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Review Article

Yeast killer toxins, molecular mechanisms of their action and their applications

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Pages 222-234 | Received 02 Oct 2012, Accepted 07 Aug 2013, Published online: 09 Oct 2013

References

  • Ahmed A, Sesti F, Ilan N, et al. (1999). A molecular target for viral killer toxin: TOK1 potassium channels. Cell, 99, 283–91
  • Antunes J, Aguiar C. (2012). Search for killer phenotypes with potential for biological control. Ann Microbiol, 62, 427--33
  • Bajaj BK, Sharma S. (2010). Construction of killer industrial yeast Saccharomyces cerevisiae and its fermentation performance. Braz J Microbiol, 41, 477–85
  • Bajaj BK, Raina S, Singh S. (2013). Killer toxin from a novel killer yeast Pichia kudriavzevii RY55 with idiosyncratic antibacterial activity. J Basic Microbiol, 53, 645–56
  • Breinig F, Tipper DJ, Schmitt MJ. (2002). Kre1p, the plasma membrane receptor for the yeast K1 viral toxin. Cell, 108, 395–405
  • Brown DW. (2011). The KP4 killer protein gene family. Curr Genet, 57, 51–62
  • Buzdar MA, Chi Z, Wang Q, et al. (2011). Production, purification, and characterization of a novel killer toxin from Kluyveromyces siamensis against a pathogenic yeast in crab. Appl Microbiol Biotechnol, 91, 1571–9
  • Buzzini P, Corazzi L, Turchetti B, et al. (2004). Characterization of the in vitro antimycotic activity of a novel killer protein from Williopsis saturnus DBVPG 4561 against emerging pathogenic yeasts. FEMS Microbiol Lett, 238, 359–65
  • Chen WB, Han YF, Jong SC, Chang SC. (2000). Isolation, purification, and characterization of a killer protein from Schwanniomyces occidentalis. Appl Environ Microbiol, 66, 5348–52
  • Chi ZM, Chi Z, Zhang T, et al. (2009). Production, characterization and gene cloning of the extracellular enzymes from the marine-derived yeasts and their potential applications. Biotechnol Adv, 27, 236–55
  • Chi ZM, Liu GL, Zhao SF, et al. (2010). Marine yeasts as biocontrol agents and producers of bio-products. Appl Microbiol Biotechnol, 86, 1227–41
  • Coelho AR, Tachi M, Pagnocca FC, et al. (2009). Purification of Candida guilliermondii and Pichia ohmeri killer toxin as an active agent against Penicillium expansum. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 26, 73–81
  • Ciani M, Fatichenti F. (2001). Killer toxin of Kluyveromyces phaffii DBVPG 6076 as a biopreservative agent to control apiculate wine yeasts. Appl Environ Microbiol, 67, 3058–63
  • Comitini F, Di Pietro N, Zacchi L, et al. (2004). Kluyveromyces phaffii killer toxin active against wine spoilage yeasts: purification and characterization. Microbiol, 150, 2535–41
  • Comitini F, Mannazzu I, Ciani M. (2009). Tetrapisispora phaffii killer toxin is a highly specific β-glucanase that disrupts the integrity of the yeast cell wall. Microb Cell Fact, 8, 1–11
  • Comitini F, Ciani M. (2011). Kluyveromyces wickerhamii killer toxin: purification and activity towards Brettanomyces/Dekkera yeasts in grape must. FEMS Microbiol Lett, 316, 77–82
  • da Silva S, Calado S, Lucas C, Aguiar C. (2008). Unusual properties of the halotolerant yeast Candida nodaensis killer toxin. CnKT Microbiol Res, 163, 243–51
  • De Ingeniis J, Raffaelli N, Ciani M, Mannazzu I. (2009). Pichia anomala DBVPG 3003 secretes a ubiquitin-like protein that has antimicrobial activity. Appl Environ Microbiol, 75, 1129–34
  • Flegelova H, Chaloupka R, Novotna D, et al. (2008). Changes in plasma membrane fluidity lower the sensitivity of S. cerevisiae to killer toxin K1. Folia Microbiol, 48, 761–6
  • Gage MJ, Bruenn J, Fischer M, et al. (2001). KP4 fungal toxin inhibits growth in Ustilago maydis by blocking calcium uptake. Mole Microbiol, 41, 775–85
  • Guo FJ, Ma Y, Xu HM, et al. (2013). A novel killer toxin produced by the marine-derived yeast Wickerhamomyces anomalus YF07b. Antonie van Leeuwenhoek, 103, 737–46
  • Guyard C, Dehecq E, Tissier JP, et al. (2002). Involvement of β-glucans in the wide spectrum antimicrobial activity of Williopsis saturnus var. mrakii MUCL 41968 killer toxin. Mol Med, 8, 686–94
  • Golubev WI, Pfeiffer I, Golub EW. (2006). Mycocin production in Pseudozyma tsukubaensis. Mycopathol, 162, 313–6
  • Hua MX, Chi Z, Liu GL, et al. (2010). Production of a novel and cold-active killer toxin by Mrakia frigida 2E00797 isolated from sea sediment in Antarctica. Extremophiles, 14, 515–21
  • Jablonowski D, Zink S, Mehlgarten C, et al. (2006). tRNAGlu wobble uridine methylation by Trm9 identifies elongator’s key role for zymocin-induced cell death in yeast. Mole Microbiol, 59, 677–88
  • Kasahara S, Yamada H, Mio T, et al. (1994). Cloning of the Saccharomyces cerevisiae gene whose overexpression overcomes the effects of HM-1 killer toxin, which inhibits β-glucan synthesis. J Bacteriol, 176, 1488–99
  • Keszthelyi A, Ohkusu M, Takeo K, et al. (2006). Characterisation of the anticryptococcal effect of the FC-1 toxin produced by Filobasidium capsuligenum. Mycoses, 49, 176–83
  • Kimura T, Kitamoto N, Iimura Y, Kito Y. (1995). Production of HM-1 killer toxin in Saccharomyces cerevisiae transformed with the PDM gene and δ-sequence-mediated multi-integration system. J Ferment Bioeng, 80, 423–8
  • Kimura T, Kitamoto N, Kito Y, et al. (1997). A novel yeast gene, RHK1, is involved in the synthesis of the cell wall receptor for the HM-1 killer toxin that inhibits β-1,3-glucan synthesis. Mole Gen Genet, 254, 139–47
  • Kimura T, Komiyama T, Furuichi Y, et al. (1999). N-glycosylation is involved in the sensitivity of Saccharomyces cerevisiae to HM-1 killer toxin secreted from Hansenula mrakii IFO 0895. Appl Microbiol Biotechnol, 51, 176–84
  • Klassen R, Meinhardt F. (2002). Linear plasmids pWR1A and pWR1B of the yeast Wingea robertsiae are associated with a killer phenotype. Plasmid, 48, 142–8
  • Klassen R, Meinhardt F. (2003). Structural and functional analysis of the killer element pPin1-3 from Pichia inositovora. Mol Gen Genom, 290, 190–9
  • Klassen R, Teichert S, Meinhardt F. (2004). Novel yeast killer toxins provoke S-phase arrest and DNA damage checkpoint activation. Mole Microbiol, 53, 263–73
  • Klassen R, Meinhardt F. (2005). Induction of DNA damage and apoptosis in Saccharomyces cerevisiae by a yeast killer toxin. Cell Microbiol, 7, 393–401
  • Klassen R, Paluszynski JP, Wemhoff S, et al. (2008). The primary target of the killer toxin from Pichia acaciae is tRNAGln. Mole Microbiol, 69, 681–97
  • Liu SQ, Tsao M. (2009). Inhibition of spoilage yeasts in cheese by killer yeast Williopsis saturnus var. saturnus. Int J Food Microbiol, 131, 280–2
  • Liu GL, Ke Wang K, Hua MX, et al. (2012). Purification and characterization of the cold-active killer toxin from the psychrotolerant yeast Mrakia frigida isolated from sea sediments in Antarctica. Proc Biochem, 47, 822–7
  • Llorente P, Marquina D, Santos A, et al. (1997). Effect of salt on the killer phenotype of yeasts from olive brines. Appl Environ Microbiol, 63, 1165–7
  • Magliani W, Conti S, Gerloni M, et al. (1997). Yeast killer systems. Clin Microbiol Rev, 10, 369–400
  • Magliani W, Conti S, Travassos LR, Polonelli L. (2008). From yeast killer toxins to antibiobodies and beyond. FEMS Microbiol Lett, 288, 1–8
  • Marquina DA, Barroso J, Santos A, Peinado JM. (2001). Production and characteristics of Debaryomyces hansenii killer toxin. Microbiol Res, 156, 387–91
  • Marquina DA, Santos A, Peinado JM. (2002). Biology of killer yeasts. Int Microbiol, 5, 65–71
  • Mehlgarten C, Schaffrath R. (2004). After chitin docking, toxicity of Kluyveromyces lactis zymocin requires Saccharomyces cerevisiae plasma membrane H+-ATPase. Cel Microbiol, 6, 569–80
  • Miyamoto M, Onozato N, Selvakumar D, et al. (2006). The role of the histidine-35 residue in the cytocidal action of HM-1 killer toxin. Microbiol, 152, 2951–8
  • Naumov GI, Kondratieva VJ, Naumova ES, et al. (2011). Polymorphism and species-specificity of killer activity formation in the yeast Zygowilliopsis californica. Biotechnologiya, 3, 29–33 (in Russian)
  • Novotn D, Flegelov H, Janderov B. (2004). Different action of killer toxins K1 and K2 on the plasma membrane and the cell wall of Saccharomyces cerevisiae. FEMS Yeast Res, 4, 803–13
  • Peng, Y, Chi ZM, Wang XH, Li J. (2009). Purification and molecular characterization of exo-β-1, 3-glucanases from the marine yeast Williopsis saturnus WC91-2. Appl Microbiol Biotechnol, 85, 85–94
  • Peng Y, Chi ZM, Wang XH, Li J. (2010). β-1, 3-Glucanase inhibits activity of the killer toxin produced by the marine-derived yeast Williopsis saturnus WC91-2. Mar Biotechnol, 12, 479–85
  • Polonelli L, Magliani W, Ciociola T, et al. (2011). From Pichia anomala killer toxin through killer antibodies to killer peptides for a comprehensive anti-infective strategy. Antonie van Leeuwenhoek, 99, 35–41
  • Price WS, Tsuchiya F, Suzuki C, Arata Y. (1999). Characterization of the solution properties of Pichia farinosa killer toxin using PGSE NMR diffusion measurements. J Biomole NMR, 13, 113–7
  • Rodríguez-Cousino N, Maqueda M, Ambrona J, et al. (2011). A new wine Saccharomyces cerevisiae killer toxin (Klus), encoded by a double-stranded RNA virus, with broad antifungal activity is evolutionarily related to a chromosomal host gene. Appl Environ Microbiol, 77, 1822–32
  • Santos A, Marquina D, Leal JA, Peinado JM. (2000). (1-6)-β-D-Glucan as cell wall receptor for Pichia membranifaciens killer toxin. Appl Environ Microbiol, 66, 1809–13
  • Santos A, Marquina D, Barroso J, Peinado JM. (2002). (1-6)-β-D-glucan as the cell wall binding site for Debaryomyces hansenii killer toxin. Lett Appl Microbiol, 34, 95–9
  • Santos A, Marquina D. (2004). Killer toxin of Pichia membranifaciens and its possible use as a biocontrol agent against grey mould disease of grapevine. Microbiol, 150, 2527–34
  • Santos A, Mauro MS, Abrusci C, Marquina D. (2007). Cwp2p, the plasma membrane receptor for Pichia membranifaciens killer toxin. Mole Microbiol, 64, 831–43
  • Santos A, San Mauro A, Bravo E, Marquina D. (2009). PMKT2, a new killer toxin from Pichia membranifaciens, and its promising biotechnological properties for control of the spoilage yeast Brettanomyces bruxellensis. Microbiol, 155, 624–34
  • Santos A, Navascués E, Bravo E, Marquina D. (2011). Ustilago maydis killer toxin as a new tool for the biocontrol of the wine spoilage yeast Brettanomyces bruxellensis. Intern J Food Microbiol, 145, 147–54
  • Schmitt MJ, Breinig F. (2002). The viral killer system in yeast: from molecular biology to application. FEMS Microbiol Rev, 26, 257–76
  • Schmitt MJ, Breinig F. (2006). Yeast viral killer toxins: lethality and self-protection. Nat Rev Microbiol, 4, 212–21
  • Schaffrath R, Meinhardt F. (2005). Kluyveromyces lactis zymocin and other plasmid-encoded yeast killer toxins. In: Schmitt MJ, Schaffrath R, eds. Topics in current genetics, Vol 11: Microbial protein toxins. Berlin, Heidelberg: Springer-Verlag, 131--55
  • Sun HY, Wang K, Chi Z, et al. (2012). Simultaneous production of single cell protein and killer toxin by Wickerhamomyces anomalus HN1-2 isolated from mangrove ecosystem. Proc Biochem, 47, 251--256
  • Suzuki C, Nikkuni S. (1994). The primary and subunit structure of a novel type killer toxin produced by a halotolerant yeast Pichia farinose. J Biol Chem, 269, 3041–6
  • Suzuki C, Ando Y, Machida S. (2001). Interaction of SMKT, a killer toxin produced by Pichia farinosa, with the yeast cell membranes. Yeast, 18, 1471–8
  • Suzuki C. (2004). Acidophilic structure and killing mechanism of the Pichia farinosa killer toxin SMKT. In: Schmitt MJ, Schaffrath R, eds. Microbial Protein Toxins. Vol 11. Berlin, Heidelberg: Springer-Verlag, 189–214
  • Wang X, Chi ZM, Yue L, et al. (2007a). A marine killer yeast against the pathogenic yeast strain in crab (Portunus trituberculatus) and an optimization of the toxin production. Microbiol Res, 162, 77–85
  • Wang XH, Chi ZM, Yue L, Li J. (2007b). Purification and characterization of killer toxin from a marine yeast Pichia anomala YF07b against the pathogenic yeast in crab. Curr Microbiol, 55, 396–401
  • Wang XH, Chi ZM, Li J. (2007c). Isolation and identification of a marine killer yeast strain YF07b and cloning of the gene encoding killer toxin from the yeast. Acta Oceanol Sin, 26, 101–8
  • Wang L, Yue L, Chi ZM, Wang X. (2008). Marine killer yeasts active against a yeast strain pathogenic to crab Portunus trituberculatus. Dis Aquat Organ, 80, 211–8
  • Wang XX, Chi Z, Peng Y, et al. (2012). Purification, characterization and gene cloning of the killer toxin produced by the marine-derived yeast Williopsis saturnus WC91-2. Microbiol Res, 167, 558–63
  • Weiler F, Rehfeldt K, Bautz F, Schmitt MJ. (2002). The Zygosaccharomyces bailii antifungal virus toxin zygocin: cloning and expression in a heterologous fungal host. Mole Microbiol, 46, 1095–105
  • Weiler F, Schmitt MJ. (2003). Zygocin, a secreted antifungal toxin of the yeast Zygosaccharomyces bailii, and its effect on sensitive fungal cells. FEMS Yeast Res, 3, 69–76
  • Xu WJ, Xu HX, Jin HW. (2003). Studies on milky disease of Portunus trituberculatus. J Oceanol Zhejiang Province, 3, 209–13
  • Xu JL, Zhang X, Sun HY, Chi ZM. (2012). Disruption of the gene encoding β-1, 3-glucanase in marine-derived Williopsis saturnus WC91-2 enhances its killer toxin activity. Mar Biotechnol, 14, 261–9

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