Google Scholar
• Vasiljevic T, Jelen P. 2001. Production of0-galactosidase for lactose hydrolysis in milk and dairy products using thermophilic lactic acid bacteria. Innov Food Sci Emerg Technol 2: 75–85.
   Google Scholar
• Vega MP, Leite RS, de Oliveira MACL. 2007. Mathematical modelling of single cell protein and ethanol production by Kluyveromyces cicerisporus fermentation on whey. Computer Aided Chem Engg 24: 1001–1006.
   Google Scholar
• Veinne P, Von Stoker U. 1983. Alcohol from whey permeate: Strain selection, temperature and medium optimisation. Biotechnol Bioeng Symp 13: 421–435.
   Google Scholar
• Venetsaneas N, Antonopoulou G, Stamatelatou K, Kornaros M, Lyberatos G. 2009. Using cheese whey for hydrogen and methane generation in a two-stage continuous process with alternative pH controlling approaches. Bioresour Technol 100: 3713–3717.
   PubMed Web of Science ®Google Scholar
• Yalcin SK, Bozdemir MT, Ozbas ZY. 2009. Utilization of whey and grape must for citric acid production by two Yarrowia lipolytica strains. Food Biotechnol 23: 266–283.
   Web of Science ®Google Scholar
• Yan JQ, Liao PH, Lo KV. 1988. Methane production from cheese whey. Biomass 17: 185–202.
   Google Scholar
• Yan JQ, Lo KV, Liao PH. 1989. Anaerobic digestion of cheese whey using up-flow anaerobic sludge blanket reactor. Biol Wastes 27: 289–305.
   Web of Science ®Google Scholar
• Yang K, Yu Y, Hwang S. 2003. Selective optimization in thermophilic acidogenesis of cheese-whey wastewater to acetic and butyric acids: partial acidification and methanation. Water Res 37: 2467–2477.
   Google Scholar
• Yang P, Zhang R, McGarvey JA, Benemann JR. 2007. Biohydrogen production from cheese processing wastewater by anaerobic fermentation using mixed microbial communities. Intl J Hydrogen Energy 32: 4761–4771.
   Web of Science ®Google Scholar
• Zafar S, Owais M. 2006. Ethanol production from crude whey by Kluyveromyces marxianus. Biochemical Engg J 27: 295–298.
   Web of Science ®Google Scholar
• Zayed G, Zahran AS. 1991. Lactic acid production from salt whey using free and agar immobilized cells. Letts Appl Microbiol 12: 241–243.
   Web of Science ®Google Scholar
• Zayed G, Winter J. 2000. Inhibition of methane production from whey by heavy metals–protective effect of sulfide. Appl Microbiol Biotechnol 53: 726–731.
   PubMed Web of Science ®Google Scholar